Primary Site >> Liver Cancer

Gene >> IGF1

1.
Journal: J Clin Endocrinol Metab. 1983 May;56(5):1003-8.
Title: Demonstration that a human hepatoma cell line produces a specific insulin-like growth factor carrier protein.
Author: Moses, A C|Freinkel, A J|Knowles, B B|Aden, D P
PMID: 6187761
2.
Journal: J Lab Clin Med. 1988 Nov;112(5):589-94.
Title: Radioimmunoassay of serum IGF-I and IGF-II in patients with chronic liver diseases and hepatocellular carcinoma with or without hypoglycemia.
Author: Wu, J C|Daughaday, W H|Lee, S D|Hsiao, T S|Chou, C K|Lin, H D|Tsai, Y T|Chiang, B N
PMID: 2460570
3.
Journal: Carcinogenesis. 1988 Feb;9(2):209-13.
Title: Expression of insulin-like growth factor I (IGF-I) and IGF-II mRNA during hepatic development, proliferation and carcinogenesis in the rat.
Author: Norstedt, G|Levinovitz, A|Moller, C|Eriksson, L C|Andersson, G
PMID: 3338103
4.
Journal: Biochem Biophys Res Commun. 1989 Jan 16;158(1):38-44.
Title: The insulin-like growth factor binding protein BP-25 is expressed by human breast cancer cells.
Author: Yee, D|Favoni, R E|Lupu, R|Cullen, K J|Lebovic, G S|Huff, K K|Lee, P D|Lee, Y L|Powell, D R|Dickson, R B
PMID: 2463838
5.
Journal: Cancer Res. 1991 Jan 1;51(1):174-80.
Title: Cytotoxic activity of a recombinant fusion protein between insulin-like growth factor I and Pseudomonas exotoxin.
Author: Prior, T I|Helman, L J|FitzGerald, D J|Pastan, I
PMID: 1846308
6.
Journal: Metabolism. 1991 May;40(5):508-12.
Title: Hypoglycemia in hepatocellular carcinoma: failure of short-term growth hormone administration to reduce enhanced glucose requirements.
Author: Wing, J R|Panz, V R|Joffe, B I|Kalk, W J|Seftel, H C|Zapf, J|Kew, M C
PMID: 1850816
7.
Journal: J Hepatol. 1992 Jan;14(1):30-4.
Title: Expression of insulin-like growth factor II (IGF-II) and IGF-II, IGF-I and insulin receptors mRNAs in isolated non-parenchymal rat liver cells.
Author: Zindy, F|Lamas, E|Schmidt, S|Kirn, A|Brechot, C
PMID: 1310705
8.
Journal: Liver. 1992 Apr;12(2):90-3.
Title: Primary hepatocellular carcinoma with severe hypoglycemia: involvement of insulin-like growth factors.
Author: Yonei, Y|Tanaka, M|Ozawa, Y|Miyazaki, K|Tsukada, N|Inada, S|Inagaki, Y|Miyamoto, K|Suzuki, O|Okawa, H
PMID: 1320177
9.
Journal: Neuroendocrinology. 1992 Dec;56(6):765-74.
Title: Differential tissue regulation of the insulin-like growth factors in rats bearing the MStT/W15 pituitary tumor.
Author: Gelato, M C|Vassalotti, J|Spatola, E|Rutherford, C|Marsh, K|Carlson, H E
PMID: 1369583
10.
Journal: Am J Gastroenterol. 1993 Oct;88(10):1744-8.
Title: Circulating growth hormone and insulin-like growth factor-I in nonalcoholic liver cirrhosis with or without superimposed hepatocarcinoma: evidence of an altered circadian rhythm.
Author: Buzzelli, G|Dattolo, P|Pinzani, M|Brocchi, A|Romano, S|Gentilini, P
PMID: 8213718
11.
Journal: Cancer Res. 1993 Feb 1;53(3):652-7.
Title: Suramin inhibits growth and yet promotes insulin-like growth factor II expression in HepG2 cells.
Author: Kraft, A|Reid, L M|Zvibel, I
PMID: 8381048
12.
Journal: J Biol Chem. 1994 May 13;269(19):13779-84.
Title: Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.
Author: Rogler, C E|Yang, D|Rossetti, L|Donohoe, J|Alt, E|Chang, C J|Rosenfeld, R|Neely, K|Hintz, R
PMID: 7514593
13.
Journal: Intern Med. 1995 Dec;34(12):1201-6.
Title: Big insulin-like growth factor II-producing hepatocellular carcinoma associated with hypoglycemia.
Author: Ishida, S|Noda, M|Kuzuya, N|Kubo, F|Yamada, S|Yamanaka, T|Isozaki, O|Hizuka, N|Kanazawa, Y
PMID: 8929651
14.
Journal: Cancer Res. 1996 Aug 15;56(16):3831-6.
Title: Increased expression of the insulin-like growth factor I (IGF-I) receptor gene in hepatocellular carcinoma cell lines: implications of IGF-I receptor gene activation by hepatitis B virus X gene product.
Author: Kim, S O|Park, J G|Lee, Y I
PMID: 8706031
15.
Journal: Actas Urol Esp. 1996 May;20(5):409-13.
Title: [Insulin growth factor I (IGF-I) in normal, hyperplastic, and tumor prostatic tissue].
Author: Tellez Martinez-Fornes, M|Balsa, J|Maganto Pavon, E|Jimenez Cidre, M|Burgos Revilla, F J
PMID: 8766797
16.
Journal: C R Seances Soc Biol Fil. 1996;190(1):165-9.
Title: [Immunotherapy of tumors expressing IGF-I].
Author: Trojan, J|Duc, H T|Lafarge-Frayssinet, C|Upegui-Gonzales, L C|Swiercz, B|Bismuth, H|Hor, F|Anthony, D|Guo, Y|Ilan, J
PMID: 8881277
17.
Journal: J Clin Invest. 1996 Nov 1;98(9):2100-8.
