Primary Site >> Colorectal Cancer
Gene >> JAK2
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Ref: Receptors for interleukin (IL)-4 do not associate with the common gamma chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells. PMID: 8530527 |
Ref: IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling. PMID: 8609418 |
Ref: Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways. PMID: 11053255 |
Ref: Mono- or dual-phosphorylation of akt kinase is regulated by distinct receptors that involve the common insulin receptor substrate. PMID: 12503617 |
Ref: Pleckstrin homology and phosphotyrosine-binding domain-dependent membrane association and tyrosine phosphorylation of Dok-4, an inhibitory adapter molecule expressed in epithelial cells. PMID: 14963042 Ref: Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL. PMID: 15604280 |
Ref: [Correlation between Stat3 signal transduction pathway and expression of cyclooxygenase-2 in colorectal cancer cells]. PMID: 16324362 |
Ref: Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways. PMID: 16442704 Ref: Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min/+) colon epithelial cell line. PMID: 16597643 Ref: Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells. PMID: 16609991 |
Ref: The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt. PMID: 16912864 |
Ref: Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. PMID: 18320073 Ref: Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways. PMID: 18767036 |
Ref: Epidermal growth factor receptor status and persistent activation of Akt and p44/42 MAPK pathways correlate with the effect of cetuximab in head and neck and colon cancer cell lines. PMID: 18813952 Ref: Expression of gastrin precursors by CD133-positive colorectal cancer cells is crucial for tumour growth. PMID: 19321126 Ref: Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling. PMID: 20196786 |
Ref: [Effect of JAK2/STAT3/vimentin signaling pathway on proliferation and migration of human colon cancer cells]. PMID: 20422486 Ref: Janus-activated kinases and signal transducer and activator of transcription control tumor growth response to camptothecin in human colon cancer cells. PMID: 20534983 Ref: A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. PMID: 20712901 Ref: Chronic inflammation, colorectal cancer and gene polymorphisms. PMID: 21088407 Ref: No evidence for JAK2 V617F mutation in colorectal cancer. PMID: 21294452 |
Ref: Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells. PMID: 21520296 Ref: Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway. PMID: 22050790 Ref: Therapeutic efficacy of CEP-33779, a novel selective JAK2 inhibitor, in a mouse model of colitis-induced colorectal cancer. PMID: 22334590 Ref: STAT3 mutations correlated with hyper-IgE syndrome lead to blockage of IL-6/STAT3 signalling pathway. PMID: 22581330 Ref: Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. PMID: 22789541 |
Ref: JAK/STAT/SOCS-signaling pathway and colon and rectal cancer. PMID: 22121102 Ref: Regulation of AKT gene expression by cisplatin. PMID: 23426872 Ref: INCB018424 induces apoptotic cell death through the suppression of pJAK1 in human colon cancer cells. PMID: 24050550 |
Ref: Functions and regulation of MUC13 mucin in colon cancer cells. PMID: 24097071 Ref: Bone marrow-derived myofibroblasts promote colon tumorigenesis through the IL-6/JAK2/STAT3 pathway. PMID: 24145153 Ref: INCB018424 induces apoptotic cell death through the suppression of pJAK1 in human colon cancer cells. PMID: 24195509 Ref: Prolactin signaling enhances colon cancer stemness by modulating Notch signaling in a Jak2-STAT3/ERK manner. PMID: 24265293 Ref: Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells. PMID: 24481553 Ref: Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Srcmediated phosphorylation of EGF receptor tyrosine kinase. PMID: 24890449 Ref: Generation of ROS by CAY10598 leads to inactivation of STAT3 signaling and induction of apoptosis in human colon cancer HCT116 cells. PMID: 25096910 Ref: AZD1480, a JAK inhibitor, inhibits cell growth and survival of colorectal cancer via modulating the JAK2/STAT3 signaling pathway. PMID: 25216185 Ref: Holo-retinol-binding protein and its receptor STRA6 drive oncogenic transformation. PMID: 25237067 Ref: Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. PMID: 25347472 Ref: The influence of the CHIEF pathway on colorectal cancer-specific mortality. PMID: 25541970 |
