Literatures

Primary Site >> Biliary tract Cancer

Gene >> IL6

1.
Journal:	Int J Oncol. 1995 Mar;6(3):639-45.
Title:	Fibroblast-tumor interaction changes constitutive expression of IL-6 and IL-8 in human carcinoma-cells.
Author:	Ishiko, T\|Mita, S\|Sakamoto, K\|Ogawa, M
PMID:	21556582

2.
Journal:	Jpn J Cancer Res. 1995 Jul;86(7):662-9.
Title:	Induction of invasive growth in a gallbladder cancer cell line by hepatocyte growth factor in vitro.
Author:	Shimura, H\|Date, K\|Matsumoto, K\|Nakamura, T\|Tanaka, M
PMID:	7559084

3.
Journal:	Dig Dis Sci. 1997 Jun;42(6):1290-4.
Title:	Biliary interleukin-6 and tumor necrosis factor-alpha in patients undergoing endoscopic retrograde cholangiopancreatography.
Author:	Rosen, H R\|Winkle, P J\|Kendall, B J\|Diehl, D L
PMID:	9201097

4.
Journal:	Oncol Rep. 1997 Sep-Oct;4(5):921-6.
Title:	Experimental study of the effect of IL-6 on cancer cachexia.
Author:	Ikeda, T\|Nishiguchi, Y\|Chung, Y\|Yamada, N\|Sowa, M
PMID:	21590167

5.
Journal:	Ann Surg. 1998 Mar;227(3):398-404.
Title:	Marked elevation of serum interleukin-6 in patients with cholangiocarcinoma: validation of utility as a clinical marker.
Author:	Goydos, J S\|Brumfield, A M\|Frezza, E\|Booth, A\|Lotze, M T\|Carty, S E
PMID:	9527063

6.
Journal:	J Gastroenterol. 1998 Aug;33(4):597-601.
Title:	Anomalous junction of the pancreaticobiliary duct accompanied by gallbladder cancer and obstructive jaundice in a patient with high serum and bile cytokine levels.
Author:	Akiyama, T\|Hasegawa, T\|Sejima, T\|Sahara, H\|Kitabayashi, K\|Seto, K\|Saito, H\|Takashima, S
PMID:	9719251

7.
Journal:	Histopathology. 1998 Aug;33(2):145-53.
Title:	Relationship between interleukin-6 and proliferation and differentiation in cholangiocarcinoma.
Author:	Sugawara, H\|Yasoshima, M\|Katayanagi, K\|Kono, N\|Watanabe, Y\|Harada, K\|Nakanuma, Y
PMID:	9762547

8.
Journal:	Hepatology. 1999 Nov;30(5):1128-33.
Title:	Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line.
Author:	Park, J\|Tadlock, L\|Gores, G J\|Patel, T
PMID:	10534331

9.
Journal:	Hepatology. 2000 Jul;32(1):26-35.
Title:	Growth control of human biliary epithelial cells by interleukin 6, hepatocyte growth factor, transforming growth factor beta1, and activin A: comparison of a cholangiocarcinoma cell line with primary cultures of non-neoplastic biliary epithelial cells.
Author:	Yokomuro, S\|Tsuji, H\|Lunz, J G 3rd\|Sakamoto, T\|Ezure, T\|Murase, N\|Demetris, A J
PMID:	10869285

10.
Journal:	In Vitro Cell Dev Biol Anim. 2001 Jan;37(1):17-25.
Title:	Characterization of a new rat cell line established from 2'AAF-induced combined hepatocellular cholangiocellular carcinoma.
Author:	Gil-Benso, R\|Martinez-Lorente, A\|Pellin-Perez, A\|Navarro-Fos, S\|Gregori-Romero, M A\|Carda, C\|Callaghan, R\|Peydro-Olaya, A\|Llombart-Bosch, A
PMID:	11249201

11.
Journal:	Hepatology. 2002 Aug;36(2):363-73.
Title:	Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells.
Author:	Wu, Tong\|Han, Chang\|Lunz, John G 3rd\|Michalopoulos, George\|Shelhamer, James H\|Demetris, A Jake
PMID:	12143044

12.
Journal:	J Hepatobiliary Pancreat Surg. 2003;10(4):265-81.
Title:	Anatomic and molecular pathology of intrahepatic cholangiocarcinoma.
Author:	Nakanuma, Yasuni\|Harada, Kenichi\|Ishikawa, Akira\|Zen, Yoh\|Sasaki, Motoko
PMID:	14598145

13.
Journal:	Semin Liver Dis. 2004 May;24(2):139-54.
Title:	Serum and bile markers for cholangiocarcinoma.
Author:	Nehls, Oliver\|Gregor, Michael\|Klump, Bodo
PMID:	15192787

