Primary Site >> Pancreatic Cancer
Gene >> IGF2
| 1. | |||||||||||
| Journal: | Diabetes. 1985 Sep;34(9):891-7. | ||||||||||
| Title: | Insulin, via its own receptor, regulates growth and amylase synthesis in pancreatic acinar AR42J cells. | ||||||||||
| Author: | Mossner, J|Logsdon, C D|Williams, J A|Goldfine, I D | ||||||||||
| PMID: | 2411617 | ||||||||||
| 2. | |||||||||||
| Journal: | Dig Dis Sci. 1989 Mar;34(3):338-42. | ||||||||||
| Title: | Serum insulin-like growth factor II in chronic liver disease. | ||||||||||
| Author: | Hayakawa, T|Kondo, T|Shibata, T|Kitagawa, M|Ono, H|Sakai, Y|Kato, K|Katada, N|Sugimoto, Y|Takeichi, M | ||||||||||
| PMID: | 2537715 | ||||||||||
| 3. | |||||||||||
| Journal: | Int J Oncol. 1996 Sep;9(3):487-92. | ||||||||||
| Title: | Insulin-like growth factor II activates mitogenic signaling in pancreatic cancer cells via IRS-1. | ||||||||||
| Author: | Bergmann, U|Funatomi, H|Kornmann, M|Ishiwata, T|Beger, H|Korc, M | ||||||||||
| PMID: | 21541539 | ||||||||||
| 4. | |||||||||||
| Journal: | Diabet Med. 1997 Apr;14(4):324-6. | ||||||||||
| Title: | Spontaneous hypoglycaemia in a noninsulin-dependent diabetes mellitus patient with disseminated pancreatic carcinoma. | ||||||||||
| Author: | Sturrock, N D|Selby, C|Hosking, D J | ||||||||||
| PMID: | 9113488 | ||||||||||
| 5. | |||||||||||
| Journal: | Environ Health Perspect. 1997 Jun;105 Suppl 4:977-9. | ||||||||||
| Title: | Cancer chemoprevention and therapy by monoterpenes. | ||||||||||
| Author: | Gould, M N | ||||||||||
| PMID: | 9255590 | ||||||||||
| 6. | |||||||||||
| Journal: | Int J Pancreatol. 1997 Oct;22(2):95-100. | ||||||||||
| Title: | Serum levels of insulin-like growth factors (IGF-I and IGF-II) and their binding protein (IGFBP-3) are not elevated in pancreatic cancer. | ||||||||||
| Author: | Evans, J D|Eggo, M C|Donovan, I A|Bramhall, S R|Neoptolemos, J P | ||||||||||
| PMID: | 9387030 | ||||||||||
| 7. | |||||||||||
| Journal: | Br J Cancer. 1998 Jul;78(1):14-20. | ||||||||||
| Title: | Microencapsulated octreotide pamoate in advanced gastrointestinal and pancreatic cancer: a phase I study. | ||||||||||
| Author: | Helle, S I|Geisler, J|Poulsen, J P|Hestdal, K|Meadows, K|Collins, W|Tveit, K M|Holly, J M|Lonning, P E | ||||||||||
| PMID: | 9662244 | ||||||||||
| 8. | |||||||||||
| Journal: | Cancer Res. 1998 Oct 1;58(19):4250-4. | ||||||||||
| Title: | Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer. | ||||||||||
| Author: | Kornmann, M|Maruyama, H|Bergmann, U|Tangvoranuntakul, P|Beger, H G|White, M F|Korc, M | ||||||||||
| PMID: | 9766646 | ||||||||||
| 9. | |||||||||||
| Journal: | J Gastroenterol. 1998 Oct;33(5):761-5. | ||||||||||
| Title: | Acinar cell carcinoma of the pancreas associated with hypoglycemia: involvement of "big" insulin-like growth factor-II. | ||||||||||
| Author: | Mizuta, Y|Isomoto, H|Futuki, Y|Ehara, N|Takeshima, F|Omagari, K|Murase, K|Yakata, Y|Senjyu, M|Masuda, J|Ikuno, N|Haraguchi, M|Iwasaki, K|Shimokawa, I|Kohno, S | ||||||||||
