Primary Site >> Liver Cancer
Gene >> JAK1
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Ref: HBx protein of hepatitis B virus activates Jak1-STAT signaling. PMID: 9738022 |
Ref: Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130. PMID: 10586060 |
Ref: Interferon-alpha delays S-phase progression in human hepatocellular carcinoma cells via inhibition of specific cyclin-dependent kinases. PMID: 11172336 |
Ref: Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643. PMID: 12729718 |
Ref: Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase. PMID: 15063116 |
Ref: Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells. PMID: 16324217 |
Ref: Combination of 5-FU and IFNalpha enhances IFN signaling pathway and caspase-8 activity, resulting in marked apoptosis in hepatoma cell lines. PMID: 17016659 |
Ref: Potential contribution of tumor suppressor p53 in the host defense against hepatitis C virus. PMID: 18220274 Ref: Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers. PMID: 18559588 |
Ref: Mutational analysis of JAK1 gene in human hepatocellular carcinoma. PMID: 19239328 |
Ref: Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. PMID: 20053498 |
Ref: gamma-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent. PMID: 21198544 |
Ref: Estrogen represses hepatocellular carcinoma (HCC) growth via inhibiting alternative activation of tumor-associated macrophages (TAMs). PMID: 22908233 Ref: Gene network analysis leads to functional validation of pathways linked to cancer cell growth and survival. PMID: 22930530 |
Ref: Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway. PMID: 23613111 Ref: Aspirin enhances IFN-alpha-induced growth inhibition and apoptosis of hepatocellular carcinoma via JAK1/STAT1 pathway. PMID: 23703473 Ref: Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes. PMID: 23707791 Ref: Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. PMID: 23788652 Ref: Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3. PMID: 23848338 Ref: Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma. PMID: 24379610 Ref: Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma. PMID: 24501689 |
Ref: Luteolin sensitizes the antiproliferative effect of interferon alpha/beta by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 i PMID: 24333668 Ref: Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation. PMID: 24735922 Ref: Transcriptomic characterization of hepatocellular carcinoma with CTNNB1 mutation. PMID: 24798046 Ref: Diverse modes of genomic alteration in hepatocellular carcinoma. PMID: 25159915 Ref: Des-gamma-carboxy prothrombin (DCP) as a potential autologous growth factor for the development of hepatocellular carcinoma. PMID: 25200250 Ref: Development of a novel azaspirane that targets the Janus kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivo. PMID: 25320076 |
Ref: LIFR functions as a metastasis suppressor in hepatocellular carcinoma by negatively regulating phosphoinositide 3-kinase/AKT pathway. PMID: 26249360 Ref: Molecular mechanisms underlying anticancer effects of myricetin. PMID: 26455550 |
Ref: Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma. PMID: 26701727 Ref: Overexpression of Jak1 Activating Mutants in Hepatocytes Is Insufficient to Generate Hepatocellular Carcinoma in Zebrafish. PMID: 26924692 Ref: (-)-Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma. PMID: 27259268 Ref: A Positive TGF-beta/c-KIT Feedback Loop Drives Tumor Progression in Advanced Primary Liver Cancer. PMID: 27292026 |
Ref: Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation. PMID: 27939373 Ref: MicroRNA-340 inhibits the proliferation and invasion of hepatocellular carcinoma cells by targeting JAK1. PMID: 27998770 Ref: Aflatoxin B1 inhibits the type 1 interferon response pathway via STAT1 suggesting another mechanism of hepatocellular carcinoma. PMID: 28344639 Ref: miR-30e acts as a tumor suppressor in hepatocellular carcinoma partly via JAK1/STAT3 pathway. PMID: 28560434 Ref: A pumpkin polysaccharide induces apoptosis by inhibiting the JAK2/STAT3 pathway in human hepatoma HepG2 cells. PMID: 28634059 Ref: APOBEC3B and IL-6 form a positive feedback loop in hepatocellular carcinoma cells. PMID: 28646470 Ref: Interferon-related genetic markers of necroinflammatory activity in chronic hepatitis C. PMID: 28704535 Ref: 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon alpha/beta by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells. PMID: 29031523 |
Ref: Inhibitory Effect and Mechanism of Mesenchymal Stem Cells Cultured in 3D System on Hepatoma Cells HepG2. PMID: 28664526 Ref: Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL-6-stimulated liver cancer cells. PMID: 29393468 Ref: A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma. PMID: 29628508 Ref: An indel polymorphism in the 3' untranslated region of JAK1 confers risk for hepatocellular carcinoma possibly by regulating JAK1 transcriptional activity in a Chinese population. PMID: 29731916 Ref: Polysaccharides Extracted from Rhizoma Pleionis Have Antitumor Properties In Vitro and in an H22 Mouse Hepatoma Ascites Model In Vivo. PMID: 29735884 Ref: Pilot study of the antifibrotic effects of the multikinase inhibitor pacritinib in a mouse model of liver fibrosis. PMID: 29785143 Ref: Chemical and genetic inhibition of STAT3 sensitizes hepatocellular carcinoma cells to sorafenib induced cell death. PMID: 29805309 |