Primary Site >> Biliary tract Cancer
Gene >> IL6
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Ref: Induction of invasive growth in a gallbladder cancer cell line by hepatocyte growth factor in vitro. PMID: 7559084 Ref: Fibroblast-tumor interaction changes constitutive expression of IL-6 and IL-8 in human carcinoma-cells. PMID: 21556582 |
Ref: Biliary interleukin-6 and tumor necrosis factor-alpha in patients undergoing endoscopic retrograde cholangiopancreatography. PMID: 9201097 Ref: Experimental study of the effect of IL-6 on cancer cachexia. PMID: 21590167 |
Ref: Marked elevation of serum interleukin-6 in patients with cholangiocarcinoma: validation of utility as a clinical marker. PMID: 9527063 Ref: Anomalous junction of the pancreaticobiliary duct accompanied by gallbladder cancer and obstructive jaundice in a patient with high serum and bile cytokine levels. PMID: 9719251 Ref: Relationship between interleukin-6 and proliferation and differentiation in cholangiocarcinoma. PMID: 9762547 |
Ref: Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line. PMID: 10534331 |
Ref: Growth control of human biliary epithelial cells by interleukin 6, hepatocyte growth factor, transforming growth factor beta1, and activin A: comparison of a cholangiocarcinoma cell line with primary cultures of non-neoplastic biliary epithelial cells. PMID: 10869285 |
Ref: Characterization of a new rat cell line established from 2'AAF-induced combined hepatocellular cholangiocellular carcinoma. PMID: 11249201 |
Ref: Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells. PMID: 12143044 |
Ref: Anatomic and molecular pathology of intrahepatic cholangiocarcinoma. PMID: 14598145 |
Ref: Serum and bile markers for cholangiocarcinoma. PMID: 15192787 |
Ref: Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy. PMID: 15690474 Ref: IL-6 activates serum and glucocorticoid kinase via p38alpha mitogen-activated protein kinase pathway. PMID: 15917303 Ref: Cyclooxygenase-2 and prostaglandin signaling in cholangiocarcinoma. PMID: 15921858 Ref: Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells. PMID: 15940637 Ref: Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells. PMID: 16317687 |
Ref: Interleukin-6 decreases senescence and increases telomerase activity in malignant human cholangiocytes. PMID: 16336976 Ref: Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes. PMID: 16469407 Ref: Cholangiocarcinoma: modern advances in understanding a deadly old disease. PMID: 17030071 Ref: Perioperative synbiotic treatment to prevent postoperative infectious complications in biliary cancer surgery: a randomized controlled trial. PMID: 17060763 Ref: Effect of transforming growth factor-beta1 on human intrahepatic cholangiocarcinoma cell growth. PMID: 17072955 Ref: Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression. PMID: 17079474 |
Ref: Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing. PMID: 17241887 Ref: Diagnostic utility of interleukin-6 (IL-6) for primary bile duct cancer and changes in serum IL-6 levels following photodynamic therapy. PMID: 17617204 Ref: Targeting IL-6 in cholangiocarcinoma therapy. PMID: 17897336 Ref: [Expressions and clinical significances of c-met, c-erbB-2, COX-2, and IL-6 in the biliary tract cancers]. PMID: 18159174 Ref: JAK-STAT pathway in carcinogenesis: is it relevant to cholangiocarcinoma progression? PMID: 18161917 Ref: Do TNFA -308 G/A and IL6 -174 G/C gene polymorphisms modulate risk of gallbladder cancer in the north Indian population? PMID: 18260730 |
Ref: Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes. PMID: 17621267 Ref: Deficient response of IL-6 impaired liver regeneration after hepatectomy in patients with viral hepatitis. PMID: 18795707 Ref: Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma. PMID: 19084911 |
Ref: Serum and bile biomarkers for cholangiocarcinoma. PMID: 19396965 Ref: Advanced periductal fibrosis from infection with the carcinogenic human liver fluke Opisthorchis viverrini correlates with elevated levels of interleukin-6. PMID: 19676135 |
Ref: Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humans. PMID: 20043322 Ref: MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes. PMID: 20146264 |
Ref: A combination of serum leucine-rich alpha-2-glycoprotein 1, CA19-9 and interleukin-6 differentiate biliary tract cancer from benign biliary strictures. PMID: 21970875 |
Ref: Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice. PMID: 21932402 Ref: Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism. PMID: 22068162 Ref: LAP2 is widely overexpressed in diverse digestive tract cancers and regulates motility of cancer cells. PMID: 22745766 Ref: Monoamine oxidase A expression is suppressed in human cholangiocarcinoma via coordinated epigenetic and IL-6-driven events. PMID: 22906985 Ref: Personalized peptide vaccination for advanced biliary tract cancer: IL-6, nutritional status and pre-existing antigen-specific immunity as possible biomarkers for patient prognosis. PMID: 22969912 Ref: Silencing of miR-370 in human cholangiocarcinoma by allelic loss and interleukin-6 induced maternal to paternal epigenotype switch. PMID: 23110045 Ref: Cytokines released from activated human macrophages induce epithelial mesenchymal transition markers of cholangiocarcinoma cells. PMID: 23480772 |
