Primary Site >> Liver Cancer
Gene >> IL6
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Ref: Regulation of major acute-phase plasma proteins by hepatocyte-stimulating factors of human squamous carcinoma cells. PMID: 2418029 |
Ref: Interaction among hepatocyte-stimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells. PMID: 2447159 |
Ref: The cascade of inflammatory cytokines regulating synthesis of acute phase proteins. PMID: 2483765 Ref: Interleukin 6, the third mediator of acute-phase reaction, modulates hepatic protein synthesis in human and mouse. Comparison with interleukin 1 beta and tumor necrosis factor-alpha. PMID: 3138137 |
Ref: Effect of cytokines on glycosylation of acute phase proteins in human hepatoma cell lines. PMID: 2467770 Ref: Human hepatocyte-stimulating factor-III and interleukin-6 are structurally and immunologically distinct but regulate the production of the same acute phase plasma proteins. PMID: 2470740 |
Ref: Cell-specific toxicity of a chimeric protein composed of interleukin-6 and Pseudomonas exotoxin (IL6-PE40) on tumor cells. PMID: 2160579 |
Ref: Specific expression of the pancreatic-secretory-trypsin-inhibitor (PSTI) gene in hepatocellular carcinoma. PMID: 8244568 Ref: Purification and characterization of IL6-PE4E, a recombinant fusion of interleukin 6 with Pseudomonas exotoxin. PMID: 8305530 Ref: [Immunological effects of locoregional immunochemotherapy for liver metastases of gastric cancer]. PMID: 8373205 |
Ref: Expression of functional receptors for human C5a anaphylatoxin (CD88) on the human hepatocellular carcinoma cell line HepG2. Stimulation of acute-phase protein-specific mRNA and protein synthesis by human C5a anaphylatoxin. PMID: 7541417 Ref: Growth control and gene expression in a new hepatocellular carcinoma cell line, Hep40: inhibitory actions of vitamin K. PMID: 7593224 |
Ref: Involvement of hepatocyte growth factor in increased integrin expression on HepG2 cells triggered by adhesion to endothelial cells. PMID: 9000597 Ref: Co-expression and regulation of Met and Ron proto-oncogenes in human hepatocellular carcinoma tissues and cell lines. PMID: 9214452 |
Ref: Secretion of acute-phase proteins before and after hepatocellular carcinoma resection. PMID: 10083762 |
Ref: Hepatocarcinoma cells stimulate hepatocyte growth factor secretion in human liver myofibroblasts. PMID: 10995891 |
Ref: Characterization of a new rat cell line established from 2'AAF-induced combined hepatocellular cholangiocellular carcinoma. PMID: 11249201 Ref: Invasiveness of hepatocellular carcinoma cell lines: contribution of hepatocyte growth factor, c-met, and transcription factor Ets-1. PMID: 11527416 |
Ref: Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma. PMID: 12668613 Ref: An absolute role of the PKC-dependent NF-kappaB activation for induction of MMP-9 in hepatocellular carcinoma cells. PMID: 12745093 Ref: [Significance of intracellular cytokines levels in peripheral lymphocytes for evaluation of surgical stress after hepatectomy in patients with hepatocellular carcinoma]. PMID: 14619536 Ref: Gene expression profile favoring phenotypic reversion: a clue for mechanism of tumor suppression by NF-IL6 3'UTR. PMID: 14728809 |
Ref: Evaluation of the potential of triethanolamine to alter hepatic choline levels in female B6C3F1 mice. PMID: 15056812 Ref: Serum hepatocyte growth factor and interleukin-6 levels can distinguish patients with primary or metastatic liver tumors from those with benign liver lesions. PMID: 15254675 Ref: Involvement of cell cycle regulatory proteins and MAP kinase signaling pathway in growth inhibition and cell cycle arrest by a selective cyclooxygenase 2 inhibitor, etodolac, in human hepatocellular carcinoma cell lines. PMID: 15298730 Ref: Protection of reduced-size liver for transplantation. PMID: 15307828 Ref: Negative regulation of hepatocellular carcinoma cell growth by signal regulatory protein alpha1. PMID: 15349900 Ref: Constitutional activation of IL-6-mediated JAK/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell line. PMID: 15354212 |