Title: A carboxy-terminal truncated insulin receptor substrate-1 dominant negative protein reverses the human hepatocellular carcinoma malignant phenotype.
Author: Tanaka, S|Wands, J R
PMID: 8903330
18.
Journal: Int J Oncol. 1996 Dec;9(6):1099-105.
Title: Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH).
Author: Pinski, J|Schally, A|Jungwirth, A|Groot, K|Halmos, G|Armatis, P|Zarandi, M|Vadillobuenfil, M
PMID: 21541617
19.
Journal: Cancer Gene Ther. 1997 Sep-Oct;4(5):276-85.
Title: Antisense insulin-like growth factor I transferred into a rat hepatoma cell line inhibits tumorigenesis by modulating major histocompatibility complex I cell surface expression.
Author: Lafarge-Frayssinet, C|Duc, H T|Frayssinet, C|Sarasin, A|Anthony, D|Guo, Y|Trojan, J
PMID: 9345599
20.
Journal: J Hepatol. 1998 Nov;29(5):807-18.
Title: Induction of apoptosis in rat hepatocarcinoma cells by expression of IGF-I antisense c-DNA.
Author: Ellouk-Achard, S|Djenabi, S|De Oliveira, G A|Desauty, G|Duc, H T|Zohair, M|Trojan, J|Claude, J R|Sarasin, A|Lafarge-Frayssinet, C
PMID: 9833920
21.
Journal: J Cell Physiol. 2000 Jan;182(1):62-8.
Title: Soluble insulin-like growth factor II/mannose 6-phosphate receptor inhibits DNA synthesis in insulin-like growth factor II sensitive cells.
Author: Scott, C D|Weiss, J
PMID: 10567917
22.
Journal: Mol Cell Biochem. 2000 Apr;207(1-2):101-4.
Title: The expression of insulin-like growth factor binding proteins in human hepatocellular carcinoma.
Author: Gong, Y|Cui, L|Minuk, G Y
PMID: 10888233
23.
Journal: Int J Oncol. 2000 Oct;17(4):777-81.
Title: Hepatocarcinoma cells stimulate hepatocyte growth factor secretion in human liver myofibroblasts.
Author: Guirouilh, J|Castroviejo, M|Balabaud, C|Desmouliere, A|Rosenbaum, J
PMID: 10995891
24.
Journal: Proc Soc Exp Biol Med. 2000 Nov;225(2):128-35.
Title: Induction of hepatic insulin-like growth factor binding protein-1 (IGFBP-1) in rats by dietary n-6 polyunsaturated fatty acids.
Author: Ghoshal, A K|Xu, Z|Wood, G A|Archer, M C
PMID: 11044255
25.
Journal: Life Sci. 2000 Dec 8;68(3):307-19.
Title: Alterations in tumorigenicity of embryonal carcinoma cells by IGF-I triple-helix induced changes in immunogenicity and apoptosis.
Author: Ly, A|Francois, J C|Upegui-Gonzalez, L C|Swiercz, B|Bedel, C|Duc, H T|Bout, D|Trojan, J
PMID: 11191646
26.
Journal: Methods Mol Med. 2000;45:221-35.
Title: Antisense igf-I for hepatocellular carcinoma.
Author: Liu, Y|Zhao, J|Lu, Y|Trojan, J|Wu, M|Guo, Y
PMID: 21341060
27.
Journal: Hepatogastroenterology. 2001 May-Jun;48(39):660-6.
Title: IGF-I triple helix strategy in hepatoma treatment.
Author: Upegui-Gonzalez, L C|Ly, A|Sierzega, M|Jarocki, P|Trojan, L|Duc, H T|Pan, Y|Shevelev, A|Henin, D|Anthony, D|Nowak, W|Popiela, T|Trojan, J
PMID: 11462897
28.
Journal: Cell Growth Differ. 2002 Mar;13(3):115-22.
Title: A possible role for insulin-like growth factor-binding protein-3 autocrine/paracrine loops in controlling hepatocellular carcinoma cell proliferation.
Author: Huynh, Hung|Chow, Pierce K H|Ooi, London L P|Soo, Khee-Chee
PMID: 11959812
29.
Journal: Lab Invest. 2002 Oct;82(10):1377-89.
Title: Impact of insulin-like growth factor receptor-I function on angiogenesis, growth, and metastasis of colon cancer.
Author: Reinmuth, Niels|Fan, Fan|Liu, Wenbiao|Parikh, Alexander A|Stoeltzing, Oliver|Jung, Young D|Bucana, Corazon D|Radinsky, Robert|Gallick, Gary E|Ellis, Lee M
PMID: 12379772
30.
Journal: Hepatology. 2002 Nov;36(5):1089-97.
Title: Insulin-like growth factor I is a comitogen for hepatocyte growth factor in a rat model of hepatocellular carcinoma.
Author: Price, Julie A|Kovach, Stephen J|Johnson, Timothy|Koniaris, Leonidas G|Cahill, Paul A|Sitzmann, James V|McKillop, Iain H
PMID: 12395318
31.
Journal: Surg Today. 2002;32(11):1008-11.
Title: Hepatocellular carcinoma in a patient with acromegaly and high serum levels of insulin-like growth factor I: report of a case.
Author: Yamaguchi, Masahiko|Tate, Genshu|Yoshizawa, Yasuo|Midorikawa, Takemasa|Sanada, Yutaka|Kumada, Kaoru
PMID: 12444442
32.
Journal: Cancer. 2002 Dec 15;95(12):2539-45.
Title: Serum insulin-like growth factor I evaluation as a useful tool for predicting the risk of developing hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis: a prospective study.
Author: Mazziotti, Gherardo|Sorvillo, Francesca|Morisco, Filomena|Carbone, Antonella|Rotondi, Mario|Stornaiuolo, Gianfranca|Precone, Davide F|Cioffi, Michele|Gaeta, Giovanni B|Caporaso, Nicola|Carella, Carlo
PMID: 12467068
33.
Journal: Anticancer Res. 2002 Nov-Dec;22(6C):3895-904.
