Primary Site >> Colorectal Cancer

Gene >> IRS1

Journal: J Biol Chem. 1995 Dec 22;270(51):30829-36.
Title: Receptors for interleukin (IL)-4 do not associate with the common gamma chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells.
Author: Murata, T|Noguchi, P D|Puri, R K
PMID: 8530527
Journal: Biochem J. 1996 May 1;315 ( Pt 3):767-74.
Title: Growth inhibition signalled through the interleukin-4/interleukin-13 receptor complex is associated with tyrosine phosphorylation of insulin receptor substrate-1.
Author: Schnyder, B|Lahm, H|Woerly, G|Odartchenko, N|Ryffel, B|Car, B D
PMID: 8645156
Journal: Braz J Med Biol Res. 1996 Dec;29(12):1593-7.
Title: Insulin receptor tyrosine kinase activity in colon carcinoma.
Author: Corleta, H E|Capp, E|Corleta, O C
PMID: 9222417
Journal: Cell Death Differ. 2002 Jul;9(7):768-79.
Title: Prevention of cytokine-induced apoptosis by insulin-like growth factor-I is independent of cell adhesion molecules in HT29-D4 colon carcinoma cells-evidence for a NF-kappaB-dependent survival mechanism.
Author: Garrouste, F|Remacle-Bonnet, M|Fauriat, C|Marvaldi, J|Luis, J|Pommier, G
PMID: 12058282
Journal: J Recept Signal Transduct Res. 2002 Feb-Nov;22(1-4):213-28.
Title: Mono- or dual-phosphorylation of akt kinase is regulated by distinct receptors that involve the common insulin receptor substrate.
Author: Schnyder, Bruno|Lahm, Harald|Pittet, Martine|Schnyder-Candrian, Silvia
PMID: 12503617
Journal: Cancer Epidemiol Biomarkers Prev. 2004 Apr;13(4):538-45.
Title: Aspirin, NSAIDs, and colorectal cancer: possible involvement in an insulin-related pathway.
Author: Slattery, Martha L|Samowitz, Wade|Hoffman, Michael|Ma, Khi Ne|Levin, Theodore R|Neuhausen, Susan
PMID: 15066917
Journal: Cancer Epidemiol Biomarkers Prev. 2004 Jul;13(7):1206-14.
Title: Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer.
Author: Slattery, Martha L|Samowitz, Wade|Curtin, Karen|Ma, Khe Ni|Hoffman, Michael|Caan, Bette|Neuhausen, Susan
PMID: 15247132
Journal: Int J Cancer. 2005 May 20;115(1):148-54.
Title: Energy balance, insulin-related genes and risk of colon and rectal cancer.
Author: Slattery, Martha L|Murtaugh, Maureen|Caan, Bette|Ma, Khe Ni|Neuhausen, Susan|Samowitz, Wade
PMID: 15688407
Journal: Cancer Res. 2005 Mar 15;65(6):2085-8.
Title: Activated Ras enhances insulin-like growth factor I induction of vascular endothelial growth factor in prostate epithelial cells.
Author: Stearns, Mark|Tran, Jordan|Francis, Mary Kay|Zhang, Hong|Sell, Christian
PMID: 15781617
Journal: Am J Pathol. 2005 Sep;167(3):761-73.
Title: Membrane rafts segregate pro- from anti-apoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily.
Author: Remacle-Bonnet, Maryse|Garrouste, Francoise|Baillat, Gilbert|Andre, Frederic|Marvaldi, Jacques|Pommier, Gilbert
PMID: 16127155
Journal: J Med Food. 2005 Winter;8(4):431-8.
Title: Genistein inhibits insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells: a possible mechanism of the growth inhibitory effect of Genistein.
Author: Kim, Eun Ji|Shin, Hyun-Kyung|Park, Jung Han Yoon
PMID: 16379552
Journal: Mutat Res. 2006 Mar 20;595(1-2):117-24.
Title: Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer.
