Primary Site >> Pancreatic Cancer
Gene >> IGF2
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Ref: Insulin, via its own receptor, regulates growth and amylase synthesis in pancreatic acinar AR42J cells. PMID: 2411617 |
Ref: Serum insulin-like growth factor II in chronic liver disease. PMID: 2537715 |
Ref: Insulin-like growth factor II activates mitogenic signaling in pancreatic cancer cells via IRS-1. PMID: 21541539 |
Ref: Spontaneous hypoglycaemia in a noninsulin-dependent diabetes mellitus patient with disseminated pancreatic carcinoma. PMID: 9113488 Ref: Cancer chemoprevention and therapy by monoterpenes. PMID: 9255590 Ref: Serum levels of insulin-like growth factors (IGF-I and IGF-II) and their binding protein (IGFBP-3) are not elevated in pancreatic cancer. PMID: 9387030 |
Ref: Microencapsulated octreotide pamoate in advanced gastrointestinal and pancreatic cancer: a phase I study. PMID: 9662244 Ref: Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer. PMID: 9766646 Ref: Acinar cell carcinoma of the pancreas associated with hypoglycemia: involvement of "big" insulin-like growth factor-II. PMID: 9773947 |
Ref: Genomic imprinting of IGF-II and H19 in adult human pancreatic tissues. PMID: 10473973 Ref: Antagonistic Analogs of Growth Hormone-releasing Hormone: New Potential Antitumor Agents. PMID: 10542394 Ref: Hypoglycemia in adults. PMID: 10633872 |
Ref: Antagonists of growth hormone-releasing hormone (GH-RH) inhibit in vivo proliferation of experimental pancreatic cancers and decrease IGF-II levels in tumours. PMID: 10741306 |
Ref: An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation. PMID: 12941837 Ref: Genetic blockade of the insulin-like growth factor-I receptor: a promising strategy for human pancreatic cancer. PMID: 14559833 Ref: A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. PMID: 14695208 |
Ref: Genetic blockade of the insulin-like growth factor 1 receptor for human malignancy. PMID: 15562829 |
Ref: Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts. PMID: 17533398 |
Ref: Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer. PMID: 18171715 Ref: Insulin-like growth factor stimulation increases radiosensitivity of a pancreatic cancer cell line through endoplasmic reticulum stress under hypoxic conditions. PMID: 19018773 Ref: Effect of insulin-like growth factor gene polymorphisms alone or in interaction with diabetes on the risk of pancreatic cancer. PMID: 19064563 |
Ref: AMG 479, a fully human anti-insulin-like growth factor receptor type I monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells. PMID: 19366899 Ref: Insulin-like growth factor mRNA binding protein 3 (IMP3) is differentially expressed in benign and malignant follicular patterned thyroid tumors. PMID: 19449140 Ref: Hypermethylation of the IGF2 differentially methylated region 2 is a specific event in insulinomas leading to loss-of-imprinting and overexpression. PMID: 19502451 |
Ref: Expression and regulation of hedgehog signaling pathway in pancreatic cancer. PMID: 19396459 Ref: Serum IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 molar ratio and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. PMID: 20699371 |
Ref: Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer. PMID: 21852217 Ref: Insulin-like growth factor I receptor involvement in proliferation of NOR-P1 cells in serum-free media. PMID: 22441995 Ref: KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling. PMID: 22871572 Ref: Development of targeted therapy for a broad spectrum of cancers (pancreatic cancer, ovarian cancer, glioblastoma and HCC) mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences. PMID: 22993648 |
Ref: Development of targeted therapy for a broad spectrum of solid tumors mediated by a double promoter plasmid expressing diphtheria toxin under the control of IGF2-P4 and IGF2-P3 regulatory sequences. PMID: 23386914 Ref: The role of insulin and IGF system in pancreatic cancer. PMID: 23493758 Ref: IGF-1R as an anti-cancer target--trials and tribulations. PMID: 23601239 |
Ref: miR-615-5p is epigenetically inactivated and functions as a tumor suppressor in pancreatic ductal adenocarcinoma. PMID: 24769899 Ref: IFN-beta is a potent inhibitor of insulin and insulin like growth factor stimulated proliferation and migration in human pancreatic cancer cells. PMID: 26269762 |
Ref: CDX2 inhibits pancreatic adenocarcinoma cell proliferation via promoting tumor suppressor miR-615-5p. PMID: 26269116 Ref: Pancreatic solitary fibrous tumor causing ectopic adrenocorticotropic hormone syndrome. PMID: 27585487 Ref: Upregulation of INS-IGF2 read-through expression and identification of a novel INS-IGF2 splice variant in insulinomas. PMID: 27667266 Ref: Epigenetic inhibition of miR-663b by long non-coding RNA HOTAIR promotes pancreatic cancer cell proliferation via up-regulation of insulin-like growth factor 2. PMID: 27895308 |
Ref: Serum Insulin-Like Growth Factor Axis and the Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis. PMID: 28420208 Ref: Prediagnosis Circulating Insulin-Like Growth Factors and Pancreatic Cancer Survival. PMID: 28681154 |
Ref: Multiplex Proximity Ligation Assay to Identify Potential Prognostic Biomarkers for Improved Survival in Locally Advanced Pancreatic Cancer Patients Treated With Stereotactic Body Radiation Therapy. PMID: 29157747 Ref: Integrated Molecular Characterization of the Lethal Pediatric Cancer Pancreatoblastoma. PMID: 29233928 Ref: Immunohistochemical analysis of IMP3 and p53 expression in endoscopic ultrasound-guided fine needle aspiration and resected specimens of pancreatic diseases. PMID: 29305088 Ref: Insulin/IGF-driven cancer cell-stroma crosstalk as a novel therapeutic target in pancreatic cancer. PMID: 29475434 Ref: The IGF pathway is activated in insulinomas but downregulated in metastatic disease. PMID: 30021864 |