Primary Site >> Liver Cancer

Gene >> IL6

1.
Journal: J Cell Biol. 1986 Feb;102(2):370-83.
Title: Regulation of major acute-phase plasma proteins by hepatocyte-stimulating factors of human squamous carcinoma cells.
Author: Baumann, H|Hill, R E|Sauder, D N|Jahreis, G P
PMID: 2418029
2.
Journal: J Immunol. 1987 Dec 15;139(12):4122-8.
Title: Interaction among hepatocyte-stimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells.
Author: Baumann, H|Richards, C|Gauldie, J
PMID: 2447159
3.
Journal: Tokai J Exp Clin Med. 1988 Dec;13(6):255-64.
Title: The cascade of inflammatory cytokines regulating synthesis of acute phase proteins.
Author: Koj, A|Magielska-Zero, D|Bereta, J|Kurdowska, A|Rokita, H|Gauldie, J
PMID: 2483765
4.
Journal: Eur J Immunol. 1988 Aug;18(8):1259-64.
Title: Interleukin 6, the third mediator of acute-phase reaction, modulates hepatic protein synthesis in human and mouse. Comparison with interleukin 1 beta and tumor necrosis factor-alpha.
Author: Ramadori, G|Van Damme, J|Rieder, H|Meyer zum Buschenfelde, K H
PMID: 3138137
5.
Journal: Clin Exp Immunol. 1989 Jan;75(1):70-5.
Title: Effect of cytokines on glycosylation of acute phase proteins in human hepatoma cell lines.
Author: Mackiewicz, A|Schultz, D|Mathison, J|Ganapathi, M|Kushner, I
PMID: 2467770
6.
Journal: J Biol Chem. 1989 May 15;264(14):8046-51.
Title: Human hepatocyte-stimulating factor-III and interleukin-6 are structurally and immunologically distinct but regulate the production of the same acute phase plasma proteins.
Author: Baumann, H|Won, K A|Jahreis, G P
PMID: 2470740
7.
Journal: Mol Cell Biol. 1990 Jun;10(6):2443-7.
Title: Cell-specific toxicity of a chimeric protein composed of interleukin-6 and Pseudomonas exotoxin (IL6-PE40) on tumor cells.
Author: Siegall, C B|Nordan, R P|FitzGerald, D J|Pastan, I
PMID: 2160579
8.
Journal: Int J Cancer. 1993 Nov 11;55(5):728-34.
Title: Specific expression of the pancreatic-secretory-trypsin-inhibitor (PSTI) gene in hepatocellular carcinoma.
Author: Ohmachi, Y|Murata, A|Matsuura, N|Yasuda, T|Yasuda, T|Monden, M|Mori, T|Ogawa, M|Matsubara, K
PMID: 8244568
9.
Journal: Bioconjug Chem. 1993 Nov-Dec;4(6):581-5.
Title: Purification and characterization of IL6-PE4E, a recombinant fusion of interleukin 6 with Pseudomonas exotoxin.
Author: Kreitman, R J|Pastan, I
PMID: 8305530
10.
Journal: Gan To Kagaku Ryoho. 1993 Aug;20(11):1461-4.
Title: [Immunological effects of locoregional immunochemotherapy for liver metastases of gastric cancer].
Author: Sugiyama, Y|Kato, M|Takao, H|Kida, H|Kunieda, K|Umemoto, T|Miya, K|Azuma, S|Furuta, T|Saji, S
PMID: 8373205
11.
Journal: J Immunol. 1995 Jul 1;155(1):308-15.
Title: Expression of functional receptors for human C5a anaphylatoxin (CD88) on the human hepatocellular carcinoma cell line HepG2. Stimulation of acute-phase protein-specific mRNA and protein synthesis by human C5a anaphylatoxin.
Author: Buchner, R R|Hugli, T E|Ember, J A|Morgan, E L
PMID: 7541417
12.
Journal: J Cell Physiol. 1995 Dec;165(3):459-67.
Title: Growth control and gene expression in a new hepatocellular carcinoma cell line, Hep40: inhibitory actions of vitamin K.
Author: Bouzahzah, B|Nishikawa, Y|Simon, D|Carr, B I
PMID: 7593224
13.
Journal: Br J Cancer. 1997;75(1):47-53.
Title: Involvement of hepatocyte growth factor in increased integrin expression on HepG2 cells triggered by adhesion to endothelial cells.
Author: Kawakami-Kimura, N|Narita, T|Ohmori, K|Yoneda, T|Matsumoto, K|Nakamura, T|Kannagi, R
PMID: 9000597
14.
Journal: Hepatology. 1997 Jul;26(1):59-66.
Title: Co-expression and regulation of Met and Ron proto-oncogenes in human hepatocellular carcinoma tissues and cell lines.
Author: Chen, Q|Seol, D W|Carr, B|Zarnegar, R
PMID: 9214452
15.
Journal: J Formos Med Assoc. 1999 Feb;98(2):85-91.
Title: Secretion of acute-phase proteins before and after hepatocellular carcinoma resection.
Author: Hu, R H|Lee, P H|Yu, S C
PMID: 10083762
16.
Journal: Int J Oncol. 2000 Oct;17(4):777-81.
Title: Hepatocarcinoma cells stimulate hepatocyte growth factor secretion in human liver myofibroblasts.
Author: Guirouilh, J|Castroviejo, M|Balabaud, C|Desmouliere, A|Rosenbaum, J
PMID: 10995891
17.
