Primary Site >> Colorectal Cancer
Gene >> INSR
| 1. | |||||||||||
| Journal: | Cancer Res. 1983 Oct;43(10):4537-42. | ||||||||||
| Title: | Insulin receptor regulation in cultured human tumor cells. | ||||||||||
| Author: | Mountjoy, K G|Holdaway, I M|Finlay, G J | ||||||||||
| PMID: | 6349794 | ||||||||||
| 2. | |||||||||||
| Journal: | J Clin Endocrinol Metab. 1986 Oct;63(4):879-85. | ||||||||||
| Title: | Insulin receptor proliferation: a mechanism for tumor-associated hypoglycemia. | ||||||||||
| Author: | Stuart, C A|Prince, M J|Peters, E J|Smith, F E|Townsend, C M 3rd|Poffenbarger, P L | ||||||||||
| PMID: | 3528210 | ||||||||||
| 3. | |||||||||||
| Journal: | Cancer Res. 1987 Dec 15;47(24 Pt 1):6500-4. | ||||||||||
| Title: | Abnormal insulin-receptor down regulation and dissociation of down regulation from insulin biological action in cultured human tumor cells. | ||||||||||
| Author: | Mountjoy, K G|Finlay, G J|Holdaway, I M | ||||||||||
| PMID: | 3315189 | ||||||||||
| 4. | |||||||||||
| Journal: | Braz J Med Biol Res. 1996 Dec;29(12):1593-7. | ||||||||||
| Title: | Insulin receptor tyrosine kinase activity in colon carcinoma. | ||||||||||
| Author: | Corleta, H E|Capp, E|Corleta, O C | ||||||||||
| PMID: | 9222417 | ||||||||||
| 5. | |||||||||||
| Journal: | J Clin Gastroenterol. 2003 May-Jun;36(5 Suppl):S84-93; discussion S94-6. | ||||||||||
| Title: | Coprocytobiology: on the nature of cellular elements from stools in the pathophysiology of colonic disease. | ||||||||||
| Author: | Nair, Padmanabhan|Lagerholm, Sara|Dutta, Sudhir|Shami, Samina|Davis, Kirk|Ma, Shuzhen|Malayeri, Mehran | ||||||||||
| PMID: | 12702972 | ||||||||||
| 6. | |||||||||||
| Journal: | Br J Cancer. 2006 Jul 17;95(2):172-80. Epub 2006 Jul 4. | ||||||||||
| Title: | Inhibition of insulin receptor isoform-A signalling restores sensitivity to gefitinib in previously de novo resistant colon cancer cells. | ||||||||||
| Author: | Jones, H E|Gee, J M W|Barrow, D|Tonge, D|Holloway, B|Nicholson, R I | ||||||||||
| PMID: | 16819546 | ||||||||||
| 7. | |||||||||||
| Journal: | Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):703-8. | ||||||||||
| Title: | Insulin resistance-related genes and advanced left-sided colorectal adenoma. | ||||||||||
| Author: | Gunter, Marc J|Hayes, Richard B|Chatterjee, Nilanjan|Yeager, Meredith|Welch, Robert|Schoen, Robert E|Yakochi, Lance|Schatzkin, Arthur|Peters, Ulrike | ||||||||||
| PMID: | 17416760 | ||||||||||
| 8. | |||||||||||
| Journal: | Mol Cancer Ther. 2007 Aug;6(8):2158-67. Epub 2007 Aug 1. | ||||||||||
| Title: | A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo. | ||||||||||
| Author: | Ji, Qun-sheng|Mulvihill, Mark J|Rosenfeld-Franklin, Maryland|Cooke, Andrew|Feng, Lixin|Mak, Gilda|O'Connor, Matthew|Yao, Yan|Pirritt, Caroline|Buck, Elizabeth|Eyzaguirre, Alexandra|Arnold, Lee D|Gibson, Neil W|Pachter, Jonathan A | ||||||||||
| PMID: | 17671083 | ||||||||||
| 9. | |||||||||||
| Journal: | Endocr Relat Cancer. 2007 Sep;14(3):733-40. | ||||||||||
