Primary Site >> Liver Cancer
Gene >> IGF1
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Demonstration that a human hepatoma cell line produces a specific insulin-like growth factor carrier protein. PMID: 6187761 |
Ref: Radioimmunoassay of serum IGF-I and IGF-II in patients with chronic liver diseases and hepatocellular carcinoma with or without hypoglycemia. PMID: 2460570 Ref: Expression of insulin-like growth factor I (IGF-I) and IGF-II mRNA during hepatic development, proliferation and carcinogenesis in the rat. PMID: 3338103 |
Ref: The insulin-like growth factor binding protein BP-25 is expressed by human breast cancer cells. PMID: 2463838 |
Ref: Cytotoxic activity of a recombinant fusion protein between insulin-like growth factor I and Pseudomonas exotoxin. PMID: 1846308 Ref: Hypoglycemia in hepatocellular carcinoma: failure of short-term growth hormone administration to reduce enhanced glucose requirements. PMID: 1850816 |
Ref: Expression of insulin-like growth factor II (IGF-II) and IGF-II, IGF-I and insulin receptors mRNAs in isolated non-parenchymal rat liver cells. PMID: 1310705 Ref: Primary hepatocellular carcinoma with severe hypoglycemia: involvement of insulin-like growth factors. PMID: 1320177 Ref: Differential tissue regulation of the insulin-like growth factors in rats bearing the MStT/W15 pituitary tumor. PMID: 1369583 |
Ref: Circulating growth hormone and insulin-like growth factor-I in nonalcoholic liver cirrhosis with or without superimposed hepatocarcinoma: evidence of an altered circadian rhythm. PMID: 8213718 Ref: Suramin inhibits growth and yet promotes insulin-like growth factor II expression in HepG2 cells. PMID: 8381048 |
Ref: Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice. PMID: 7514593 |
Ref: Big insulin-like growth factor II-producing hepatocellular carcinoma associated with hypoglycemia. PMID: 8929651 |
Ref: Increased expression of the insulin-like growth factor I (IGF-I) receptor gene in hepatocellular carcinoma cell lines: implications of IGF-I receptor gene activation by hepatitis B virus X gene product. PMID: 8706031 Ref: [Insulin growth factor I (IGF-I) in normal, hyperplastic, and tumor prostatic tissue]. PMID: 8766797 Ref: [Immunotherapy of tumors expressing IGF-I]. PMID: 8881277 Ref: A carboxy-terminal truncated insulin receptor substrate-1 dominant negative protein reverses the human hepatocellular carcinoma malignant phenotype. PMID: 8903330 Ref: Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH). PMID: 21541617 |
Ref: Antisense insulin-like growth factor I transferred into a rat hepatoma cell line inhibits tumorigenesis by modulating major histocompatibility complex I cell surface expression. PMID: 9345599 |
Ref: Induction of apoptosis in rat hepatocarcinoma cells by expression of IGF-I antisense c-DNA. PMID: 9833920 |
Ref: Soluble insulin-like growth factor II/mannose 6-phosphate receptor inhibits DNA synthesis in insulin-like growth factor II sensitive cells. PMID: 10567917 Ref: The expression of insulin-like growth factor binding proteins in human hepatocellular carcinoma. PMID: 10888233 Ref: Hepatocarcinoma cells stimulate hepatocyte growth factor secretion in human liver myofibroblasts. PMID: 10995891 Ref: Induction of hepatic insulin-like growth factor binding protein-1 (IGFBP-1) in rats by dietary n-6 polyunsaturated fatty acids. PMID: 11044255 Ref: Alterations in tumorigenicity of embryonal carcinoma cells by IGF-I triple-helix induced changes in immunogenicity and apoptosis. PMID: 11191646 Ref: Antisense igf-I for hepatocellular carcinoma. PMID: 21341060 |
Ref: IGF-I triple helix strategy in hepatoma treatment. PMID: 11462897 |
Ref: A possible role for insulin-like growth factor-binding protein-3 autocrine/paracrine loops in controlling hepatocellular carcinoma cell proliferation. PMID: 11959812 Ref: Impact of insulin-like growth factor receptor-I function on angiogenesis, growth, and metastasis of colon cancer. PMID: 12379772 Ref: Insulin-like growth factor I is a comitogen for hepatocyte growth factor in a rat model of hepatocellular carcinoma. PMID: 12395318 Ref: Hepatocellular carcinoma in a patient with acromegaly and high serum levels of insulin-like growth factor I: report of a case. PMID: 12444442 Ref: Serum insulin-like growth factor I evaluation as a useful tool for predicting the risk of developing hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis: a prospective study. PMID: 12467068 Ref: Adenovirus-mediated anti insulin-like growth factor I gene transfer for the treatment of hepatocellular carcinoma. PMID: 12553010 |