Journal: In Vitro Cell Dev Biol Anim. 2001 Jan;37(1):17-25.
Title: Characterization of a new rat cell line established from 2'AAF-induced combined hepatocellular cholangiocellular carcinoma.
Author: Gil-Benso, R|Martinez-Lorente, A|Pellin-Perez, A|Navarro-Fos, S|Gregori-Romero, M A|Carda, C|Callaghan, R|Peydro-Olaya, A|Llombart-Bosch, A
PMID: 11249201
18.
Journal: Biochem Biophys Res Commun. 2001 Sep 7;286(5):1123-30.
Title: Invasiveness of hepatocellular carcinoma cell lines: contribution of hepatocyte growth factor, c-met, and transcription factor Ets-1.
Author: Jiang, Y|Xu, W|Lu, J|He, F|Yang, X
PMID: 11527416
19.
Journal: Hum Mol Genet. 2003 Apr 15;12(8):901-6.
Title: Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma.
Author: Shin, Hyoung Doo|Park, Byung Lae|Kim, Lyoung Hyo|Jung, Ji Hyun|Kim, Jun Yeon|Yoon, Jung Hwan|Kim, Yoon Jun|Lee, Hyo-Suk
PMID: 12668613
20.
Journal: Biochem Biophys Res Commun. 2003 May 30;305(2):428-33.
Title: An absolute role of the PKC-dependent NF-kappaB activation for induction of MMP-9 in hepatocellular carcinoma cells.
Author: Hah, Nasun|Lee, Seung-Taek
PMID: 12745093
21.
Journal: Gan To Kagaku Ryoho. 2003 Oct;30(11):1848-50.
Title: [Significance of intracellular cytokines levels in peripheral lymphocytes for evaluation of surgical stress after hepatectomy in patients with hepatocellular carcinoma].
Author: Kato, Masatoshi|Hazama, Shoichi|Sakamoto, Kazuhiko|Yoshino, Shigefumi|Tangoku, Akira|Oka, Masaaki
PMID: 14619536
22.
Journal: Cell Res. 2003 Dec;13(6):509-14.
Title: Gene expression profile favoring phenotypic reversion: a clue for mechanism of tumor suppression by NF-IL6 3'UTR.
Author: Liu, Ding Gan|Jiang, Qiu Hong|Wei, Yun Yi|Sun, Li|Fu, Bei Bei|Zhao, Fu Kun|Zhou, Qiong
PMID: 14728809
23.
Journal: Toxicol Sci. 2004 Jun;79(2):242-7.
Title: Evaluation of the potential of triethanolamine to alter hepatic choline levels in female B6C3F1 mice.
Author: Stott, W T|Radtke, B J|Linscombe, V A|Mar, M-H|Zeisel, S H
PMID: 15056812
24.
Journal: Neoplasma. 2004;51(3):209-13.
Title: Serum hepatocyte growth factor and interleukin-6 levels can distinguish patients with primary or metastatic liver tumors from those with benign liver lesions.
Author: Coskun, U|Bukan, N|Sancak, B|Gunel, N|Ozenirler, S|Unal, A|Yucel, A
PMID: 15254675
25.
Journal: Cancer Sci. 2004 Aug;95(8):666-73.
Title: Involvement of cell cycle regulatory proteins and MAP kinase signaling pathway in growth inhibition and cell cycle arrest by a selective cyclooxygenase 2 inhibitor, etodolac, in human hepatocellular carcinoma cell lines.
Author: Cheng, Jidong|Imanishi, Hiroyasu|Liu, Weidong|Nakamura, Hideji|Morisaki, Takayuki|Higashino, Kazuya|Hada, Toshikazu
PMID: 15298730
26.
Journal: Am J Transplant. 2004 Sep;4(9):1408-20.
Title: Protection of reduced-size liver for transplantation.
Author: Franco-Gou, R|Peralta, C|Massip-Salcedo, M|Xaus, C|Serafin, A|Rosello-Catafau, J
PMID: 15307828
27.
Journal: Hepatology. 2004 Sep;40(3):618-28.
Title: Negative regulation of hepatocellular carcinoma cell growth by signal regulatory protein alpha1.
Author: Yan, He-Xin|Wang, Hong-Yang|Zhang, Rui|Chen, Lei|Li, Bao-An|Liu, Shu-Qin|Cao, Hui-Fang|Qiu, Xiu-Hua|Shan, Yun-Feng|Yan, Zhong-Hua|Wu, Hong-Ping|Tan, Ye-Xiong|Wu, Meng-Chao
PMID: 15349900
28.
Journal: Br J Cancer. 2004 Oct 4;91(7):1335-41.
Title: Constitutional activation of IL-6-mediated JAK/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell line.
Author: To, K F|Chan, M W Y|Leung, W K|Ng, E K W|Yu, J|Bai, A H C|Lo, A W I|Chu, S H|Tong, J H M|Lo, K W|Sung, J J Y|Chan, F K L
PMID: 15354212
29.
Journal: Virology. 2005 Feb 5;332(1):130-44.
Title: Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection.
Author: Bieche, Ivan|Asselah, Tarik|Laurendeau, Ingrid|Vidaud, Dominique|Degot, Claude|Paradis, Valerie|Bedossa, Pierre|Valla, Dominique-Charles|Marcellin, Patrick|Vidaud, Michel
PMID: 15661146
30.
Journal: Hepatogastroenterology. 2006 Jan-Feb;53(67):115-9.