| PMID: | 9773947 | ||||||||||
| 10. | |||||||||||
| Journal: | Digestion. 1999 Sep-Oct;60(5):477-83. | ||||||||||
| Title: | Genomic imprinting of IGF-II and H19 in adult human pancreatic tissues. | ||||||||||
| Author: | Micha, A E|Hahnel, S|Friess, H|Buchler, M W|Adler, G|Gress, T M | ||||||||||
| PMID: | 10473973 | ||||||||||
| 11. | |||||||||||
| Journal: | Trends Endocrinol Metab. 1999 Dec;10(10):383-391. | ||||||||||
| Title: | Antagonistic Analogs of Growth Hormone-releasing Hormone: New Potential Antitumor Agents. | ||||||||||
| Author: | Schally|Varga | ||||||||||
| PMID: | 10542394 | ||||||||||
| 12. | |||||||||||
| Journal: | Diabetes Metab. 1999 Dec;25(6):477-90. | ||||||||||
| Title: | Hypoglycemia in adults. | ||||||||||
| Author: | Virally, M L|Guillausseau, P J | ||||||||||
| PMID: | 10633872 | ||||||||||
| 13. | |||||||||||
| Journal: | Eur J Cancer. 2000 Jan;36(1):128-36. | ||||||||||
| Title: | Antagonists of growth hormone-releasing hormone (GH-RH) inhibit in vivo proliferation of experimental pancreatic cancers and decrease IGF-II levels in tumours. | ||||||||||
| Author: | Szepeshazi, K|Schally, A V|Groot, K|Armatis, P|Hebert, F|Halmos, G | ||||||||||
| PMID: | 10741306 | ||||||||||
| 14. | |||||||||||
| Journal: | Cancer Res. 2003 Aug 15;63(16):5073-83. | ||||||||||
| Title: | An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation. | ||||||||||
| Author: | Maloney, Erin K|McLaughlin, Jennifer L|Dagdigian, Nancy E|Garrett, Lisa M|Connors, Katherine M|Zhou, Xiao-Mai|Blattler, Walter A|Chittenden, Thomas|Singh, Rajeeva | ||||||||||
| PMID: | 12941837 | ||||||||||
| 15. | |||||||||||
| Journal: | Cancer Res. 2003 Oct 1;63(19):6432-41. | ||||||||||
| Title: | Genetic blockade of the insulin-like growth factor-I receptor: a promising strategy for human pancreatic cancer. | ||||||||||
| Author: | Min, Yongfen|Adachi, Yasushi|Yamamoto, Hiroyuki|Ito, Hideto|Itoh, Fumio|Lee, Choon-Taek|Nadaf, Sorena|Carbone, David P|Imai, Kohzoh | ||||||||||
| PMID: | 14559833 | ||||||||||
| 16. | |||||||||||
| Journal: | Cancer Res. 2003 Dec 15;63(24):8912-21. | ||||||||||
| Title: | A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. | ||||||||||
| Author: | Burtrum, Douglas|Zhu, Zhenping|Lu, Dan|Anderson, Donna Marie|Prewett, Marie|Pereira, Daniel S|Bassi, Rajiv|Abdullah, Rashed|Hooper, Andrea T|Koo, Henry|Jimenez, Xenia|Johnson, Danielle|Apblett, Robin|Kussie, Paul|Bohlen, Peter|Witte, Larry|Hicklin, Daniel | ||||||||||
| PMID: | 14695208 | ||||||||||
| 17. | |||||||||||
| Journal: | Novartis Found Symp. 2004;262:177-89; discussion 190-2, 265-8. | ||||||||||
| Title: | Genetic blockade of the insulin-like growth factor 1 receptor for human malignancy. | ||||||||||
| Author: | Adachi, Yasushi|Lee, Choon-Taek|Carbone, David P | ||||||||||
| PMID: | 15562829 | ||||||||||
| 18. | |||||||||||
