Primary Site >> Colorectal Cancer
Gene >> KEAP1
| 1. | |||||||||||
| Journal: | Mutat Res. 2005 Dec 11;591(1-2):74-92. | ||||||||||
| Title: | Modulation of xenobiotic metabolising enzymes by anticarcinogens -- focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis. | ||||||||||
| Author: | Pool-Zobel, Beatrice|Veeriah, Selvaraju|Bohmer, Frank-D | ||||||||||
| PMID: | 16083918 | ||||||||||
| 2. | |||||||||||
| Journal: | Chem Res Toxicol. 2008 Feb;21(2):432-44. | ||||||||||
| Title: | Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives. | ||||||||||
| Author: | Vila, Andrew|Tallman, Keri A|Jacobs, Aaron T|Liebler, Daniel C|Porter, Ned A|Marnett, Lawrence J | ||||||||||
| PMID: | 18232660 | ||||||||||
| 3. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14547-51. | ||||||||||
| Title: | Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells. | ||||||||||
| Author: | Li, Chun-Qi|Kim, Min Young|Godoy, Luiz C|Thiantanawat, Apinya|Trudel, Laura J|Wogan, Gerald N | ||||||||||
| PMID: | 19706542 | ||||||||||
| 4. | |||||||||||
| Journal: | Molecules. 2010 May 7;15(5):3338-55. | ||||||||||
| Title: | The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells. | ||||||||||
| Author: | Wondrak, Georg Thomas|Villeneuve, Nicole F|Lamore, Sarah D|Bause, Alexandra S|Jiang, Tao|Zhang, Donna D | ||||||||||
| PMID: | 20657484 | ||||||||||
| 5. | |||||||||||
| Journal: | Carcinogenesis. 2012 Mar;33(3):620-8. | ||||||||||
| Title: | Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply. | ||||||||||
| Author: | Krehl, Susanne|Loewinger, Maria|Florian, Simone|Kipp, Anna P|Banning, Antje|Wessjohann, Ludger A|Brauer, Martin N|Iori, Renato|Esworthy, Robert S|Chu, Fong-Fong|Brigelius-Flohe, Regina | ||||||||||
| PMID: | 22180572 | ||||||||||
| 6. | |||||||||||
| Journal: | BMC Cancer. 2012 Feb 13;12:66. | ||||||||||
| Title: | Methylation of the KEAP1 gene promoter region in human colorectal cancer. | ||||||||||
| Author: | Hanada, Naoyuki|Takahata, Takenori|Zhou, Qiliang|Ye, Xulu|Sun, Ruowen|Itoh, Jugoh|Ishiguro, Atsushi|Kijima, Hiroshi|Mimura, Junsei|Itoh, Ken|Fukuda, Shinsaku|Saijo, Yasuo | ||||||||||
| PMID: | 22325485 | ||||||||||
| 7. | |||||||||||
| Journal: | Epigenomics. 2012 Jun;4(3):253-4. | ||||||||||
| Title: | Is there a decrease in Keap1 RNA expression in colorectal cancer cells, and is this decrease in expression due to hypermethylation? | ||||||||||
| Author: | Jazirehi, Ali R|Wenn, Peter B|Arle, Dylan | ||||||||||
| PMID: | 22872918 | ||||||||||
| 8. | |||||||||||
| Journal: | Zhonghua Nei Ke Za Zhi. 2012 Jul;51(7):531-5. | ||||||||||
| Title: | [The UGT1A, Nrf2 and Keap1 protein expression and significance in colon tumor]. | ||||||||||
| Author: | Wang, Min|Qi, Ying-ying|Chen, Shuo|Liu, Liang|Chen, Jian|Li, Yan-qing | ||||||||||
| PMID: | 22943825 | ||||||||||
| 9. | |||||||||||
| Journal: | Biol Trace Elem Res. 2013 Mar;151(3):384-99. | ||||||||||
| Title: | Feeding of selenium alone or in combination with glucoraphanin differentially affects intestinal and hepatic antioxidant and phase II enzymes in growing rats. | ||||||||||
| Author: | Blum, Nicole M|Mueller, Kristin|Lippmann, Doris|Metges, Cornelia C|Linn, Thomas|Pallauf, Josef|Mueller, Andreas S | ||||||||||
| PMID: | 23271678 | ||||||||||
| 10. | |||||||||||
| Journal: | Appl Immunohistochem Mol Morphol. 2013 Dec;21(6):511-7. | ||||||||||
| Title: | Immunohistochemical study of the Nrf2 pathway in colorectal cancer: Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue. | ||||||||||