Title: The role of a protease inhibitor against hepatectomy.
Author: Gotohda, Naoto|Iwagaki, Hiromi|Ozaki, Michitaka|Konishi, Masaru|Nakagohri, Toshio|Takahashi, Shinichiro|Yagi, Takahito|Kinoshita, Taira|Tanaka, Noriaki
PMID: 16506388
31.
Journal: Life Sci. 2007 Jan 9;80(5):484-92.
Title: Potential involvement of the cyclooxygenase-2 pathway in hepatocellular carcinoma-associated angiogenesis.
Author: Zhao, Qing-Tao|Yue, Shu-Qiang|Cui, Zhong|Wang, Qi|Cui, Xin|Zhai, Hui-Hong|Zhang, Li-Hui|Dou, Ke-Feng
PMID: 17097688
32.
Journal: Eur J Surg Oncol. 2007 Mar;33(2):208-12.
Title: Evaluation of interleukin-6, interleukin-10 and human hepatocyte growth factor as tumor markers for hepatocellular carcinoma.
Author: Hsia, C-Y|Huo, T-I|Chiang, S-Y|Lu, M-F|Sun, C-L|Wu, J-C|Lee, P-C|Chi, C-W|Lui, W-Y|Lee, S-D
PMID: 17140760
33.
Journal: Toxicology. 2007 May 20;234(3):157-66.
Title: Interactions between aflatoxin B1 and dietary iron overload in hepatic mutagenesis.
Author: Asare, George A|Bronz, Michelle|Naidoo, Vivash|Kew, Michael C
PMID: 17399882
34.
Journal: Zhonghua Gan Zang Bing Za Zhi. 2007 Jun;15(6):441-4.
Title: [Molecular mechanisms of DHEA and DHEAs on apoptosis and cell cycle arrest via Akt pathway in hepatoma cell lines].
Author: Jiang, Yan-fang|Zhao, Ping-wei|Tan, Yan|Liu, Li-hua|Li, Ming-hui|Matsuzaki, Yasushi|Niu, Jun-qi
PMID: 17594810
35.
Journal: Transplantation. 2007 Nov 27;84(10):1262-71.
Title: Angiogenesis soluble factors as hepatocellular carcinoma noninvasive markers for monitoring hepatitis C virus cirrhotic patients awaiting liver transplantation.
Author: Mas, Valeria R|Maluf, Daniel G|Archer, Kellie J|Yanek, Kenneth C|Fisher, Robert A
PMID: 18049111
36.
Journal: Gastrointest Cancer Res. 2007;1(4 Suppl 2):S13-21.
Title: Liver stem cells and molecular signaling pathways in hepatocellular carcinoma.
Author: Kitisin, Krit|Pishvaian, Michael J|Johnson, Lynt B|Mishra, Lopa
PMID: 19360142
37.
Journal: Regul Pept. 2008 Feb 7;146(1-3):285-92.
Title: VIP inhibits human HepG2 cell proliferation in vitro.
Author: Absood, Afaf|Hu, Bin|Bassily, Nermine|Colletti, Lisa
PMID: 18077011
38.
Journal: Br J Cancer. 2008 Jul 8;99(1):151-9.
Title: New cellular tools reveal complex epithelial-mesenchymal interactions in hepatocarcinogenesis.
Author: Sagmeister, S|Eisenbauer, M|Pirker, C|Mohr, T|Holzmann, K|Zwickl, H|Bichler, C|Kandioler, D|Wrba, F|Mikulits, W|Gerner, C|Shehata, M|Majdic, O|Streubel, B|Berger, W|Micksche, M|Zatloukal, K|Schulte-Hermann, R|Grasl-Kraupp, B
PMID: 18594539
39.
Journal: Cancer Lett. 2008 Dec 18;272(2):268-76.
Title: A novel and effective hepatocyte growth factor kringle 1 domain and p53 cocktail viral gene therapy for the treatment of hepatocellular carcinoma.
Author: Shen, Zan|Wong, Oscar Gee Wan|Yao, Ru Yong|Liang, Jun|Kung, Hsiang-Fu|Lin, Marie C M
PMID: 18722051
40.
Journal: Hepatogastroenterology. 2008 Jul-Aug;55(85):1400-3.
Title: Significant correlation between surgical stress of hepatectomy and changes in the serum levels of HGF, IL-6 and soluble Fas in patients with viral hepatitis.
Author: Gotohda, Naoto|Iwagaki, Hiromi|Ozaki, Michitaka|Kinoshita, Taira|Konishi, Masaru|Nakagohri, Toshio|Takahashi, Shinichiro|Saito, Shinya|Yagi, Takahito|Tanaka, Noriaki
PMID: 18795698
41.
Journal: Hepatogastroenterology. 2008 Jul-Aug;55(85):1439-44.
Title: Deficient response of IL-6 impaired liver regeneration after hepatectomy in patients with viral hepatitis.
Author: Gotohda, Naoto|Iwagaki, Hiromi|Ozaki, Michitaka|Kinoshita, Taira|Konishi, Masaru|Nakagohri, Toshio|Takahashi, Shinichiro|Saito, Shinya|Yagi, Takahito|Tanaka, Noriaki
PMID: 18795707
42.
Journal: Langenbecks Arch Surg. 2009 Nov;394(6):1041-6.
Title: Protective effect of Verapamil on hepatic ischemia-reperfusion injury during hepatectomy in the cirrhotic patients with hepatocellular carcinoma.