Ref: Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection. PMID: 15661146 |
Ref: The role of a protease inhibitor against hepatectomy. PMID: 16506388 |
Ref: Potential involvement of the cyclooxygenase-2 pathway in hepatocellular carcinoma-associated angiogenesis. PMID: 17097688 Ref: Evaluation of interleukin-6, interleukin-10 and human hepatocyte growth factor as tumor markers for hepatocellular carcinoma. PMID: 17140760 Ref: Interactions between aflatoxin B1 and dietary iron overload in hepatic mutagenesis. PMID: 17399882 Ref: [Molecular mechanisms of DHEA and DHEAs on apoptosis and cell cycle arrest via Akt pathway in hepatoma cell lines]. PMID: 17594810 Ref: Angiogenesis soluble factors as hepatocellular carcinoma noninvasive markers for monitoring hepatitis C virus cirrhotic patients awaiting liver transplantation. PMID: 18049111 Ref: Liver stem cells and molecular signaling pathways in hepatocellular carcinoma. PMID: 19360142 |
Ref: VIP inhibits human HepG2 cell proliferation in vitro. PMID: 18077011 Ref: New cellular tools reveal complex epithelial-mesenchymal interactions in hepatocarcinogenesis. PMID: 18594539 Ref: A novel and effective hepatocyte growth factor kringle 1 domain and p53 cocktail viral gene therapy for the treatment of hepatocellular carcinoma. PMID: 18722051 Ref: Significant correlation between surgical stress of hepatectomy and changes in the serum levels of HGF, IL-6 and soluble Fas in patients with viral hepatitis. PMID: 18795698 Ref: Deficient response of IL-6 impaired liver regeneration after hepatectomy in patients with viral hepatitis. PMID: 18795707 |
Ref: Protective effect of Verapamil on hepatic ischemia-reperfusion injury during hepatectomy in the cirrhotic patients with hepatocellular carcinoma. PMID: 19350266 Ref: Down-regulation of the HGF/MET autocrine loop induced by celecoxib and mediated by P-gp in MDR-positive human hepatocellular carcinoma cell line. PMID: 19447220 |
Ref: Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patients. PMID: 19720422 Ref: Inhibition of poly adenosine diphosphate-ribose polymerase decreases hepatocellular carcinoma growth by modulation of tumor-related gene expression. PMID: 20034026 Ref: The identification of stem cells in human liver diseases and hepatocellular carcinoma. PMID: 20080086 Ref: [An effective case of liver metastasis of breast cancer treated with capecitabine + docetaxel combination therapy using vitamin B6]. PMID: 20414027 Ref: Low temperature of radiofrequency ablation at the target sites can facilitate rapid progression of residual hepatic VX2 carcinoma. PMID: 20667141 Ref: miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines. PMID: 21055388 Ref: Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice. PMID: 21060154 Ref: Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice. PMID: 21209952 Ref: Tumorigenesis of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), but not enhancing effects of concomitant high-fat diet, on lung carcinogenesis in female A/J mice. PMID: 22966271 |
Ref: Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by beta-naphthoflavone involving TNFalpha-signaling due to oxidative cellular stress in rats. PMID: 21295105 Ref: Sorafenib-associated hand-foot syndrome in Japanese patients. PMID: 21342228 Ref: miR-198 inhibits migration and invasion of hepatocellular carcinoma cells by targeting the HGF/c-MET pathway. PMID: 21658389 Ref: SOCS1 controls liver regeneration by regulating HGF signaling in hepatocytes. PMID: 21703184 Ref: Regulation of human hepatocellular carcinoma cells by Spred2 and correlative studies on its mechanism. PMID: 21703232 Ref: Differences in the properties and mirna expression profiles between side populations from hepatic cancer cells and normal liver cells. PMID: 21826246 Ref: Hepatic regeneration after sublethal partial liver irradiation in cirrhotic rats. PMID: 21952315 Ref: HGF/c-Met related activation of beta-catenin in hepatoblastoma. PMID: 21992464 Ref: Targeting liver cancer: first steps toward a miRacle? PMID: 22172719 |