14.
Journal:	Hepatology. 2005 Jan;41(1):5-15.
Title:	Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy.
Author:	Sirica, Alphonse E
PMID:	15690474

15.
Journal:	Am J Physiol Cell Physiol. 2005 Oct;289(4):C971-81.
Title:	IL-6 activates serum and glucocorticoid kinase via p38alpha mitogen-activated protein kinase pathway.
Author:	Meng, Fanyin\|Yamagiwa, Yoko\|Taffetani, Silvia\|Han, Jiahuai\|Patel, Tushar
PMID:	15917303

16.
Journal:	Biochim Biophys Acta. 2005 Jul 25;1755(2):135-50.
Title:	Cyclooxygenase-2 and prostaglandin signaling in cholangiocarcinoma.
Author:	Wu, Tong
PMID:	15921858

17.
Journal:	Gastroenterology. 2005 Jun;128(7):2054-65.
Title:	Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells.
Author:	Kobayashi, Shogo\|Werneburg, Nathan W\|Bronk, Steven F\|Kaufmann, Scott H\|Gores, Gregory J
PMID:	15940637

18.
Journal:	Hepatology. 2005 Dec;42(6):1329-38.
Title:	Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells.
Author:	Isomoto, Hajime\|Kobayashi, Shogo\|Werneburg, Nathan W\|Bronk, Steve F\|Guicciardi, Maria Eugenia\|Frank, David A\|Gores, Gregory J
PMID:	16317687

19.
Journal:	J Hepatol. 2006 Dec;45(6):856-67.
Title:	Cholangiocarcinoma: modern advances in understanding a deadly old disease.
Author:	Malhi, Harmeet\|Gores, Gregory J
PMID:	17030071

20.
Journal:	Cancer Res. 2006 Nov 1;66(21):10517-24.
Title:	Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression.
Author:	Wehbe, Hania\|Henson, Roger\|Meng, Fanyin\|Mize-Berge, Janna\|Patel, Tushar
PMID:	17079474

21.
Journal:	World J Gastroenterol. 2006 Oct 21;12(39):6316-24.
Title:	Effect of transforming growth factor-beta1 on human intrahepatic cholangiocarcinoma cell growth.
Author:	Shimizu, Tetsuya\|Yokomuro, Shigeki\|Mizuguchi, Yoshiaki\|Kawahigashi, Yutaka\|Arima, Yasuo\|Taniai, Nobuhiko\|Mamada, Yasuhiro\|Yoshida, Hiroshi\|Akimaru, Koho\|Tajiri, Takashi
PMID:	17072955

22.
Journal:	Ann Surg. 2006 Nov;244(5):706-14.
Title:	Perioperative synbiotic treatment to prevent postoperative infectious complications in biliary cancer surgery: a randomized controlled trial.
Author:	Sugawara, Gen\|Nagino, Masato\|Nishio, Hideki\|Ebata, Tomoki\|Takagi, Kenji\|Asahara, Takashi\|Nomoto, Koji\|Nimura, Yuji
PMID:	17060763

23.
Journal:	Life Sci. 2006 Apr 18;78(21):2494-502.
Title:	Interleukin-6 decreases senescence and increases telomerase activity in malignant human cholangiocytes.
Author:	Yamagiwa, Yoko\|Meng, Fanyin\|Patel, Tushar
PMID:	16336976

24.
Journal:	J Hepatol. 2006 Jun;44(6):1055-65.
Title:	Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes.
Author:	Meng, Fanyin\|Yamagiwa, Yoko\|Ueno, Yoshiyuki\|Patel, Tushar
PMID:	16469407

25.
Journal:	Gastroenterology. 2007 Jan;132(1):384-96.
Title:	Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing.
Author:	Isomoto, Hajime\|Mott, Justin L\|Kobayashi, Shogo\|Werneburg, Nathan W\|Bronk, Steve F\|Haan, Serge\|Gores, Gregory J
PMID:	17241887

26.
Journal:	Am J Gastroenterol. 2007 Oct;102(10):2164-70.
Title:	Diagnostic utility of interleukin-6 (IL-6) for primary bile duct cancer and changes in serum IL-6 levels following photodynamic therapy.
Author:	Cheon, Young Koog\|Cho, Young Deok\|Moon, Jong Ho\|Jang, Jae Young\|Kim, Young Seok\|Kim, Yun Soo\|Lee, Moon Sung\|Lee, Joon Seong\|Shim, Chan Sup
PMID:	17617204

27.
Journal:	Am J Gastroenterol. 2007 Oct;102(10):2171-2.
Title:	Targeting IL-6 in cholangiocarcinoma therapy.
Author:	Mott, Justin L\|Gores, Gregory J
PMID:	17897336