Ref: [Hypoglycemia associated with the production of insulin-like growth factor (IGF)-II by a hemangiopericytoma]. PMID: 12571793 Ref: Insulin-like growth factor binding protein-1 over-expression in transgenic mice inhibits hepatic preneoplasia. PMID: 12619036 Ref: Ghrelin in chronic liver disease. PMID: 12663236 Ref: Pilot study of elevated levels of insulin-like growth factor-binding protein-2 as indicators of hepatocellular carcinoma. PMID: 14530605 Ref: Increased IGF-I : IGFBP-3 ratio in patients with hepatocellular carcinoma. PMID: 14974910 |
Ref: Development of rainbow trout hepatoma cell lines: effect of pro-IGF-I Ea4-peptide on morphological changes and anchorage-independent growth. PMID: 15311963 Ref: Role of constitutively activated and insulin-like growth factor-stimulated ERK1/2 signaling in human hepatoma cell proliferation and apoptosis: evidence for heterogeneity of tumor cell lines. PMID: 15659801 |
Ref: Body composition and time course changes in regional distribution of fat and lean tissue in unselected cancer patients on palliative care--correlations with food intake, metabolism, exercise capacity, and hormones. PMID: 15822132 Ref: Blockade of paracrine supply of insulin-like growth factors using neutralizing antibodies suppresses the liver metastasis of human colorectal cancers. PMID: 15867252 Ref: Expression of albumin, IGF-1, IGFBP-3 in tumor tissues and adjacent non-tumor tissues of hepatocellular carcinoma patients with cirrhosis. PMID: 16015705 Ref: Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. PMID: 16039586 Ref: Endosomal proteolysis of insulin-like growth factor-I at its C-terminal D-domain by cathepsin B. PMID: 16051222 Ref: Cyclic AMP inhibition of proliferation of hepatocellular carcinoma cells is mediated by Akt. PMID: 16177565 Ref: Steatosis and hepatocellular carcinoma risk. PMID: 16231592 |
Ref: Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells. PMID: 16530734 Ref: Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness. PMID: 16564107 Ref: IGF-1 is downregulated in experimental cancer cachexia. PMID: 16614058 Ref: Possible contribution of serum activin A and IGF-1 in the development of hepatocellular carcinoma in Egyptian patients suffering from combined hepatitis C virus infection and hepatic schistosomiasis. PMID: 16624274 Ref: Increased hepatic expression of insulin-like growth factor-I receptor in chronic hepatitis C. PMID: 16804965 Ref: Impact of biomarkers on disease survival and progression in patients treated with octreotide for advanced hepatocellular carcinoma. PMID: 16835748 Ref: Signaling pathways involved in the inhibition of epidermal growth factor receptor by erlotinib in hepatocellular cancer. PMID: 16937526 Ref: High expression of insulin-like growth factor binding protein-3 is correlated with lower portal invasion and better prognosis in human hepatocellular carcinoma. PMID: 16965600 Ref: Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. PMID: 17030190 Ref: Pleiotropic effects of PI-3' kinase/Akt signaling in human hepatoma cell proliferation and drug-induced apoptosis. PMID: 17384242 |
Ref: Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals. PMID: 17001312 Ref: Doping with growth hormone/IGF-1, anabolic steroids or erythropoietin: is there a cancer risk? PMID: 17349798 Ref: Induction of glutathione transferase in insulin-like growth factor type I receptor-overexpressed hepatoma cells. PMID: 17615245 Ref: Targeting of insulin-like growth factor-I receptor with a monoclonal antibody inhibits growth of hepatic metastases from human colon carcinoma in mice. PMID: 17653802 Ref: Effects of parenteral nutrition without and with growth hormone on growth hormone/insulin-like growth factor-1 axis after hepatectomy in hepatocellular carcinoma with liver cirrhosis. PMID: 17947606 Ref: Effects of parenteral nutrition with and without GH on the GH/IGF-1 axis after hepatectomy in hepatocellular carcinoma with liver cirrhosis. PMID: 24573868 |
Ref: EGCG inhibits activation of the insulin-like growth factor (IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells. PMID: 18164805 Ref: Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression. PMID: 18451161 Ref: Autocrine insulin-like growth factor-II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis. PMID: 18537183 Ref: Transgenic overexpression of insulin receptor substrate 1 in hepatocytes enhances hepatocellular proliferation in young mice only. PMID: 18631251 Ref: [Different expression of liver-specific insulin-like growth factor I gene in breast cancer; expression with mice]. PMID: 18956639 Ref: [Analysis of apoptosis-related gene expression in different serum level of insulin-like growth factor-1 in mice breast cancer tissue]. PMID: 19035207 Ref: Association of elevated IGFBP-1 with increased IGF-II concentration in patients with carcinoma of the liver. PMID: 19199270 |
