Literatures

Primary Site >> Colorectal Cancer

Gene >> JAK2

1.
Journal:	J Biol Chem. 1995 Dec 22;270(51):30829-36.
Title:	Receptors for interleukin (IL)-4 do not associate with the common gamma chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells.
Author:	Murata, T\|Noguchi, P D\|Puri, R K
PMID:	8530527

2.
Journal:	J Immunol. 1996 Apr 15;156(8):2972-8.
Title:	IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling.
Author:	Murata, T\|Noguchi, P D\|Puri, R K
PMID:	8609418

3.
Journal:	FASEB J. 2000 Nov;14(14):2329-38.
Title:	Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways.
Author:	Attoub, S\|Noe, V\|Pirola, L\|Bruyneel, E\|Chastre, E\|Mareel, M\|Wymann, M P\|Gespach, C
PMID:	11053255

4.
Journal:	J Recept Signal Transduct Res. 2002 Feb-Nov;22(1-4):213-28.
Title:	Mono- or dual-phosphorylation of akt kinase is regulated by distinct receptors that involve the common insulin receptor substrate.
Author:	Schnyder, Bruno\|Lahm, Harald\|Pittet, Martine\|Schnyder-Candrian, Silvia
PMID:	12503617

5.
Journal:	J Biol Chem. 2004 Apr 30;279(18):19335-49. Epub 2004 Feb 12.
Title:	Pleckstrin homology and phosphotyrosine-binding domain-dependent membrane association and tyrosine phosphorylation of Dok-4, an inhibitory adapter molecule expressed in epithelial cells.
Author:	Bedirian, Arda\|Baldwin, Cindy\|Abe, Jun-ichi\|Takano, Tomoko\|Lemay, Serge
PMID:	14963042

6.
Journal:	Cancer Res. 2004 Dec 15;64(24):9105-14.
Title:	Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL.
Author:	Ravi, Rajani\|Jain, Ajay J\|Schulick, Richard D\|Pham, Vui\|Prouser, Traci S\|Allen, Heather\|Mayer, Elizabeth Garrett\|Yu, Hua\|Pardoll, Drew M\|Ashkenazi, Avi\|Bedi, Atul
PMID:	15604280

7.
Journal:	Zhonghua Yi Xue Za Zhi. 2005 Nov 2;85(41):2899-904.
Title:	[Correlation between Stat3 signal transduction pathway and expression of cyclooxygenase-2 in colorectal cancer cells].
Author:	Zhang, Hui\|Wang, Shan\|Zhang, You-cheng\|Ye, Ying-jiang\|Cui, Zhi-rong\|Fang, Wei-gang
PMID:	16324362

8.
Journal:	Mol Cell Endocrinol. 2006 Mar 9;247(1-2):140-9. Epub 2006 Jan 27.
Title:	Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways.
Author:	Beales, Ian L P\|Ogunwobi, O
PMID:	16442704

9.
Journal:	Carcinogenesis. 2006 Jul;27(7):1507-15. Epub 2006 Apr 5.
Title:	Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min/+) colon epithelial cell line.
Author:	Fenton, Jenifer I\|Hursting, Stephen D\|Perkins, Susan N\|Hord, Norman G
PMID:	16597643

10.
Journal:	World J Gastroenterol. 2006 Mar 28;12(12):1859-64.
Title:	Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells.
Author:	Ferrand, Audrey\|Kowalski-Chauvel, Aline\|Pannequin, Julie\|Bertrand, Claudine\|Fourmy, Daniel\|Dufresne, Marlene\|Seva, Catherine
PMID:	16609991

11.
Journal:	Int J Colorectal Dis. 2007 Apr;22(4):401-9. Epub 2006 Aug 16.
Title:	The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt.
Author:	Ogunwobi, Olorunseun O\|Beales, Ian L P
PMID:	16912864

12.
Journal:	Neoplasia. 2008 Mar;10(3):287-97.
Title:	Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells.
Author:	Xiong, Hua\|Zhang, Zhi-Gang\|Tian, Xiao-Qing\|Sun, Dan-Feng\|Liang, Qin-Chuan\|Zhang, Yan-Jie\|Lu, Rong\|Chen, Ying-Xuan\|Fang, Jing-Yuan
PMID:	18320073

13.
Journal:	Int J Cancer. 2008 Dec 1;123(11):2543-56.
Title:	Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways.
Author:	Jaffe, Tamara\|Schwartz, Betty
PMID:	18767036