Ref: Estrogen suppresses metastasis in rat hepatocellular carcinoma through decreasing interleukin-6 and hepatocyte growth factor expression. PMID: 21302136 Ref: Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. PMID: 22318941 Ref: Genes responsible for the characteristics of primary cultured invasive phenotype hepatocellular carcinoma cells. PMID: 22681909 Ref: Cancer-associated fibroblasts up-regulate CCL2, CCL26, IL6 and LOXL2 genes related to promotion of cancer progression in hepatocellular carcinoma cells. PMID: 22739041 Ref: beta-Catenin loss in hepatocytes promotes hepatocellular cancer after diethylnitrosamine and phenobarbital administration to mice. PMID: 22761897 Ref: [Relationship between IL6 -572G/C polymorphism and hepatocellular carcinoma in men]. PMID: 23044206 Ref: High therapeutic concentration of prazosin up-regulates angiogenic IL6 and CCL2 genes in hepatocellular carcinoma cells. PMID: 23089469 Ref: Inhibition of PCAF histone acetyltransferase, cytotoxicity and cell permeability of 2-acylamino-1-(3- or 4-carboxy-phenyl)benzamides. PMID: 23128090 Ref: [Applicability of the multiplex quantitative antibody array system for early diagnosis of hepatocellular carcinoma]. PMID: 23207342 Ref: Emerging signaling pathways in hepatocellular carcinoma. PMID: 24159576 |
Ref: Molecular classification of hepatocellular adenomas. PMID: 23401783 Ref: Microarray analyses reveal liver metastasis-related genes in metastatic colorectal cancer cell model. PMID: 23563852 Ref: Celastrol exerts synergistic effects with PHA-665752 and inhibits tumor growth of c-Met-deficient hepatocellular carcinoma in vivo. PMID: 23649759 Ref: Hepatocellular carcinoma cells cause different responses in expressions of cancer-promoting genes in different cancer-associated fibroblasts. PMID: 23684136 Ref: Ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling. PMID: 23749170 Ref: Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma. PMID: 23796475 Ref: Linking MLL and the HGF-MET signaling pathway in liver cancer. PMID: 23934122 Ref: Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma. PMID: 23954207 Ref: Cell surface glycan alterations in epithelial mesenchymal transition process of Huh7 hepatocellular carcinoma cell. PMID: 23977005 |
Ref: Impact of cytokine gene variants on the prediction and prognosis of hepatocellular carcinoma in patients with cirrhosis. PMID: 24751829 Ref: A novel oxygen carrier "YQ23" suppresses the liver tumor metastasis by decreasing circulating endothelial progenitor cells and regulatory T cells. PMID: 24766798 Ref: Antineoplastic activity of monocrotaline against hepatocellular carcinoma. PMID: 25028149 Ref: Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells. PMID: 25098666 Ref: Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells. PMID: 25181692 Ref: Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice. PMID: 25293877 Ref: Overview of fundamental study of pazopanib in cancer. PMID: 26767042 |
Ref: Radioembolization of hepatocellular carcinoma activates liver regeneration, induces inflammation and endothelial stress and activates coagulation. PMID: 24836705 Ref: Leishmanial lipid affords protection against oxidative stress induced hepatic injury by regulating inflammatory mediators and confining apoptosis progress. PMID: 25445725 Ref: Activation of IL6/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression. PMID: 25564572 Ref: Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cells. PMID: 25596735 Ref: Damnacanthal, a noni anthraquinone, inhibits c-Met and is a potent antitumor compound against Hep G2 human hepatocellular carcinoma cells. PMID: 25620570 Ref: MACC1 suppresses cell apoptosis in hepatocellular carcinoma by targeting the HGF/c-MET/AKT pathway. PMID: 25660117 Ref: High-Mobility Group Box 1 Promotes