Title: Adenovirus-mediated anti insulin-like growth factor I gene transfer for the treatment of hepatocellular carcinoma.
Author: Lafarge-Frayssinet, Christiane|Martin, Chantal|Van Binh, Pascale Nguyen|Achard-Ellouk, Sophie|Duc, Huynh T|Frayssinet, Charles|Cardoso, Georges|Desauty, Genevieve|Warnet, Jean-Michel|Brechot, Christian|Sarasin, Alain
PMID: 12553010
34.
Journal: Dtsch Med Wochenschr. 2003 Feb 7;128(6):257-60.
Title: [Hypoglycemia associated with the production of insulin-like growth factor (IGF)-II by a hemangiopericytoma].
Author: Plikat, K|Reichle, A|Elmlinger, M W|Scholmerich, J
PMID: 12571793
35.
Journal: Mol Carcinog. 2003 Mar;36(3):142-6.
Title: Insulin-like growth factor binding protein-1 over-expression in transgenic mice inhibits hepatic preneoplasia.
Author: Lu, Suying|Archer, Michael C
PMID: 12619036
36.
Journal: J Hepatol. 2003 Apr;38(4):447-54.
Title: Ghrelin in chronic liver disease.
Author: Tacke, Frank|Brabant, Georg|Kruck, Elmar|Horn, Rudiger|Schoffski, Patrick|Hecker, Hartmut|Manns, Michael P|Trautwein, Christian
PMID: 12663236
37.
Journal: Horm Res. 2003;60(4):174-80.
Title: Pilot study of elevated levels of insulin-like growth factor-binding protein-2 as indicators of hepatocellular carcinoma.
Author: Ranke, Michael B|Maier, Klaus-Peter|Schweizer, Roland|Stadler, Bernd|Schleicher, Sabine|Elmlinger, Martin W|Flehmig, Bertram
PMID: 14530605
38.
Journal: Clin Endocrinol (Oxf). 2003 Dec;59(6):699-706.
Title: Increased IGF-I : IGFBP-3 ratio in patients with hepatocellular carcinoma.
Author: Mattera, Daniele|Capuano, Gaetano|Colao, Annamaria|Pivonello, Rosario|Manguso, Francesco|Puzziello, Alessandro|D'Agostino, Luciano
PMID: 14974910
39.
Journal: In Vitro Cell Dev Biol Anim. 2004 Mar-Apr;40(3-4):118-28.
Title: Development of rainbow trout hepatoma cell lines: effect of pro-IGF-I Ea4-peptide on morphological changes and anchorage-independent growth.
Author: Chen, Maria J|Chiou, P Peter|Yang, Bih-Ying|Lo, Hung Chieh|Son, Jin-Ki|Hendricks, Jerry|Bailey, George|Chen, Thomas T
PMID: 15311963
40.
Journal: Ann N Y Acad Sci. 2004 Dec;1030:219-29.
Title: Role of constitutively activated and insulin-like growth factor-stimulated ERK1/2 signaling in human hepatoma cell proliferation and apoptosis: evidence for heterogeneity of tumor cell lines.
Author: Alexia, Catherine|Lasfer, Malika|Groyer, Andre
PMID: 15659801
41.
Journal: Cancer. 2005 May 15;103(10):2189-98.
Title: Body composition and time course changes in regional distribution of fat and lean tissue in unselected cancer patients on palliative care--correlations with food intake, metabolism, exercise capacity, and hormones.
Author: Fouladiun, Marita|Korner, Ulla|Bosaeus, Ingvar|Daneryd, Peter|Hyltander, Anders|Lundholm, Kent G
PMID: 15822132
42.
Journal: Clin Cancer Res. 2005 May 1;11(9):3494-502.
Title: Blockade of paracrine supply of insulin-like growth factors using neutralizing antibodies suppresses the liver metastasis of human colorectal cancers.
Author: Miyamoto, Shin'ichi|Nakamura, Michio|Shitara, Kenya|Nakamura, Kazuyasu|Ohki, Yuji|Ishii, Genichiro|Goya, Masato|Kodama, Keiji|Sangai, Takafumi|Maeda, Hiroyuki|Shi-Chuang, Zhang|Chiba, Tsutomu|Ochiai, Atsushi
PMID: 15867252
43.
Journal: World J Gastroenterol. 2005 Jul 21;11(27):4272-6.
Title: Expression of albumin, IGF-1, IGFBP-3 in tumor tissues and adjacent non-tumor tissues of hepatocellular carcinoma patients with cirrhosis.
Author: Luo, Shi-Min|Tan, Wei-Min|Deng, Wei-Xiong|Zhuang, Si-Min|Luo, Jian-Wei
PMID: 16015705
44.
Journal: Mol Cell. 2005 Jul 22;19(2):159-70.
Title: Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
Author: Ding, Qingqing|Xia, Weiya|Liu, Jaw-Ching|Yang, Jer-Yen|Lee, Dung-Fang|Xia, Jiahong|Bartholomeusz, Geoffrey|Li, Yan|Pan, Yong|Li, Zheng|Bargou, Ralf C|Qin, Jun|Lai, Chien-Chen|Tsai, Fuu-Jen|Tsai, Chang-Hai|Hung, Mien-Chie
PMID: 16039586
45.
Journal: FEBS Lett. 2005 Aug 15;579(20):4309-16.
Title: Endosomal proteolysis of insulin-like growth factor-I at its C-terminal D-domain by cathepsin B.
Author: Authier, Francois|Kouach, Mostafa|Briand, Gilbert
PMID: 16051222
46.
Journal: Cancer Biol Ther. 2005 Nov;4(11):1240-7. Epub 2005 Nov 15.
Title: Cyclic AMP inhibition of proliferation of hepatocellular carcinoma cells is mediated by Akt.
Author: Liu, Lunhua|Xie, Yili|Lou, Liguang
PMID: 16177565
47.
Journal: Eur Rev Med Pharmacol Sci. 2005 Sep-Oct;9(5):291-3.