| Title: | Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect. | ||||||||||
| Author: | Pechlivanis, Sonali|Pardini, Barbara|Bermejo, Justo Lorenzo|Wagner, Kerstin|Naccarati, Alessio|Vodickova, Ludmila|Novotny, Jan|Hemminki, Kari|Vodicka, Pavel|Forsti, Asta | ||||||||||
| PMID: | 17914103 | ||||||||||
| 10. | |||||||||||
| Journal: | Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G679-86. | ||||||||||
| Title: | Reduced susceptibility of muscle-specific insulin receptor knockout mice to colon carcinogenesis. | ||||||||||
| Author: | Ealey, Kafi N|Lu, Suying|Lau, Dominic|Archer, Michael C | ||||||||||
| PMID: | 18174274 | ||||||||||
| 11. | |||||||||||
| Journal: | Carcinogenesis. 2008 Mar;29(3):579-84. | ||||||||||
| Title: | Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer. | ||||||||||
| Author: | Landi, Debora|Gemignani, Federica|Naccarati, Alessio|Pardini, Barbara|Vodicka, Pavel|Vodickova, Ludmila|Novotny, Jan|Forsti, Asta|Hemminki, Kari|Canzian, Federico|Landi, Stefano | ||||||||||
| PMID: | 18192692 | ||||||||||
| 12. | |||||||||||
| Journal: | Diabetes Metab Res Rev. 2009 Jan;25(1):41-9. | ||||||||||
| Title: | Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells. | ||||||||||
| Author: | Weinstein, Doron|Simon, Meital|Yehezkel, Einat|Laron, Zvi|Werner, Haim | ||||||||||
| PMID: | 19145584 | ||||||||||
| 13. | |||||||||||
| Journal: | J Biol Chem. 2009 Nov 13;284(46):32178-87. | ||||||||||
| Title: | Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications. | ||||||||||
| Author: | Zhao, Ming|Wan, Zhu-li|Whittaker, Linda|Xu, Bin|Phillips, Nelson B|Katsoyannis, Panayotis G|Ismail-Beigi, Faramarz|Whittaker, Jonathan|Weiss, Michael A | ||||||||||
| PMID: | 19773552 | ||||||||||
| 14. | |||||||||||
| Journal: | Diabetologia. 2010 Dec;53(12):2667-75. | ||||||||||
| Title: | Long-acting insulin analogues elicit atypical signalling events mediated by the insulin receptor and insulin-like growth factor-I receptor. | ||||||||||
| Author: | Yehezkel, E|Weinstein, D|Simon, M|Sarfstein, R|Laron, Z|Werner, H | ||||||||||
| PMID: | 20835859 | ||||||||||
| 15. | |||||||||||
| Journal: | Mutat Res. 2011 Dec 1;717(1-2):109-15. | ||||||||||
| Title: | Polymorphisms affecting micro-RNA regulation and associated with the risk of dietary-related cancers: a review from the literature and new evidence for a functional role of rs17281995 (CD86) and rs1051690 (INSR), previously associated with colorectal canc | ||||||||||
| Author: | Landi, Debora|Moreno, Victor|Guino, Elisabeth|Vodicka, Pavel|Pardini, Barbara|Naccarati, Alessio|Canzian, Federico|Barale, Roberto|Gemignani, Federica|Landi, Stefano | ||||||||||
| PMID: | 20971123 | ||||||||||
| 16. | |||||||||||
| Journal: | PLoS One. 2012;7(4):e36190. | ||||||||||
| Title: | The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer. | ||||||||||
| Author: | Esposito, Diana L|Aru, Federica|Lattanzio, Rossano|Morgano, Annalisa|Abbondanza, Michela|Malekzadeh, Reza|Bishehsari, Faraz|Valanzano, Rosa|Russo, Antonio|Piantelli, Mauro|Moschetta, Antonio|Lotti, Lavinia Vittoria|Mariani-Costantini, Renato | ||||||||||