28.
Journal:	Korean J Gastroenterol. 2007 Dec;50(6):370-8.
Title:	[Expressions and clinical significances of c-met, c-erbB-2, COX-2, and IL-6 in the biliary tract cancers].
Author:	Joo, Hyun Ho\|Song, Eun Young\|Jin, Sang Hwa\|Oh, Sang Hoon\|Choi, Young Kil
PMID:	18159174

29.
Journal:	World J Gastroenterol. 2007 Dec 28;13(48):6478-91.
Title:	JAK-STAT pathway in carcinogenesis: is it relevant to cholangiocarcinoma progression?
Author:	Smirnova, Olga V\|Ostroukhova, Tatiana Yu\|Bogorad, Roman L
PMID:	18161917

30.
Journal:	Asian Pac J Cancer Prev. 2007 Oct-Dec;8(4):567-72.
Title:	Do TNFA -308 G/A and IL6 -174 G/C gene polymorphisms modulate risk of gallbladder cancer in the north Indian population?
Author:	Vishnoi, Monika\|Pandey, Sachchida Nand\|Choudhury, Gourdas\|Kumar, Ashok\|Modi, Dinesh Raj\|Mittal, Balraj
PMID:	18260730

31.
Journal:	Oncogene. 2008 Jan 10;27(3):378-86.
Title:	Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes.
Author:	Meng, F\|Wehbe-Janek, H\|Henson, R\|Smith, H\|Patel, T
PMID:	17621267

32.
Journal:	Hepatogastroenterology. 2008 Jul-Aug;55(85):1439-44.
Title:	Deficient response of IL-6 impaired liver regeneration after hepatectomy in patients with viral hepatitis.
Author:	Gotohda, Naoto\|Iwagaki, Hiromi\|Ozaki, Michitaka\|Kinoshita, Taira\|Konishi, Masaru\|Nakagohri, Toshio\|Takahashi, Shinichiro\|Saito, Shinya\|Yagi, Takahito\|Tanaka, Noriaki
PMID:	18795707

33.
Journal:	World J Gastroenterol. 2008 Dec 14;14(46):7033-58.
Title:	Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma.
Author:	Sirica, Alphonse-E
PMID:	19084911

34.
Journal:	Curr Opin Gastroenterol. 2009 May;25(3):279-84.
Title:	Serum and bile biomarkers for cholangiocarcinoma.
Author:	Alvaro, Domenico
PMID:	19396965

35.
Journal:	Hepatology. 2009 Oct;50(4):1273-81.
Title:	Advanced periductal fibrosis from infection with the carcinogenic human liver fluke Opisthorchis viverrini correlates with elevated levels of interleukin-6.
Author:	Sripa, Banchob\|Mairiang, Eimorn\|Thinkhamrop, Bandit\|Laha, Thewarach\|Kaewkes, Sasithorn\|Sithithaworn, Paiboon\|Tessana, Smarn\|Loukas, Alex\|Brindley, Paul J\|Bethony, Jeffrey M
PMID:	19676135

36.
Journal:	Hepatology. 2010 Mar;51(3):869-80.
Title:	Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humans.
Author:	Isse, Kumiko\|Specht, Susan M\|Lunz, John G 3rd\|Kang, Liang-I\|Mizuguchi, Yoshiaki\|Demetris, Anthony J
PMID:	20043322

37.
Journal:	Hepatology. 2010 Mar;51(3):881-90.
Title:	MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes.
Author:	Braconi, Chiara\|Huang, Nianyuan\|Patel, Tushar
PMID:	20146264

38.
Journal:	Br J Cancer. 2011 Oct 25;105(9):1370-8.
Title:	A combination of serum leucine-rich alpha-2-glycoprotein 1, CA19-9 and interleukin-6 differentiate biliary tract cancer from benign biliary strictures.
Author:	Sandanayake, N S\|Sinclair, J\|Andreola, F\|Chapman, M H\|Xue, A\|Webster, G J\|Clarkson, A\|Gill, A\|Norton, I D\|Smith, R C\|Timms, J F\|Pereira, S P
PMID:	21970875

39.
Journal:	Exp Ther Med. 2012 Mar;3(3):463-469. Epub 2011 Dec 20.
Title:	Personalized peptide vaccination for advanced biliary tract cancer: IL-6, nutritional status and pre-existing antigen-specific immunity as possible biomarkers for patient prognosis.
Author:	Yoshitomi, Munehiro\|Yutani, Shigeru\|Matsueda, Satoko\|Ioji, Tetsuya\|Komatsu, Nobukazu\|Shichijo, Shigeki\|Yamada, Akira\|Itoh, Kyogo\|Sasada, Tetsuro\|Kinoshita, Hisafumi
PMID:	22969912