Author: Xia, Feng|Wang, Shuguang|Chen, Min|Wang, Xiaojun|Feng, Xiaobin|Dong, Jiahong
PMID: 19350266
43.
Journal: Biochem Pharmacol. 2009 Jul 1;78(1):21-32.
Title: Down-regulation of the HGF/MET autocrine loop induced by celecoxib and mediated by P-gp in MDR-positive human hepatocellular carcinoma cell line.
Author: Mazzanti, Roberto|Platini, Francesca|Bottini, Consuelo|Fantappie, Ornella|Solazzo, Michela|Tessitore, Luciana
PMID: 19447220
44.
Journal: J Hepatol. 2010 Mar;52(3):370-9.
Title: Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patients.
Author: Chew, Valerie|Tow, Charlene|Teo, Marissa|Wong, Hing Lok|Chan, Jasmine|Gehring, Adam|Loh, Marie|Bolze, Alexandre|Quek, Richard|Lee, Victor K M|Lee, Kang Hoe|Abastado, Jean-Pierre|Toh, Han Chong|Nardin, Alessandra
PMID: 19720422
45.
Journal: Hepatology. 2010 Jan;51(1):255-66.
Title: Inhibition of poly adenosine diphosphate-ribose polymerase decreases hepatocellular carcinoma growth by modulation of tumor-related gene expression.
Author: Quiles-Perez, Rosa|Munoz-Gamez, Jose Antonio|Ruiz-Extremera, Angeles|O'Valle, Francisco|Sanjuan-Nunez, Laura|Martin-Alvarez, Ana Belen|Martin-Oliva, David|Caballero, Trinidad|Munoz de Rueda, Paloma|Leon, Josefa|Gonzalez, Raul|Muntane, Jordi|Oliver, Franci
PMID: 20034026
46.
Journal: Exp Mol Pathol. 2010 Jun;88(3):331-40.
Title: The identification of stem cells in human liver diseases and hepatocellular carcinoma.
Author: Oliva, Joan|French, Barbara A|Qing, X|French, Samuel W
PMID: 20080086
47.
Journal: Gan To Kagaku Ryoho. 2010 Apr;37(4):687-9.
Title: [An effective case of liver metastasis of breast cancer treated with capecitabine + docetaxel combination therapy using vitamin B6].
Author: Umeda, Tomoko|Abe, Hajime|Cho, Hirotomi|Shimizu, Tomoharu|Mori, Tsuyoshi|Kubota, Yoshihiro|Kawai, Yuki|Tanaka, Makiko|Kurumi, Yoshimasa|Tani, Tohru
PMID: 20414027
48.
Journal: J Transl Med. 2010 Jul 29;8:73.
Title: Low temperature of radiofrequency ablation at the target sites can facilitate rapid progression of residual hepatic VX2 carcinoma.
Author: Ke, Shan|Ding, Xue-mei|Kong, Jian|Gao, Jun|Wang, Shao-hong|Cheng, Yan|Sun, Wen-bing
PMID: 20667141
49.
Journal: Biochem Biophys Res Commun. 2010 Dec 3;403(1):120-5.
Title: miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines.
Author: Henry, Jon C|Park, Jong-Kook|Jiang, Jinmai|Kim, Ji Hye|Nagorney, David M|Roberts, Lewis R|Banerjee, Soma|Schmittgen, Thomas D
PMID: 21055388
50.
Journal: J Clin Invest. 2010 Dec;120(12):4493-506.
Title: Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice.
Author: Jung, Cho-Rok|Lim, Jung Hwa|Choi, Yoonjung|Kim, Dae-Ghon|Kang, Koo Jeong|Noh, Seung-Moo|Im, Dong-Soo
PMID: 21060154
51.
Journal: PLoS One. 2010 Dec 29;5(12):e15690.
Title: Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice.
Author: Latasa, M Ujue|Gil-Puig, Carmen|Fernandez-Barrena, Maite G|Rodriguez-Ortigosa, Carlos M|Banales, Jesus M|Urtasun, Raquel|Goni, Saioa|Mendez, Miriam|Arcelus, Sara|Juanarena, Nerea|Recio, Juan A|Lotersztajn, Sophie|Prieto, Jesus|Berasain, Carmen|Corrales, F
PMID: 21209952
52.
Journal: Oncol Lett. 2010 Jan;1(1):137-142.
Title: Tumorigenesis of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), but not enhancing effects of concomitant high-fat diet, on lung carcinogenesis in female A/J mice.
Author: Takeuchi, Hijiri|Saoo, Kousuke|Yamakawa, Keiko|Matsuda, Yoko|Yokohira, Masanao|Zeng, Yu|Kuno, Totshiya|Totsuka, Yukari|Takahashi, Mami|Wakabayashi, Keiji|Imaida, Katsumi
PMID: 22966271
53.
Journal: Toxicology. 2011 Apr 28;283(1):8-17.
Title: Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by beta-naphthoflavone involving TNFalpha-signaling due to oxidative cellular stress in rats.
Author: Kuwata, Kazunori|Shibutani, Makoto|Hayashi, Hitomi|Shimamoto, Keisuke|Hayashi, Shim-Mo|Suzuki, Kazuhiko|Mitsumori, Kunitoshi
PMID: 21295105
54.
Journal: J Dermatol. 2011 Mar;38(3):261-6.
Title: Sorafenib-associated hand-foot syndrome in Japanese patients.