| Journal: | Br J Cancer. 2007 Jul 2;97(1):98-104. | ||||||||||
| Title: | Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts. | ||||||||||
| Author: | Wolpin, B M|Michaud, D S|Giovannucci, E L|Schernhammer, E S|Stampfer, M J|Manson, J E|Cochrane, B B|Rohan, T E|Ma, J|Pollak, M N|Fuchs, C S | ||||||||||
| PMID: | 17533398 | ||||||||||
| 19. | |||||||||||
| Journal: | Clin Chem. 2008 Mar;54(3):582-9. | ||||||||||
| Title: | Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer. | ||||||||||
| Author: | Fredriksson, Simon|Horecka, Joe|Brustugun, Odd Terje|Schlingemann, Joerg|Koong, Albert C|Tibshirani, Rob|Davis, Ronald W | ||||||||||
| PMID: | 18171715 | ||||||||||
| 20. | |||||||||||
| Journal: | Cancer Sci. 2008 Dec;99(12):2395-401. | ||||||||||
| Title: | Insulin-like growth factor stimulation increases radiosensitivity of a pancreatic cancer cell line through endoplasmic reticulum stress under hypoxic conditions. | ||||||||||
| Author: | Isohashi, Fumiaki|Endo, Hiroko|Mukai, Mutsuko|Inoue, Takehiro|Inoue, Masahiro | ||||||||||
| PMID: | 19018773 | ||||||||||
| 21. | |||||||||||
| Journal: | Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3467-73. | ||||||||||
| Title: | Effect of insulin-like growth factor gene polymorphisms alone or in interaction with diabetes on the risk of pancreatic cancer. | ||||||||||
| Author: | Suzuki, Hideo|Li, Yanan|Dong, Xiaoqun|Hassan, Manal M|Abbruzzese, James L|Li, Donghui | ||||||||||
| PMID: | 19064563 | ||||||||||
| 22. | |||||||||||
| Journal: | Endocr Relat Cancer. 2009 Sep;16(3):939-52. | ||||||||||
| Title: | Hypermethylation of the IGF2 differentially methylated region 2 is a specific event in insulinomas leading to loss-of-imprinting and overexpression. | ||||||||||
| Author: | Dejeux, Emelyne|Olaso, Robert|Dousset, Bertrand|Audebourg, Anne|Gut, Ivo G|Terris, Benoit|Tost, Jorg | ||||||||||
| PMID: | 19502451 | ||||||||||
| 23. | |||||||||||
| Journal: | Mol Cancer Ther. 2009 May;8(5):1095-105. | ||||||||||
| Title: | AMG 479, a fully human anti-insulin-like growth factor receptor type I monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells. | ||||||||||
| Author: | Beltran, Pedro J|Mitchell, Petia|Chung, Young-A|Cajulis, Elaina|Lu, John|Belmontes, Brian|Ho, Joanne|Tsai, Mei Mei|Zhu, Min|Vonderfecht, Steven|Baserga, Renato|Kendall, Richard|Radinsky, Robert|Calzone, Frank J | ||||||||||
| PMID: | 19366899 | ||||||||||
| 24. | |||||||||||
| Journal: | Endocr Pathol. 2009 Fall;20(3):149-57. | ||||||||||
| Title: | Insulin-like growth factor mRNA binding protein 3 (IMP3) is differentially expressed in benign and malignant follicular patterned thyroid tumors. | ||||||||||
| Author: | Slosar, Magdalena|Vohra, Poonam|Prasad, Manju|Fischer, Andrew|Quinlan, Robert|Khan, Ashraf | ||||||||||
| PMID: | 19449140 | ||||||||||
| 25. | |||||||||||
| Journal: | Langenbecks Arch Surg. 2010 Jun;395(5):515-25. | ||||||||||