Hepatocellular Carcinoma Progression through miR-21-Mediated Matrix Metalloproteinase Activity. PMID: 25720799 Ref: Knockdown of c-MET induced apoptosis in ABCB1-overexpressed multidrug-resistance cancer cell lines. PMID: 25908454 Ref: Characterization of solid tumors induced by polycyclic aromatic hydrocarbons in mice. PMID: 25913077 Ref: Study of the effects of cyclooxygenase-2 inhibitor on the promotion of hepatic tumorigenesis in rats fed a high fat diet. PMID: 25941430 Ref: Celecoxib and Ibuprofen Restore the ATP Content and the Gluconeogenesis Activity in the Liver of Walker-256 Tumor-Bearing Rats. PMID: 26160389 Ref: Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis. PMID: 26297436 Ref: Profiling of promoter occupancy by the SND1 transcriptional coactivator identifies downstream glycerolipid metabolic genes involved in TNFalpha response in human hepatoma cells. PMID: 26323317 Ref: Hydrogen peroxide inducible clone-5 mediates reactive oxygen species signaling for hepatocellular carcinoma progression. PMID: 26416447 Ref: Tivantinib induces G2/M arrest and apoptosis by disrupting tubulin polymerization in hepatocellular carcinoma. PMID: 26458953 Ref: Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer. PMID: 26556861 |
Ref: CCL20-CCR6 Cytokine Network Facilitate Treg Activity in Advanced Grades and Metastatic Variants of Hepatocellular Carcinoma. PMID: 26331965 Ref: SENP1 regulates hepatocyte growth factor-induced migration and epithelial-mesenchymal transition of hepatocellular carcinoma. PMID: 26695141 Ref: Na+/H+ exchanger 1, Na+/Ca2+ exchanger 1 and calmodulin complex regulates interleukin 6-mediated cellular behavior of human hepatocellular carcinoma. PMID: 26775040 Ref: A Preclinical Model of Chronic Alcohol Consumption Reveals Increased Metastatic Seeding of Colon Cancer Cells in the Liver. PMID: 26857263 Ref: Immune-mediated liver injury of the cancer therapeutic antibody catumaxomab targeting EpCAM, CD3 and Fcgamma receptors. PMID: 27058902 Ref: TLR7 agonist induced repression of hepatocellular carcinoma via the TLR7-IKK-NF-kappaB-IL6 signaling pathway. PMID: 27123047 Ref: Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling. PMID: 27134167 Ref: Interleukin-6-174 Promoter Polymorphism and Susceptibility to Hepatitis B Virus Infection as a Risk Factor for Hepatocellular Carcinoma in Iran. PMID: 27268603 Ref: TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver. PMID: 27391331 Ref: Hepatic Thermal Ablation: Effect of Device and Heating Parameters on Local Tissue Reactions and Distant Tumor Growth. PMID: 27409564 Ref: miR-451 acts as a suppressor of angiogenesis in hepatocellular carcinoma by targeting the IL-6R-STAT3 pathway. PMID: 27461244 Ref: The effect of sequential transcatheter arterial chemoembolization (TACE) and portal venous embolizations (PVE) vs. TACE or PVE alone on rabbit VX2 liver carcinoma and on liver regeneration. PMID: 27466990 Ref: Distinct role of interleukin-6 and tumor necrosis factor receptor-1 in oval cell- mediated liver regeneration and inflammation-associated hepatocarcinogenesis. PMID: 27556180 Ref: Exosomes derived from HCC cells induce sorafenib resistance in hepatocellular carcinoma both in vivo and in vitro. PMID: 27716356 Ref: Peritumoral stromal neutrophils are essential for c-Met-elicited metastasis in human hepatocellular carcinoma. PMID: 27853643 Ref: Correction: Activation of IL6/IGFIR Confers Poor Prognosis of HBV-Related Hepatocellular Carcinoma through Induction of OCT4/NANOG Expression. PMID: 27980027 |