Title: Steatosis and hepatocellular carcinoma risk.
Author: Smedile, A|Bugianesi, E
PMID: 16231592
48.
Journal: Biochem Pharmacol. 2006 May 14;71(10):1435-48.
Title: Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells.
Author: Hopfner, Michael|Huether, Alexander|Sutter, Andreas P|Baradari, Viola|Schuppan, Detlef|Scherubl, Hans
PMID: 16530734
49.
Journal: J Hepatol. 2006 May;44(5):971-83.
Title: Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness.
Author: de la Monte, Suzanne M|Tamaki, Seishu|Cantarini, M Chiara|Ince, Nedim|Wiedmann, Marcus|Carter, Jade J|Lahousse, Stephanie A|Califano, Sophia|Maeda, Takashi|Ueno, Takato|D'Errico, Antonia|Trevisani, Franco|Wands, Jack R
PMID: 16564107
50.
Journal: Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R674-83.
Title: IGF-1 is downregulated in experimental cancer cachexia.
Author: Costelli, Paola|Muscaritoli, Maurizio|Bossola, Maurizio|Penna, Fabio|Reffo, Patrizia|Bonetto, Andrea|Busquets, Silvia|Bonelli, Gabriella|Lopez-Soriano, Francisco J|Doglietto, Giovanni Battista|Argiles, Josep M|Baccino, Francesco M|Rossi Fanelli, Filippo
PMID: 16614058
51.
Journal: Clin Biochem. 2006 Jun;39(6):623-9.
Title: Possible contribution of serum activin A and IGF-1 in the development of hepatocellular carcinoma in Egyptian patients suffering from combined hepatitis C virus infection and hepatic schistosomiasis.
Author: Elsammak, Mohamed Yousry|Amin, Gamal M|Khalil, Gehan M|Ragab, Wafaa S|Abaza, Mona M
PMID: 16624274
52.
Journal: World J Gastroenterol. 2006 Jun 28;12(24):3821-8.
Title: Increased hepatic expression of insulin-like growth factor-I receptor in chronic hepatitis C.
Author: Stefano, Jose Tadeu|Correa-Giannella, Maria Lucia|Ribeiro, Cristiane Maria Freitas|Alves, Venancio Avancini Ferreira|Massarollo, Paulo Celso Bosco|Machado, Marcel Cerqueira Cesar|Giannella-Neto, Daniel
PMID: 16804965
53.
Journal: J Cancer Res Clin Oncol. 2006 Nov;132(11):699-708.
Title: Impact of biomarkers on disease survival and progression in patients treated with octreotide for advanced hepatocellular carcinoma.
Author: Treiber, G|Wex, T|Rocken, C|Fostitsch, P|Malfertheiner, P
PMID: 16835748
54.
Journal: World J Gastroenterol. 2006 Aug 28;12(32):5160-7.
Title: Signaling pathways involved in the inhibition of epidermal growth factor receptor by erlotinib in hepatocellular cancer.
Author: Huether, Alexander|Hopfner, Michael|Sutter, Andreas P|Baradari, Viola|Schuppan, Detlef|Scherubl, Hans
PMID: 16937526
55.
Journal: Cancer Sci. 2006 Nov;97(11):1182-90.
Title: High expression of insulin-like growth factor binding protein-3 is correlated with lower portal invasion and better prognosis in human hepatocellular carcinoma.
Author: Aishima, Shinichi|Basaki, Yuji|Oda, Yoshinao|Kuroda, Yousuke|Nishihara, Yunosuke|Taguchi, Kenichi|Taketomi, Akinobu|Maehara, Yoshihiko|Hosoi, Fumihito|Maruyama, Yuichiro|Fotovati, Abbas|Oie, Shinji|Ono, Mayumi|Ueno, Takato|Sata, Michio|Yano, Hirohisa|Koji
PMID: 16965600
56.
Journal: Gastroenterology. 2006 Oct;131(4):1208-17.
Title: Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells.
Author: Lee, Han Chu|Tian, Bo|Sedivy, John M|Wands, Jack R|Kim, Miran
PMID: 17030190
57.
Journal: Ann N Y Acad Sci. 2006 Dec;1090:1-17.
Title: Pleiotropic effects of PI-3' kinase/Akt signaling in human hepatoma cell proliferation and drug-induced apoptosis.
Author: Alexia, Catherine|Bras, Marlene|Fallot, Guillaume|Vadrot, Nathalie|Daniel, Fanny|Lasfer, Malika|Tamouza, Houda|Groyer, Andre
PMID: 17384242
58.
Journal: Oncogene. 2007 Mar 22;26(13):1941-8.
Title: Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals.
Author: Evans, M K|Yu, C-R|Lohani, A|Mahdi, R M|Liu, X|Trzeciak, A R|Egwuagu, C E
PMID: 17001312
59.
Journal: Pharmacol Res. 2007 May;55(5):359-69.
Title: Doping with growth hormone/IGF-1, anabolic steroids or erythropoietin: is there a cancer risk?
Author: Tentori, Lucio|Graziani, Grazia
PMID: 17349798
60.
Journal: Mol Pharmacol. 2007 Oct;72(4):1082-93.
Title: Induction of glutathione transferase in insulin-like growth factor type I receptor-overexpressed hepatoma cells.
Author: Lee, Jeong Yong|Han, Chang Yeob|Yang, Jin Won|Smith, Christopher|Kim, Sang Kyum|Lee, Eva Y-H P|Kim, Sang Geon|Kang, Keon Wook
PMID: 17615245
61.
Journal: Ann Surg Oncol. 2007 Oct;14(10):2838-46.
Title: Targeting of insulin-like growth factor-I receptor with a monoclonal antibody inhibits growth of hepatic metastases from human colon carcinoma in mice.
Author: Bauer, Todd W|Fan, Fan|Liu, Wenbiao|Camp, Ernest R|Yang, Anthony|Somcio, Ray J|Bucana, Corazon D|Singh, Rajeeva|Ellis, Lee M
PMID: 17653802
62.
