Primary Site >> Pancreatic Cancer
Gene >> JAK2
| 1. | |||||||||||
| Journal: | J Biol Chem. 2005 Mar 18;280(11):10710-5. Epub 2005 Jan 7. | ||||||||||
| Title: | A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models. | ||||||||||
| Author: | Ferrand, Audrey|Kowalski-Chauvel, Aline|Bertrand, Claudine|Escrieut, Chantal|Mathieu, Anne|Portolan, Ghislaine|Pradayrol, Lucien|Fourmy, Daniel|Dufresne, Marlene|Seva, Catherine | ||||||||||
| PMID: | 15640156 | ||||||||||
| 2. | |||||||||||
| Journal: | Gastroenterology. 2007 Nov;133(5):1637-48. Epub 2007 Aug 14. | ||||||||||
| Title: | NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases. | ||||||||||
| Author: | Lee, Jong Kyun|Edderkaoui, Mouad|Truong, Patrick|Ohno, Izumi|Jang, Kee-Taek|Berti, Andrea|Pandol, Stephen J|Gukovskaya, Anna S | ||||||||||
| PMID: | 17983808 | ||||||||||
| 3. | |||||||||||
| Journal: | Cancer Res. 2009 Jul 15;69(14):5876-84. | ||||||||||
| Title: | Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells. | ||||||||||
| Author: | Thoennissen, Nils H|Iwanski, Gabriela B|Doan, Ngan B|Okamoto, Ryoko|Lin, Patricia|Abbassi, Sam|Song, Jee Hoon|Yin, Dong|Toh, Melvin|Xie, Wei Dong|Said, Jonathan W|Koeffler, H Phillip | ||||||||||
| PMID: | 19605406 | ||||||||||
| 4. | |||||||||||
| Journal: | Mol Cancer. 2010 Apr 23;9:88. | ||||||||||
| Title: | Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells. | ||||||||||
| Author: | Erkan, Mert|Weis, Nadine|Pan, Zheng|Schwager, Christian|Samkharadze, Tamar|Jiang, Xiaohua|Wirkner, Ute|Giese, Nathalia A|Ansorge, Wilhelm|Debus, Jurgen|Huber, Peter E|Friess, Helmut|Abdollahi, Amir|Kleeff, Jorg | ||||||||||
| PMID: | 20416094 | ||||||||||
| 5. | |||||||||||
| Journal: | Anticancer Res. 2011 Jun;31(6):2029-35. | ||||||||||
| Title: | LLL12 inhibits endogenous and exogenous interleukin-6-induced STAT3 phosphorylation in human pancreatic cancer cells. | ||||||||||
| Author: | Liu, Aiguo|Liu, Yan|Li, Pui-Kai|Li, Chenglong|Lin, Jiayuh | ||||||||||
| PMID: | 21737619 | ||||||||||
| 6. | |||||||||||
| Journal: | PLoS One. 2013 May 1;8(5):e61532. | ||||||||||
| Title: | Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice. | ||||||||||
| Author: | Mackenzie, Gerardo G|Huang, Liqun|Alston, Ninche|Ouyang, Nengtai|Vrankova, Kvetoslava|Mattheolabakis, George|Constantinides, Panayiotis P|Rigas, Basil | ||||||||||
| PMID: | 23650499 | ||||||||||
| 7. | |||||||||||
| Journal: | Clin Cancer Res. 2013 Apr 15;19(8):1933-40. | ||||||||||
| Title: | Molecular pathways: Jak/STAT pathway: mutations, inhibitors, and resistance. | ||||||||||
| Author: | Quintas-Cardama, Alfonso|Verstovsek, Srdan | ||||||||||
| PMID: | 23406773 | ||||||||||
| 8. | |||||||||||
| Journal: | Mol Oncol. 2013 Jun;7(3):369-78. | ||||||||||
| Title: | Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells. | ||||||||||
| Author: | Nam, Sangkil|Wen, Wei|Schroeder, Anne|Herrmann, Andreas|Yu, Hua|Cheng, Xinlai|Merz, Karl-Heinz|Eisenbrand, Gerhard|Li, Hongzhi|Yuan, Yate-Ching|Jove, Richard | ||||||||||
| PMID: | 23206899 | ||||||||||
| 9. | |||||||||||
| Journal: | Oncogene. 2013 Mar 14;32(11):1384-95. | ||||||||||
| Title: | Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through alpha7nAChR-mediated MUC4 upregulation. | ||||||||||