Author: Samowitz, Wade S|Wolff, Roger K|Ma, Khe Ni|Andersen, Kristen|Caan, Bette|Slattery, Martha L
PMID: 16448675
Journal: Cancer Causes Control. 2006 Apr;17(3):239-49.
Title: PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States).
Author: Slattery, Martha L|Curtin, Karen|Wolff, Roger|Ma, Khe Ni|Sweeney, Carol|Murtaugh, Maureen|Potter, John D|Levin, Theodore R|Samowitz, Wade
PMID: 16489531
Journal: J Biol Chem. 2007 Nov 9;282(45):32582-90.
Title: Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells.
Author: Shi, Bin|Sepp-Lorenzino, Laura|Prisco, Marco|Linsley, Peter|deAngelis, Tiziana|Baserga, Renato
PMID: 17827156
Journal: Endocr Relat Cancer. 2007 Sep;14(3):733-40.
Title: Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect.
Author: Pechlivanis, Sonali|Pardini, Barbara|Bermejo, Justo Lorenzo|Wagner, Kerstin|Naccarati, Alessio|Vodickova, Ludmila|Novotny, Jan|Hemminki, Kari|Vodicka, Pavel|Forsti, Asta
PMID: 17914103
Journal: Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):703-8.
Title: Insulin resistance-related genes and advanced left-sided colorectal adenoma.
Author: Gunter, Marc J|Hayes, Richard B|Chatterjee, Nilanjan|Yeager, Meredith|Welch, Robert|Schoen, Robert E|Yakochi, Lance|Schatzkin, Arthur|Peters, Ulrike
PMID: 17416760
Journal: Int J Cancer. 2008 Apr 1;122(7):1611-7.
Title: Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions.
Author: Slattery, Martha L|Wolff, Roger K|Herrick, Jennifer|Caan, Bette J|Potter, John D
PMID: 18059035
Journal: J Clin Invest. 2008 Jan;118(1):352-63.
Title: Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.
Author: Scamuffa, Nathalie|Siegfried, Geraldine|Bontemps, Yannick|Ma, Liming|Basak, Ajoy|Cherel, Ghislaine|Calvo, Fabien|Seidah, Nabil G|Khatib, Abdel-Majid
PMID: 18064302
Journal: J Cell Physiol. 2009 Aug;220(2):485-91.
Title: Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway.
Author: La Rocca, Gaspare|Badin, Margherita|Shi, Bin|Xu, Shi-Qiong|Deangelis, Tiziana|Sepp-Lorenzinoi, Laura|Baserga, Renato
PMID: 19391107
Journal: Oncology. 2009;77(1):12-21.
Title: Decreased expression of microRNA-143 and -145 in human gastric cancers.
Author: Takagi, Takeshi|Iio, Akio|Nakagawa, Yoshihito|Naoe, Tomoki|Tanigawa, Nobuhiko|Akao, Yukihiro
PMID: 19439999
Journal: Mol Cancer Ther. 2009 Aug;8(8):2110-21.
Title: Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer.
Author: Zha, Jiping|O'Brien, Carol|Savage, Heidi|Huw, Ling-Yuh|Zhong, Fiona|Berry, Leanne|Lewis Phillips, Gail D|Luis, Elizabeth|Cavet, Guy|Hu, Xiaolan|Amler, Lukas C|Lackner, Mark R
PMID: 19671761
Journal: J Biol Chem. 2010 Jan 15;285(3):1928-38.
Title: IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype.
Author: Bommer, Guido T|Feng, Ying|Iura, Ayaka|Giordano, Thomas J|Kuick, Rork|Kadikoy, Huseyin|Sikorski, Deanna|Wu, Rong|Cho, Kathleen R|Fearon, Eric R
PMID: 19843521
Journal: J Pharmacol Exp Ther. 2010 Nov;335(2):351-61.
Title: Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor.
Author: Liu, Yanxia|Salvador, Lilibeth A|Byeon, Seongrim|Ying, Yongcheng|Kwan, Jason C|Law, Brian K|Hong, Jiyong|Luesch, Hendrik
PMID: 20739454
Journal: Mol Cancer. 2010 Oct 26;9:281.
Title: IGFBP-rP1, a potential molecule associated with colon cancer differentiation.