14.
Journal:	J Cancer Res Clin Oncol. 2009 Mar;135(3):395-402.
Title:	Epidermal growth factor receptor status and persistent activation of Akt and p44/42 MAPK pathways correlate with the effect of cetuximab in head and neck and colon cancer cell lines.
Author:	Yamatodani, Takashi\|Ekblad, Lars\|Kjellen, Elisabeth\|Johnsson, Anders\|Mineta, Hiroyuki\|Wennerberg, Johan
PMID:	18813952

15.
Journal:	Biochim Biophys Acta. 2009 Mar;1793(3):477-88.
Title:	Expression of gastrin precursors by CD133-positive colorectal cancer cells is crucial for tumour growth.
Author:	Ferrand, Audrey\|Sandrin, Mauro S\|Shulkes, Arthur\|Baldwin, Graham S
PMID:	19321126

16.
Journal:	J Cell Mol Med. 2009 Sep;13(9B):3668-79.
Title:	Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling.
Author:	Xiong, Hua\|Chen, Zhao-Fei\|Liang, Qin-Chuan\|Du, Wan\|Chen, Hui-Min\|Su, Wen-Yu\|Chen, Guo-Qiang\|Han, Ze-Guang\|Fang, Jing-Yuan
PMID:	20196786

17.
Journal:	Zhonghua Wei Chang Wai Ke Za Zhi. 2010 Apr;13(4):282-5.
Title:	[Effect of JAK2/STAT3/vimentin signaling pathway on proliferation and migration of human colon cancer cells].
Author:	Xu, Jian-hua\|Zhang, Chao\|Tang, Bo\|Hao, Ying-xue\|Chen, Jun\|Liu, Tao\|Cui, Hao
PMID:	20422486

18.
Journal:	Cancer Biol Ther. 2010 Aug 15;10(4):354-61. Epub 2010 Aug 18.
Title:	Janus-activated kinases and signal transducer and activator of transcription control tumor growth response to camptothecin in human colon cancer cells.
Author:	Yun, Hyun Jin\|Kim, Sun Young\|Kwon, Young Yon\|Kim, Chun-Ho\|Kang, Chang-Mo\|Kim, Eun Ju
PMID:	20534983

19.
Journal:	Mol Cancer. 2010 Aug 16;9:217.
Title:	A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.
Author:	Lin, Li\|Deangelis, Stephanie\|Foust, Elizabeth\|Fuchs, James\|Li, Chenglong\|Li, Pui-Kai\|Schwartz, Eric B\|Lesinski, Gregory B\|Benson, Don\|Lu, Jiagao\|Hoyt, Dale\|Lin, Jiayuh
PMID:	20712901

20.
Journal:	Dig Dis. 2010;28(4-5):590-5.
Title:	Chronic inflammation, colorectal cancer and gene polymorphisms.
Author:	Boland, C Richard
PMID:	21088407

21.
Journal:	Br J Biomed Sci. 2010;67(4):220-2.
Title:	No evidence for JAK2 V617F mutation in colorectal cancer.
Author:	Herreros-Villanueva, M\|Garcia-Giron, C\|Er, T K
PMID:	21294452

22.
Journal:	J Biosci. 2012 Jun;37(2):243-57.
Title:	STAT3 mutations correlated with hyper-IgE syndrome lead to blockage of IL-6/STAT3 signalling pathway.
Author:	He, Jianxin\|Shi, Jie\|Xu, Ximing\|Zhang, Wenhua\|Wang, Yuxin\|Chen, Xing\|Du, Yuping\|Zhu, Ning\|Zhang, Jing\|Wang, Qin\|Yang, Jinbo
PMID:	22581330

23.
Journal:	Cancer Cell. 2012 Jul 10;22(1):91-105.
Title:	Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway.
Author:	Wolf, Monika Julia\|Hoos, Alexandra\|Bauer, Judith\|Boettcher, Steffen\|Knust, Markus\|Weber, Achim\|Simonavicius, Nicole\|Schneider, Christoph\|Lang, Matthias\|Sturzl, Michael\|Croner, Roland S\|Konrad, Andreas\|Manz, Markus G\|Moch, Holger\|Aguzzi, Adriano\|van Loo, G
PMID:	22789541

24.
Journal:	Mol Cancer Ther. 2012 Apr;11(4):984-93.
Title:	Therapeutic efficacy of CEP-33779, a novel selective JAK2 inhibitor, in a mouse model of colitis-induced colorectal cancer.
Author:	Seavey, Matthew M\|Lu, Lily D\|Stump, Kristine L\|Wallace, Nate H\|Hockeimer, William\|O'Kane, Teresa M\|Ruggeri, Bruce A\|Dobrzanski, Pawel
PMID:	22334590