40.
Journal:	Asian Pac J Cancer Prev. 2012;13 Suppl:115-8.
Title:	Cytokines released from activated human macrophages induce epithelial mesenchymal transition markers of cholangiocarcinoma cells.
Author:	Techasen, Anchalee\|Loilome, Watcharin\|Namwat, Nisana\|Dokduang, Hasaya\|Jongthawin, Jurairat\|Yongvanit, Puangrat
PMID:	23480772

41.
Journal:	PLoS One. 2012;7(10):e45606.
Title:	Silencing of miR-370 in human cholangiocarcinoma by allelic loss and interleukin-6 induced maternal to paternal epigenotype switch.
Author:	An, Fangmei\|Yamanaka, Sumitaka\|Allen, Sarah\|Roberts, Lewis R\|Gores, Gregory J\|Pawlik, Timothy M\|Xie, Qing\|Ishida, Masaharu\|Mezey, Esteban\|Ferguson-Smith, Anne C\|Mori, Yuriko\|Selaru, Florin M
PMID:	23110045

42.
Journal:	PLoS One. 2012;7(6):e39482.
Title:	LAP2 is widely overexpressed in diverse digestive tract cancers and regulates motility of cancer cells.
Author:	Kim, Hyun-Jung\|Hwang, Sun-Hwi\|Han, Myoung-Eun\|Baek, Sungmin\|Sim, Hey-Eun\|Yoon, Sik\|Baek, Sun-Yong\|Kim, Bong-Seon\|Kim, Jeong-Hwan\|Kim, Seon-Young\|Oh, Sae-Ock
PMID:	22745766

43.
Journal:	Gut. 2012 Feb;61(2):268-77.
Title:	Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism.
Author:	Frampton, Gabriel\|Invernizzi, Pietro\|Bernuzzi, Francesca\|Pae, Hae Yong\|Quinn, Matthew\|Horvat, Darijana\|Galindo, Cheryl\|Huang, Li\|McMillin, Matthew\|Cooper, Brandon\|Rimassa, Lorenza\|DeMorrow, Sharon
PMID:	22068162

44.
Journal:	Hepatology. 2012 Jan;55(1):108-20.
Title:	Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice.
Author:	Wang, Chao\|Yang, Wen\|Yan, He-Xin\|Luo, Tao\|Zhang, Jian\|Tang, Liang\|Wu, Fu-Quan\|Zhang, Hui-Lu\|Yu, Le-Xing\|Zheng, Long-Yi\|Li, Yu-Qiong\|Dong, Wei\|He, Ya-Qin\|Liu, Qiong\|Zou, Shan-Shan\|Lin, Yan\|Hu, Liang\|Li, Zhong\|Wu, Meng-Chao\|Wang, Hong-Yang
PMID:	21932402

45.
Journal:	Lab Invest. 2012 Oct;92(10):1451-60.
Title:	Monoamine oxidase A expression is suppressed in human cholangiocarcinoma via coordinated epigenetic and IL-6-driven events.
Author:	Huang, Li\|Frampton, Gabriel\|Rao, Arundhati\|Zhang, Kun-song\|Chen, Wei\|Lai, Jia-ming\|Yin, Xiao-yu\|Walker, Kimberly\|Culbreath, Brianne\|Leyva-Illades, Dinorah\|Quinn, Matthew\|McMillin, Matthew\|Bradley, Michelle\|Liang, Li-Jian\|DeMorrow, Sharon
PMID:	22906985

46.
Journal:	Nucl Med Commun. 2013 Jan;34(1):64-70.
Title:	Impact of cytokines on diffuse splenic 18F-fluorodeoxyglucose uptake during positron emission tomography/computed tomography.
Author:	Pak, Kyoungjune\|Kim, Seong-Jang\|Kim, In Joo\|Kim, Dong Uk\|Kim, Keunyoung\|Kim, Heeyoung
PMID:	23076270

47.
Journal:	Eur J Cancer. 2013 May;49(7):1725-40.
Title:	Role of crosstalk between interleukin-6 and transforming growth factor-beta 1 in epithelial-mesenchymal transition and chemoresistance in biliary tract cancer.
Author:	Yamada, Daisaku\|Kobayashi, Shogo\|Wada, Hiroshi\|Kawamoto, Koichi\|Marubashi, Shigeru\|Eguchi, Hidetoshi\|Ishii, Hideshi\|Nagano, Hiroaki\|Doki, Yuichiro\|Mori, Masaki
PMID:	23298711

48.
Journal:	Pathol Oncol Res. 2013 Oct;19(4):785-94.
Title:	Tumor-related gene changes in immunosuppressive Syrian hamster cholangiocarcinoma.
Author:	Juasook, Amornrat\|Aukkanimart, Ratchadawan\|Boonmars, Thidarut\|Sudsarn, Pakkayanee\|Wonkchalee, Nadchanan\|Laummaunwai, Porntip\|Sriraj, Pranee
PMID:	23645518