Author: Ruan, Wenjing|Zhu, Shuzhen|Wang, Haibing|Xu, Fangying|Deng, Hong|Ma, Yu|Lai, Maode
PMID: 20977730
Journal: BMC Cancer. 2011 Aug 5;11:339.
Title: Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins.
Author: Abuli, Anna|Fernandez-Rozadilla, Ceres|Alonso-Espinaco, Virginia|Munoz, Jenifer|Gonzalo, Victoria|Bessa, Xavier|Gonzalez, Dolors|Clofent, Joan|Cubiella, Joaquin|Morillas, Juan D|Rigau, Joaquim|Latorre, Mercedes|Fernandez-Banares, Fernando|Pena, Elena|Ries
PMID: 21819567
Journal: Int J Immunopathol Pharmacol. 2011 Jul-Sep;24(3):781-7.
Title: Analysis of expression profile of gene encoding proteins of signal cascades activated by insulin-like growth factors in colorectal cancer.
Author: Nowakowska-Zajdel, E|Mazurek, U|Ziolko, E|Niedworok, E|Fatyga, E|Kokot, T|Muc-Wierzgon, Malgorzata
PMID: 21978709
Journal: Inflamm Bowel Dis. 2012 Jan;18(1):94-100.
Title: miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes.
Author: Pekow, Joel R|Dougherty, Urszula|Mustafi, Reba|Zhu, Hongyan|Kocherginsky, Masha|Rubin, David T|Hanauer, Stephen B|Hart, John|Chang, Eugene B|Fichera, Alessandro|Joseph, Loren J|Bissonnette, Marc
PMID: 21557394
Journal: PLoS One. 2012;7(10):e46716.
Title: Cytosolic malic enzyme 1 (ME1) mediates high fat diet-induced adiposity, endocrine profile, and gastrointestinal tract proliferation-associated biomarkers in male mice.
Author: Al-Dwairi, Ahmed|Pabona, John Mark P|Simmen, Rosalia C M|Simmen, Frank A
PMID: 23056418
Journal: PLoS One. 2012;7(4):e36190.
Title: The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer.
Author: Esposito, Diana L|Aru, Federica|Lattanzio, Rossano|Morgano, Annalisa|Abbondanza, Michela|Malekzadeh, Reza|Bishehsari, Faraz|Valanzano, Rosa|Russo, Antonio|Piantelli, Mauro|Moschetta, Antonio|Lotti, Lavinia Vittoria|Mariani-Costantini, Renato
PMID: 22558377
Journal: Biochim Biophys Acta. 2013 Feb;1829(2):239-47.
Title: Downregulation of miR-145 associated with cancer progression and VEGF transcriptional activation by targeting N-RAS and IRS1.
Author: Yin, Yu|Yan, Zhi-Ping|Lu, Na-Na|Xu, Qing|He, Jun|Qian, Xu|Yu, Jing|Guan, Xin|Jiang, Bing-Hua|Liu, Ling-Zhi
PMID: 23201159
Journal: Oncol Rep. 2013 Oct;30(4):1553-60.
Title: Novel insulin receptor substrate 1 and 2 variants in breast and colorectal cancer.
Author: Esposito, Diana Liberata|Verginelli, Fabio|Toracchio, Sonia|Mammarella, Sandra|De Lellis, Laura|Vanni, Cinzia|Russo, Antonio|Mariani-Costantini, Renato|Cama, Alessandro
PMID: 23877285
Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Aug;38(8):809-17.
Title: [miR-126 inhibits colon cancer proliferation and invasion through targeting IRS1, SLC7A5 and TOM1 gene].
Author: Li, Nan|Li, Xiayu|Huang, Shuo|Shen, Shourong|Wang, Xiaoyan
PMID: 23981989
Journal: PLoS One. 2013 Nov 29;8(11):e81203.
Title: Down-regulation of miR-126 is associated with colorectal cancer cells proliferation, migration and invasion by targeting IRS-1 via the AKT and ERK1/2 signaling pathways.