25.
Journal:	Mol Carcinog. 2012 Feb;51(2):174-84.
Title:	Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells.
Author:	Xiong, Hua\|Du, Wan\|Zhang, Yan-Jie\|Hong, Jie\|Su, Wen-Yu\|Tang, Jie-Ting\|Wang, Ying-Chao\|Lu, Rong\|Fang, Jing-Yuan
PMID:	21520296

26.
Journal:	J Cell Mol Med. 2012 Aug;16(8):1878-88.
Title:	Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway.
Author:	Du, Wan\|Hong, Jie\|Wang, Ying-Chao\|Zhang, Yan-Jie\|Wang, Ping\|Su, Wen-Yu\|Lin, Yan-Wei\|Lu, Rong\|Zou, Wei-Ping\|Xiong, Hua\|Fang, Jing-Yuan
PMID:	22050790

27.
Journal:	Mol Carcinog. 2013 Feb;52(2):155-66.
Title:	JAK/STAT/SOCS-signaling pathway and colon and rectal cancer.
Author:	Slattery, Martha L\|Lundgreen, Abbie\|Kadlubar, Susan A\|Bondurant, Kristina L\|Wolff, Roger K
PMID:	22121102

28.
Journal:	Oncol Lett. 2013 Mar;5(3):756-760.
Title:	Regulation of AKT gene expression by cisplatin.
Author:	Zhang, Jun\|Zhang, Ling-Li\|Shen, Lei\|Xu, Xi-Ming\|Yu, Hong-Gang
PMID:	23426872

29.
Journal:	Neoplasma. 2013 Sep 20.
Title:	INCB018424 induces apoptotic cell death through the suppression of pJAK1 in human colon cancer cells.
Author:	An, H J\|Choi, E K\|Kim, J S\|Hong, S W\|Moon, J H\|Shin, J S\|Ha, S H\|Kim, K P\|Hong, Y S\|Lee, J L\|Choi, E K\|Lee, J S\|Jin, D H\|Kim, T W
PMID:	24050550

30.
Journal:	Oncol Rep. 2014 Aug;32(2):821-8.
Title:	Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Srcmediated phosphorylation of EGF receptor tyrosine kinase.
Author:	Kundu, Juthika\|Choi, Bu Young\|Jeong, Chul-Ho\|Kundu, Joydeb Kumar\|Chun, Kyung-Soo
PMID:	24890449

31.
Journal:	PLoS One. 2014 Dec 26;9(12):e116169.
Title:	The influence of the CHIEF pathway on colorectal cancer-specific mortality.
Author:	Slattery, Martha L\|Lundgreen, Abbie
PMID:	25541970

32.
Journal:	J Clin Invest. 2014 Dec;124(12):5368-84.
Title:	Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.
Author:	Degagne, Emilie\|Pandurangan, Ashok\|Bandhuvula, Padmavathi\|Kumar, Ashok\|Eltanawy, Abeer\|Zhang, Meng\|Yoshinaga, Yuko\|Nefedov, Mikhail\|de Jong, Pieter J\|Fong, Loren G\|Young, Stephen G\|Bittman, Robert\|Ahmedi, Yasmin\|Saba, Julie D
PMID:	25347472

33.
Journal:	Cancer Res. 2014 Nov 1;74(21):6341-51.
Title:	Holo-retinol-binding protein and its receptor STRA6 drive oncogenic transformation.
Author:	Berry, Daniel C\|Levi, Liraz\|Noy, Noa
PMID:	25237067

34.
Journal:	Oncol Rep. 2014 Nov;32(5):1991-8.
Title:	AZD1480, a JAK inhibitor, inhibits cell growth and survival of colorectal cancer via modulating the JAK2/STAT3 signaling pathway.
Author:	Wang, Shu-Wei\|Hu, Jun\|Guo, Qin-Hao\|Zhao, Yan\|Cheng, Jie-Jing\|Zhang, Dong-Sheng\|Fei, Qiang\|Li, Juan\|Sun, Yue-Ming
PMID:	25216185

35.
Journal:	Free Radic Res. 2014 Nov;48(11):1311-21.
Title:	Generation of ROS by CAY10598 leads to inactivation of STAT3 signaling and induction of apoptosis in human colon cancer HCT116 cells.
Author:	Chae, I G\|Kim, D-H\|Kundu, J\|Jeong, C-H\|Kundu, J K\|Chun, K-S
PMID:	25096910