Author: Iijima, Masafumi|Fukino, Koichi|Adachi, Masatoshi|Tsukamoto, Taiji|Murai, Masaru|Naito, Seiji|Minami, Hironobu|Furuse, Junji|Akaza, Hideyuki
PMID: 21342228
55.
Journal: FEBS Lett. 2011 Jul 21;585(14):2229-34.
Title: miR-198 inhibits migration and invasion of hepatocellular carcinoma cells by targeting the HGF/c-MET pathway.
Author: Tan, Sheng|Li, Rui|Ding, Keshuo|Lobie, Peter E|Zhu, Tao
PMID: 21658389
56.
Journal: J Hepatol. 2011 Dec;55(6):1300-8.
Title: SOCS1 controls liver regeneration by regulating HGF signaling in hepatocytes.
Author: Gui, Yirui|Yeganeh, Mehdi|Ramanathan, Sheela|Leblanc, Chantal|Pomerleau, Veronique|Ferbeyre, Gerardo|Saucier, Caroline|Ilangumaran, Subburaj
PMID: 21703184
57.
Journal: Biochem Biophys Res Commun. 2011 Jul 15;410(4):803-8.
Title: Regulation of human hepatocellular carcinoma cells by Spred2 and correlative studies on its mechanism.
Author: Ma, Xiao-Ni|Liu, Xiao-Yun|Yang, Yue-Feng|Xiao, Feng-Jun|Li, Qing-Fang|Yan, Jun|Zhang, Qun-Wei|Wang, Li-Sheng|Li, Xue-Yan|Wang, Hua
PMID: 21703232
58.
Journal: PLoS One. 2011;6(8):e23311.
Title: Differences in the properties and mirna expression profiles between side populations from hepatic cancer cells and normal liver cells.
Author: Liu, Wei-hui|Tao, Kai-shan|You, Nan|Liu, Zheng-cai|Zhang, Hong-tao|Dou, Ke-feng
PMID: 21826246
59.
Journal: J Radiat Res. 2011;52(5):582-91.
Title: Hepatic regeneration after sublethal partial liver irradiation in cirrhotic rats.
Author: Gu, Ke|Lai, Song-Tao|Ma, Ning-Yi|Zhao, Jian-Dong|Ren, Zhi-Gang|Wang, Jian|Liu, Jin|Jiang, Guo-Liang
PMID: 21952315
60.
Journal: J Exp Clin Cancer Res. 2011 Oct 12;30:96.
Title: HGF/c-Met related activation of beta-catenin in hepatoblastoma.
Author: Purcell, Rachel|Childs, Margaret|Maibach, Rudolf|Miles, Carina|Turner, Clinton|Zimmermann, Arthur|Sullivan, Michael
PMID: 21992464
61.
Journal: Cancer Cell. 2011 Dec 13;20(6):698-9.
Title: Targeting liver cancer: first steps toward a miRacle?
Author: Schwabe, Robert F|Wang, Timothy C
PMID: 22172719
62.
Journal: Inflammation. 2012 Feb;35(1):143-9.
Title: Estrogen suppresses metastasis in rat hepatocellular carcinoma through decreasing interleukin-6 and hepatocyte growth factor expression.
Author: Wang, Yong-Cang|Xu, Ge-Liang|Jia, Wei-Dong|Han, Sheng-Jin|Ren, Wei-Hua|Wang, Wei|Liu, Wen-Bin|Zhang, Chuan-Hai|Chen, Hao
PMID: 21302136
63.
Journal: Hepatology. 2012 Jul;56(1):186-97.
Title: Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.
Author: Wang, Bo|Hsu, Shu-Hao|Frankel, Wendy|Ghoshal, Kalpana|Jacob, Samson T
PMID: 22318941
64.
Journal: Biomed Pharmacother. 2012 Sep;66(6):454-8.
Title: Genes responsible for the characteristics of primary cultured invasive phenotype hepatocellular carcinoma cells.
Author: Lin, Zu-Yau|Chuang, Wan-Long
PMID: 22681909
65.
Journal: Biomed Pharmacother. 2012 Oct;66(7):525-9.
Title: Cancer-associated fibroblasts up-regulate CCL2, CCL26, IL6 and LOXL2 genes related to promotion of cancer progression in hepatocellular carcinoma cells.
Author: Lin, Zu-Yau|Chuang, Yen-Hwang|Chuang, Wan-Long
PMID: 22739041
66.
Journal: PLoS One. 2012;7(6):e39771.
Title: beta-Catenin loss in hepatocytes promotes hepatocellular cancer after diethylnitrosamine and phenobarbital administration to mice.
Author: Awuah, Prince Kwaku|Rhieu, Byung Han|Singh, Sucha|Misse, Amalea|Monga, Satdarshan P S
PMID: 22761897
67.
Journal: Zhonghua Gan Zang Bing Za Zhi. 2012 Jun;20(6):463-7.
Title: [Relationship between IL6 -572G/C polymorphism and hepatocellular carcinoma in men].
Author: Liu, Shun|Qiu, Xiao-qiang|Zeng, Xiao-yun|Bai, Hua|Bei, Chun-hua|Yang, Yan
PMID: 23044206
68.
Journal: Biomed Pharmacother. 2012 Dec;66(8):583-6.
Title: High therapeutic concentration of prazosin up-regulates angiogenic IL6 and CCL2 genes in hepatocellular carcinoma cells.