Author: Zhou, Yu|Feng, Xiao|Liu, Ya-ling|Ye, Shi-cai|Wang, Hao|Tan, Wen-kai|Tian, Ting|Qiu, Yu-mei|Luo, He-sheng
PMID: 24312276
Journal: Genet Mol Res. 2013 Dec 4;12(4):6268-74.
Title: Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population.
Author: Wei, W|Jiang, M|Luo, L|Li, Z|Wang, P|Dong, W Q
PMID: 24338422
Journal: Horm Metab Res. 2014 Feb;46(2):85-93.
Title: Chronic insulin exposure does not cause insulin resistance but is associated with chemo-resistance in colon cancer cells.
Author: Baricevic, I|Roberts, D L|Renehan, A G
PMID: 24068609
Journal: Tumour Biol. 2014 Jul;35(7):6581-5.
Title: Association between IRS-1 Gly972Arg polymorphism and colorectal cancer risk.
Author: Li, Peng|Wang, Lingjun|Liu, Lihua|Jiang, Hong|Ma, Chong|Hao, Tao
PMID: 24696264
Journal: Am J Physiol Gastrointest Liver Physiol. 2015 Feb 1;308(3):G179-87.
Title: Tumor suppressors miR-143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon.
Author: Pekow, Joel|Meckel, Katherine|Dougherty, Urszula|Butun, Fatma|Mustafi, Reba|Lim, John|Crofton, Charis|Chen, Xindi|Joseph, Loren|Bissonnette, Marc
PMID: 25477374
Journal: Tumour Biol. 2015 May;36(5):3709-15.
Title: An exon variant in insulin receptor gene is associated with susceptibility to colorectal cancer in women.
Author: Mahmoudi, Touraj|Majidzadeh-A, Keivan|Karimi, Khatoon|Karimi, Negar|Farahani, Hamid|Dabiri, Reza|Nobakht, Hossein|Dolatmoradi, Hesamodin|Arkani, Maral|Zali, Mohammad Reza
PMID: 25557790
Journal: Hum Pathol. 2015 May;46(5):753-60.
Title: Frameshift mutations in mammalian target of rapamycin pathway genes and their regional heterogeneity in sporadic colorectal cancers.
Author: Choi, Mi Ryoung|Yoo, Nam Jin|An, Chang Hyeok|Lee, Sug Hyung
PMID: 25776026
Journal: Oncol Rep. 2015 Nov;34(5):2797-805.
Title: MicroRNA-128 suppresses cell growth and metastasis in colorectal carcinoma by targeting IRS1.
Author: Wu, Lan|Shi, Bo|Huang, Kexin|Fan, Guoyu
PMID: 26352220
Journal: Int J Biol Markers. 2016 Feb 28;31(1):e68-72.
Title: Gly972Arg variant of insulin receptor substrate 1 gene and colorectal cancer risk in overweight/obese subjects.
Author: Mahmoudi, Touraj|Majidzadeh-A, Keivan|Karimi, Khatoon|Farahani, Hamid|Dabiri, Reza|Nobakht, Hossein|Asadi, Asadollah|Karimi, Negar|Arkani, Maral|Zali, Mohammad Reza
PMID: 26349669
Journal: Sci Signal. 2016 Nov 22;9(455):ra114.
Title: Integrating network reconstruction with mechanistic modeling to predict cancer therapies.
Author: Halasz, Melinda|Kholodenko, Boris N|Kolch, Walter|Santra, Tapesh
PMID: 27879396
Journal: Clin Cancer Res. 2016 Oct 1;22(19):4766-4775.
Title: Physical Activity and Cancer Outcomes: A Precision Medicine Approach.
Author: Friedenreich, Christine M|Neilson, Heather K|Farris, Megan S|Courneya, Kerry S
PMID: 27407093
Journal: Oncotarget. 2016 Jun 21;7(25):38143-38153.
Title: Down-regulation of tensin2 enhances tumorigenicity and is associated with a variety of cancers.