| Title: | Expression and regulation of hedgehog signaling pathway in pancreatic cancer. | ||||||||||
| Author: | Yang, Yinmo|Tian, Xiaodong|Xie, Xuehai|Zhuang, Yan|Wu, Wenhan|Wang, Weimin | ||||||||||
| PMID: | 19396459 | ||||||||||
| 26. | |||||||||||
| Journal: | Cancer Epidemiol Biomarkers Prev. 2010 Sep;19(9):2298-306. | ||||||||||
| Title: | Serum IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 molar ratio and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. | ||||||||||
| Author: | Douglas, Jason B|Silverman, Debra T|Pollak, Michael N|Tao, Yuzhen|Soliman, Amr S|Stolzenberg-Solomon, Rachael Z | ||||||||||
| PMID: | 20699371 | ||||||||||
| 27. | |||||||||||
| Journal: | Cancer Epidemiol. 2012 Apr;36(2):206-11. | ||||||||||
| Title: | Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer. | ||||||||||
| Author: | Dong, Xiaoqun|Li, Yanan|Tang, Hongwei|Chang, Ping|Hess, Kenneth R|Abbruzzese, James L|Li, Donghui | ||||||||||
| PMID: | 21852217 | ||||||||||
| 28. | |||||||||||
| Journal: | J Cell Biochem. 2012 Aug;113(8):2714-20. | ||||||||||
| Title: | Insulin-like growth factor I receptor involvement in proliferation of NOR-P1 cells in serum-free media. | ||||||||||
| Author: | Tomizawa, Minoru|Shinozaki, Fuminobu|Sugiyama, Takao|Yamamoto, Shigenori|Sueishi, Makoto|Yoshida, Takanobu | ||||||||||
| PMID: | 22441995 | ||||||||||
| 29. | |||||||||||
| Journal: | Mol Cancer Res. 2012 Sep;10(9):1228-39. Epub 2012 Aug 7. | ||||||||||
| Title: | KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling. | ||||||||||
| Author: | Appleman, Victoria A|Ahronian, Leanne G|Cai, JiuFeng|Klimstra, David S|Lewis, Brian C | ||||||||||
| PMID: | 22871572 | ||||||||||
| 30. | |||||||||||
| Journal: | Int J Clin Exp Med. 2012;5(4):296-305. Epub 2012 Aug 22. | ||||||||||
| Title: | Development of targeted therapy for a broad spectrum of cancers (pancreatic cancer, ovarian cancer, glioblastoma and HCC) mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences. | ||||||||||
| Author: | Amit, Doron|Hochberg, Abraham | ||||||||||
| PMID: | 22993648 | ||||||||||
| 31. | |||||||||||
| Journal: | Int J Clin Exp Med. 2013;6(2):110-8. Epub 2013 Jan 26. | ||||||||||
| Title: | Development of targeted therapy for a broad spectrum of solid tumors mediated by a double promoter plasmid expressing diphtheria toxin under the control of IGF2-P4 and IGF2-P3 regulatory sequences. | ||||||||||
| Author: | Amit, Doron|Tamir, Sagi|Hochberg, Abraham | ||||||||||
| PMID: | 23386914 | ||||||||||
| 32. | |||||||||||
| Journal: | J Mol Endocrinol. 2013 Apr 23;50(3):R67-74. | ||||||||||
| Title: | The role of insulin and IGF system in pancreatic cancer. | ||||||||||
| Author: | Trajkovic-Arsic, Marija|Kalideris, Evdokia|Siveke, Jens T | ||||||||||
| PMID: | 23493758 | ||||||||||
| 33. | |||||||||||
| Journal: | Chin J Cancer. 2013 May;32(5):242-52. | ||||||||||
| Title: | IGF-1R as an anti-cancer target--trials and tribulations. | ||||||||||