49.
Journal:	ISRN Hepatol. 2013 Nov 17;2013:601071.
Title:	Protective Effects of Guava Pulp on Cholestatic Liver Injury.
Author:	Peng, Jian\|Yue, Chunyan\|Qiu, Kai\|Chen, Jie\|Aller, Maria-Angeles\|Ko, Kwang Suk\|Yang, Heping
PMID:	27335829

50.
Journal:	Hepatology. 2014 Sep;60(3):858-71.
Title:	Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer.
Author:	Aleksandrova, Krasimira\|Boeing, Heiner\|Nothlings, Ute\|Jenab, Mazda\|Fedirko, Veronika\|Kaaks, Rudolf\|Lukanova, Annekatrin\|Trichopoulou, Antonia\|Trichopoulos, Dimitrios\|Boffetta, Paolo\|Trepo, Elisabeth\|Westhpal, Sabine\|Duarte-Salles, Talita\|Stepien, Magdalen
PMID:	24443059

51.
Journal:	Turk J Gastroenterol. 2014 Dec;25 Suppl 1:133-7.
Title:	Evaluation of concentrations of pro/anti-inflammatory cytokines after complication-free ECRP in cholangiocarcinoma.
Author:	Yildiz, Kemal\|Ince, Ali Tuzun\|Gangarapu, Venkatanarayana\|Bugdaci, Mehmet Sait\|Baysal, Birol\|Kayar, Yusuf\|Sarbay Kemik, Ahu\|Senturk, Hakan
PMID:	25910291

52.
Journal:	Am J Pathol. 2014 Oct;184(10):2828-39.
Title:	miR-17-92 cluster promotes cholangiocarcinoma growth: evidence for PTEN as downstream target and IL-6/Stat3 as upstream activator.
Author:	Zhu, Hanqing\|Han, Chang\|Lu, Dongdong\|Wu, Tong
PMID:	25239565

53.
Journal:	BMC Complement Altern Med. 2014 Jul 19;14:254.
Title:	Differentiation therapy: sesamin as an effective agent in targeting cancer stem-like side population cells of human gallbladder carcinoma.
Author:	Kong, Xiang\|Ma, Ming-zhe\|Zhang, Yan\|Weng, Ming-zhe\|Gong, Wei\|Guo, Li-qun\|Zhang, Jun-xiu\|Wang, Guo-dong\|Su, Qing\|Quan, Zhi-wei\|Yang, Jie-ren
PMID:	25038821

54.
Journal:	Asian Pac J Cancer Prev. 2014;15(12):5071-6.
Title:	Luteolin arrests cell cycling, induces apoptosis and inhibits the JAK/STAT3 pathway in human cholangiocarcinoma cells.
Author:	Aneknan, Ploypailin\|Kukongviriyapan, Veerapol\|Prawan, Auemduan\|Kongpetch, Sarinya\|Sripa, Banchob\|Senggunprai, Laddawan
PMID:	24998588

55.
Journal:	J Immunol Res. 2014;2014:149185.
Title:	Chronic inflammation and cytokines in the tumor microenvironment.
Author:	Landskron, Glauben\|De la Fuente, Marjorie\|Thuwajit, Peti\|Thuwajit, Chanitra\|Hermoso, Marcela A
PMID:	24901008

56.
Journal:	Phytother Res. 2014 Jun;28(6):841-8.
Title:	Quercetin and EGCG exhibit chemopreventive effects in cholangiocarcinoma cells via suppression of JAK/STAT signaling pathway.
Author:	Senggunprai, Laddawan\|Kukongviriyapan, Veerapol\|Prawan, Auemduan\|Kukongviriyapan, Upa
PMID:	24038588

57.
Journal:	Hepatology. 2014 Mar;59(3):935-46.
Title:	Gankyrin promotes tumor growth and metastasis through activation of IL-6/STAT3 signaling in human cholangiocarcinoma.
Author:	Zheng, Tongsen\|Hong, Xuehui\|Wang, Jiabei\|Pei, Tiemin\|Liang, Yingjian\|Yin, Dalong\|Song, Ruipeng\|Song, Xuan\|Lu, Zhaoyang\|Qi, Shuyi\|Liu, Jiaren\|Sun, Boshi\|Xie, Changming\|Pan, Shangha\|Li, Yuejin\|Luo, Xiaohe\|Li, Shuai\|Fang, Xiang\|Bhatta, Nishant\|Jiang, Hongchi
PMID:	24037855