Ref: A Phase I/II Multicenter Study of Single-Agent Foretinib as First-Line Therapy in Patients with Advanced Hepatocellular Carcinoma. PMID: 27821605 Ref: IL6-mediated inflammatory loop reprograms normal to epithelial-mesenchymal transition(+) metastatic cancer stem cells in preneoplastic liver of transforming growth factor beta-deficient beta2-spectrin(+/-) mice. PMID: 27863449 Ref: Crosstalk between different family members: IL27 recapitulates IFNgamma responses in HCC cells, but is inhibited by IL6-type cytokines. PMID: 27939431 Ref: Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model. PMID: 27980102 Ref: Hepatic expression of oncogenes Bmi1 and Dkk1 is up-regulated in hepatitis B virus surface antigen-transgenic mice and can be induced by treatment with HBV particles or lipopolysaccharides in vitro. PMID: 28419472 Ref: Tumor-Derived alpha-Fetoprotein Directly Drives Human Natural Killer-Cell Activation and Subsequent Cell Death. PMID: 28468916 Ref: Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis. PMID: 28508871 Ref: Intestine-Specific Homeobox Gene ISX Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression. PMID: 28625979 Ref: Peri-tumor associated fibroblasts promote intrahepatic metastasis of hepatocellular carcinoma by recruiting cancer stem cells. PMID: 28716525 Ref: [The association between single-nucleotide polymorphisms in IL6, IL10 genes and the susceptibility to primary hepatic carcinoma in Shunde District of Foshan City]. PMID: 28763918 Ref: Effect of TALEN-mediated IL-6 knockout on cell proliferation, apoptosis, invasion and anti-cancer therapy in hepatocellular carcinoma (HCC-LM3) cells. PMID: 29100435 Ref: Serum cytokine profiles predict survival benefits in patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective cohort study. PMID: 29258450 |
Ref: Heat stress induced, ligand-independent MET and EGFR signalling in hepatocellular carcinoma. PMID: 28954551 Ref: Deficiency of periostin impairs liver regeneration in mice after partial hepatectomy. PMID: 28965986 Ref: CCL26 Participates in the PRL-3-Induced Promotion of Colorectal Cancer Invasion by Stimulating Tumor-Associated Macrophage Infiltration. PMID: 29051319 Ref: Splenectomy after partial hepatectomy accelerates liver regeneration in mice by promoting tight junction formation via polarity protein Par 3-aPKC. PMID: 29166570 Ref: Transplantation of bone marrow-derived endothelial progenitor cells and hepatocyte stem cells from liver fibrosis rats ameliorates liver fibrosis. PMID: 29375209 Ref: Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH. PMID: 29402900 Ref: Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway. PMID: 29454618 Ref: hPCL3s Promotes Hepatocellular Carcinoma Metastasis by Activating beta-Catenin Signaling. PMID: 29483096 Ref: Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma. PMID: 29556041 Ref: CD44 directed nanomicellar payload delivery platform for selective anticancer effect and tumor specific imaging of triple negative breast cancer. PMID: 29678787 Ref: The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway. PMID: 29722127 Ref: Group I Paks support muscle regeneration and counteract cancer-associated muscle atrophy. PMID: 29781585 Ref: Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties. PMID: 29861624 Ref: Fatty acid binding protein 5 promotes tumor angiogenesis and activates the IL6/STAT3/VEGFA pathway in hepatocellular carcinoma. PMID: 29957468 Ref: IL-6/STAT3 pathway intermediates M1/M2 macrophage polarization during the development of hepatocellular carcinoma. PMID: 30015355 Ref: Essential role of suppressor of cytokine signaling 1 (SOCS1) in hepatocytes and macrophages in the regulation of liver fibrosis. PMID: 30097285 Ref: ID1-induced p16/IL6 axis activation contributes to the resistant of hepatocellular carcinoma cells to sorafenib. PMID: 30154433 Ref: Colorectal Cancer-derived Small Extracellular Vesicles Establish an Inflammatory Pre-metastatic Niche in Liver Metastasis. PMID: 30184100 Ref: Chemopreventive and antitumor effects of benzyl isothiocynate on HCC models: A possible role of HGF /pAkt/ STAT3 axis and VEGF. PMID: 30216802 Ref: PRMT1-dependent macrophage IL6 production is required for alcohol-induced HCC progression. PMID: 30236171 Ref: Inhibition of SRC/FAK cue: A novel pathway for the synergistic effect of rosuvastatin on the anti-cancer effect of dasatinib in hepatocellular carcinoma. PMID: 30292831 |