| Author: | Momi, N|Ponnusamy, M P|Kaur, S|Rachagani, S|Kunigal, S S|Chellappan, S|Ouellette, M M|Batra, S K | ||||||||||
| PMID: | 22614008 | ||||||||||
| 10. | |||||||||||
| Journal: | Carcinogenesis. 2014 Apr;35(4):859-66. | ||||||||||
| Title: | Combined inhibition of Notch and JAK/STAT is superior to monotherapies and impairs pancreatic cancer progression. | ||||||||||
| Author: | Palagani, Vindhya|Bozko, Przemyslaw|El Khatib, Mona|Belahmer, Hanane|Giese, Nathalia|Sipos, Bence|Malek, Nisar P|Plentz, Ruben R | ||||||||||
| PMID: | 24293409 | ||||||||||
| 11. | |||||||||||
| Journal: | Cancer Lett. 2014 May 28;347(1):54-64. | ||||||||||
| Title: | MicroRNA let-7 downregulates STAT3 phosphorylation in pancreatic cancer cells by increasing SOCS3 expression. | ||||||||||
| Author: | Patel, Kripa|Kollory, Anita|Takashima, Asami|Sarkar, Sibaji|Faller, Douglas V|Ghosh, Sajal K | ||||||||||
| PMID: | 24491408 | ||||||||||
| 12. | |||||||||||
| Journal: | J Cell Physiol. 2014 Oct;229(10):1437-43. | ||||||||||
| Title: | Pancreatic cancer-induced cachexia is Jak2-dependent in mice. | ||||||||||
| Author: | Gilabert, Marine|Calvo, Ezequiel|Airoldi, Ana|Hamidi, Tewfik|Moutardier, Vincent|Turrini, Olivier|Iovanna, Juan | ||||||||||
| PMID: | 24648112 | ||||||||||
| 13. | |||||||||||
| Journal: | Oncol Rep. 2014 Dec;32(6):2824-30. | ||||||||||
| Title: | MicroRNA-216a inhibits pancreatic cancer by directly targeting Janus kinase 2. | ||||||||||
| Author: | Wang, Siliang|Chen, Xiaodong|Tang, Meiyue | ||||||||||
| PMID: | 25220761 | ||||||||||
| 14. | |||||||||||
| Journal: | Oncotarget. 2015 Dec 29;6(42):44509-22. | ||||||||||
| Title: | Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer. | ||||||||||
| Author: | Mace, Thomas A|Shakya, Reena|Elnaggar, Omar|Wilson, Kristin|Komar, Hannah M|Yang, Jennifer|Pitarresi, Jason R|Young, Gregory S|Ostrowski, Michael C|Ludwig, Thomas|Bekaii-Saab, Tanios|Bloomston, Mark|Lesinski, Gregory B | ||||||||||
| PMID: | 26575024 | ||||||||||
| 15. | |||||||||||
| Journal: | Sci Rep. 2015 Nov 4;5:16067. | ||||||||||
| Title: | Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer. | ||||||||||
| Author: | Niu, Zheyu|Wang, Mengyi|Zhou, Li|Yao, Lutian|Liao, Quan|Zhao, Yupei | ||||||||||
| PMID: | 26530532 | ||||||||||
| 16. | |||||||||||
| Journal: | Cancer Res. 2015 Nov 15;75(22):4852-62. | ||||||||||
| Title: | IL17 Functions through the Novel REG3beta-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer. | ||||||||||
| Author: | Loncle, Celine|Bonjoch, Laia|Folch-Puy, Emma|Lopez-Millan, Maria Belen|Lac, Sophie|Molejon, Maria Ines|Chuluyan, Eduardo|Cordelier, Pierre|Dubus, Pierre|Lomberk, Gwen|Urrutia, Raul|Closa, Daniel|Iovanna, Juan L | ||||||||||
| PMID: | 26404002 | ||||||||||
| 17. | |||||||||||
| Journal: | J Clin Oncol. 2015 Dec 1;33(34):4039-47. | ||||||||||
| Title: | Randomized, Double-Blind, Phase II Study of Ruxolitinib or Placebo in Combination With Capecitabine in Patients With Metastatic Pancreatic Cancer for Whom Therapy With Gemcitabine Has Failed. | ||||||||||
| Author: | Hurwitz, Herbert I|Uppal, Nikhil|Wagner, Stephanie A|Bendell, Johanna C|Beck, J Thaddeus|Wade, Seaborn M 3rd|Nemunaitis, John J|Stella, Philip J|Pipas, J Marc|Wainberg, Zev A|Manges, Robert|Garrett, William M|Hunter, Deborah S|Clark, Jason|Leopold, Lance| | ||||||||||
