Primary Site >> Colorectal Cancer
Gene >> INSR
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Ref: Insulin receptor regulation in cultured human tumor cells. PMID: 6349794 |
Ref: Insulin receptor proliferation: a mechanism for tumor-associated hypoglycemia. PMID: 3528210 |
Ref: Abnormal insulin-receptor down regulation and dissociation of down regulation from insulin biological action in cultured human tumor cells. PMID: 3315189 |
Ref: Insulin receptor tyrosine kinase activity in colon carcinoma. PMID: 9222417 |
Ref: Coprocytobiology: on the nature of cellular elements from stools in the pathophysiology of colonic disease. PMID: 12702972 |
Ref: Inhibition of insulin receptor isoform-A signalling restores sensitivity to gefitinib in previously de novo resistant colon cancer cells. PMID: 16819546 |
Ref: Insulin resistance-related genes and advanced left-sided colorectal adenoma. PMID: 17416760 Ref: A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo. PMID: 17671083 Ref: Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect. PMID: 17914103 |
Ref: Reduced susceptibility of muscle-specific insulin receptor knockout mice to colon carcinogenesis. PMID: 18174274 Ref: Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer. PMID: 18192692 |
Ref: Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells. PMID: 19145584 Ref: Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications. PMID: 19773552 |
Ref: Long-acting insulin analogues elicit atypical signalling events mediated by the insulin receptor and insulin-like growth factor-I receptor. PMID: 20835859 |
Ref: Polymorphisms affecting micro-RNA regulation and associated with the risk of dietary-related cancers: a review from the literature and new evidence for a functional role of rs17281995 (CD86) and rs1051690 (INSR), previously associated with colorectal canc PMID: 20971123 |
Ref: The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer. PMID: 22558377 |
Ref: Insulin receptor isoform switching in intestinal stem cells, progenitors, differentiated lineages and tumors: evidence that IR-B limits proliferation. PMID: 24127567 Ref: Is there an association between variants in candidate insulin pathway genes IGF-I, IGFBP-3, INSR, and IRS2 and risk of colorectal cancer in the Iranian population? PMID: 24175768 Ref: The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer. PMID: 25250132 |
Ref: Detection of phosphorylated insulin receptor in colorectal adenoma and adenocarcinoma: implications for prognosis and clinical outcome. PMID: 25102778 Ref: MicroRNA polymorphisms and risk of colorectal cancer. PMID: 25342389 Ref: An exon variant in insulin receptor gene is associated with susceptibility to colorectal cancer in women. PMID: 25557790 Ref: Insulin receptor variants and obesity-related cancers in the Framingham Heart Study. PMID: 26077721 Ref: BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis. PMID: 26438154 Ref: The Insulin/IGF System in Colorectal Cancer Development and Resistance to Therapy. PMID: 26528439 |
Ref: Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors. PMID: 26831715 Ref: Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis. PMID: 27028006 |
Ref: The IGF1R/INSR Inhibitor BI 885578 Selectively Inhibits Growth of IGF2-Overexpressing Colorectal Cancer Tumors and Potentiates the Efficacy of Anti-VEGF Therapy. PMID: 28729397 |
Ref: beta-catenin/TCF activity regulates IGF-1R tyrosine kinase inhibitor sensitivity in colon cancer. PMID: 29895971 Ref: Rectal insulin instillation inhibits inflammation and tumor development in chemically-induced colitis. PMID: 30137286 |