58.
Journal:	Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1524-31.
Title:	Prognostic Impact of Peritumoral IL-17-Positive Cells and IL-17 Axis in Patients with Intrahepatic Cholangiocarcinoma.
Author:	Asukai, Kei\|Kawamoto, Koichi\|Eguchi, Hidetoshi\|Konno, Masamitsu\|Nishida, Naohiro\|Koseki, Jun\|Noguchi, Kozo\|Hasegawa, Shinichiro\|Ogawa, Hisataka\|Yamada, Daisaku\|Tomimaru, Yoshito\|Tomokuni, Akira\|Asaoka, Tadafumi\|Noda, Takehiro\|Wada, Hiroshi\|Gotoh, Kunihito
PMID:	26228109

59.
Journal:	Zhonghua Gan Zang Bing Za Zhi. 2015 Oct;23(10):748-53.
Title:	[Regulatory role of serum miR-224 in invasiveness and metastasis of cholangiocarcinoma].
Author:	Huang, Mindan\|Wu, Xiongbo\|Cao, Hui\|Zhan, Qiang\|Xia, Min\|Zhou, Qunyan\|Cai, Xiaogang\|An, Fangmei
PMID:	26573191

60.
Journal:	Med Oncol. 2015 Nov;32(11):245.
Title:	Cholangiocarcinoma: from molecular biology to treatment.
Author:	Brito, Ana F\|Abrantes, Ana M\|Encarnacao, Joao C\|Tralhao, Jose G\|Botelho, Maria F
PMID:	26427701

61.
Journal:	Int J Parasitol. 2015 Oct;45(12):773-81.
Title:	Excretory/secretory products of the carcinogenic liver fluke are endocytosed by human cholangiocytes and drive cell proliferation and IL6 production.
Author:	Chaiyadet, Sujittra\|Smout, Michael\|Johnson, Michael\|Whitchurch, Cynthia\|Turnbull, Lynne\|Kaewkes, Sasithorn\|Sotillo, Javier\|Loukas, Alex\|Sripa, Banchob
PMID:	26187786

62.
Journal:	Med Oncol. 2015 Apr;32(4):105.
Title:	Enhanced expression of suppresser of cytokine signaling 3 inhibits the IL-6-induced epithelial-to-mesenchymal transition and cholangiocarcinoma cell metastasis.
Author:	Zhou, Qing-Xin\|Jiang, Xing-Ming\|Wang, Zhi-Dong\|Li, Chun-Long\|Cui, Yun-Fu
PMID:	25744243

63.
Journal:	Hepatology. 2015 May;61(5):1627-42.
Title:	IL-33 facilitates oncogene-induced cholangiocarcinoma in mice by an interleukin-6-sensitive mechanism.
Author:	Yamada, Daisaku\|Rizvi, Sumera\|Razumilava, Nataliya\|Bronk, Steven F\|Davila, Jaime I\|Champion, Mia D\|Borad, Mitesh J\|Bezerra, Jorge A\|Chen, Xin\|Gores, Gregory J
PMID:	25580681

64.
Journal:	Mol Med Rep. 2015 May;11(5):3539-46.
Title:	Expression of interleukin-6 is associated with epithelial-mesenchymal transition and survival rates in gallbladder cancer.
Author:	Zhang, Mingdi\|Gong, Wei\|Zhang, Yong\|Yang, Yong\|Zhou, Di\|Weng, Mingzhe\|Qin, Yiyu\|Jiang, Alex\|Ma, Fei\|Quan, Zhiwei
PMID:	25573292

65.
Journal:	J Extracell Vesicles. 2015 Jan 2;4:24900.
Title:	Tumour cell-derived extracellular vesicles interact with mesenchymal stem cells to modulate the microenvironment and enhance cholangiocarcinoma growth.
Author:	Haga, Hiroaki\|Yan, Irene K\|Takahashi, Kenji\|Wood, Joseph\|Zubair, Abba\|Patel, Tushar
PMID:	25557794

66.
Journal:	J Hepatobiliary Pancreat Sci. 2015 Sep;22(9):675-82.
Title:	Cholangiocyte senescence caused by lysophosphatidylcholine as a potential implication in carcinogenesis.
Author:	Shimizu, Rina\|Kanno, Keishi\|Sugiyama, Akiko\|Ohata, Hiroki\|Araki, Anna\|Kishikawa, Nobusuke\|Kimura, Yasuhiro\|Yamamoto, Hiroya\|Kodama, Masanobu\|Kihira, Kenji\|Tazuma, Susumu
PMID:	25921542

67.
Journal:	Int J Parasitol. 2016 Mar;46(3):195-204.
Title:	Oxidative stress-mediated mouse liver lesions caused by Clonorchis sinensis infection.
Author:	Maeng, Sejung\|Lee, Hye Won\|Bashir, Qudsia\|Kim, Tae Im\|Hong, Sung-Jong\|Lee, Tae Jin\|Sohn, Woon-Mok\|Na, Byoung-Kuk\|Kim, Tong-Soo\|Pak, Jhang Ho
PMID:	26718397