Journal: JPEN J Parenter Enteral Nutr. 2007 Nov-Dec;31(6):496-501.
Title: Effects of parenteral nutrition without and with growth hormone on growth hormone/insulin-like growth factor-1 axis after hepatectomy in hepatocellular carcinoma with liver cirrhosis.
Author: Cao, Jie|Luo, Shi-Min|Liang, Lijian|Lai, Jiaming
PMID: 17947606
63.
Journal: Front Med China. 2007 Jul;1(3):287-93.
Title: Effects of parenteral nutrition with and without GH on the GH/IGF-1 axis after hepatectomy in hepatocellular carcinoma with liver cirrhosis.
Author: Cao, Jie|Luo, Shimin|Liang, Lijian|Lai, Jiaming|Chen, Shanming
PMID: 24573868
64.
Journal: Cancer Lett. 2008 Apr 8;262(1):10-8.
Title: EGCG inhibits activation of the insulin-like growth factor (IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells.
Author: Shimizu, Masahito|Shirakami, Yohei|Sakai, Hiroyasu|Tatebe, Hideharu|Nakagawa, Takayuki|Hara, Yukihiko|Weinstein, I Bernard|Moriwaki, Hisataka
PMID: 18164805
65.
Journal: Cancer Res. 2008 May 1;68(9):3342-9.
Title: Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression.
Author: Anzo, Makoto|Cobb, Laura J|Hwang, David L|Mehta, Hemal|Said, Jonathan W|Yakar, Shoshana|LeRoith, Derek|Cohen, Pinchas
PMID: 18451161
66.
Journal: Hepatology. 2008 Jul;48(1):146-56.
Title: Autocrine insulin-like growth factor-II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis.
Author: Nussbaum, Tanja|Samarin, Jana|Ehemann, Volker|Bissinger, Michaela|Ryschich, Eduard|Khamidjanov, Akmal|Yu, Xiaolei|Gretz, Norbert|Schirmacher, Peter|Breuhahn, Kai
PMID: 18537183
67.
Journal: Hepatol Res. 2008 Dec;38(12):1233-40.
Title: Transgenic overexpression of insulin receptor substrate 1 in hepatocytes enhances hepatocellular proliferation in young mice only.
Author: Mohr, Leonhard|Banerjee, Kakoli|Kleinschmidt, Manuela|Bartolome Rodriguez, Maria Matilde|Wands, Jack R
PMID: 18631251
68.
Journal: Zhonghua Yi Xue Za Zhi. 2008 Jun 10;88(22):1553-6.
Title: [Different expression of liver-specific insulin-like growth factor I gene in breast cancer; expression with mice].
Author: Tang, Hong-Bo|Ren, Yu-Ping|Hu, Ying|Zhu, Zhan-Yong|Shuai, Yong-Feng|Wu, Yi-Ping
PMID: 18956639
69.
Journal: Zhonghua Wai Ke Za Zhi. 2008 Jul 1;46(13):1018-21.
Title: [Analysis of apoptosis-related gene expression in different serum level of insulin-like growth factor-1 in mice breast cancer tissue].
Author: Tang, Hong-Bo|Ye, Zi-Rong|Ren, Yu-Ping|Zhang, Shan|Chen, Guo-Qing|Wu, Yi-Ping
PMID: 19035207
70.
Journal: Int J Biol Markers. 2008 Oct-Dec;23(4):225-30.
Title: Association of elevated IGFBP-1 with increased IGF-II concentration in patients with carcinoma of the liver.
Author: Nedic, O|Malenkovic, V|Dukanovic, B|Baricevic, I
PMID: 19199270
71.
Journal: Clin Cancer Res. 2009 May 1;15(9):3068-75.
Title: Supplementation with branched-chain amino acids inhibits azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice.
Author: Shimizu, Masahito|Shirakami, Yohei|Iwasa, Junpei|Shiraki, Makoto|Yasuda, Yoichi|Hata, Kazuya|Hirose, Yoshinobu|Tsurumi, Hisashi|Tanaka, Takuji|Moriwaki, Hisataka
PMID: 19366832
72.
Journal: J Mol Endocrinol. 2010 Feb;44(2):99-113.
Title: Identification of a region in the human IRS2 promoter essential for stress induced transcription depending on SP1, NFI binding and ERK activation in HepG2 cells.
Author: Udelhoven, M|Leeser, U|Freude, S|Hettich, M M|Laudes, M|Schnitker, J|Krone, W|Schubert, M
PMID: 19755487
73.
Journal: Cancer Sci. 2010 Feb;101(2):460-7.
Title: Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice.
Author: Iwasa, Junpei|Shimizu, Masahito|Shiraki, Makoto|Shirakami, Yohei|Sakai, Hiroyasu|Terakura, Yoichi|Takai, Koji|Tsurumi, Hisashi|Tanaka, Takuji|Moriwaki, Hisataka
PMID: 19906067
74.
Journal: Int J Cancer. 2010 Oct 1;127(7):1706-17.
Title: Muscle atrophy in experimental cancer cachexia: is the IGF-1 signaling pathway involved?
Author: Penna, Fabio|Bonetto, Andrea|Muscaritoli, Maurizio|Costamagna, Domiziana|Minero, Valerio Giacomo|Bonelli, Gabriella|Rossi Fanelli, Filippo|Baccino, Francesco Maria|Costelli, Paola
PMID: 20039316
75.
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Title: Relationship of insulin-like growth factors system gene polymorphisms with the susceptibility and pathological development of hepatocellular carcinoma.
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Title: Differential diagnosis of liver diseases using serum biomarkers.
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Journal: Mol Cancer Ther. 2010 Jun;9(6):1809-19.
Title: A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo.
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Title: Combination of two insulin-like growth factor-I receptor inhibitory antibodies targeting distinct epitopes leads to an enhanced antitumor response.
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Title: Insulin-like growth factors and liver cancer risk in male smokers.
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Title: Predictive value of serum biomarkers in patients after portal vein embolization (PVE): a pilot study.