| Author: | Chen, Helen X|Sharon, Elad | ||||||||||
| PMID: | 23601239 | ||||||||||
| 34. | |||||||||||
| Journal: | Am J Cancer Res. 2015 May 15;5(6):2035-46. eCollection 2015. | ||||||||||
| Title: | IFN-beta is a potent inhibitor of insulin and insulin like growth factor stimulated proliferation and migration in human pancreatic cancer cells. | ||||||||||
| Author: | Booy, Stephanie|van Eijck, Casper Hj|Janssen, Joseph Amjl|Dogan, Fadime|van Koetsveld, Peter M|Hofland, Leo J | ||||||||||
| PMID: | 26269762 | ||||||||||
| 35. | |||||||||||
| Journal: | Oncogene. 2015 Mar 26;34(13):1629-40. | ||||||||||
| Title: | miR-615-5p is epigenetically inactivated and functions as a tumor suppressor in pancreatic ductal adenocarcinoma. | ||||||||||
| Author: | Gao, W|Gu, Y|Li, Z|Cai, H|Peng, Q|Tu, M|Kondo, Y|Shinjo, K|Zhu, Y|Zhang, J|Sekido, Y|Han, B|Qian, Z|Miao, Y | ||||||||||
| PMID: | 24769899 | ||||||||||
| 36. | |||||||||||
| Journal: | Tumour Biol. 2016 Jan;37(1):1041-9. | ||||||||||
| Title: | CDX2 inhibits pancreatic adenocarcinoma cell proliferation via promoting tumor suppressor miR-615-5p. | ||||||||||
| Author: | Jiang, Yuanyuan|Zhang, Yan|Li, Fuqing|Du, Xiaolin|Zhang, Jinping | ||||||||||
| PMID: | 26269116 | ||||||||||
| 37. | |||||||||||
| Journal: | Mol Cell Endocrinol. 2016 Nov 15;436:268-73. | ||||||||||
| Title: | Pancreatic solitary fibrous tumor causing ectopic adrenocorticotropic hormone syndrome. | ||||||||||
| Author: | Murakami, Keigo|Nakamura, Yasuhiro|Felizola, Saulo J A|Morimoto, Ryo|Satoh, Fumitoshi|Takanami, Kentaro|Katakami, Hideki|Hirota, Seiichi|Takeda, Yoshiyu|Meguro-Horike, Makiko|Horike, Shin-Ichi|Unno, Michiaki|Sasano, Hironobu | ||||||||||
| PMID: | 27585487 | ||||||||||
| 38. | |||||||||||
| Journal: | Oncol Rep. 2016 Nov;36(5):2653-2662. | ||||||||||
| Title: | Upregulation of INS-IGF2 read-through expression and identification of a novel INS-IGF2 splice variant in insulinomas. | ||||||||||
| Author: | Johannessen, Lene E|Panagopoulos, Ioannis|Haugvik, Sven-Petter|Gladhaug, Ivar Prydz|Heim, Sverre|Micci, Francesca | ||||||||||
| PMID: | 27667266 | ||||||||||
| 39. | |||||||||||
| Journal: | Oncotarget. 2016 Dec 27;7(52):86857-86870. | ||||||||||
| Title: | Epigenetic inhibition of miR-663b by long non-coding RNA HOTAIR promotes pancreatic cancer cell proliferation via up-regulation of insulin-like growth factor 2. | ||||||||||
| Author: | Cai, Huihua|An, Yong|Chen, Xuemin|Sun, Donglin|Chen, Tongbing|Peng, Yan|Zhu, Feng|Jiang, Yong|He, Xiaozhou | ||||||||||
| PMID: | 27895308 | ||||||||||
| 40. | |||||||||||
| Journal: | Nutrients. 2017 Apr 18;9(4). pii: nu9040394. | ||||||||||
| Title: | Serum Insulin-Like Growth Factor Axis and the Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis. | ||||||||||
| Author: | Gong, Yuanfeng|Zhang, Bingyi|Liao, Yadi|Tang, Yunqiang|Mai, Cong|Chen, Tiejun|Tang, Hui | ||||||||||