| Author: | Chang, Liang-Che|Fan, Chung-Wei|Tseng, Wen-Ko|Chen, Jim-Ray|Chein, Hui-Ping|Hwang, Cheng-Cheng|Hua, Chung-Ching | ||||||||||
| PMID: | 23455180 | ||||||||||
| 11. | |||||||||||
| Journal: | Oxid Med Cell Longev. 2013;2013:423965. | ||||||||||
| Title: | Enhanced 4-hydroxynonenal resistance in KEAP1 silenced human colon cancer cells. | ||||||||||
| Author: | Jung, Kyeong-Ah|Kwak, Mi-Kyoung | ||||||||||
| PMID: | 23766854 | ||||||||||
| 12. | |||||||||||
| Journal: | Toxicol Mech Methods. 2014 Jan;24(1):13-20. | ||||||||||
| Title: | Luteolin, a bioflavonoid inhibits Azoxymethane-induced colorectal cancer through activation of Nrf2 signaling. | ||||||||||
| Author: | Pandurangan, Ashok Kumar|Ananda Sadagopan, Suresh Kumar|Dharmalingam, Prakash|Ganapasam, Sudhandiran | ||||||||||
| PMID: | 24024667 | ||||||||||
| 13. | |||||||||||
| Journal: | Free Radic Biol Med. 2014 May;70:68-77. | ||||||||||
| Title: | Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs. | ||||||||||
| Author: | Wang, Xiu Jun|Li, Yinyan|Luo, Lin|Wang, Hongyan|Chi, Zhexu|Xin, Ai|Li, Xin|Wu, Jiaguo|Tang, Xiuwen | ||||||||||
| PMID: | 24556415 | ||||||||||
| 14. | |||||||||||
| Journal: | Int J Oncol. 2014 Jul;45(1):426-38. | ||||||||||
| Title: | Evaluation of 2-pioglitazone, an analogue of pioglitazone, on colon cancer cell survival: Evidence of drug treatment association with autophagy and activation of the Nrf2/Keap1 pathway. | ||||||||||
| Author: | Huber, Sophie|Valente, Sergio|Chaimbault, Patrick|Schohn, Herve | ||||||||||
| PMID: | 24788124 | ||||||||||
| 15. | |||||||||||
| Journal: | Anat Rec (Hoboken). 2015 Feb;298(2):376-85. | ||||||||||
| Title: | 2-(Pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl) thiophene induces apoptosis through reactive oxygen species-mediated JNK activation in human colon cancer SW620 cells. | ||||||||||
| Author: | Xu, Dao Gun|Lv, Wang|Dai, Chun Yan|Zhu, Fan Fan|Xu, Gua Hua|Ma, Zhong Jun|Chen, Zhe | ||||||||||
| PMID: | 25178491 | ||||||||||
| 16. | |||||||||||
| Journal: | Cancer Prev Res (Phila). 2015 May;8(5):444-54. | ||||||||||
| Title: | Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde. | ||||||||||
| Author: | Long, Min|Tao, Shasha|Rojo de la Vega, Montserrat|Jiang, Tao|Wen, Qing|Park, Sophia L|Zhang, Donna D|Wondrak, Georg T | ||||||||||
| PMID: | 25712056 | ||||||||||
| 17. | |||||||||||
| Journal: | Biofactors. 2015 Jan-Feb;41(1):1-14. | ||||||||||
| Title: | Dietary cocoa protects against colitis-associated cancer by activating the Nrf2/Keap1 pathway. | ||||||||||
| Author: | Pandurangan, Ashok Kumar|Saadatdoust, Zeinab|Esa, Norhaizan Mohd|Hamzah, Hazilawati|Ismail, Amin | ||||||||||
| PMID: | 25545372 | ||||||||||
| 18. | |||||||||||
| Journal: | Oncogene. 2015 Sep 3;34(36):4692-701. | ||||||||||
| Title: | Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness. | ||||||||||
| Author: | Gong, X|Yi, J|Carmon, K S|Crumbley, C A|Xiong, W|Thomas, A|Fan, X|Guo, S|An, Z|Chang, J T|Liu, Q J | ||||||||||
| PMID: | 25531322 | ||||||||||
| 19. | |||||||||||
| Journal: | Sci Rep. 2016 May 24;6:26585. | ||||||||||
| Title: | An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis. | ||||||||||
| Author: | Lu, Meng-Chen|Ji, Jian-Ai|Jiang, Yong-Lin|Chen, Zhi-Yun|Yuan, Zhen-Wei|You, Qi-Dong|Jiang, Zheng-Yu | ||||||||||
| PMID: | 27215610 | ||||||||||
| 20. | |||||||||||
| Journal: | Dis Markers. 2016;2016:8143465. | ||||||||||
| Title: | The Ratio of Hmox1/Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer. | ||||||||||
