Literatures

Primary Site >> Liver Cancer

Gene >> JAK1

1.
Journal:	J Biol Chem. 1998 Sep 25;273(39):25510-5.
Title:	HBx protein of hepatitis B virus activates Jak1-STAT signaling.
Author:	Lee, Y H\|Yun, Y
PMID:	9738022

2.
Journal:	J Immunol. 1999 Dec 15;163(12):6651-8.
Title:	Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130.
Author:	Hermanns, H M\|Radtke, S\|Haan, C\|Schmitz-Van de Leur, H\|Tavernier, J\|Heinrich, P C\|Behrmann, I
PMID:	10586060

3.
Journal:	Hepatology. 2001 Feb;33(2):346-56.
Title:	Interferon-alpha delays S-phase progression in human hepatocellular carcinoma cells via inhibition of specific cyclin-dependent kinases.
Author:	Murphy, D\|Detjen, K M\|Welzel, M\|Wiedenmann, B\|Rosewicz, S
PMID:	11172336

4.
Journal:	Toxicol Appl Pharmacol. 2003 May 1;188(3):185-98.
Title:	Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643.
Author:	Vanden Heuvel, John P\|Kreder, Dirk\|Belda, Benjamin\|Hannon, Daniel B\|Nugent, Courtney A\|Burns, Katherine A\|Taylor, Michael J
PMID:	12729718

5.
Journal:	Virology. 2004 Apr 25;322(1):51-60.
Title:	Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase.
Author:	Sarcar, Bhaswati\|Ghosh, Asish K\|Steele, Robert\|Ray, Ranjit\|Ray, Ratna B
PMID:	15063116

6.
Journal:	Virol J. 2005 Dec 2;2:89.
Title:	Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells.
Author:	Plumlee, Courtney R\|Lazaro, Catherine A\|Fausto, Nelson\|Polyak, Stephen J
PMID:	16324217

7.
Journal:	Int J Oncol. 2006 Nov;29(5):1253-61.
Title:	Combination of 5-FU and IFNalpha enhances IFN signaling pathway and caspase-8 activity, resulting in marked apoptosis in hepatoma cell lines.
Author:	Koike, Kazuko\|Takaki, Akinobu\|Tatsukawa, Masashi\|Suzuki, Mayumi\|Shiraha, Hidenori\|Iwasaki, Yoshiaki\|Sakaguchi, Kohsaku\|Shiratori, Yasushi
PMID:	17016659

8.
Journal:	Hepatology. 2008 Apr;47(4):1136-49.
Title:	Potential contribution of tumor suppressor p53 in the host defense against hepatitis C virus.
Author:	Dharel, Narayan\|Kato, Naoya\|Muroyama, Ryosuke\|Taniguchi, Hiroyoshi\|Otsuka, Motoyuki\|Wang, Yue\|Jazag, Amarsanaa\|Shao, Run-Xuan\|Chang, Jin-Hai\|Adler, Mark K\|Kawabe, Takao\|Omata, Masao
PMID:	18220274

9.
Journal:	Clin Cancer Res. 2008 Jun 15;14(12):3716-21.
Title:	Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers.
Author:	Jeong, Eun Goo\|Kim, Min Sung\|Nam, Hyo Kyung\|Min, Chang Ki\|Lee, Seok\|Chung, Yeun Jun\|Yoo, Nam Jin\|Lee, Sug Hyung
PMID:	18559588

10.
Journal:	Neoplasma. 2009;56(2):136-40.
Title:	Mutational analysis of JAK1 gene in human hepatocellular carcinoma.
Author:	Xie, H J\|Bae, H J\|Noh, J H\|Eun, J W\|Kim, J K\|Jung, K H\|Ryu, J C\|Ahn, Y M\|Kim, S Y\|Lee, S H\|Yoo, N J\|Lee, J Y\|Park, W S\|Nam, S W
PMID:	19239328

11.
Journal:	Cancer Lett. 2010 Jun 28;292(2):197-207.
Title:	Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells.
Author:	Li, Feng\|Fernandez, Prasana Priscilla\|Rajendran, Peramaiyan\|Hui, Kam M\|Sethi, Gautam
PMID:	20053498

12.
Journal:	Br J Pharmacol. 2011 May;163(2):283-98.
Title:	gamma-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent.
Author:	Rajendran, Peramaiyan\|Li, Feng\|Manu, Kanjoormana Aryan\|Shanmugam, Muthu K\|Loo, Ser Yue\|Kumar, Alan Prem\|Sethi, Gautam
PMID:	21198544