| PMID: | 26351344 | ||||||||||
| 18. | |||||||||||
| Journal: | FEBS Lett. 2015 Aug 4;589(17):2224-32. | ||||||||||
| Title: | miR-216a may inhibit pancreatic tumor growth by targeting JAK2. | ||||||||||
| Author: | Hou, Bao-hua|Jian, Zhi-xiang|Cui, Peng|Li, Shao-jie|Tian, Rui-qing|Ou, Jin-rui | ||||||||||
| PMID: | 26149212 | ||||||||||
| 19. | |||||||||||
| Journal: | Oncotarget. 2015 Jun 30;6(18):16120-34. | ||||||||||
| Title: | Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production. | ||||||||||
| Author: | Fan, Yingchao|Gan, Yu|Shen, Yuling|Cai, Xiaojin|Song, Yanfang|Zhao, Fangyu|Yao, Ming|Gu, Jianren|Tu, Hong | ||||||||||
| PMID: | 25948792 | ||||||||||
| 20. | |||||||||||
| Journal: | Cancer Lett. 2015 Jun 28;362(1):45-60. | ||||||||||
| Title: | REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involvement of a REG3A-JAK2/STAT3 positive feedback loop. | ||||||||||
| Author: | Liu, Xiulan|Wang, Jun|Wang, Hongjie|Yin, Guoxiao|Liu, Yang|Lei, Xiang|Xiang, Ming | ||||||||||
| PMID: | 25779676 | ||||||||||
| 21. | |||||||||||
| Journal: | Oncotarget. 2015 Mar 20;6(8):5772-87. | ||||||||||
| Title: | Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells. | ||||||||||
| Author: | Das, Srustidhar|Rachagani, Satyanarayana|Torres-Gonzalez, Maria P|Lakshmanan, Imayavaramban|Majhi, Prabin D|Smith, Lynette M|Wagner, Kay-Uwe|Batra, Surinder K | ||||||||||
| PMID: | 25691062 | ||||||||||
| 22. | |||||||||||
| Journal: | Cancer Genet. 2015 Sep;208(9):441-7. | ||||||||||
| Title: | Diagnostic yield of targeted next generation sequencing in various cancer types: an information-theoretic approach. | ||||||||||
| Author: | Hagemann, Ian S|O'Neill, Patrick K|Erill, Ivan|Pfeifer, John D | ||||||||||
| PMID: | 26227479 | ||||||||||
| 23. | |||||||||||
| Journal: | Pancreas. 2016 Mar;45(3):409-19. | ||||||||||
| Title: | Blockage of STAT3 Signaling Pathway by Morusin Induces Apoptosis and Inhibits Invasion in Human Pancreatic Tumor Cells. | ||||||||||
| Author: | Kim, Chulwon|Kim, Jin Ho|Oh, Eun Young|Nam, Dongwoo|Lee, Seok Geun|Lee, Junhee|Kim, Sung-Hoon|Shim, Bum Sang|Ahn, Kwang Seok | ||||||||||
| PMID: | 26646273 | ||||||||||
| 24. | |||||||||||
| Journal: | Eur J Cancer. 2016 Jan;52:109-19. | ||||||||||
| Title: | Targeting the Janus-activated kinase-2-STAT3 signalling pathway in pancreatic cancer using the HSP90 inhibitor ganetespib. | ||||||||||
| Author: | Nagaraju, Ganji Purnachandra|Mezina, Anya|Shaib, Walid L|Landry, Jerome|El-Rayes, Bassel F | ||||||||||
| PMID: | 26682870 | ||||||||||
| 25. | |||||||||||
| Journal: | Gastroenterology. 2016 Jul;151(1):180-193.e12. | ||||||||||
| Title: | Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival. | ||||||||||
| Author: | Wormann, Sonja M|Song, Liang|Ai, Jiaoyu|Diakopoulos, Kalliope N|Kurkowski, Magdalena U|Gorgulu, Kivanc|Ruess, Dietrich|Campbell, Andrew|Doglioni, Claudio|Jodrell, Duncan|Neesse, Albrecht|Demir, Ihsan E|Karpathaki, Angelica-Phaedra|Barenboim, Maxim|Hageman | ||||||||||
| PMID: | 27003603 | ||||||||||
| 26. | |||||||||||
| Journal: | Oncotarget. 2016 May 17;7(20):29177-86. | ||||||||||
| Title: | Which patients with para-aortic lymph node (LN16) metastasis will truly benefit from curative pancreaticoduodenectomy for pancreatic head cancer? | ||||||||||