Author: Hong, Shiao-Ya|Shih, Yi-Ping|Sun, Peng|Hsieh, Wang-Ju|Lin, Wen-Chang|Lo, Su Hao
PMID: 27203214
Journal: Ann Surg Oncol. 2016 Mar;23(3):908-17.
Title: Survival Benefit of Exercise Differs by Tumor IRS1 Expression Status in Colorectal Cancer.
Author: Hanyuda, Akiko|Kim, Sun A|Martinez-Fernandez, Alejandro|Qian, Zhi Rong|Yamauchi, Mai|Nishihara, Reiko|Morikawa, Teppei|Liao, Xiaoyun|Inamura, Kentaro|Mima, Kosuke|Cao, Yin|Zhang, Xuehong|Wu, Kana|Chan, Andrew T|Giovannucci, Edward L|Meyerhardt, Jeffrey A|
PMID: 26577117
Journal: Int J Oncol. 2017 Feb;50(2):736-744.
Title: Insulin induction instigates cell proliferation and metastasis in human colorectal cancer cells.
Author: Lu, Chi-Cheng|Chu, Pei-Yi|Hsia, Shih-Min|Wu, Chi-Hao|Tung, Yu-Tang|Yen, Gow-Chin
PMID: 28101572
Journal: Int J Cancer. 2017 Jun 15;140(12):2648-2656.
Title: Dietary glycemic and insulin scores and colorectal cancer survival by tumor molecular biomarkers.
Author: Keum, NaNa|Yuan, Chen|Nishihara, Reiko|Zoltick, Emilie|Hamada, Tsuyoshi|Martinez Fernandez, Alejandro|Zhang, Xuehong|Hanyuda, Akiko|Liu, Li|Kosumi, Keisuke|Nowak, Jonathan A|Jhun, Iny|Soong, T Rinda|Morikawa, Teppei|Tabung, Fred K|Qian, Zhi Rong|Fuchs, Ch
PMID: 28268248
Journal: PLoS One. 2017 Apr 17;12(4):e0176096.
Title: TGFbeta/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cells.
Author: Bailey, Katie L|Agarwal, Ekta|Chowdhury, Sanjib|Luo, Jiangtao|Brattain, Michael G|Black, Jennifer D|Wang, Jing
PMID: 28414818
Journal: PLoS One. 2017 Oct 12;12(10):e0186296.
Title: Genetic variants and traits related to insulin-like growth factor-I and insulin resistance and their interaction with lifestyles on postmenopausal colorectal cancer risk.
Author: Jung, Su Yon|Rohan, Thomas|Strickler, Howard|Bea, Jennifer|Zhang, Zuo-Feng|Ho, Gloria|Crandall, Carolyn
PMID: 29023587
Journal: Bioorg Med Chem Lett. 2017 Dec 15;27(24):5446-5449.
Title: Novel all-hydrocarbon stapled p110alpha[E545K] peptides as blockers of the oncogenic p110alpha[E545K]-IRS1 interaction.
Author: Hu, Xiao|He, Yanhua|Wu, Liping|Hao, Yujun|Wang, Zhenghe|Zheng, Weiping
PMID: 29138025
Journal: Oncol Lett. 2017 Dec;14(6):6379-6386.
Title: MicroRNA-497 inhibits tumor growth through targeting insulin receptor substrate 1 in colorectal cancer.
Author: Xu, Yanjie|Chen, Jianping|Gao, Cao|Zhu, Danxia|Xu, Xiaoli|Wu, Changping|Jiang, Jingting
PMID: 29163678
Journal: Oncol Rep. 2018 Mar;39(3):1516-1522.
Title: Fucoidan downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells.
Author: Kim, In-Hye|Nam, Taek-Jeong
PMID: 29328495
Journal: Cancer Biomark. 2018;21(4):883-891.
Title: Expressions of IGF-1, ERK, GLUT4, IRS-1 in metabolic syndrome complicated with colorectal cancer and their associations with the clinical characteristics of CRC.
Author: Hu, Jianxia|Liu, Xiaoyi|Chi, Jingwei|Che, Kui|Feng, Yan|Zhao, Shihua|Wang, Zhongchao|Wang, Yangang
PMID: 29504525