68.
Journal:	Int J Cancer. 2016 Aug 15;139(4):869-81.
Title:	IL17 producing gammadeltaT cells induce angiogenesis and are associated with poor survival in gallbladder cancer patients.
Author:	Sudam Patil, Rushikesh\|Umesh Shah, Sagar\|Vinayak Shrikhande, Shailesh\|Goel, Mahesh\|Prabhakar Dikshit, Rajesh\|Vivek Chiplunkar, Shubhada
PMID:	27062572

69.
Journal:	Am J Cancer Res. 2015 Dec 15;6(1):15-26. eCollection 2016.
Title:	Upregulation of H19 indicates a poor prognosis in gallbladder carcinoma and promotes epithelial-mesenchymal transition.
Author:	Wang, Shou-Hua\|Wu, Xiao-Cai\|Zhang, Ming-Di\|Weng, Ming-Zhe\|Zhou, Di\|Quan, Zhi-Wei
PMID:	27073719

70.
Journal:	FEBS J. 2016 Oct;283(20):3839-3850.
Title:	TLR2 promotes human intrahepatic cholangiocarcinoma cell migration and invasion by modulating NF-kappaB pathway-mediated inflammatory responses.
Author:	Liu, Bingyan\|Yan, Shuo\|Jia, Yiping\|Ma, Jun\|Wu, Shaoqiu\|Xu, Yuyao\|Shang, Mingyi\|Mao, Aiwu
PMID:	27616304

71.
Journal:	Photodiagnosis Photodyn Ther. 2016 Dec;16:110-118.
Title:	Treatment of unresectable extrahepatic cholangiocarcinoma using hematoporphyrin photodynamic therapy: A prospective study.
Author:	Yang, Jianfeng\|Shen, Hongzhang\|Jin, Hangbin\|Lou, Qifeng\|Zhang, Xiaofeng
PMID:	27720942

72.
Journal:	Oncotarget. 2016 Nov 29;7(48):78640-78652.
Title:	The microRNA miR-33a suppresses IL-6-induced tumor progression by binding Twist in gallbladder cancer.
Author:	Zhang, Mingdi\|Gong, Wei\|Zuo, Bin\|Chu, Bingfeng\|Tang, Zhaohui\|Zhang, Yong\|Yang, Yong\|Zhou, Di\|Weng, Mingzhe\|Qin, Yiyu\|Ma, Mingzhe\|Jiang, Alex\|Ma, Fei\|Quan, Zhiwei
PMID:	27769047

73.
Journal:	J Invest Surg. 2017 Sep 19:1-8.
Title:	Clinical Significance of Soluble Intercellular Adhesion Molecule-1 and Interleukin-6 in Patients with Extrahepatic Cholangiocarcinoma.
Author:	Shimura, Tatsuo\|Shibata, Masahiko\|Gonda, Kenji\|Kofunato, Yasuhide\|Okada, Ryo\|Ishigame, Teruhide\|Kimura, Takashi\|Kenjo, Akira\|Marubashi, Shigeru\|Kono, Koji\|Takenoshita, Seiichi
PMID:	28925763

74.
Journal:	Biomed Res Int. 2017;2017:2979307.
Title:	The Diagnostic Roles of Cytokines in Hepatobiliary Cancers.
Author:	Koca, Yavuz Savas\|Bulbul, Mahmut\|Barut, Ibrahim
PMID:	29410961

75.
Journal:	Tumour Biol. 2017 Apr;39(4):1010428317695949.
Title:	Mesothelin-targeting chimeric antigen receptor-modified T cells by piggyBac transposon system suppress the growth of bile duct carcinoma.
Author:	Xu, Jie-Ying\|Ye, Zhen-Long\|Jiang, Du-Qing\|He, Jiang-Chuan\|Ding, Yong-Mei\|Li, Lin-Fang\|Lv, Sai-Qun\|Wang, Ying\|Jin, Hua-Jun\|Qian, Qi-Jun
PMID:	28381173

76.
Journal:	Transl Oncol. 2018 Jun;11(3):585-592.
Title:	Methylation-Mediated Silencing of GATA5 Gene Suppresses Cholangiocarcinoma Cell Proliferation and Metastasis.
Author:	Liu, Peng\|Zhou, Teng-Fei\|Qiu, Bao-An\|Yang, Ying-Xiang\|Zhu, Yong-Jian\|An, Yang\|Zhao, Wen-Chao\|Wu, Yin-Tao\|Ma, Peng-Fei\|Li, Jing-Bo\|Xia, Nian-Xin
PMID:	29547757