| PMID: | 22558377 | ||||||||||
| 17. | |||||||||||
| Journal: | J Cell Sci. 2013 Dec 15;126(Pt 24):5645-56. | ||||||||||
| Title: | Insulin receptor isoform switching in intestinal stem cells, progenitors, differentiated lineages and tumors: evidence that IR-B limits proliferation. | ||||||||||
| Author: | Andres, Sarah F|Simmons, James G|Mah, Amanda T|Santoro, M Agostina|Van Landeghem, Laurianne|Lund, P Kay | ||||||||||
| PMID: | 24127567 | ||||||||||
| 18. | |||||||||||
| Journal: | Asian Pac J Cancer Prev. 2013;14(9):5011-6. | ||||||||||
| Title: | Is there an association between variants in candidate insulin pathway genes IGF-I, IGFBP-3, INSR, and IRS2 and risk of colorectal cancer in the Iranian population? | ||||||||||
| Author: | Karimi, Khatoon|Mahmoudi, Touraj|Karimi, Negar|Dolatmoradi, Hesamodin|Arkani, Maral|Farahani, Hamid|Vahedi, Mohsen|Parsimehr, Elham|Dabiri, Reza|Nobakht, Hossein|Asadi, Asadollah|Zali, Mohammad Reza | ||||||||||
| PMID: | 24175768 | ||||||||||
| 19. | |||||||||||
| Journal: | Iran J Cancer Prev. 2013 Fall;6(4):179-85. | ||||||||||
| Title: | The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer. | ||||||||||
| Author: | Rezaei-Tavirani, Mostafa|Safaei, Akram|Zali, Mohammad Reza | ||||||||||
| PMID: | 25250132 | ||||||||||
| 20. | |||||||||||
| Journal: | J Cell Physiol. 2015 Mar;230(3):562-7. | ||||||||||
| Title: | Detection of phosphorylated insulin receptor in colorectal adenoma and adenocarcinoma: implications for prognosis and clinical outcome. | ||||||||||
| Author: | Abbruzzese, Claudia|Diodoro, Maria Grazia|Sperduti, Isabella|Mileo, Anna Maria|Pattaro, Giada|De Salvo, Laura|Cosimelli, Maurizio|Perrotti, Nicola|Paggi, Marco G | ||||||||||
| PMID: | 25102778 | ||||||||||
| 21. | |||||||||||
| Journal: | Cancer Epidemiol Biomarkers Prev. 2015 Jan;24(1):65-72. | ||||||||||
| Title: | MicroRNA polymorphisms and risk of colorectal cancer. | ||||||||||
| Author: | Schmit, Stephanie L|Gollub, Jeremy|Shapero, Michael H|Huang, Shu-Chen|Rennert, Hedy S|Finn, Andrea|Rennert, Gad|Gruber, Stephen B | ||||||||||
| PMID: | 25342389 | ||||||||||
| 22. | |||||||||||
| Journal: | Tumour Biol. 2015 May;36(5):3709-15. | ||||||||||
| Title: | An exon variant in insulin receptor gene is associated with susceptibility to colorectal cancer in women. | ||||||||||
| Author: | Mahmoudi, Touraj|Majidzadeh-A, Keivan|Karimi, Khatoon|Karimi, Negar|Farahani, Hamid|Dabiri, Reza|Nobakht, Hossein|Dolatmoradi, Hesamodin|Arkani, Maral|Zali, Mohammad Reza | ||||||||||
| PMID: | 25557790 | ||||||||||
| 23. | |||||||||||
| Journal: | Cancer Causes Control. 2015 Aug;26(8):1189-95. | ||||||||||
| Title: | Insulin receptor variants and obesity-related cancers in the Framingham Heart Study. | ||||||||||
| Author: | Parekh, Niyati|Guffanti, Guia|Lin, Yong|Ochs-Balcom, Heather M|Makarem, Nour|Hayes, Richard | ||||||||||
| PMID: | 26077721 | ||||||||||
| 24. | |||||||||||
| Journal: | Mol Cancer Ther. 2015 Dec;14(12):2762-72. | ||||||||||