Author: Lin, Zu-Yau|Chuang, Wan-Long
PMID: 23089469
69.
Journal: Molecules. 2012 Nov 5;17(11):13116-31.
Title: Inhibition of PCAF histone acetyltransferase, cytotoxicity and cell permeability of 2-acylamino-1-(3- or 4-carboxy-phenyl)benzamides.
Author: Park, Woong Jae|Ma, Eunsook
PMID: 23128090
70.
Journal: Zhonghua Gan Zang Bing Za Zhi. 2012 Oct;20(10):785-8.
Title: [Applicability of the multiplex quantitative antibody array system for early diagnosis of hepatocellular carcinoma].
Author: Gao, Dong-mei|Sun, Lu|Guo, Kun|Li, Yan|Liu, Yin-kun|Kang, Xiao-nan
PMID: 23207342
71.
Journal: Liver Cancer. 2012 Sep;1(2):83-93.
Title: Emerging signaling pathways in hepatocellular carcinoma.
Author: Moeini, Agrin|Cornella, Helena|Villanueva, Augusto
PMID: 24159576
72.
Journal: Int J Hepatol. 2013;2013:315947.
Title: Molecular classification of hepatocellular adenomas.
Author: Nault, Jean Charles|Zucman Rossi, Jessica
PMID: 23401783
73.
Journal: J Cancer Res Clin Oncol. 2013 Jul;139(7):1169-78.
Title: Microarray analyses reveal liver metastasis-related genes in metastatic colorectal cancer cell model.
Author: Chen, Qiang|Chen, Lei|Zhao, Ren|Yang, Xiao-dong|Imran, Khan|Xing, Chun-gen
PMID: 23563852
74.
Journal: Mol Biol Rep. 2013 Jul;40(7):4203-9.
Title: Celastrol exerts synergistic effects with PHA-665752 and inhibits tumor growth of c-Met-deficient hepatocellular carcinoma in vivo.
Author: Jiang, Hong-Lei|Jin, Jun-Zhe|Wu, Dan|Xu, Dong|Lin, Guo-Fu|Yu, Hao|Ma, Dong-Yan|Liang, Jian
PMID: 23649759
75.
Journal: Kaohsiung J Med Sci. 2013 Jun;29(6):312-8.
Title: Hepatocellular carcinoma cells cause different responses in expressions of cancer-promoting genes in different cancer-associated fibroblasts.
Author: Lin, Zu-Yau|Chuang, Wan-Long
PMID: 23684136
76.
Journal: Mol Cell Biochem. 2013 Oct;382(1-2):83-92.
Title: Ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling.
Author: Li, Ying|Huang, Xiaohua|Zhong, Weiliang|Zhang, Jianing|Ma, Keli
PMID: 23749170
77.
Journal: J Hepatol. 2013 Nov;59(5):1007-13.
Title: Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma.
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Title: Linking MLL and the HGF-MET signaling pathway in liver cancer.
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Title: Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma.
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Title: Cell surface glycan alterations in epithelial mesenchymal transition process of Huh7 hepatocellular carcinoma cell.
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Title: Impact of cytokine gene variants on the prediction and prognosis of hepatocellular carcinoma in patients with cirrhosis.
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Title: A novel oxygen carrier "YQ23" suppresses the liver tumor metastasis by decreasing circulating endothelial progenitor cells and regulatory T cells.
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Title: Antineoplastic activity of monocrotaline against hepatocellular carcinoma.
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Title: Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells.
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Title: Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells.
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Journal: Cancer Prev Res (Phila). 2014 Dec;7(12):1219-27.
Title: Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.
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Title: Overview of fundamental study of pazopanib in cancer.
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Journal: Liver Int. 2015 May;35(5):1590-6.
Title: Radioembolization of hepatocellular carcinoma activates liver regeneration, induces inflammation and endothelial stress and activates coagulation.
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Title: Leishmanial lipid affords protection against oxidative stress induced hepatic injury by regulating inflammatory mediators and confining apoptosis progress.
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Journal: Clin Cancer Res. 2015 Jan 1;21(1):201-10.
Title: Activation of IL6/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression.
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Title: Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cells.
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Title: Damnacanthal, a noni anthraquinone, inhibits c-Met and is a potent antitumor compound against Hep G2 human hepatocellular carcinoma cells.
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Title: MACC1 suppresses cell apoptosis in hepatocellular carcinoma by targeting the HGF/c-MET/AKT pathway.
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Title: High-Mobility Group Box 1 Promotes Hepatocellular Carcinoma Progression through miR-21-Mediated Matrix Metalloproteinase Activity.
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Title: Characterization of solid tumors induced by polycyclic aromatic hydrocarbons in mice.
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Title: Study of the effects of cyclooxygenase-2 inhibitor on the promotion of hepatic tumorigenesis in rats fed a high fat diet.
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Title: Celecoxib and Ibuprofen Restore the ATP Content and the Gluconeogenesis Activity in the Liver of Walker-256 Tumor-Bearing Rats.
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Title: Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis.
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Title: Profiling of promoter occupancy by the SND1 transcriptional coactivator identifies downstream glycerolipid metabolic genes involved in TNFalpha response in human hepatoma cells.
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Title: Hydrogen peroxide inducible clone-5 mediates reactive oxygen species signaling for hepatocellular carcinoma progression.
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Title: Tivantinib induces G2/M arrest and apoptosis by disrupting tubulin polymerization in hepatocellular carcinoma.