36.
Journal:	Int J Oncol. 2014 Apr;44(4):1309-15.
Title:	Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells.
Author:	Park, Ki-Woong\|Kundu, Juthika\|Chae, In-Gyeong\|Kim, Do-Hee\|Yu, Mi-Hee\|Kundu, Joydeb Kumar\|Chun, Kyung-Soo
PMID:	24481553

37.
Journal:	Carcinogenesis. 2014 Apr;35(4):795-806.
Title:	Prolactin signaling enhances colon cancer stemness by modulating Notch signaling in a Jak2-STAT3/ERK manner.
Author:	Neradugomma, Naveen K\|Subramaniam, Dharmalingam\|Tawfik, Ossama W\|Goffin, Vincent\|Kumar, T Rajendra\|Jensen, Roy A\|Anant, Shrikant
PMID:	24265293

38.
Journal:	Neoplasma. 2014;61(1):56-62.
Title:	INCB018424 induces apoptotic cell death through the suppression of pJAK1 in human colon cancer cells.
Author:	An, H J\|Choi, E K\|Kim, J S\|Hong, S W\|Moon, J H\|Shin, J S\|Ha, S H\|Kim, K P\|Hong, Y S\|Lee, J L\|Choi, E K\|Lee, J S\|Jin, D H\|Kim, T W
PMID:	24195509

39.
Journal:	Cancer Lett. 2014 Feb 1;343(1):80-9.
Title:	Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway.
Author:	Zhu, Liming\|Cheng, Xiaojiao\|Ding, Yanfei\|Shi, Jindong\|Jin, Huanyu\|Wang, Hong\|Wu, Yunlin\|Ye, Jing\|Lu, Yiming\|Wang, Timothy C\|Yang, Chung S\|Tu, Shui Ping
PMID:	24145153

40.
Journal:	J Gastroenterol. 2014 Oct;49(10):1378-91.
Title:	Functions and regulation of MUC13 mucin in colon cancer cells.
Author:	Gupta, Brij K\|Maher, Diane M\|Ebeling, Mara C\|Stephenson, Phillip D\|Puumala, Susan E\|Koch, Michael R\|Aburatani, Hiroyuki\|Jaggi, Meena\|Chauhan, Subhash C
PMID:	24097071

41.
Journal:	J Biol Chem. 2015 Aug 7;290(32):19976-86.
Title:	A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia.
Author:	Seto, Danielle N\|Kandarian, Susan C\|Jackman, Robert W
PMID:	26092726

42.
Journal:	Mol Med Rep. 2015 Oct;12(4):5455-60.
Title:	B7H3 promotes cell migration and invasion through the Jak2/Stat3/MMP9 signaling pathway in colorectal cancer.
Author:	Liu, Fen\|Zhang, Ting\|Zou, Shitao\|Jiang, Bo\|Hua, Dong
PMID:	26151358

43.
Journal:	Cancer Genet. 2015 Sep;208(9):441-7.
Title:	Diagnostic yield of targeted next generation sequencing in various cancer types: an information-theoretic approach.
Author:	Hagemann, Ian S\|O'Neill, Patrick K\|Erill, Ivan\|Pfeifer, John D
PMID:	26227479

44.
Journal:	Biomed Res Int. 2015;2015:326981.
Title:	Role of B7-H4 siRNA in Proliferation, Migration, and Invasion of LOVO Colorectal Carcinoma Cell Line.
Author:	Peng, Hai-Xia\|Wu, Wei-Qi\|Yang, Da-Ming\|Jing, Rong\|Li, Ji\|Zhou, Feng-Li\|Jin, Yun-Fei\|Wang, Sai-Yu\|Chu, Yi-Min
PMID:	26078947

45.
Journal:	Oncotarget. 2015 Sep 22;6(28):26483-93.
Title:	Genomic amplification of 9p24.1 targeting JAK2, PD-L1, and PD-L2 is enriched in high-risk triple negative breast cancer.
Author:	Barrett, Michael T\|Anderson, Karen S\|Lenkiewicz, Elizabeth\|Andreozzi, Mariacarla\|Cunliffe, Heather E\|Klassen, Christine L\|Dueck, Amylou C\|McCullough, Ann E\|Reddy, Srikanth K\|Ramanathan, Ramesh K\|Northfelt, Donald W\|Pockaj, Barbara A
PMID:	26317899

46.
Journal:	Curr Cancer Drug Targets. 2015;15(8):703-15.
Title:	Prognostic and Predictive Biomarkers in Colorectal Cancer. From the Preclinical Setting to Clinical Practice.
Author:	Maurel, Joan\|Postigo, Antonio
PMID:	26452385