| PMID: | 28420208 | ||||||||||
| 41. | |||||||||||
| Journal: | Ann Surg Oncol. 2017 Oct;24(11):3212-3219. | ||||||||||
| Title: | Prediagnosis Circulating Insulin-Like Growth Factors and Pancreatic Cancer Survival. | ||||||||||
| Author: | Toriola, Adetunji T|Ziegler, Mark|Li, Yize|Pollak, Michael|Stolzenberg-Solomon, Rachael | ||||||||||
| PMID: | 28681154 | ||||||||||
| 42. | |||||||||||
| Journal: | Int J Radiat Oncol Biol Phys. 2018 Feb 1;100(2):486-489. | ||||||||||
| Title: | Multiplex Proximity Ligation Assay to Identify Potential Prognostic Biomarkers for Improved Survival in Locally Advanced Pancreatic Cancer Patients Treated With Stereotactic Body Radiation Therapy. | ||||||||||
| Author: | Rao, Avani D|Liu, Yufei|von Eyben, Rie|Hsu, Charles C|Hu, Chen|Rosati, Lauren M|Parekh, Arti|Ng, Kendall|Hacker-Prietz, Amy|Zheng, Lei|Pawlik, Timothy M|Laheru, Daniel A|Jaffee, Elizabeth M|Weiss, Matthew J|Le, Dung T|Hruban, Ralph H|De Jesus-Acosta, Ana| | ||||||||||
| PMID: | 29157747 | ||||||||||
| 43. | |||||||||||
| Journal: | Cancer Res. 2018 Feb 15;78(4):865-876. | ||||||||||
| Title: | Integrated Molecular Characterization of the Lethal Pediatric Cancer Pancreatoblastoma. | ||||||||||
| Author: | Isobe, Tomoya|Seki, Masafumi|Yoshida, Kenichi|Sekiguchi, Masahiro|Shiozawa, Yusuke|Shiraishi, Yuichi|Kimura, Shunsuke|Yoshida, Misa|Inoue, Yoshikage|Yokoyama, Akira|Kakiuchi, Nobuyuki|Suzuki, Hiromichi|Kataoka, Keisuke|Sato, Yusuke|Kawai, Tomoko|Chiba, Ke | ||||||||||
| PMID: | 29233928 | ||||||||||
| 44. | |||||||||||
| Journal: | Pancreatology. 2018 Mar;18(2):176-183. | ||||||||||
| Title: | Immunohistochemical analysis of IMP3 and p53 expression in endoscopic ultrasound-guided fine needle aspiration and resected specimens of pancreatic diseases. | ||||||||||
| Author: | Senoo, Junichi|Mikata, Rintaro|Kishimoto, Takashi|Hayashi, Masahiro|Kusakabe, Yuko|Yasui, Shin|Yamato, Mutsumi|Ohyama, Hiroshi|Sugiyama, Harutoshi|Tsuyuguchi, Toshio|Yoshitomi, Hideyuki|Ohtsuka, Masayuki|Maeda, Juri|Ota, Satoshi|Nakatani, Yukio|Kato, Naoy | ||||||||||
| PMID: | 29305088 | ||||||||||
| 45. | |||||||||||
| Journal: | Mol Cancer. 2018 Feb 23;17(1):66. | ||||||||||
| Title: | Insulin/IGF-driven cancer cell-stroma crosstalk as a novel therapeutic target in pancreatic cancer. | ||||||||||
| Author: | Mutgan, Ayse Ceren|Besikcioglu, H Erdinc|Wang, Shenghan|Friess, Helmut|Ceyhan, Guralp O|Demir, Ihsan Ekin | ||||||||||
| PMID: | 29475434 | ||||||||||
| 46. | |||||||||||
| Journal: | Endocr Relat Cancer. 2018 Jul 18. pii: ERC-18-0222. | ||||||||||
| Title: | The IGF pathway is activated in insulinomas but downregulated in metastatic disease. | ||||||||||
| Author: | Henfling, Mieke|Perren, Aurel|Schmitt, Anja Maria|Saddig, Christiane M|Starke, Achim A|Riedl, Robert G|Versleijen-Jonkers, Yvonne M H|Sprij-Mooij, Diane M|Ramaekers, Frans C S|Hofland, Leo|Speel, Ernst-Jan M | ||||||||||
| PMID: | 30021864 | ||||||||||