| Author: | Chang, Liang-Che|Fan, Chung-Wei|Tseng, Wen-Ko|Chein, Hui-Ping|Hsieh, Tsan-Yu|Chen, Jim-Ray|Hwang, Cheng-Cheng|Hua, Chung-Ching | ||||||||||
| PMID: | 27999449 | ||||||||||
| 21. | |||||||||||
| Journal: | Free Radic Biol Med. 2017 Oct;111:196-208. | ||||||||||
| Title: | 4-Hydroxynonenal metabolites and adducts in pre-carcinogenic conditions and cancer. | ||||||||||
| Author: | Gueraud, Francoise | ||||||||||
| PMID: | 28065782 | ||||||||||
| 22. | |||||||||||
| Journal: | Free Radic Biol Med. 2017 Jul;108:715-724. | ||||||||||
| Title: | Oxidized 5-aminosalicylic acid activates Nrf2-HO-1 pathway by covalently binding to Keap1: Implication in anti-inflammatory actions of 5-aminosalicylic acid. | ||||||||||
| Author: | Kang, Sookjin|Kim, Wooseong|Jeong, Seongkeun|Lee, Yonghyun|Nam, Joon|Lee, Sunyoung|Jung, Yunjin | ||||||||||
| PMID: | 28473247 | ||||||||||
| 23. | |||||||||||
| Journal: | PLoS One. 2017 May 18;12(5):e0177549. | ||||||||||
| Title: | The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review. | ||||||||||
| Author: | Gonzalez-Donquiles, C|Alonso-Molero, J|Fernandez-Villa, T|Vilorio-Marques, L|Molina, A J|Martin, V | ||||||||||
| PMID: | 28542357 | ||||||||||
| 24. | |||||||||||
| Journal: | Tumour Biol. 2017 Jun;39(6):1010428317705510. | ||||||||||
| Title: | The role of Nrf2-Keap1 axis in colorectal cancer, progression, and chemoresistance. | ||||||||||
| Author: | Sadeghi, Mohammad Reza|Jeddi, Farhad|Soozangar, Narges|Somi, Mohammad Hossein|Samadi, Nasser | ||||||||||
| PMID: | 28621229 | ||||||||||
| 25. | |||||||||||
| Journal: | Biomark Med. 2017 Dec;11(12):1103-1111. | ||||||||||
| Title: | The ratio of thioredoxin/Keap1 protein level is a predictor of distant metastasis in colorectal cancer. | ||||||||||
| Author: | Chang, Liang-Che|Fan, Chung-Wei|Tseng, Wen-Ko|Chein, Hui-Ping|Hsieh, Tsan-Yu|Chen, Jim-Ray|Hwang, Cheng-Cheng|Hua, Chung-Ching | ||||||||||
| PMID: | 29053012 | ||||||||||
| 26. | |||||||||||
| Journal: | Pharmacol Ther. 2018 Jun;186:138-151. | ||||||||||
| Title: | CCRK is a novel signalling hub exploitable in cancer immunotherapy. | ||||||||||
| Author: | Mok, Myth T|Zhou, Jingying|Tang, Wenshu|Zeng, Xuezhen|Oliver, Antony W|Ward, Simon E|Cheng, Alfred S | ||||||||||
| PMID: | 29360538 | ||||||||||
| 27. | |||||||||||
| Journal: | Food Funct. 2018 May 23;9(5):2809-2819. | ||||||||||
| Title: | Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway. | ||||||||||
| Author: | Bi, Wu|He, Chun-Nian|Li, Xiao-Xiao|Zhou, Liu-Ying|Liu, Rui-Jie|Zhang, Sai|Li, Guo-Qing|Chen, Zhu-Chu|Zhang, Peng-Fei | ||||||||||
| PMID: | 29693091 | ||||||||||
| 28. | |||||||||||
| Journal: | Biomed Pharmacother. 2018 Aug;104:458-464. | ||||||||||
| Title: | Nrf2/P-glycoprotein axis is associated with clinicopathological characteristics in colorectal cancer. | ||||||||||
| Author: | Sadeghi, Mohammad Reza|Jeddi, Farhad|Soozangar, Narges|Somi, Mohammad Hossein|Shirmohamadi, Masoud|Khaze, Vahid|Samadi, Nasser | ||||||||||
| PMID: | 29793178 | ||||||||||
| 29. | |||||||||||
| Journal: | Biochim Biophys Acta Mol Basis Dis. 2018 Sep 26;1864(12):3668-3678. | ||||||||||
| Title: | Senescence marker protein 30 protects intestinal epithelial cells against inflammation-induced cell death by enhancing Nrf2 activity. | ||||||||||
| Author: | Choo, Jieun|Heo, Gwangbeom|Kim, Su Jin|Lee, Yunna|Ishigami, Akihito|Maruyama, Naoki|Chung, Hae Young|Im, Eunok | ||||||||||
| PMID: | 30266650 | ||||||||||