13.
Journal:	Biotechnol J. 2012 Nov;7(11):1395-404.
Title:	Gene network analysis leads to functional validation of pathways linked to cancer cell growth and survival.
Author:	Berger, Emmanuelle\|Vega, Nathalie\|Vidal, Hubert\|Geloen, Alain
PMID:	22930530

14.
Journal:	J Biol Chem. 2012 Nov 23;287(48):40140-9.
Title:	Estrogen represses hepatocellular carcinoma (HCC) growth via inhibiting alternative activation of tumor-associated macrophages (TAMs).
Author:	Yang, Weiwei\|Lu, Yan\|Xu, Yichen\|Xu, Lizhi\|Zheng, Wei\|Wu, Yuanyuan\|Li, Long\|Shen, Pingping
PMID:	22908233

15.
Journal:	Int J Mol Med. 2013 Jul;32(1):79-84.
Title:	Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway.
Author:	Liao, Jun\|Xu, Teng\|Zheng, Jia-Xuan\|Lin, Jiu-Mao\|Cai, Qiao-Yan\|Yu, De-Biao\|Peng, Jun
PMID:	23613111

16.
Journal:	Cancer Gene Ther. 2013 Jun;20(6):366-74.
Title:	Aspirin enhances IFN-alpha-induced growth inhibition and apoptosis of hepatocellular carcinoma via JAK1/STAT1 pathway.
Author:	Li, T\|Dong, Z-R\|Guo, Z-Y\|Wang, C-H\|Tang, Z-Y\|Qu, S-F\|Chen, Z-T\|Li, X-W\|Zhi, X-T
PMID:	23703473

17.
Journal:	Mol Cell Endocrinol. 2013 Aug 15;375(1-2):68-78.
Title:	Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes.
Author:	Nerstedt, Annika\|Cansby, Emmelie\|Amrutkar, Manoj\|Smith, Ulf\|Mahlapuu, Margit
PMID:	23707791

18.
Journal:	Genome Res. 2013 Sep;23(9):1422-33.
Title:	Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma.
Author:	Kan, Zhengyan\|Zheng, Hancheng\|Liu, Xiao\|Li, Shuyu\|Barber, Thomas D\|Gong, Zhuolin\|Gao, Huan\|Hao, Ke\|Willard, Melinda D\|Xu, Jiangchun\|Hauptschein, Robert\|Rejto, Paul A\|Fernandez, Julio\|Wang, Guan\|Zhang, Qinghui\|Wang, Bo\|Chen, Ronghua\|Wang, Jian\|Lee, Nikki P
PMID:	23788652

19.
Journal:	Br J Pharmacol. 2013 Oct;170(4):807-21.
Title:	Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3.
Author:	Subramaniam, Aruljothi\|Shanmugam, Muthu K\|Ong, Tina H\|Li, Feng\|Perumal, Ekambaram\|Chen, Luxi\|Vali, Shireen\|Abbasi, Taher\|Kapoor, Shweta\|Ahn, Kwang Seok\|Kumar, Alan Prem\|Hui, Kam M\|Sethi, Gautam
PMID:	23848338

20.
Journal:	World J Gastroenterol. 2013 Dec 21;19(47):8873-9.
Title:	Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma.
Author:	Gu, De-Leung\|Chen, Yen-Hsieh\|Shih, Jou-Ho\|Lin, Chi-Hung\|Jou, Yuh-Shan\|Chen, Chian-Feng
PMID:	24379610

21.
Journal:	Oncoimmunology. 2013 Dec 1;2(12):e27090.
Title:	Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma.
Author:	Poussin, Karine\|Pilati, Camilla\|Couchy, Gabrielle\|Calderaro, Julien\|Bioulac-Sage, Paulette\|Bacq, Yannick\|Paradis, Valerie\|Leteurtre, Emmanuelle\|Sturm, Nathalie\|Ramos, Jeanne\|Guettier, Catherine\|Bardier-Dupas, Armelle\|Boulai, Anais\|Wendum, Dominique\|Selves
PMID:	24501689

