Primary Site >> Colorectal Cancer
Gene >> IRS1
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Ref: Receptors for interleukin (IL)-4 do not associate with the common gamma chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells. PMID: 8530527 |
Ref: Growth inhibition signalled through the interleukin-4/interleukin-13 receptor complex is associated with tyrosine phosphorylation of insulin receptor substrate-1. PMID: 8645156 Ref: Insulin receptor tyrosine kinase activity in colon carcinoma. PMID: 9222417 |
Ref: Prevention of cytokine-induced apoptosis by insulin-like growth factor-I is independent of cell adhesion molecules in HT29-D4 colon carcinoma cells-evidence for a NF-kappaB-dependent survival mechanism. PMID: 12058282 Ref: Mono- or dual-phosphorylation of akt kinase is regulated by distinct receptors that involve the common insulin receptor substrate. PMID: 12503617 |
Ref: Aspirin, NSAIDs, and colorectal cancer: possible involvement in an insulin-related pathway. PMID: 15066917 Ref: Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer. PMID: 15247132 |
Ref: Energy balance, insulin-related genes and risk of colon and rectal cancer. PMID: 15688407 Ref: Activated Ras enhances insulin-like growth factor I induction of vascular endothelial growth factor in prostate epithelial cells. PMID: 15781617 Ref: Membrane rafts segregate pro- from anti-apoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily. PMID: 16127155 Ref: Genistein inhibits insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells: a possible mechanism of the growth inhibitory effect of Genistein. PMID: 16379552 |
Ref: Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer. PMID: 16448675 Ref: PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States). PMID: 16489531 |
Ref: Insulin resistance-related genes and advanced left-sided colorectal adenoma. PMID: 17416760 Ref: Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells. PMID: 17827156 Ref: Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect. PMID: 17914103 |
Ref: Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions. PMID: 18059035 Ref: Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells. PMID: 18064302 |
Ref: Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway. PMID: 19391107 Ref: Decreased expression of microRNA-143 and -145 in human gastric cancers. PMID: 19439999 Ref: Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer. PMID: 19671761 |
Ref: IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype. PMID: 19843521 Ref: Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor. PMID: 20739454 Ref: IGFBP-rP1, a potential molecule associated with colon cancer differentiation. PMID: 20977730 |
Ref: Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins. PMID: 21819567 Ref: Analysis of expression profile of gene encoding proteins of signal cascades activated by insulin-like growth factors in colorectal cancer. PMID: 21978709 |
Ref: miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes. PMID: 21557394 Ref: The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer. PMID: 22558377 Ref: Cytosolic malic enzyme 1 (ME1) mediates high fat diet-induced adiposity, endocrine profile, and gastrointestinal tract proliferation-associated biomarkers in male mice. PMID: 23056418 |
Ref: Downregulation of miR-145 associated with cancer progression and VEGF transcriptional activation by targeting N-RAS and IRS1. PMID: 23201159 Ref: Novel insulin receptor substrate 1 and 2 variants in breast and colorectal cancer. PMID: 23877285 Ref: [miR-126 inhibits colon cancer proliferation and invasion through targeting IRS1, SLC7A5 and TOM1 gene]. PMID: 23981989 Ref: Down-regulation of miR-126 is associated with colorectal cancer cells proliferation, migration and invasion by targeting IRS-1 via the AKT and ERK1/2 signaling pathways. PMID: 24312276 Ref: Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population. PMID: 24338422 |
Ref: Chronic insulin exposure does not cause insulin resistance but is associated with chemo-resistance in colon cancer cells. PMID: 24068609 Ref: Association between IRS-1 Gly972Arg polymorphism and colorectal cancer risk. PMID: 24696264 |
Ref: Tumor suppressors miR-143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon. PMID: 25477374 Ref: An exon variant in insulin receptor gene is associated with susceptibility to colorectal cancer in women. PMID: 25557790 Ref: Frameshift mutations in mammalian target of rapamycin pathway genes and their regional heterogeneity in sporadic colorectal cancers. PMID: 25776026 Ref: MicroRNA-128 suppresses cell growth and metastasis in colorectal carcinoma by targeting IRS1. PMID: 26352220 |
Ref: Gly972Arg variant of insulin receptor substrate 1 gene and colorectal cancer risk in overweight/obese subjects. PMID: 26349669 Ref: Survival Benefit of Exercise Differs by Tumor IRS1 Expression Status in Colorectal Cancer. PMID: 26577117 Ref: Down-regulation of tensin2 enhances tumorigenicity and is associated with a variety of cancers. PMID: 27203214 Ref: Physical Activity and Cancer Outcomes: A Precision Medicine Approach. PMID: 27407093 Ref: Integrating network reconstruction with mechanistic modeling to predict cancer therapies. PMID: 27879396 |
Ref: Insulin induction instigates cell proliferation and metastasis in human colorectal cancer cells. PMID: 28101572 Ref: Dietary glycemic and insulin scores and colorectal cancer survival by tumor molecular biomarkers. PMID: 28268248 Ref: TGFbeta/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cells. PMID: 28414818 Ref: Genetic variants and traits related to insulin-like growth factor-I and insulin resistance and their interaction with lifestyles on postmenopausal colorectal cancer risk. PMID: 29023587 Ref: Novel all-hydrocarbon stapled p110alpha[E545K] peptides as blockers of the oncogenic p110alpha[E545K]-IRS1 interaction. PMID: 29138025 Ref: MicroRNA-497 inhibits tumor growth through targeting insulin receptor substrate 1 in colorectal cancer. PMID: 29163678 |
Ref: Fucoidan downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. PMID: 29328495 Ref: Expressions of IGF-1, ERK, GLUT4, IRS-1 in metabolic syndrome complicated with colorectal cancer and their associations with the clinical characteristics of CRC. PMID: 29504525 |