| Author: | Liu, Chen|Lu, Yu|Luo, Guopei|Cheng, He|Guo, Meng|Liu, Zuqiang|Xu, Jin|Long, Jiang|Liu, Liang|Fu, Deliang|Ni, Quanxing|Li, Min|Yu, Xianjun | ||||||||||
| PMID: | 27081079 | ||||||||||
| 27. | |||||||||||
| Journal: | Bull Cancer. 2016 Jul-Aug;103(7-8):643-50. | ||||||||||
| Title: | [New molecular classification of colorectal cancer, pancreatic cancer and stomach cancer: Towards "a la carte" treatment?]. | ||||||||||
| Author: | Dreyer, Chantal|Afchain, Pauline|Trouilloud, Isabelle|Andre, Thierry | ||||||||||
| PMID: | 27345450 | ||||||||||
| 28. | |||||||||||
| Journal: | Onco Targets Ther. 2016 Jul 11;9:4225-37. | ||||||||||
| Title: | Interleukin-32alpha inactivates JAK2/STAT3 signaling and reverses interleukin-6-induced epithelial-mesenchymal transition, invasion, and metastasis in pancreatic cancer cells. | ||||||||||
| Author: | Chen, Jingfeng|Wang, Silu|Su, Jiadong|Chu, Guanyu|You, Heyi|Chen, Zongjing|Sun, Hongwei|Chen, Bicheng|Zhou, Mengtao | ||||||||||
| PMID: | 27471397 | ||||||||||
| 29. | |||||||||||
| Journal: | Oncol Rep. 2016 Nov;36(5):2875-2883. | ||||||||||
| Title: | Antitumor effects of herbal mixture extract in the pancreatic adenocarcinoma cell line PANC1. | ||||||||||
| Author: | Pak, Pyo June|Kang, Beob Hwa|Park, Sung Hyo|Sung, Ji Hyun|Joo, Yong Hoon|Jung, Seung Hyun|Chung, Namhyun | ||||||||||
| PMID: | 27599899 | ||||||||||
| 30. | |||||||||||
| Journal: | Oncol Rep. 2017 Mar;37(3):1545-1554. | ||||||||||
| Title: | The JAK/STAT pathway is involved in the upregulation of PD-L1 expression in pancreatic cancer cell lines. | ||||||||||
| Author: | Doi, Toshifumi|Ishikawa, Takeshi|Okayama, Tetsuya|Oka, Kaname|Mizushima, Katsura|Yasuda, Tomoyo|Sakamoto, Naoyuki|Katada, Kazuhiro|Kamada, Kazuhiro|Uchiyama, Kazuhiko|Handa, Osamu|Takagi, Tomohisa|Naito, Yuji|Itoh, Yoshito | ||||||||||
| PMID: | 28112370 | ||||||||||
| 31. | |||||||||||
| Journal: | Cell Death Dis. 2017 Sep 7;8(9):e3033. | ||||||||||
| Title: | Acceleration of pancreatic tumorigenesis under immunosuppressive microenvironment induced by Reg3g overexpression. | ||||||||||
| Author: | Liu, Xiulan|Zhou, Zhongshi|Cheng, Qi|Wang, Hongjie|Cao, Hui|Xu, Qianqian|Tuo, Yali|Jiang, Li|Zou, You|Ren, Hongyu|Xiang, Ming | ||||||||||
| PMID: | 28880262 | ||||||||||
| 32. | |||||||||||
| Journal: | Cancer Lett. 2017 Aug 28;402:213-224. | ||||||||||
| Title: | BRM/SMARCA2 promotes the proliferation and chemoresistance of pancreatic cancer cells by targeting JAK2/STAT3 signaling. | ||||||||||
| Author: | Zhang, Zhengkui|Wang, Feng|Du, Chong|Guo, Huahu|Ma, Ling|Liu, Xiaoran|Kornmann, Marko|Tian, Xiaodong|Yang, Yinmo | ||||||||||
| PMID: | 28602977 | ||||||||||
| 33. | |||||||||||
| Journal: | J Hematol Oncol. 2017 Mar 28;10(1):76. | ||||||||||
| Title: | The role of stromal cancer-associated fibroblasts in pancreatic cancer. | ||||||||||
| Author: | von Ahrens, Dagny|Bhagat, Tushar D|Nagrath, Deepak|Maitra, Anirban|Verma, Amit | ||||||||||
| PMID: | 28351381 | ||||||||||
| 34. | |||||||||||
| Journal: | Cancer Lett. 2018 Apr 1;418:167-175. | ||||||||||
| Title: | MUC16 C terminal-induced secretion of tumor-derived IL-6 contributes to tumor-associated Treg enrichment in pancreatic cancer. | ||||||||||