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Title: Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice.
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Title: Long-term ethanol consumption promotes hepatic tumorigenesis but impairs normal hepatocyte proliferation in rats.
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Title: A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines.
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Journal: J Cachexia Sarcopenia Muscle. 2011 Jun;2(2):105-109.
Title: IGF-1 treatment reduces weight loss and improves outcome in a rat model of cancer cachexia.
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Title: I-CLIP: improved stratification of advanced hepatocellular carcinoma patients by integrating plasma IGF-1 into CLIP score.
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Title: Serum IGF-1, IGF-2 and IGFBP-3 as parameters in the assessment of liver dysfunction in patients with hepatic cirrhosis and in the diagnosis of hepatocellular carcinoma.
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Title: Clinical and prognostic implications of plasma insulin-like growth factor-1 and vascular endothelial growth factor in patients with hepatocellular carcinoma.
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Journal: For Immunopathol Dis Therap. 2011;2(2):195-204.
Title: Role of Raf Kinase Inhibitor Protein in Hepatocellular Carcinoma.
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Title: Male germ cell-specific RNA binding protein RBMY: a new oncogene explaining male predominance in liver cancer.
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Journal: J Cell Physiol. 2012 Jul;227(7):2947-52.
Title: Gefitinib resistance in HCC mahlavu cells: upregulation of CD133 expression, activation of IGF-1R signaling pathway, and enhancement of IGF-1R nuclear translocation.
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Title: Lignan transformation by gut bacteria lowers tumor burden in a gnotobiotic rat model of breast cancer.
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Title: Serum insulin-like growth factor-1 levels predict outcomes of patients with advanced hepatocellular carcinoma receiving antiangiogenic therapy.
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Title: Serum IGFBP-3 is a more effective predictor than IGF-1 and IGF-2 for the development of hepatocellular carcinoma in patients with chronic HCV infection.
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Title: The transcription factor c-Jun protects against liver damage following activated beta-Catenin signaling.
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Title: Effect of insulin-like growth factor-1 on bone morphogenetic protein-2 expression in hepatic carcinoma SMMC7721 cells through the p38 MAPK signaling pathway.
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Title: Human tumor cells induce angiogenesis through positive feedback between CD147 and insulin-like growth factor-I.
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Title: Inhibition of hepatocellular carcinoma cell growth by an anti-insulin-like growth factor-I receptor monoclonal antibody.
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Title: Development of IGF signaling antibody arrays for the identification of hepatocellular carcinoma biomarkers.
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Title: The insulin-like growth factor (IGF) signaling axis and hepatitis C virus-associated carcinogenesis (review).
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Title: Alterations of insulin-like growth factor I (IGF-I) and estradiol serum levels in chronic hepatitis C.
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Title: Effect of occupational exposure to aflatoxins on some liver tumor markers in textile workers.
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Title: Efficacy, safety, pharmacokinetics, and biomarkers of cediranib monotherapy in advanced hepatocellular carcinoma: a phase II study.
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Journal: Liver Int. 2013 May;33(5):714-21.
Title: MuRF-1 and p-GSK3beta expression in muscle atrophy of cirrhosis.
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Title: GRK2 negatively regulates IGF-1R signaling pathway and cyclins' expression in HepG2 cells.
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Title: Sustained production of a soluble IGF-I receptor by gutless adenovirus-transduced host cells protects from tumor growth in the liver.
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Title: Serotonin and the 5-HT7 receptor: the link between hepatocytes, IGF-1 and small intestinal neuroendocrine tumors.
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Title: Upregulation of T-cell factor-4 isoform-responsive target genes in hepatocellular carcinoma.
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Title: Serum insulin-like growth factor-I level is an independent predictor of recurrence and survival in early hepatocellular carcinoma: a prospective cohort study.
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Title: The insulin-like growth factor-1 and expression of its binding protein3 in chronic hepatitis C and hepatocellular carcinoma.
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Journal: Toxicol Appl Pharmacol. 2013 Nov 1;272(3):568-78.
Title: Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1.
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Journal: Oncol Res. 2013;21(2):103-10.
Title: The insulin-like growth factor-I receptor inhibitor picropodophyllin-induced selective apoptosis of hepatocellular carcinoma cell through a caspase-dependent mitochondrial pathway.
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Journal: Fukuoka Igaku Zasshi. 2013 Oct;104(10):334-8.
Title: Differential expression of insulin-like growth factor 1 in human primary liver cancer.
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Journal: Izv Akad Nauk Ser Biol. 2013 Nov-Dec;(6):673-81.
Title: [Igf-1 and its isoform expression in hepatic cell tumors and the surrounding tissue in mice liver carcinogenesis induced by diethylnitrozamine].
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Journal: Int J Cancer. 2014 Jan 1;134(1):164-73.
Title: Prediagnostic plasma testosterone, sex hormone-binding globulin, IGF-I and hepatocellular carcinoma: etiological factors or risk markers?
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Journal: Tumour Biol. 2014 Mar;35(3):2729-39.
Title: Clinical significance of serum circulating insulin-like growth factor-1 (IGF-1) mRNA in hepatocellular carcinoma.
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Journal: Aging Cell. 2014 Jun;13(3):408-18.
Title: Reductions in serum IGF-1 during aging impair health span.
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Journal: BMC Genomics. 2014 Jan 15;15:28.
Title: Alterations in hepatic miRNA expression during negative energy balance in postpartum dairy cattle.
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Journal: Eur J Endocrinol. 2014 Mar 14;170(4):R147-57.
Title: Management of endocrine disease: a clinical update on tumor-induced hypoglycemia.
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Title: Biochemical/metabolic changes associated with hepatocellular carcinoma development in mice.
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Journal: PLoS One. 2014 Feb 20;9(2):e89446.
Title: Up-regulation of microRNA-190b plays a role for decreased IGF-1 that induces insulin resistance in human hepatocellular carcinoma.
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Journal: PLoS One. 2014 Mar 4;9(3):e90862.