Ref: Impact of cytokines on diffuse splenic 18F-fluorodeoxyglucose uptake during positron emission tomography/computed tomography. PMID: 23076270 Ref: Role of crosstalk between interleukin-6 and transforming growth factor-beta 1 in epithelial-mesenchymal transition and chemoresistance in biliary tract cancer. PMID: 23298711 Ref: Tumor-related gene changes in immunosuppressive Syrian hamster cholangiocarcinoma. PMID: 23645518 Ref: Protective Effects of Guava Pulp on Cholestatic Liver Injury. PMID: 27335829 |
Ref: Gankyrin promotes tumor growth and metastasis through activation of IL-6/STAT3 signaling in human cholangiocarcinoma. PMID: 24037855 Ref: Quercetin and EGCG exhibit chemopreventive effects in cholangiocarcinoma cells via suppression of JAK/STAT signaling pathway. PMID: 24038588 Ref: Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer. PMID: 24443059 Ref: Chronic inflammation and cytokines in the tumor microenvironment. PMID: 24901008 Ref: Luteolin arrests cell cycling, induces apoptosis and inhibits the JAK/STAT3 pathway in human cholangiocarcinoma cells. PMID: 24998588 Ref: Differentiation therapy: sesamin as an effective agent in targeting cancer stem-like side population cells of human gallbladder carcinoma. PMID: 25038821 Ref: miR-17-92 cluster promotes cholangiocarcinoma growth: evidence for PTEN as downstream target and IL-6/Stat3 as upstream activator. PMID: 25239565 Ref: Evaluation of concentrations of pro/anti-inflammatory cytokines after complication-free ECRP in cholangiocarcinoma. PMID: 25910291 |
Ref: Tumour cell-derived extracellular vesicles interact with mesenchymal stem cells to modulate the microenvironment and enhance cholangiocarcinoma growth. PMID: 25557794 Ref: Expression of interleukin-6 is associated with epithelial-mesenchymal transition and survival rates in gallbladder cancer. PMID: 25573292 Ref: IL-33 facilitates oncogene-induced cholangiocarcinoma in mice by an interleukin-6-sensitive mechanism. PMID: 25580681 Ref: Enhanced expression of suppresser of cytokine signaling 3 inhibits the IL-6-induced epithelial-to-mesenchymal transition and cholangiocarcinoma cell metastasis. PMID: 25744243 Ref: Cholangiocyte senescence caused by lysophosphatidylcholine as a potential implication in carcinogenesis. PMID: 25921542 Ref: Excretory/secretory products of the carcinogenic liver fluke are endocytosed by human cholangiocytes and drive cell proliferation and IL6 production. PMID: 26187786 Ref: Prognostic Impact of Peritumoral IL-17-Positive Cells and IL-17 Axis in Patients with Intrahepatic Cholangiocarcinoma. PMID: 26228109 Ref: Cholangiocarcinoma: from molecular biology to treatment. PMID: 26427701 Ref: [Regulatory role of serum miR-224 in invasiveness and metastasis of cholangiocarcinoma]. PMID: 26573191 |
Ref: Oxidative stress-mediated mouse liver lesions caused by Clonorchis sinensis infection. PMID: 26718397 Ref: IL17 producing gammadeltaT cells induce angiogenesis and are associated with poor survival in gallbladder cancer patients. PMID: 27062572 Ref: Upregulation of H19 indicates a poor prognosis in gallbladder carcinoma and promotes epithelial-mesenchymal transition. PMID: 27073719 Ref: TLR2 promotes human intrahepatic cholangiocarcinoma cell migration and invasion by modulating NF-kappaB pathway-mediated inflammatory responses. PMID: 27616304 Ref: Treatment of unresectable extrahepatic cholangiocarcinoma using hematoporphyrin photodynamic therapy: A prospective study. PMID: 27720942 Ref: The microRNA miR-33a suppresses IL-6-induced tumor progression by binding Twist in gallbladder cancer. PMID: 27769047 |
Ref: Mesothelin-targeting chimeric antigen receptor-modified T cells by piggyBac transposon system suppress the growth of bile duct carcinoma. PMID: 28381173 Ref: Clinical Significance of Soluble Intercellular Adhesion Molecule-1 and Interleukin-6 in Patients with Extrahepatic Cholangiocarcinoma. PMID: 28925763 Ref: The Diagnostic Roles of Cytokines in Hepatobiliary Cancers. PMID: 29410961 |
Ref: Methylation-Mediated Silencing of GATA5 Gene Suppresses Cholangiocarcinoma Cell Proliferation and Metastasis. PMID: 29547757 Ref: Circulating inflammatory proteins and gallbladder cancer: Potential for risk stratification to improve prioritization for cholecystectomy in high-risk regions. PMID: 29554539 Ref: Interleukin-33 overexpression reflects less aggressive tumour features in large-duct type cholangiocarcinomas. PMID: 29675965 Ref: Genistein reduces the activation of AKT and EGFR, and the production of IL6 in cholangiocarcinoma cells involving estrogen and estrogen receptors. PMID: 29693152 Ref: Identification of a serum biomarker panel for the differential diagnosis of cholangiocarcinoma and primary sclerosing cholangitis. PMID: 29707118 Ref: MicroRNA-31 reflects IL-6 expression in cancer tissue and is related with poor prognosis in bile duct cancer. PMID: 29860474 Ref: Gene expression profile of TLR7 signaling pathway in the liver of rhesus rotavirus-induced murine biliary atresia. PMID: 29909011 Ref: FXR Acts as a Metastasis Suppressor in Intrahepatic Cholangiocarcinoma by Inhibiting IL-6-Induced Epithelial-Mesenchymal Transition. PMID: 30001540 Ref: Systematic literature review of IL-6 as a biomarker or treatment target in patients with gastric, bile duct, pancreatic and colorectal cancer. PMID: 30038723 Ref: The maximum chemiluminescence intensity predicts severe neutropenia in gemcitabine-treated patients with pancreatic or biliary tract cancer. PMID: 30218151 Ref: Clinical significance of interleukin-6 in diagnosis of lung, oral, esophageal, and gall bladder carcinomas. PMID: 30249899 |