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Title: Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer.
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Journal: Scand J Immunol. 2016 Jan;83(1):33-7.
Title: CCL20-CCR6 Cytokine Network Facilitate Treg Activity in Advanced Grades and Metastatic Variants of Hepatocellular Carcinoma.
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Journal: Tumour Biol. 2016 Jun;37(6):7741-8.
Title: SENP1 regulates hepatocyte growth factor-induced migration and epithelial-mesenchymal transition of hepatocellular carcinoma.
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Journal: Carcinogenesis. 2016 Mar;37(3):290-300.
Title: Na+/H+ exchanger 1, Na+/Ca2+ exchanger 1 and calmodulin complex regulates interleukin 6-mediated cellular behavior of human hepatocellular carcinoma.
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Journal: Cancer Res. 2016 Apr 1;76(7):1698-704.
Title: A Preclinical Model of Chronic Alcohol Consumption Reveals Increased Metastatic Seeding of Colon Cancer Cells in the Liver.
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Journal: Oncotarget. 2016 May 10;7(19):28059-74.
Title: Immune-mediated liver injury of the cancer therapeutic antibody catumaxomab targeting EpCAM, CD3 and Fcgamma receptors.
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Title: TLR7 agonist induced repression of hepatocellular carcinoma via the TLR7-IKK-NF-kappaB-IL6 signaling pathway.
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Journal: Cell Rep. 2016 May 10;15(6):1175-89.
Title: Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling.
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Title: Interleukin-6-174 Promoter Polymorphism and Susceptibility to Hepatitis B Virus Infection as a Risk Factor for Hepatocellular Carcinoma in Iran.
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Title: TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver.
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Journal: Radiology. 2016 Dec;281(3):782-792.
Title: Hepatic Thermal Ablation: Effect of Device and Heating Parameters on Local Tissue Reactions and Distant Tumor Growth.
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Title: miR-451 acts as a suppressor of angiogenesis in hepatocellular carcinoma by targeting the IL-6R-STAT3 pathway.
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Journal: Eur Rev Med Pharmacol Sci. 2016 Jul;20(15):3186-93.
Title: The effect of sequential transcatheter arterial chemoembolization (TACE) and portal venous embolizations (PVE) vs. TACE or PVE alone on rabbit VX2 liver carcinoma and on liver regeneration.
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Journal: Oncotarget. 2016 Oct 11;7(41):66635-66646.
Title: Distinct role of interleukin-6 and tumor necrosis factor receptor-1 in oval cell- mediated liver regeneration and inflammation-associated hepatocarcinogenesis.
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Title: Exosomes derived from HCC cells induce sorafenib resistance in hepatocellular carcinoma both in vivo and in vitro.
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Journal: Oncoimmunology. 2016 Sep 27;5(10):e1219828.
Title: Peritumoral stromal neutrophils are essential for c-Met-elicited metastasis in human hepatocellular carcinoma.
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Journal: Clin Cancer Res. 2016 Dec 15;22(24):6303.
Title: Correction: Activation of IL6/IGFIR Confers Poor Prognosis of HBV-Related Hepatocellular Carcinoma through Induction of OCT4/NANOG Expression.
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Journal: Clin Cancer Res. 2017 May 15;23(10):2405-2413.
Title: A Phase I/II Multicenter Study of Single-Agent Foretinib as First-Line Therapy in Patients with Advanced Hepatocellular Carcinoma.
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Journal: Hepatology. 2017 Apr;65(4):1222-1236.
Title: IL6-mediated inflammatory loop reprograms normal to epithelial-mesenchymal transition(+) metastatic cancer stem cells in preneoplastic liver of transforming growth factor beta-deficient beta2-spectrin(+/-) mice.
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Journal: Biochim Biophys Acta Mol Cell Res. 2017 Mar;1864(3):516-526.
Title: Crosstalk between different family members: IL27 recapitulates IFNgamma responses in HCC cells, but is inhibited by IL6-type cytokines.
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Journal: Mol Cancer Ther. 2017 Feb;16(2):312-322.
Title: Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model.
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Title: Hepatic expression of oncogenes Bmi1 and Dkk1 is up-regulated in hepatitis B virus surface antigen-transgenic mice and can be induced by treatment with HBV particles or lipopolysaccharides in vitro.
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Title: Tumor-Derived alpha-Fetoprotein Directly Drives Human Natural Killer-Cell Activation and Subsequent Cell Death.
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Journal: Nat Commun. 2017 May 16;8:15433.
Title: Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis.
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Title: Intestine-Specific Homeobox Gene ISX Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression.
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Title: Peri-tumor associated fibroblasts promote intrahepatic metastasis of hepatocellular carcinoma by recruiting cancer stem cells.
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Journal: Zhonghua Yu Fang Yi Xue Za Zhi. 2017 Aug 6;51(8):698-702.
Title: [The association between single-nucleotide polymorphisms in IL6, IL10 genes and the susceptibility to primary hepatic carcinoma in Shunde District of Foshan City].
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Title: Effect of TALEN-mediated IL-6 knockout on cell proliferation, apoptosis, invasion and anti-cancer therapy in hepatocellular carcinoma (HCC-LM3) cells.
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Title: Serum cytokine profiles predict survival benefits in patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective cohort study.
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Title: Heat stress induced, ligand-independent MET and EGFR signalling in hepatocellular carcinoma.
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Journal: Matrix Biol. 2018 Mar;66:81-92.