47.
Journal:	Int J Mol Sci. 2015 Nov 16;16(11):27411-21.
Title:	Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells.
Author:	Zhao, Lv-Cui\|Li, Jing\|Liao, Ke\|Luo, Nian\|Shi, Qing-Qiang\|Feng, Zi-Qiang\|Chen, Di-Long
PMID:	26580615

48.
Journal:	World J Gastroenterol. 2015 Feb 14;21(6):1804-13.
Title:	Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3.
Author:	Zhang, Ting\|Jiang, Bo\|Zou, Shi-Tao\|Liu, Fen\|Hua, Dong
PMID:	25684945

49.
Journal:	PLoS One. 2015 May 8;10(5):e0123478.
Title:	Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway.
Author:	Liu, Xuan\|Ji, Qing\|Ye, Naijing\|Sui, Hua\|Zhou, Lihong\|Zhu, Huirong\|Fan, Zhongze\|Cai, Jianfeng\|Li, Qi
PMID:	25954974

50.
Journal:	Oncotarget. 2015 Apr 10;6(10):7713-26.
Title:	Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production.
Author:	Wei, Hong-Jian\|Zeng, Rong\|Lu, Jui-Hua\|Lai, Wen-Fu T\|Chen, Wei-Hong\|Liu, Hen-Yu\|Chang, Ya-Ting\|Deng, Win-Ping
PMID:	25797257

51.
Journal:	Int J Clin Exp Pathol. 2015 Jan 1;8(1):615-21. eCollection 2015.
Title:	Anticancer effect of salidroside on colon cancer through inhibiting JAK2/STAT3 signaling pathway.
Author:	Sun, Kuan-Xue\|Xia, Hong-Wei\|Xia, Rong-Long
PMID:	25755753

52.
Journal:	Phytomedicine. 2015 Jan 15;22(1):103-10.
Title:	Raddeanin A, a triterpenoid saponin isolated from Anemone raddeana, suppresses the angiogenesis and growth of human colorectal tumor by inhibiting VEGFR2 signaling.
Author:	Guan, Ying-Yun\|Liu, Hai-Jun\|Luan, Xin\|Xu, Jian-Rong\|Lu, Qin\|Liu, Ya-Rong\|Gao, Yun-Ge\|Zhao, Mei\|Chen, Hong-Zhuan\|Fang, Chao
PMID:	25636878

53.
Journal:	Gene. 2015 Feb 10;556(2):227-34.
Title:	Genome-wide analysis of long noncoding RNA signature in human colorectal cancer.
Author:	Xue, Yao\|Ma, Gaoxiang\|Gu, Dongying\|Zhu, Lingjun\|Hua, Qiuhan\|Du, Mulong\|Chu, Haiyan\|Tong, Na\|Chen, Jinfei\|Zhang, Zhengdong\|Wang, Meilin
PMID:	25456707

54.
Journal:	Cell Signal. 2015 Feb;27(2):293-305.
Title:	HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells.
Author:	Lee, Dae-Hee\|Sung, Ki Sa\|Bartlett, David L\|Kwon, Yong Tae\|Lee, Yong J
PMID:	25446253

55.
Journal:	DNA Cell Biol. 2015 Aug;34(8):541-9.
Title:	The Tumor Suppressive Effects of HPP1 Are Mediated Through JAK-STAT-Interferon Signaling Pathways.
Author:	Hernandez, Jonathan M\|Elahi, Abul\|Clark, Whalen\|Humphries, Leigh Ann\|Wang, Jian\|Achille, Alex\|Seto, Ed\|Shibata, David
PMID:	26061044

56.
Journal:	Mol Med Rep. 2016 Mar;13(3):2235-40.
Title:	Eriocalyxin B blocks human SW1116 colon cancer cell proliferation, migration, invasion, cell cycle progression and angiogenesis via the JAK2/STAT3 signaling pathway.
Author:	Lu, Yun-Min\|Chen, Wei\|Zhu, Jin-Shui\|Chen, Wei-Xiong\|Chen, Ni-Wei
PMID:	26795301

57.
Journal:	Med Oncol. 2016 Oct;33(10):106.
Title:	Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing.
Author:	Jauhri, Mayank\|Bhatnagar, Akanksha\|Gupta, Satish\|Shokeen, Yogender\|Minhas, Sachin\|Aggarwal, Shyam
PMID:	27568332

