Primary Site >> Pancreatic Cancer
Gene >> JAK2
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Ref: A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models. PMID: 15640156 |
Ref: NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases. PMID: 17983808 |
Ref: Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells. PMID: 19605406 |
Ref: Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells. PMID: 20416094 |
Ref: LLL12 inhibits endogenous and exogenous interleukin-6-induced STAT3 phosphorylation in human pancreatic cancer cells. PMID: 21737619 |
Ref: Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through alpha7nAChR-mediated MUC4 upregulation. PMID: 22614008 Ref: Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells. PMID: 23206899 Ref: Molecular pathways: Jak/STAT pathway: mutations, inhibitors, and resistance. PMID: 23406773 Ref: Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice. PMID: 23650499 |
Ref: Combined inhibition of Notch and JAK/STAT is superior to monotherapies and impairs pancreatic cancer progression. PMID: 24293409 Ref: MicroRNA let-7 downregulates STAT3 phosphorylation in pancreatic cancer cells by increasing SOCS3 expression. PMID: 24491408 Ref: Pancreatic cancer-induced cachexia is Jak2-dependent in mice. PMID: 24648112 Ref: MicroRNA-216a inhibits pancreatic cancer by directly targeting Janus kinase 2. PMID: 25220761 |
Ref: Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells. PMID: 25691062 Ref: REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involvement of a REG3A-JAK2/STAT3 positive feedback loop. PMID: 25779676 Ref: Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production. PMID: 25948792 Ref: miR-216a may inhibit pancreatic tumor growth by targeting JAK2. PMID: 26149212 Ref: Diagnostic yield of targeted next generation sequencing in various cancer types: an information-theoretic approach. PMID: 26227479 Ref: Randomized, Double-Blind, Phase II Study of Ruxolitinib or Placebo in Combination With Capecitabine in Patients With Metastatic Pancreatic Cancer for Whom Therapy With Gemcitabine Has Failed. PMID: 26351344 Ref: IL17 Functions through the Novel REG3beta-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer. PMID: 26404002 Ref: Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer. PMID: 26530532 Ref: Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer. PMID: 26575024 |
Ref: Blockage of STAT3 Signaling Pathway by Morusin Induces Apoptosis and Inhibits Invasion in Human Pancreatic Tumor Cells. PMID: 26646273 Ref: Targeting the Janus-activated kinase-2-STAT3 signalling pathway in pancreatic cancer using the HSP90 inhibitor ganetespib. PMID: 26682870 Ref: Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival. PMID: 27003603 Ref: Which patients with para-aortic lymph node (LN16) metastasis will truly benefit from curative pancreaticoduodenectomy for pancreatic head cancer? PMID: 27081079 Ref: [New molecular classification of colorectal cancer, pancreatic cancer and stomach cancer: Towards "a la carte" treatment?]. PMID: 27345450 Ref: Interleukin-32alpha inactivates JAK2/STAT3 signaling and reverses interleukin-6-induced epithelial-mesenchymal transition, invasion, and metastasis in pancreatic cancer cells. PMID: 27471397 Ref: Antitumor effects of herbal mixture extract in the pancreatic adenocarcinoma cell line PANC1. PMID: 27599899 |
Ref: The JAK/STAT pathway is involved in the upregulation of PD-L1 expression in pancreatic cancer cell lines. PMID: 28112370 Ref: The role of stromal cancer-associated fibroblasts in pancreatic cancer. PMID: 28351381 Ref: BRM/SMARCA2 promotes the proliferation and chemoresistance of pancreatic cancer cells by targeting JAK2/STAT3 signaling. PMID: 28602977 Ref: Acceleration of pancreatic tumorigenesis under immunosuppressive microenvironment induced by Reg3g overexpression. PMID: 28880262 |
Ref: MUC16 C terminal-induced secretion of tumor-derived IL-6 contributes to tumor-associated Treg enrichment in pancreatic cancer. PMID: 29337110 Ref: Tyrphostin B42 attenuates trichostatin A-mediated resistance in pancreatic cancer cells by antagonizing IL-6/JAK2/STAT3 signaling. PMID: 29393444 Ref: MiR-7-5p functions as a tumor suppressor by targeting SOX18 in pancreatic ductal adenocarcinoma. PMID: 29408481 Ref: Ruxolitinib + capecitabine in advanced/metastatic pancreatic cancer after disease progression/intolerance to first-line therapy: JANUS 1 and 2 randomized phase III studies. PMID: 29508247 Ref: Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42. PMID: 29853638 Ref: Association between methylation of tumor suppressor gene SOCS1 and acute myeloid leukemia. PMID: 29916533 Ref: Overexpression of PEAK1 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer through modulating ERK1/2 and JAK2 signaling. PMID: 30038287 Ref: Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor kappaB and STAT3 in vitro and in vivo. PMID: 30078206 Ref: EGFR may participate in immune evasion through regulation of B7H5 expression in nonsmall cell lung carcinoma. PMID: 30106102 |