| Author: | Fan, Kun|Yang, Chao|Fan, Zhiyao|Huang, Qiuyi|Zhang, Yiyin|Cheng, He|Jin, Kaizhou|Lu, Yu|Wang, Zhengshi|Luo, Guopei|Yu, Xianjun|Liu, Chen | ||||||||||
| PMID: | 29337110 | ||||||||||
| 35. | |||||||||||
| Journal: | Oncol Rep. 2018 Apr;39(4):1892-1900. | ||||||||||
| Title: | Tyrphostin B42 attenuates trichostatin A-mediated resistance in pancreatic cancer cells by antagonizing IL-6/JAK2/STAT3 signaling. | ||||||||||
| Author: | Zhang, Xing|Lu, Hong|Hong, Weilong|Liu, Leping|Wang, Silu|Zhou, Mengtao|Chen, Bicheng|Bai, Yongheng | ||||||||||
| PMID: | 29393444 | ||||||||||
| 36. | |||||||||||
| Journal: | Biochem Biophys Res Commun. 2018 Mar 18;497(4):963-970. | ||||||||||
| Title: | MiR-7-5p functions as a tumor suppressor by targeting SOX18 in pancreatic ductal adenocarcinoma. | ||||||||||
| Author: | Zhu, Weihua|Wang, Yazhou|Zhang, Dafang|Yu, Xin|Leng, Xisheng | ||||||||||
| PMID: | 29408481 | ||||||||||
| 37. | |||||||||||
| Journal: | Invest New Drugs. 2018 Aug;36(4):683-695. | ||||||||||
| Title: | Ruxolitinib + capecitabine in advanced/metastatic pancreatic cancer after disease progression/intolerance to first-line therapy: JANUS 1 and 2 randomized phase III studies. | ||||||||||
| Author: | Hurwitz, Herbert|Van Cutsem, Eric|Bendell, Johanna|Hidalgo, Manuel|Li, Chung-Pin|Salvo, Marcelo Garrido|Macarulla, Teresa|Sahai, Vaibhav|Sama, Ashwin|Greeno, Edward|Yu, Kenneth H|Verslype, Chris|Dawkins, Fitzroy|Walker, Chris|Clark, Jason|O'Reilly, Eileen | ||||||||||
| PMID: | 29508247 | ||||||||||
| 38. | |||||||||||
| Journal: | J Biol Chem. 2018 Jul 13;293(28):11143-11153. | ||||||||||
| Title: | Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42. | ||||||||||
| Author: | Razidlo, Gina L|Burton, Kevin M|McNiven, Mark A | ||||||||||
| PMID: | 29853638 | ||||||||||
| 39. | |||||||||||
| Journal: | Oncol Rep. 2018 Aug;40(2):1008-1016. | ||||||||||
| Title: | Association between methylation of tumor suppressor gene SOCS1 and acute myeloid leukemia. | ||||||||||
| Author: | Zhang, Xiao-Hui|Yang, Lin|Liu, Xiao-Jun|Zhan, Ying|Pan, Yu-Xia|Wang, Xing-Zhe|Luo, Jian-Min | ||||||||||
| PMID: | 29916533 | ||||||||||
| 40. | |||||||||||
| Journal: | Cell Death Dis. 2018 Jul 23;9(8):802. | ||||||||||
| Title: | Overexpression of PEAK1 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer through modulating ERK1/2 and JAK2 signaling. | ||||||||||
| Author: | Ding, Chenbo|Tang, Wendong|Fan, Xiaobo|Wang, Xiyong|Wu, Hairu|Xu, Hongbo|Xu, Wei|Gao, Wei|Wu, Guoqiu | ||||||||||
| PMID: | 30038287 | ||||||||||
| 41. | |||||||||||
| Journal: | J Cell Physiol. 2018 Aug 4. | ||||||||||
| Title: | Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor kappaB and STAT3 in vitro and in vivo. | ||||||||||
| Author: | Song, Yanlin|Gao, Lei|Tang, Zhongyuan|Li, Hailong|Sun, Bin|Chu, Peng|Qaed, Eskandar|Ma, Xiaodong|Peng, Jinyong|Wang, Shisheng|Hu, Min|Tang, Zeyao | ||||||||||
| PMID: | 30078206 | ||||||||||
| 42. | |||||||||||
| Journal: | Mol Med Rep. 2018 Oct;18(4):3769-3779. | ||||||||||
| Title: | EGFR may participate in immune evasion through regulation of B7H5 expression in nonsmall cell lung carcinoma. | ||||||||||
| Author: | Dong, Zhaohui|Zhang, Lanying|Xu, Wei|Zhang, Gensheng | ||||||||||
| PMID: | 30106102 | ||||||||||