77.
Journal:	Cancer Epidemiol. 2018 Jun;54:25-30.
Title:	Circulating inflammatory proteins and gallbladder cancer: Potential for risk stratification to improve prioritization for cholecystectomy in high-risk regions.
Author:	Koshiol, Jill\|Gao, Yu-Tang\|Corbel, Amanda\|Kemp, Troy J\|Shen, Ming-Chang\|Hildesheim, Allan\|Hsing, Ann W\|Rashid, Asif\|Wang, Bingsheng\|Pfeiffer, Ruth M\|Pinto, Ligia A
PMID:	29554539

78.
Journal:	Histopathology. 2018 Aug;73(2):259-272.
Title:	Interleukin-33 overexpression reflects less aggressive tumour features in large-duct type cholangiocarcinomas.
Author:	Sawada, Ryuichiro\|Ku, Yuna\|Akita, Masayuki\|Otani, Kyoko\|Fujikura, Kohei\|Itoh, Tomoo\|Ajiki, Tetsuo\|Fukumoto, Takumi\|Kakeji, Yoshihiro\|Zen, Yoh
PMID:	29675965

79.
Journal:	Int J Oncol. 2018 Jul;53(1):177-188.
Title:	Genistein reduces the activation of AKT and EGFR, and the production of IL6 in cholangiocarcinoma cells involving estrogen and estrogen receptors.
Author:	Tanjak, Pariyada\|Thiantanawat, Apinya\|Watcharasit, Piyajit\|Satayavivad, Jutamaad
PMID:	29693152

80.
Journal:	Oncotarget. 2018 Apr 3;9(25):17430-17442.
Title:	Identification of a serum biomarker panel for the differential diagnosis of cholangiocarcinoma and primary sclerosing cholangitis.
Author:	Cuenco, Joy\|Wehnert, Natascha\|Blyuss, Oleg\|Kazarian, Anna\|Whitwell, Harry J\|Menon, Usha\|Dawnay, Anne\|Manns, Michael P\|Pereira, Stephen P\|Timms, John F
PMID:	29707118

81.
Journal:	Carcinogenesis. 2018 Sep 21;39(9):1127-1134.
Title:	MicroRNA-31 reflects IL-6 expression in cancer tissue and is related with poor prognosis in bile duct cancer.
Author:	Ishigami, Keisuke\|Nosho, Katsuhiko\|Koide, Hideyuki\|Kanno, Shinichi\|Mitsuhashi, Kei\|Igarashi, Hisayoshi\|Shitani, Masahiro\|Motoya, Masayo\|Kimura, Yasutoshi\|Hasegawa, Tadashi\|Kaneto, Hiroyuki\|Takemasa, Ichiro\|Suzuki, Hiromu\|Nakase, Hiroshi
PMID:	29860474

82.
Journal:	Biochem Biophys Res Commun. 2018 Sep 3;503(1):291-296.
Title:	Gene expression profile of TLR7 signaling pathway in the liver of rhesus rotavirus-induced murine biliary atresia.
Author:	Wu, Yue\|Liu, Tingzheng\|Yuan, Yuhang\|Zhang, Zhibo
PMID:	29909011

83.
Journal:	Cell Physiol Biochem. 2018;48(1):158-172.
Title:	FXR Acts as a Metastasis Suppressor in Intrahepatic Cholangiocarcinoma by Inhibiting IL-6-Induced Epithelial-Mesenchymal Transition.
Author:	Lv, Bei\|Ma, Lijie\|Tang, Wenqing\|Huang, Peixin\|Yang, Biwei\|Wang, Lingxiao\|Chen, She\|Gao, Qiang\|Zhang, Si\|Xia, Jinglin
PMID:	30001540

84.
Journal:	Oncotarget. 2018 Jul 3;9(51):29820-29841.
Title:	Systematic literature review of IL-6 as a biomarker or treatment target in patients with gastric, bile duct, pancreatic and colorectal cancer.
Author:	Vainer, Noomi\|Dehlendorff, Christian\|Johansen, Julia S
PMID:	30038723

85.
Journal:	Cancer Chemother Pharmacol. 2018 Sep 14. pii: 10.1007/s00280-018-3685-6.
Title:	The maximum chemiluminescence intensity predicts severe neutropenia in gemcitabine-treated patients with pancreatic or biliary tract cancer.
Author:	Goto, Koki\|Matsuyama, Ryusei\|Suwa, Yusuke\|Arisaka, Sayaka\|Kadokura, Toshiaki\|Sato, Mari\|Mori, Ryutaro\|Kumamoto, Takafumi\|Taguri, Masataka\|Endo, Itaru
PMID:	30218151

86.
Journal:	J Cancer Res Ther. 2018 Sep;14(Supplement):S758-S760.
Title:	Clinical significance of interleukin-6 in diagnosis of lung, oral, esophageal, and gall bladder carcinomas.
Author:	Vinocha, Anjali\|Grover, Rajesh K\|Deepak, Rani
PMID:	30249899