22.
Journal:	J Biol Chem. 2014 Dec 5;289(49):34296-307.
Title:	Development of a novel azaspirane that targets the Janus kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivo.
Author:	Mohan, Chakrabhavi Dhananjaya\|Bharathkumar, Hanumantharayappa\|Bulusu, Krishna C\|Pandey, Vijay\|Rangappa, Shobith\|Fuchs, Julian E\|Shanmugam, Muthu K\|Dai, Xiaoyun\|Li, Feng\|Deivasigamani, Amudha\|Hui, Kam M\|Kumar, Alan Prem\|Lobie, Peter E\|Bender, Andreas\|Basap
PMID:	25320076

23.
Journal:	Cell Physiol Biochem. 2014;34(3):903-15.
Title:	Des-gamma-carboxy prothrombin (DCP) as a potential autologous growth factor for the development of hepatocellular carcinoma.
Author:	Zhang, Yu-Sheng\|Chu, Jia-Hui\|Cui, Shu-Xiang\|Song, Zhi-Yu\|Qu, Xian-Jun
PMID:	25200250

24.
Journal:	Genome Biol. 2014 Aug 26;15(8):436.
Title:	Diverse modes of genomic alteration in hepatocellular carcinoma.
Author:	Jhunjhunwala, Suchit\|Jiang, Zhaoshi\|Stawiski, Eric W\|Gnad, Florian\|Liu, Jinfeng\|Mayba, Oleg\|Du, Pan\|Diao, Jingyu\|Johnson, Stephanie\|Wong, Kwong-Fai\|Gao, Zhibo\|Li, Yingrui\|Wu, Thomas D\|Kapadia, Sharookh B\|Modrusan, Zora\|French, Dorothy M\|Luk, John M\|Seshag
PMID:	25159915

25.
Journal:	Cancer Cell. 2014 Apr 14;25(4):428-41.
Title:	Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation.
Author:	Pilati, Camilla\|Letouze, Eric\|Nault, Jean-Charles\|Imbeaud, Sandrine\|Boulai, Anais\|Calderaro, Julien\|Poussin, Karine\|Franconi, Andrea\|Couchy, Gabrielle\|Morcrette, Guillaume\|Mallet, Maxime\|Taouji, Said\|Balabaud, Charles\|Terris, Benoit\|Canal, Frederic\|Paradi
PMID:	24735922

26.
Journal:	Cell Signal. 2014 Mar;26(3):619-28.
Title:	Luteolin sensitizes the antiproliferative effect of interferon alpha/beta by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 i
Author:	Tai, Zhengfu\|Lin, Yuan\|He, Yujiao\|Huang, Junmei\|Guo, Jiajia\|Yang, Lijuan\|Zhang, Guolin\|Wang, Fei
PMID:	24333668

27.
Journal:	PLoS One. 2014 May 5;9(5):e95307.
Title:	Transcriptomic characterization of hepatocellular carcinoma with CTNNB1 mutation.
Author:	Ding, Xiao\|Yang, Yuan\|Han, Baoda\|Du, Chengzhi\|Xu, Naiqing\|Huang, Huanwei\|Cai, Tao\|Zhang, Aiqun\|Han, Ze-Guang\|Zhou, Weiping\|Chen, Liang
PMID:	24798046

28.
Journal:	Carcinogenesis. 2015 Oct;36(10):1201-12.
Title:	LIFR functions as a metastasis suppressor in hepatocellular carcinoma by negatively regulating phosphoinositide 3-kinase/AKT pathway.
Author:	Luo, Qin\|Wang, Cun\|Jin, Guangzhi\|Gu, Dishui\|Wang, Ning\|Song, Jin\|Jin, Haojie\|Hu, Fangyuan\|Zhang, Yurong\|Ge, Tianxiang\|Huo, Xisong\|Chu, Wei\|Shu, Huiqun\|Fang, Jingyuan\|Yao, Ming\|Gu, Jianren\|Cong, Wenming\|Qin, Wenxin
PMID:	26249360

29.
Journal:	Life Sci. 2015 Dec 1;142:19-25.
Title:	Molecular mechanisms underlying anticancer effects of myricetin.
Author:	Devi, Kasi Pandima\|Rajavel, Tamilselvam\|Habtemariam, Solomon\|Nabavi, Seyed Fazel\|Nabavi, Seyed Mohammad
PMID:	26455550