Title: Deficiency of periostin impairs liver regeneration in mice after partial hepatectomy.
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Journal: Mol Cancer Ther. 2018 Jan;17(1):276-289.
Title: CCL26 Participates in the PRL-3-Induced Promotion of Colorectal Cancer Invasion by Stimulating Tumor-Associated Macrophage Infiltration.
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Title: Splenectomy after partial hepatectomy accelerates liver regeneration in mice by promoting tight junction formation via polarity protein Par 3-aPKC.
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Journal: World J Gastroenterol. 2018 Jan 14;24(2):237-247.
Title: Transplantation of bone marrow-derived endothelial progenitor cells and hepatocyte stem cells from liver fibrosis rats ameliorates liver fibrosis.
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Journal: Sci Rep. 2018 Feb 5;8(1):2362.
Title: Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH.
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Journal: Biochem Pharmacol. 2018 Apr;150:191-201.
Title: Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway.
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Title: hPCL3s Promotes Hepatocellular Carcinoma Metastasis by Activating beta-Catenin Signaling.
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Journal: Cell Death Dis. 2018 Apr 1;9(4):422.
Title: Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma.
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Journal: Nanomedicine. 2018 Apr 17;14(4):1441-1454.
Title: CD44 directed nanomicellar payload delivery platform for selective anticancer effect and tumor specific imaging of triple negative breast cancer.
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Title: The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway.
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Journal: J Cachexia Sarcopenia Muscle. 2018 Aug;9(4):727-746.
Title: Group I Paks support muscle regeneration and counteract cancer-associated muscle atrophy.
Author: Cerquone Perpetuini, Andrea|Re Cecconi, Andrea David|Chiappa, Michela|Martinelli, Giulia Benedetta|Fuoco, Claudia|Desiderio, Giovanni|Castagnoli, Luisa|Gargioli, Cesare|Piccirillo, Rosanna|Cesareni, Gianni
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Journal: Drug Des Devel Ther. 2018 May 21;12:1321-1336.
Title: Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties.
Author: Wang, Rui|Li, Yang|Huai, Xu-Dong|Zheng, Qing-Xuan|Wang, Wei|Li, Hui-Jing|Huai, Qi-Yong
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Journal: Biomed Pharmacother. 2018 Oct;106:68-76.
Title: Fatty acid binding protein 5 promotes tumor angiogenesis and activates the IL6/STAT3/VEGFA pathway in hepatocellular carcinoma.
Author: Pan, Long|Xiao, Heng|Liao, Rui|Chen, Qingsong|Peng, Chong|Zhang, Yuchi|Mu, Tong|Wu, Zhongjun
PMID: 29957468
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Journal: J Cell Biochem. 2018 Jul 17.
Title: IL-6/STAT3 pathway intermediates M1/M2 macrophage polarization during the development of hepatocellular carcinoma.
Author: Yin, Zi|Ma, Tingting|Lin, Ye|Lu, Xin|Zhang, Chuanzhao|Chen, Sheng|Jian, Zhixiang
PMID: 30015355
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Journal: Cytokine. 2018 Aug 7. pii: S1043-4666(18)30330-2.
Title: Essential role of suppressor of cytokine signaling 1 (SOCS1) in hepatocytes and macrophages in the regulation of liver fibrosis.
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PMID: 30097285
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Journal: Cell Death Dis. 2018 Aug 28;9(9):852.
Title: ID1-induced p16/IL6 axis activation contributes to the resistant of hepatocellular carcinoma cells to sorafenib.
Author: Niu, Lei-Lei|Cheng, Chuan-le|Li, Ming-Yue|Yang, Sheng-Li|Hu, Bao-Guang|Chong, Charing C N|Chan, Stephen L|Ren, Jianwei|Chen, George G|Lai, Paul B S
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Journal: Carcinogenesis. 2018 Sep 4. pii: 5090278.
Title: Colorectal Cancer-derived Small Extracellular Vesicles Establish an Inflammatory Pre-metastatic Niche in Liver Metastasis.
Author: Shao, Yingkuan|Chen, Ting|Zheng, Xi|Yang, Sheng|Xu, Kailun|Chen, Xuewen|Xu, Fei|Wang, Lantian|Shen, Yanwei|Wang, Tingyang|Zhang, Mengwen|Hu, Wangxiong|Ye, Chenyang|Yu, XiaoFang|Shao, Jimin|Zheng, Shu
PMID: 30184100
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Journal: Biomed Pharmacother. 2018 Sep 11;108:65-75.
Title: Chemopreventive and antitumor effects of benzyl isothiocynate on HCC models: A possible role of HGF /pAkt/ STAT3 axis and VEGF.
Author: Zakaria, Sherin|Helmy, Maged Wasfy|Salahuddin, Ahmed|Omran, Gamal
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Journal: Gene Expr. 2018 Sep 18.
Title: PRMT1-dependent macrophage IL6 production is required for alcohol-induced HCC progression.
Author: Zhao, Jie|O'Neil, Maura|Vittal, Anusha|Weinman, Steven A|Tikhanovich, Irina
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Journal: Life Sci. 2018 Oct 4. pii: S0024-3205(18)30619-2.
Title: Inhibition of SRC/FAK cue: A novel pathway for the synergistic effect of rosuvastatin on the anti-cancer effect of dasatinib in hepatocellular carcinoma.
Author: El Sayed, Ibrahim|Helmy, Maged W|El-Abhar, Hanan S
PMID: 30292831