58.
Journal:	J Ethnopharmacol. 2016 Dec 24;194:83-90.
Title:	Ginsenoside 20(S)-Rh2 exerts anti-cancer activity through targeting IL-6-induced JAK2/STAT3 pathway in human colorectal cancer cells.
Author:	Han, Songhee\|Jeong, Ae Jin\|Yang, Heejung\|Bin Kang, Kyo\|Lee, Haeri\|Yi, Eun Hee\|Kim, Byung-Hak\|Cho, Chung-Hyun\|Chung, Jin Woong\|Sung, Sang Hyun\|Ye, Sang-Kyu
PMID:	27566200

59.
Journal:	Oncol Rep. 2016 Sep;36(3):1411-8.
Title:	RNA interference against TRIM29 inhibits migration and invasion of colorectal cancer cells.
Author:	Xu, Weihong\|Xu, Bin\|Yao, Yiting\|Yu, Xiaoling\|Cao, Hua\|Zhang, Jun\|Liu, Jie\|Sheng, Huiming
PMID:	27430345

60.
Journal:	Bull Cancer. 2016 Jul-Aug;103(7-8):643-50.
Title:	[New molecular classification of colorectal cancer, pancreatic cancer and stomach cancer: Towards "a la carte" treatment?].
Author:	Dreyer, Chantal\|Afchain, Pauline\|Trouilloud, Isabelle\|Andre, Thierry
PMID:	27345450

61.
Journal:	Tumour Biol. 2016 May;37(5):6561-9.
Title:	Genetic variants in IL-6/JAK/STAT3 pathway and the risk of CRC.
Author:	Wang, Shuwei\|Zhang, Weidong
PMID:	26638167

62.
Journal:	Mol Carcinog. 2016 Jun;55(6):1096-110.
Title:	Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells.
Author:	Kim, Do-Hee\|Park, Ki-Woong\|Chae, In Gyeong\|Kundu, Juthika\|Kim, Eun-Hee\|Kundu, Joydeb Kumar\|Chun, Kyung-Soo
PMID:	26152521

63.
Journal:	Mol Carcinog. 2016 Mar;55(3):233-44.
Title:	PAC exhibits potent anti-colon cancer properties through targeting cyclin D1 and suppressing epithelial-to-mesenchymal transition.
Author:	Al-Qasem, Abeer\|Al-Howail, Huda A\|Al-Swailem, Mashael\|Al-Mazrou, Amer\|Al-Otaibi, Basem\|Al-Jammaz, Ibrahim\|Al-Khalaf, Huda H\|Aboussekhra, Abdelilah
PMID:	25641341

64.
Journal:	Mol Carcinog. 2017 Nov;56(11):2434-2445.
Title:	CRH promotes human colon cancer cell proliferation via IL-6/JAK2/STAT3 signaling pathway and VEGF-induced tumor angiogenesis.
Author:	Fang, Xianjun\|Hong, Yali\|Dai, Li\|Qian, Yuanyuan\|Zhu, Chao\|Wu, Biao\|Li, Shengnan
PMID:	28618089

65.
Journal:	BMC Complement Altern Med. 2017 Dec 16;17(1):538.
Title:	Inhibition of autophagy enhances synergistic effects of Salidroside and anti-tumor agents against colorectal cancer.
Author:	Li, Hai\|Chen, Chen
PMID:	29246220

66.
Journal:	Am J Cancer Res. 2017 Oct 1;7(10):2051-2069. eCollection 2017.
Title:	MiR-216b functions as a tumor suppressor by targeting HMGB1-mediated JAK2/STAT3 signaling way in colorectal cancer.
Author:	Chen, Xiaoxiang\|Liu, Xiangxiang\|He, Bangshun\|Pan, Yuqin\|Sun, Huiling\|Xu, Tao\|Hu, Xiuxiu\|Wang, Shukui
PMID:	29119054

67.
Journal:	Oncol Rep. 2017 Nov;38(5):2619-2628.
Title:	alpha7 nicotinic acetylcholine receptor in tumor-associated macrophages inhibits colorectal cancer metastasis through the JAK2/STAT3 signaling pathway.
Author:	Fei, Rushan\|Zhang, Yuanwei\|Wang, Saisai\|Xiang, Tao\|Chen, Wenbin
PMID:	28901507

68.
Journal:	Mol Cancer. 2017 Aug 7;16(1):135.
Title:	Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis.
Author:	Chang, Yu-Chan\|Su, Chia-Yi\|Chen, Ming-Huang\|Chen, Wei-Shone\|Chen, Chi-Long\|Hsiao, Michael
PMID:	28784136