| Title: | BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis. | ||||||||||
| Author: | Sanderson, Michael P|Apgar, Joshua|Garin-Chesa, Pilar|Hofmann, Marco H|Kessler, Dirk|Quant, Jens|Savchenko, Alexander|Schaaf, Otmar|Treu, Matthias|Tye, Heather|Zahn, Stephan K|Zoephel, Andreas|Haaksma, Eric|Adolf, Gunther R|Kraut, Norbert | ||||||||||
| PMID: | 26438154 | ||||||||||
| 25. | |||||||||||
| Journal: | Front Oncol. 2015 Oct 15;5:230. | ||||||||||
| Title: | The Insulin/IGF System in Colorectal Cancer Development and Resistance to Therapy. | ||||||||||
| Author: | Vigneri, Paolo Giovanni|Tirro, Elena|Pennisi, Maria Stella|Massimino, Michele|Stella, Stefania|Romano, Chiara|Manzella, Livia | ||||||||||
| PMID: | 26528439 | ||||||||||
| 26. | |||||||||||
| Journal: | Clin Cancer Res. 2016 Jun 15;22(12):2897-907. | ||||||||||
| Title: | Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors. | ||||||||||
| Author: | Macaulay, Valentine M|Middleton, Mark R|Eckhardt, S Gail|Rudin, Charles M|Juergens, Rosalyn A|Gedrich, Richard|Gogov, Sven|McCarthy, Sean|Poondru, Srinivasu|Stephens, Andrew W|Gadgeel, Shirish M | ||||||||||
| PMID: | 26831715 | ||||||||||
| 27. | |||||||||||
| Journal: | Mol Nutr Food Res. 2016 Sep;60(9):1912-23. | ||||||||||
| Title: | Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis. | ||||||||||
| Author: | Kim, Hyemee|Banerjee, Nivedita|Ivanov, Ivan|Pfent, Catherine M|Prudhomme, Kalan R|Bisson, William H|Dashwood, Roderick H|Talcott, Stephen T|Mertens-Talcott, Susanne U | ||||||||||
| PMID: | 27028006 | ||||||||||
| 28. | |||||||||||
| Journal: | Mol Cancer Ther. 2017 Oct;16(10):2223-2233. | ||||||||||
| Title: | The IGF1R/INSR Inhibitor BI 885578 Selectively Inhibits Growth of IGF2-Overexpressing Colorectal Cancer Tumors and Potentiates the Efficacy of Anti-VEGF Therapy. | ||||||||||
| Author: | Sanderson, Michael P|Hofmann, Marco H|Garin-Chesa, Pilar|Schweifer, Norbert|Wernitznig, Andreas|Fischer, Stefan|Jeschko, Astrid|Meyer, Reiner|Moll, Jurgen|Pecina, Thomas|Arnhof, Heribert|Weyer-Czernilofsky, Ulrike|Zahn, Stephan K|Adolf, Gunther R|Kraut, N | ||||||||||
| PMID: | 28729397 | ||||||||||
| 29. | |||||||||||
| Journal: | Oncogene. 2018 Jun 12. pii: 10.1038/s41388-018-0362-5. | ||||||||||
| Title: | beta-catenin/TCF activity regulates IGF-1R tyrosine kinase inhibitor sensitivity in colon cancer. | ||||||||||
| Author: | Lee, Hani|Kim, Nayoung|Yoo, Young Ji|Kim, Hyejin|Jeong, Euna|Choi, SeokGyeong|Moon, Sung Un|Oh, Seung Hyun|Mills, Gordon B|Yoon, Sukjoon|Kim, Woo-Young | ||||||||||
| PMID: | 29895971 | ||||||||||
| 30. | |||||||||||
| Journal: | J Crohns Colitis. 2018 Aug 18. pii: 5076185. | ||||||||||
| Title: | Rectal insulin instillation inhibits inflammation and tumor development in chemically-induced colitis. | ||||||||||
| Author: | Yassin, Mohammad|Sadowska, Zuzanna|Tritsaris, Katerina|Kissow, Hannelouise|Hansen, Camilla H F|Forman, Julie L|Rogler, Gerhard|Troelsen, Jesper T|Pedersen, Anders E|Olsen, Jorgen | ||||||||||
| PMID: | 30137286 | ||||||||||