30.
Journal:	Oncotarget. 2016 Feb 2;7(5):5461-9.
Title:	Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma.
Author:	Yang, Shuqun\|Luo, Chonglin\|Gu, Qingyang\|Xu, Qiang\|Wang, Guan\|Sun, Hongye\|Qian, Ziliang\|Tan, Yexiong\|Qin, Yuxin\|Shen, Yuhong\|Xu, Xiaowei\|Chen, Shu-Hui\|Chan, Chi-Chung\|Wang, Hongyang\|Mao, Mao\|Fang, Douglas D
PMID:	26701727

31.
Journal:	J Genet Genomics. 2016 Feb 20;43(2):99-102.
Title:	Overexpression of Jak1 Activating Mutants in Hepatocytes Is Insufficient to Generate Hepatocellular Carcinoma in Zebrafish.
Author:	Yuan, Yue\|Zhang, Jian\|Zhou, Qin
PMID:	26924692

32.
Journal:	Oncotarget. 2016 Jul 12;7(28):43475-43491.
Title:	(-)-Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma.
Author:	Pei, Tiemin\|Meng, Qinghui\|Han, Jihua\|Sun, Haobo\|Li, Long\|Song, Ruipeng\|Sun, Boshi\|Pan, Shangha\|Liang, Desen\|Liu, Lianxin
PMID:	27259268

33.
Journal:	Neoplasia. 2016 Jun;18(6):371-86.
Title:	A Positive TGF-beta/c-KIT Feedback Loop Drives Tumor Progression in Advanced Primary Liver Cancer.
Author:	Rojas, Andres\|Zhang, Pingyu\|Wang, Ying\|Foo, Wai Chin\|Munoz, Nina M\|Xiao, Lianchun\|Wang, Jing\|Gores, Gregory J\|Hung, Mien-Chie\|Blechacz, Boris
PMID:	27292026

34.
Journal:	Oncol Rep. 2017 Jul;38(1):393-401.
Title:	miR-30e acts as a tumor suppressor in hepatocellular carcinoma partly via JAK1/STAT3 pathway.
Author:	Mao, Junjie\|Hu, Xiaojun\|Pang, Pengfei\|Zhou, Bin\|Li, Dan\|Shan, Hong
PMID:	28560434

35.
Journal:	Toxicol Appl Pharmacol. 2017 Dec 1;336:31-39.
Title:	6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon alpha/beta by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells.
Author:	Wonganan, Orawan\|He, Yu-Jiao\|Shen, Xiao-Fei\|Wongkrajang, Kanjana\|Suksamrarn, Apichart\|Zhang, Guo-Lin\|Wang, Fei
PMID:	29031523

36.
Journal:	PLoS One. 2017 Jul 12;12(7):e0180927.
Title:	Interferon-related genetic markers of necroinflammatory activity in chronic hepatitis C.
Author:	Lopez-Rodriguez, Rosario\|Hernandez-Bartolome, Angel\|Borque, Maria Jesus\|Rodriguez-Munoz, Yolanda\|Martin-Vilchez, Samuel\|Garcia-Buey, Luisa\|Gonzalez-Moreno, Leticia\|Real-Martinez, Yolanda\|Munoz de Rueda, Paloma\|Salmeron, Javier\|Vidal-Castineira, Jose Ramon
PMID:	28704535

37.
Journal:	Sci China Life Sci. 2017 Jun;60(6):617-626.
Title:	APOBEC3B and IL-6 form a positive feedback loop in hepatocellular carcinoma cells.
Author:	Li, Shuran\|Bao, Xueyang\|Wang, Duowei\|You, Linjun\|Li, Xianjing\|Yang, Hongbao\|Bian, Jinsong\|Wang, Yun\|Yang, Yong
PMID:	28646470

38.
Journal:	Int J Biol Macromol. 2017 Nov;104(Pt A):681-686.
Title:	A pumpkin polysaccharide induces apoptosis by inhibiting the JAK2/STAT3 pathway in human hepatoma HepG2 cells.
Author:	Shen, Weixi\|Chen, Chunhong\|Guan, Yuanyuan\|Song, Xiaowei\|Jin, Yinghua\|Wang, Jingfang\|Hu, Yu\|Xin, Tao\|Jiang, Qiuying\|Zhong, Li
PMID:	28634059

39.
Journal:	Infect Agent Cancer. 2017 Mar 20;12:17.
Title:	Aflatoxin B1 inhibits the type 1 interferon response pathway via STAT1 suggesting another mechanism of hepatocellular carcinoma.
Author:	Narkwa, Patrick W\|Blackbourn, David J\|Mutocheluh, Mohamed
PMID:	28344639