69.
Journal:	Stem Cell Reports. 2017 Aug 8;9(2):438-450.
Title:	RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis.
Author:	Karunanithi, Sheelarani\|Levi, Liraz\|DeVecchio, Jennifer\|Karagkounis, George\|Reizes, Ofer\|Lathia, Justin D\|Kalady, Matthew F\|Noy, Noa
PMID:	28689994

70.
Journal:	FEBS Lett. 2017 May;591(10):1371-1382.
Title:	Resistin causes G1 arrest in colon cancer cells through upregulation of SOCS3.
Author:	Singh, Snahlata\|Chouhan, Surbhi\|Mohammad, Naoshad\|Bhat, Manoj Kumar
PMID:	28417458

71.
Journal:	Evid Based Complement Alternat Med. 2017;2017:5180707.
Title:	Helicteric Acid, Oleanic Acid, and Betulinic Acid, Three Triterpenes from Helicteres angustifolia L., Inhibit Proliferation and Induce Apoptosis in HT-29 Colorectal Cancer Cells via Suppressing NF-kappaB and STAT3 Signaling.
Author:	Su, Dan\|Gao, Yu-Qiao\|Dai, Wei-Bo\|Hu, Ying\|Wu, Yan-Fen\|Mei, Quan-Xi
PMID:	28331523

72.
Journal:	Oncotarget. 2017 Mar 7;8(10):16633-16641.
Title:	microRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways.
Author:	Wei, Ran\|Yang, Qin\|Han, Bing\|Li, Yan\|Yao, Kun\|Yang, Xiuyu\|Chen, Zexi\|Yang, Shanshan\|Zhou, Jiaqi\|Li, Meizhang\|Yu, Haijing\|Yu, Min\|Cui, Qinghua
PMID:	28186962

73.
Journal:	Oncogene. 2017 Apr 20;36(16):2328-2336.
Title:	HSP110 promotes colorectal cancer growth through STAT3 activation.
Author:	Berthenet, K\|Bokhari, A'dem\|Lagrange, A\|Marcion, G\|Boudesco, C\|Causse, S\|De Thonel, A\|Svrcek, M\|Goloudina, A R\|Dumont, S\|Hammann, A\|Biard, D S\|Demidov, O N\|Seigneuric, R\|Duval, A\|Collura, A\|Jego, G\|Garrido, C
PMID:	27819670

74.
Journal:	Oncol Rep. 2017 Aug;38(2):926-932.
Title:	Cetuximab promotes SN38 sensitivity via suppression of heat shock protein 27 in colorectal cancer cells with wild-type RAS.
Author:	Ishida, Takashi\|Ishii, Yoshiyuki\|Tsuruta, Masashi\|Okabayashi, Koji\|Akimoto, Shingo\|Koishikawa, Kaoru\|Hasegawa, Hirotoshi\|Kitagawa, Yuko
PMID:	28656305

75.
Journal:	Cancer Cell. 2018 Aug 13;34(2):298-314.e7.
Title:	Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion.
Author:	Schulz-Heddergott, Ramona\|Stark, Nadine\|Edmunds, Shelley J\|Li, Jinyu\|Conradi, Lena-Christin\|Bohnenberger, Hanibal\|Ceteci, Fatih\|Greten, Florian R\|Dobbelstein, Matthias\|Moll, Ute M
PMID:	30107178

76.
Journal:	Onco Targets Ther. 2018 Jun 5;11:3313-3322.
Title:	Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2-STAT3 pathway.
Author:	Al-Obeed, Omar\|Vaali-Mohammed, Mansoor-Ali\|Eldehna, Wagdy M\|Al-Khayal, Khayal\|Mahmood, Amer\|Abdel-Aziz, Hatem A\|Zubaidi, Ahmed\|Alafeefy, Ahmed\|Abdulla, Maha\|Ahmad, Rehan
PMID:	29892198

77.
Journal:	Oncol Rep. 2018 Jul;40(1):283-293.
Title:	Downregulation of RPN2 induces apoptosis and inhibits migration and invasion in colon carcinoma.
Author:	Bi, Chongyao\|Jiang, Baofei
PMID:	29749494

78.
Journal:	PLoS One. 2018 Apr 11;13(4):e0194098.
Title:	Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers.
Author:	Pritchard, Antonia L\|Johansson, Peter A\|Nathan, Vaishnavi\|Howlie, Madeleine\|Symmons, Judith\|Palmer, Jane M\|Hayward, Nicholas K
PMID:	29641532

