Primary Site >> Colorectal Cancer
Gene >> KEAP1
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Ref: Modulation of xenobiotic metabolising enzymes by anticarcinogens -- focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis. PMID: 16083918 |
Ref: Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives. PMID: 18232660 |
Ref: Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells. PMID: 19706542 |
Ref: The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells. PMID: 20657484 |
Ref: Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply. PMID: 22180572 Ref: Methylation of the KEAP1 gene promoter region in human colorectal cancer. PMID: 22325485 Ref: Is there a decrease in Keap1 RNA expression in colorectal cancer cells, and is this decrease in expression due to hypermethylation? PMID: 22872918 Ref: [The UGT1A, Nrf2 and Keap1 protein expression and significance in colon tumor]. PMID: 22943825 |
Ref: Feeding of selenium alone or in combination with glucoraphanin differentially affects intestinal and hepatic antioxidant and phase II enzymes in growing rats. PMID: 23271678 Ref: Immunohistochemical study of the Nrf2 pathway in colorectal cancer: Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue. PMID: 23455180 Ref: Enhanced 4-hydroxynonenal resistance in KEAP1 silenced human colon cancer cells. PMID: 23766854 |
Ref: Luteolin, a bioflavonoid inhibits Azoxymethane-induced colorectal cancer through activation of Nrf2 signaling. PMID: 24024667 Ref: Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs. PMID: 24556415 Ref: Evaluation of 2-pioglitazone, an analogue of pioglitazone, on colon cancer cell survival: Evidence of drug treatment association with autophagy and activation of the Nrf2/Keap1 pathway. PMID: 24788124 |
Ref: 2-(Pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl) thiophene induces apoptosis through reactive oxygen species-mediated JNK activation in human colon cancer SW620 cells. PMID: 25178491 Ref: Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness. PMID: 25531322 Ref: Dietary cocoa protects against colitis-associated cancer by activating the Nrf2/Keap1 pathway. PMID: 25545372 Ref: Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde. PMID: 25712056 |
Ref: An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis. PMID: 27215610 Ref: The Ratio of Hmox1/Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer. PMID: 27999449 |
Ref: 4-Hydroxynonenal metabolites and adducts in pre-carcinogenic conditions and cancer. PMID: 28065782 Ref: Oxidized 5-aminosalicylic acid activates Nrf2-HO-1 pathway by covalently binding to Keap1: Implication in anti-inflammatory actions of 5-aminosalicylic acid. PMID: 28473247 Ref: The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review. PMID: 28542357 Ref: The role of Nrf2-Keap1 axis in colorectal cancer, progression, and chemoresistance. PMID: 28621229 Ref: The ratio of thioredoxin/Keap1 protein level is a predictor of distant metastasis in colorectal cancer. PMID: 29053012 |
Ref: CCRK is a novel signalling hub exploitable in cancer immunotherapy. PMID: 29360538 Ref: Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway. PMID: 29693091 Ref: Nrf2/P-glycoprotein axis is associated with clinicopathological characteristics in colorectal cancer. PMID: 29793178 Ref: Senescence marker protein 30 protects intestinal epithelial cells against inflammation-induced cell death by enhancing Nrf2 activity. PMID: 30266650 |