40.
Journal:	Biochem Biophys Res Commun. 2017 Jan 29;483(1):578-584.
Title:	MicroRNA-340 inhibits the proliferation and invasion of hepatocellular carcinoma cells by targeting JAK1.
Author:	Yuan, Jianyong\|Ji, Hongxiang\|Xiao, Feng\|Lin, Zhipeng\|Zhao, Xijun\|Wang, Zhouchong\|Zhao, Jun\|Lu, Junhua
PMID:	27998770

41.
Journal:	Gastroenterology. 2017 Mar;152(4):880-894.e6.
Title:	Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.
Author:	Nault, Jean-Charles\|Couchy, Gabrielle\|Balabaud, Charles\|Morcrette, Guillaume\|Caruso, Stefano\|Blanc, Jean-Frederic\|Bacq, Yannick\|Calderaro, Julien\|Paradis, Valerie\|Ramos, Jeanne\|Scoazec, Jean-Yves\|Gnemmi, Viviane\|Sturm, Nathalie\|Guettier, Catherine\|Fabre,
PMID:	27939373

42.
Journal:	Appl Biochem Biotechnol. 2018 Jan;184(1):212-227.
Title:	Inhibitory Effect and Mechanism of Mesenchymal Stem Cells Cultured in 3D System on Hepatoma Cells HepG2.
Author:	Zhao, Diandian\|Hou, Lingling\|Pan, Mengwu\|Hua, Jilei\|Wang, Ziling\|He, Jinsheng\|Hu, Honggang
PMID:	28664526

43.
Journal:	Oncol Rep. 2018 Apr;39(4):1883-1891.
Title:	Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL-6-stimulated liver cancer cells.
Author:	Kim, Buyun\|Park, Byoungduck
PMID:	29393468

44.
Journal:	Oncogene. 2018 Jul;37(27):3740-3752.
Title:	A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma.
Author:	Labgaa, Ismail\|Villacorta-Martin, Carlos\|D'Avola, Delia\|Craig, Amanda J\|von Felden, Johann\|Martins-Filho, Sebastiao N\|Sia, Daniela\|Stueck, Ashley\|Ward, Stephen C\|Fiel, M Isabel\|Mahajan, Milind\|Tabrizian, Parissa\|Thung, Swan N\|Ang, Celina\|Friedman, Scott L
PMID:	29628508

45.
Journal:	Oncol Lett. 2018 May;15(5):8088-8094.
Title:	An indel polymorphism in the 3' untranslated region of JAK1 confers risk for hepatocellular carcinoma possibly by regulating JAK1 transcriptional activity in a Chinese population.
Author:	Yu, Qiang\|Qian, Weifeng\|Wang, Jian\|Wu, Yejiao\|Zhang, Jinkun\|Chen, Weichang
PMID:	29731916

46.
Journal:	Int J Mol Sci. 2018 May 7;19(5). pii: ijms19051386.
Title:	Polysaccharides Extracted from Rhizoma Pleionis Have Antitumor Properties In Vitro and in an H22 Mouse Hepatoma Ascites Model In Vivo.
Author:	Fang, Yukun\|Ning, Anhong\|Li, Sha\|Zhou, Shaozheng\|Liu, Lei\|Joseph, Thomson Patrick\|Zhong, Mintao\|Jiao, Jilong\|Zhang, Wei\|Shi, Yonghui\|Zhang, Meishan\|Huang, Min
PMID:	29735884

47.
Journal:	J Exp Pharmacol. 2018 May 9;10:9-17.
Title:	Pilot study of the antifibrotic effects of the multikinase inhibitor pacritinib in a mouse model of liver fibrosis.
Author:	Al-Fayoumi, Suliman\|Hashiguchi, Taishi\|Shirakata, Yuka\|Mascarenhas, John\|Singer, Jack W
PMID:	29785143

48.
Journal:	Int J Biol Sci. 2018 Apr 25;14(5):577-585.
Title:	Chemical and genetic inhibition of STAT3 sensitizes hepatocellular carcinoma cells to sorafenib induced cell death.
Author:	Xie, Linna\|Zeng, Yanhua\|Dai, Zichan\|He, Wensheng\|Ke, Huozhao\|Lin, Qiaofa\|Chen, Yan\|Bu, Jingjing\|Lin, Dexin\|Zheng, Min
PMID:	29805309