Ref: HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells. PMID: 25446253 Ref: Genome-wide analysis of long noncoding RNA signature in human colorectal cancer. PMID: 25456707 Ref: Raddeanin A, a triterpenoid saponin isolated from Anemone raddeana, suppresses the angiogenesis and growth of human colorectal tumor by inhibiting VEGFR2 signaling. PMID: 25636878 Ref: Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3. PMID: 25684945 Ref: Anticancer effect of salidroside on colon cancer through inhibiting JAK2/STAT3 signaling pathway. PMID: 25755753 Ref: Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production. PMID: 25797257 Ref: Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway. PMID: 25954974 Ref: The Tumor Suppressive Effects of HPP1 Are Mediated Through JAK-STAT-Interferon Signaling Pathways. PMID: 26061044 Ref: Role of B7-H4 siRNA in Proliferation, Migration, and Invasion of LOVO Colorectal Carcinoma Cell Line. PMID: 26078947 Ref: A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia. PMID: 26092726 Ref: B7H3 promotes cell migration and invasion through the Jak2/Stat3/MMP9 signaling pathway in colorectal cancer. PMID: 26151358 Ref: Diagnostic yield of targeted next generation sequencing in various cancer types: an information-theoretic approach. PMID: 26227479 Ref: Genomic amplification of 9p24.1 targeting JAK2, PD-L1, and PD-L2 is enriched in high-risk triple negative breast cancer. PMID: 26317899 Ref: Prognostic and Predictive Biomarkers in Colorectal Cancer. From the Preclinical Setting to Clinical Practice. PMID: 26452385 Ref: Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells. PMID: 26580615 |
Ref: PAC exhibits potent anti-colon cancer properties through targeting cyclin D1 and suppressing epithelial-to-mesenchymal transition. PMID: 25641341 Ref: Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. PMID: 26152521 Ref: Genetic variants in IL-6/JAK/STAT3 pathway and the risk of CRC. PMID: 26638167 Ref: Eriocalyxin B blocks human SW1116 colon cancer cell proliferation, migration, invasion, cell cycle progression and angiogenesis via the JAK2/STAT3 signaling pathway. PMID: 26795301 Ref: [New molecular classification of colorectal cancer, pancreatic cancer and stomach cancer: Towards "a la carte" treatment?]. PMID: 27345450 Ref: RNA interference against TRIM29 inhibits migration and invasion of colorectal cancer cells. PMID: 27430345 Ref: Ginsenoside 20(S)-Rh2 exerts anti-cancer activity through targeting IL-6-induced JAK2/STAT3 pathway in human colorectal cancer cells. PMID: 27566200 Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. PMID: 27568332 |
Ref: HSP110 promotes colorectal cancer growth through STAT3 activation. PMID: 27819670 Ref: microRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways. PMID: 28186962 Ref: Helicteric Acid, Oleanic Acid, and Betulinic Acid, Three Triterpenes from Helicteres angustifolia L., Inhibit Proliferation and Induce Apoptosis in HT-29 Colorectal Cancer Cells via Suppressing NF-kappaB and STAT3 Signaling. PMID: 28331523 Ref: Resistin causes G1 arrest in colon cancer cells through upregulation of SOCS3. PMID: 28417458 Ref: CRH promotes human colon cancer cell proliferation via IL-6/JAK2/STAT3 signaling pathway and VEGF-induced tumor angiogenesis. PMID: 28618089 Ref: Cetuximab promotes SN38 sensitivity via suppression of heat shock protein 27 in colorectal cancer cells with wild-type RAS. PMID: 28656305 Ref: RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis. PMID: 28689994 Ref: Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis. PMID: 28784136 Ref: alpha7 nicotinic acetylcholine receptor in tumor-associated macrophages inhibits colorectal cancer metastasis through the JAK2/STAT3 signaling pathway. PMID: 28901507 Ref: MiR-216b functions as a tumor suppressor by targeting HMGB1-mediated JAK2/STAT3 signaling way in colorectal cancer. PMID: 29119054 Ref: Inhibition of autophagy enhances synergistic effects of Salidroside and anti-tumor agents against colorectal cancer. PMID: 29246220 |
Ref: Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer. PMID: 29229353 Ref: Human colorectal cancer-derived mesenchymal stem cells promote colorectal cancer progression through IL-6/JAK2/STAT3 signaling. PMID: 29348540 Ref: P16 promotes the growth and mobility potential of breast cancer both in vitro and in vivo: the key role of the activation of IL-6/JAK2/STAT3 signaling. PMID: 29388151 Ref: Dihydroartemisinin increases apoptosis of colon cancer cells through targeting Janus kinase 2/signal transducer and activator of transcription 3 signaling. PMID: 29434895 Ref: 6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid attenuates colon carcinogenesis via blockade of IL-6 mediated signals. PMID: 29448205 Ref: alpha-Hederin inhibits interleukin 6-induced epithelial-to-mesenchymal transition associated with disruption of JAK2/STAT3 signaling in colon cancer cells. PMID: 29477470 Ref: Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway. PMID: 29512698 Ref: Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2/STAT3 signaling in colorectal cancer. PMID: 29575334 Ref: Novel 1,3,4-thiadiazoles inhibit colorectal cancer via blockade of IL-6/COX-2 mediated JAK2/STAT3 signals as evidenced through data-based mathematical modeling. PMID: 29580751 Ref: Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers. PMID: 29641532 Ref: Downregulation of RPN2 induces apoptosis and inhibits migration and invasion in colon carcinoma. PMID: 29749494 Ref: Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2-STAT3 pathway. PMID: 29892198 Ref: Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion. PMID: 30107178 |