Title: Serum insulin-like growth factor-1 predicts disease progression and survival in patients with hepatocellular carcinoma who undergo transarterial chemoembolization.
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Journal: Int J Cancer. 2014 Oct 1;135(7):1662-72.
Title: Dairy products and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition.
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Title: Maintenance of stemness in oxaliplatin-resistant hepatocellular carcinoma is associated with increased autocrine of IGF1.
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Journal: Tissue Antigens. 2014 Sep;84(3):264-70.
Title: Association of IGF1R polymorphisms with the development of HBV-related hepatocellular carcinoma.
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Journal: BMC Cancer. 2014 May 21;14:351.
Title: Antagonism of sorafenib and regorafenib actions by platelet factors in hepatocellular carcinoma cell lines.
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Title: An inducible hepatocellular carcinoma model for preclinical evaluation of antiangiogenic therapy in adult mice.
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Journal: World J Surg Oncol. 2014 Jul 22;12:231.
Title: Expression levels of insulin-like growth factors and receptors in hepatocellular carcinoma: a retrospective study.
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Title: GSK3 protein positively regulates type I insulin-like growth factor receptor through forkhead transcription factors FOXO1/3/4.
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Title: The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets.
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Journal: Ir J Med Sci. 2015 Jun;184(2):357-64.
Title: Identifying hepatocellular carcinoma-related genes and pathways by system biology analysis.
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Journal: Ann Surg. 2015 Jul;262(1):105-11.
Title: Anatomical Liver Resections Guided by 3-Dimensional Parenchymal Staining Using Fusion Indocyanine Green Fluorescence Imaging.
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Journal: Hepatology. 2015 Feb;61(2):613-26.
Title: Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis.
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Journal: Int J Oncol. 2015 Feb;46(2):782-90.
Title: Mechanistic and biological significance of DNA methyltransferase 1 upregulated by growth factors in human hepatocellular carcinoma.
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Journal: Oncol Lett. 2015 Jan;9(1):411-417.
Title: PDCD5 transfection increases cisplatin sensitivity and decreases invasion in hepatic cancer cells.
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Title: Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion.
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Journal: Clin Cancer Res. 2015 Jan 1;21(1):201-10.
Title: Activation of IL6/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression.
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Title: Effect of hypoxia on hypoxia inducible factor-1alpha, insulin-like growth factor I and vascular endothelial growth factor expression in hepatocellular carcinoma HepG2 cells.
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Title: Predictive value of serum insulin-like growth factor-1 in hepatocellular carcinoma.
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Title: Gene expression analysis for evaluation of potential biomarkers in hepatocellular carcinoma.
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Title: Study of the effects of cyclooxygenase-2 inhibitor on the promotion of hepatic tumorigenesis in rats fed a high fat diet.
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Title: Daintain/AIF-1 accelerates the activation of insulin-like growth factor-1 receptor signaling pathway in HepG2 cells.
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Title: Regulation of Aspartyl-(Asparaginyl)-beta-Hydroxylase Protein Expression and Function by Phosphorylation in Hepatocellular Carcinoma Cells.
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Journal: Growth Horm IGF Res. 2015 Aug;25(4):174-81.
Title: The Circulating IGF System in Hepatocellular Carcinoma: The Impact of Liver Status and Treatment.
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Title: Caveolin-1 Confers Resistance of Hepatoma Cells to Anoikis by Activating IGF-1 Pathway.
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Title: Down-regulated miR-28-5p in human hepatocellular carcinoma correlated with tumor proliferation and migration by targeting insulin-like growth factor-1 (IGF-1).
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Title: Resistance to multikinase inhibitor actions mediated by insulin like growth factor-1.
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Journal: Chem Biol Interact. 2015 Dec 5;242:107-22.
Title: Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells.
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Journal: Int J Clin Exp Med. 2015 Sep 15;8(9):14906-15. eCollection 2015.
Title: The effects of self-assembling peptide RADA16 hydrogel on malignant phenotype of human hepatocellular carcinoma cell.
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Journal: Bone Res. 2015 Dec 22;3:15033.
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Journal: J Hepatocell Carcinoma. 2015 Sep 18;2:131-42.
Title: Type I insulin-like growth factor as a liver reserve assessment tool in hepatocellular carcinoma.
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Title: Activation of signal transduction pathways during hepatic oncogenesis.
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Journal: Exp Ther Med. 2016 Feb;11(2):607-612.
Title: Prognostic significance of serum insulin-like growth factor-1 in patients with hepatocellular carcinoma following transarterial chemoembolization.
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Journal: PLoS One. 2016 Feb 26;11(2):e0149897.
Title: Inflammation Promotes Expression of Stemness-Related Properties in HBV-Related Hepatocellular Carcinoma.
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Journal: Oncol Rep. 2016 May;35(5):3068-74.
Title: GRK2 overexpression inhibits IGF1-induced proliferation and migration of human hepatocellular carcinoma cells by downregulating EGR1.
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Journal: Dalton Trans. 2016 Apr 21;45(15):6667-73.
Title: Antitumor and biological investigation of doubly cyclometalated ruthenium(II) organometallics derived from benzimidazolyl derivatives.
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Journal: Oncology. 2016;91(2):90-100.
Title: Validation of a Preclinical Model of Diethylnitrosamine-Induced Hepatic Neoplasia in Yucatan Miniature Pigs.
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Journal: Growth Factors. 2016 Aug;34(3-4):128-40.
Title: Contradicting interplay between insulin-like growth factor-1 and miR-486-5p in primary NK cells and hepatoma cell lines with a contemporary inhibitory impact on HCC tumor progression.
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Journal: Biochem Biophys Res Commun. 2016 Sep 16;478(2):964-9.
Title: Insulin-like growth factor-binding protein-3 inhibits IGF-1-induced proliferation of human hepatocellular carcinoma cells by controlling bFGF and PDGF autocrine/paracrine loops.
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Journal: Gastroenterology. 2016 Dec;151(6):1192-1205.