79.
Journal:	Cytokine. 2018 Mar 23. pii: S1043-4666(18)30112-1.
Title:	Novel 1,3,4-thiadiazoles inhibit colorectal cancer via blockade of IL-6/COX-2 mediated JAK2/STAT3 signals as evidenced through data-based mathematical modeling.
Author:	Raj, Vinit\|Bhadauria, Archana S\|Singh, Ashok K\|Kumar, Umesh\|Rai, Amit\|Keshari, Amit K\|Kumar, Pranesh\|Kumar, Dinesh\|Maity, Biswanath\|Nath, Sneha\|Prakash, Anand\|Ansari, Kausar M\|Jat, Jawahar L\|Saha, Sudipta
PMID:	29580751

80.
Journal:	Cancer Sci. 2018 May;109(5):1369-1381.
Title:	Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2/STAT3 signaling in colorectal cancer.
Author:	Liu, Kaili\|Gao, Hui\|Wang, Qiaoyun\|Wang, Longyuan\|Zhang, Bin\|Han, Zhiwu\|Chen, Xuehong\|Han, Mei\|Gao, Mingquan
PMID:	29575334

81.
Journal:	Int J Oncol. 2018 Mar 5.
Title:	Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway.
Author:	Li, Ning\|Mao, Dong\|Cao, Yansha\|Li, Hua\|Ren, Fu\|Li, Keyan
PMID:	29512698

82.
Journal:	Biomed Pharmacother. 2018 May;101:107-114.
Title:	alpha-Hederin inhibits interleukin 6-induced epithelial-to-mesenchymal transition associated with disruption of JAK2/STAT3 signaling in colon cancer cells.
Author:	Sun, Dongdong\|Shen, Weixing\|Zhang, Feng\|Fan, Huisen\|Xu, Changliang\|Li, Liu\|Tan, Jiani\|Miao, Yunjie\|Zhang, Haibin\|Yang, Ye\|Cheng, Haibo
PMID:	29477470

83.
Journal:	Biomed Pharmacother. 2018 Apr;100:282-295.
Title:	6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid attenuates colon carcinogenesis via blockade of IL-6 mediated signals.
Author:	Mishra, Priyanka\|Raj, Vinit\|Bhadauria, Archana S\|Singh, Ashok K\|Rai, Amit\|Kumar, Pranesh\|Keshari, Amit K\|De, Arnab\|Samanta, Amalesh\|Kumar, Umesh\|Kumar, Dinesh\|Maity, Biswanath\|Nath, Sneha\|Prakash, Anand\|Ansari, Kausar M\|Saha, Sudipta
PMID:	29448205

84.
Journal:	Oncol Lett. 2018 Feb;15(2):1949-1954.
Title:	Dihydroartemisinin increases apoptosis of colon cancer cells through targeting Janus kinase 2/signal transducer and activator of transcription 3 signaling.
Author:	Wang, Dongsheng\|Zhong, Bei\|Li, Yu\|Liu, Xiaodong
PMID:	29434895

85.
Journal:	Mol Cell Biochem. 2018 Sep;446(1-2):137-148.
Title:	P16 promotes the growth and mobility potential of breast cancer both in vitro and in vivo: the key role of the activation of IL-6/JAK2/STAT3 signaling.
Author:	Wang, Le\|Zhan, Xiangwen\|Shen, Xiaomeng\|Li, Mingzhe\|Yang, Jianming\|Yu, Wenhua\|Chen, Hao\|Jin, Bo\|Mao, Zebin
PMID:	29388151

86.
Journal:	Cell Death Dis. 2018 Jan 18;9(2):25.
Title:	Human colorectal cancer-derived mesenchymal stem cells promote colorectal cancer progression through IL-6/JAK2/STAT3 signaling.
Author:	Zhang, Xiaochao\|Hu, Fayong\|Li, Geng\|Li, Guodong\|Yang, Xi\|Liu, Liang\|Zhang, Rongsheng\|Zhang, Bixiang\|Feng, Yongdong
PMID:	29348540

87.
Journal:	Pharmacol Res. 2018 Jun;132:188-203.
Title:	Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer.
Author:	Rai, Amit\|Kumar, Umesh\|Raj, Vinit\|Singh, Ashok K\|Kumar, Pranesh\|Keshari, Amit K\|Kumar, Dinesh\|Maity, Biswanath\|De, Arnab\|Samanta, Amalesh\|Nath, Sneha\|Prakash, Anand\|Gosipatala, Sunil Babu\|Chand, Gyan\|Saha, Sudipta
PMID:	29229353