Title: IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models.
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Journal: Tumour Biol. 2016 Nov;37(11):15125-15132.
Title: Insulin-like growth factor-related components and the risk of liver cancer in a nested case-control study.
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Title: Bioinformatic identification of IGF1 as a hub gene in hepatocellular carcinoma (HCC) and in-vitro analysis of the chemosensitizing effect of miR-379 via suppressing the IGF1/IGF1R signaling pathway.
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Journal: Oncotarget. 2017 Jan 10;8(2):3683-3695.
Title: The role of extracellular vesicles in mediating progression, metastasis and potential treatment of hepatocellular carcinoma.
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Journal: PLoS One. 2017 Jan 20;12(1):e0170394.
Title: Validation of a Modified Child-Turcotte-Pugh Classification System Utilizing Insulin-Like Growth Factor-1 for Patients with Hepatocellular Carcinoma in an HBV Endemic Area.
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Journal: Nihon Shokakibyo Gakkai Zasshi. 2017;114(2):256-263.
Title: Production of insulin-like growth factor-II in hepatocellular carcinoma with recurrent hypoglycemia: a case report.
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Journal: Clin Lab. 2017 Feb 1;63(2):261-270.
Title: Serum Insulin-Like Growth Factor-1 (IGF-1): a Novel Prognostic Factor for Early Recurrence of Hepatocellular Carcinoma (HCC).
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Journal: Curr Diab Rep. 2017 Apr;17(4):20.
Title: Type 2 Diabetes and Hepatocellular Carcinoma: Risk Factors and Pathogenesis.
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Journal: Cell Signal. 2017 Jul;35:154-162.
Title: Cell surface GRP78 facilitates hepatoma cells proliferation and migration by activating IGF-IR.
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Journal: Mol Immunol. 2017 Jul;87:132-140.
Title: IL-37 induces autophagy in hepatocellular carcinoma cells by inhibiting the PI3K/AKT/mTOR pathway.
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Journal: Endocrinol Diabetes Metab Case Rep. 2017 May 16;2017. pii: EDM170004.
Title: Pro-IGF2-induced hypoglycaemia associated with hepatocellular carcinoma.
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Title: B lymphocytes repress hepatic tumorigenesis but not development in Hras12V transgenic mice.
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Title: Co-targeting of IGF1R/mTOR pathway by miR-497 and miR-99a impairs hepatocellular carcinoma development.
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Journal: Int J Mol Sci. 2017 Jul 5;18(7). pii: ijms18071447.
Title: The Role of Growth Hormone and Insulin-Like Growth Factor-I in the Liver.
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Title: Classifier of cross talk genes predicts the prognosis of hepatocellular carcinoma.
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Journal: Zhongguo Fei Ai Za Zhi. 2017 Jul 20;20(7):459-467.
Title: [Circular RNA CircHIPK3 Promotes NCI-H1299 and NCI-H2170 Cell Proliferation through miR-379 and its Target IGF1].
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Journal: Growth Factors. 2017 Jun;35(2-3):76-87.
Title: MiR-615-5p depresses natural killer cells cytotoxicity through repressing IGF-1R in hepatocellular carcinoma patients.
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Title: The type I insulin-like growth factor regulates the liver stromal response to metastatic colon carcinoma cells.
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Title: Glypican-3 induces oncogenicity by preventing IGF-1R degradation, a process that can be blocked by Grb10.
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Title: Serum insulin-like growth factor-1 and its binding protein 3 as prognostic factors for the incidence, progression, and outcome of hepatocellular carcinoma: a systematic review and meta-analysis.
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Title: Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP.
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Title: IGF-1 induces the epithelial-mesenchymal transition via Stat5 in hepatocellular carcinoma.
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Journal: Cell Oncol (Dordr). 2018 Jun;41(3):283-296.
Title: Strong enhancement by IGF1-R antagonists of hepatocellular carcinoma cell migration inhibition by Sorafenib and/or vitamin K1.
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Title: MicroRNA-190b regulates lipid metabolism and insulin sensitivity by targeting IGF-1 and ADAMTS9 in non-alcoholic fatty liver disease.
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Journal: J Interferon Cytokine Res. 2018 Apr;38(4):153-160.
Title: Preoperative Serum Insulin-Like Growth Factor 1 Level as a Prognostic Factor in Patients Undergoing Hepatic Resection for Hepatocellular Carcinoma.
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Journal: Int J Mol Sci. 2018 Apr 27;19(5). pii: ijms19051308.
Title: Insulin-Like Growth Factor (IGF) System in Liver Diseases.
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Journal: Exp Ther Med. 2018 May;15(5):4325-4331.
Title: Decreased expression of microRNA-223 promotes cell proliferation in hepatocellular carcinoma cells via the insulin-like growth factor-1 signaling pathway.
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Journal: Exp Cell Res. 2018 Sep 15;370(2):399-408.
Title: Hepatitis B virus suppresses the secretion of insulin-like growth factor binding protein 1 to facilitate anti-apoptotic IGF-1 effects in HepG2 cells.
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Journal: Oncol Rep. 2018 Aug;40(2):952-958.
Title: Insulin-like growth factor-1 induces epithelial-mesenchymal transition in hepatocellular carcinoma by activating survivin.
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Journal: Cancer Manag Res. 2018 Jul 2;10:1817-1826.
Title: Downregulation of lncRNA OGFRP1 inhibits hepatocellular carcinoma progression by AKT/mTOR and Wnt/beta-catenin signaling pathways.
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Journal: BMC Cancer. 2018 Jul 31;18(1):774.
Title: Validation of insulin-like growth factor-1 as a prognostic parameter in patients with hepatocellular carcinoma in a European cohort.
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Journal: J Transl Med. 2018 Aug 9;16(1):220.
Title: A circRNA-miRNA-mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma.
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Journal: Biosci Rep. 2018 Oct 19. pii: BSR20181441.
Title: Bioinformatics identification of crucial genes and pathways associated with hepatocellular carcinoma.
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