Ref: Supplementation with branched-chain amino acids inhibits azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice. PMID: 19366832 |
Ref: Identification of a region in the human IRS2 promoter essential for stress induced transcription depending on SP1, NFI binding and ERK activation in HepG2 cells. PMID: 19755487 Ref: Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice. PMID: 19906067 Ref: Muscle atrophy in experimental cancer cachexia: is the IGF-1 signaling pathway involved? PMID: 20039316 Ref: Relationship of insulin-like growth factors system gene polymorphisms with the susceptibility and pathological development of hepatocellular carcinoma. PMID: 20119675 Ref: Differential diagnosis of liver diseases using serum biomarkers. PMID: 20414942 Ref: A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo. PMID: 20515953 Ref: Combination of two insulin-like growth factor-I receptor inhibitory antibodies targeting distinct epitopes leads to an enhanced antitumor response. PMID: 20716637 Ref: Insulin-like growth factors and liver cancer risk in male smokers. PMID: 20717109 |
Ref: Predictive value of serum biomarkers in patients after portal vein embolization (PVE): a pilot study. PMID: 21273621 Ref: Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice. PMID: 21372039 Ref: Long-term ethanol consumption promotes hepatic tumorigenesis but impairs normal hepatocyte proliferation in rats. PMID: 21490289 Ref: A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines. PMID: 21569410 Ref: IGF-1 treatment reduces weight loss and improves outcome in a rat model of cancer cachexia. PMID: 21766056 Ref: I-CLIP: improved stratification of advanced hepatocellular carcinoma patients by integrating plasma IGF-1 into CLIP score. PMID: 21822028 Ref: Serum IGF-1, IGF-2 and IGFBP-3 as parameters in the assessment of liver dysfunction in patients with hepatic cirrhosis and in the diagnosis of hepatocellular carcinoma. PMID: 21830422 Ref: Clinical and prognostic implications of plasma insulin-like growth factor-1 and vascular endothelial growth factor in patients with hepatocellular carcinoma. PMID: 21911725 Ref: Role of Raf Kinase Inhibitor Protein in Hepatocellular Carcinoma. PMID: 21984963 Ref: Male germ cell-specific RNA binding protein RBMY: a new oncogene explaining male predominance in liver cancer. PMID: 22073224 |
Ref: Gefitinib resistance in HCC mahlavu cells: upregulation of CD133 expression, activation of IGF-1R signaling pathway, and enhancement of IGF-1R nuclear translocation. PMID: 21959795 Ref: Lignan transformation by gut bacteria lowers tumor burden in a gnotobiotic rat model of breast cancer. PMID: 22080573 Ref: Serum insulin-like growth factor-1 levels predict outcomes of patients with advanced hepatocellular carcinoma receiving antiangiogenic therapy. PMID: 22623732 Ref: Serum IGFBP-3 is a more effective predictor than IGF-1 and IGF-2 for the development of hepatocellular carcinoma in patients with chronic HCV infection. PMID: 22740980 Ref: The transcription factor c-Jun protects against liver damage following activated beta-Catenin signaling. PMID: 22792392 Ref: Effect of insulin-like growth factor-1 on bone morphogenetic protein-2 expression in hepatic carcinoma SMMC7721 cells through the p38 MAPK signaling pathway. PMID: 22799302 Ref: Human tumor cells induce angiogenesis through positive feedback between CD147 and insulin-like growth factor-I. PMID: 22844419 Ref: Inhibition of hepatocellular carcinoma cell growth by an anti-insulin-like growth factor-I receptor monoclonal antibody. PMID: 22895605 Ref: Development of IGF signaling antibody arrays for the identification of hepatocellular carcinoma biomarkers. PMID: 23071652 Ref: The insulin-like growth factor (IGF) signaling axis and hepatitis C virus-associated carcinogenesis (review). PMID: 23076735 Ref: Alterations of insulin-like growth factor I (IGF-I) and estradiol serum levels in chronic hepatitis C. PMID: 23788886 |
Ref: Effect of occupational exposure to aflatoxins on some liver tumor markers in textile workers. PMID: 23359393 Ref: Efficacy, safety, pharmacokinetics, and biomarkers of cediranib monotherapy in advanced hepatocellular carcinoma: a phase II study. PMID: 23362324 Ref: MuRF-1 and p-GSK3beta expression in muscle atrophy of cirrhosis. PMID: 23432902 Ref: GRK2 negatively regulates IGF-1R signaling pathway and cyclins' expression in HepG2 cells. PMID: 23460259 Ref: Sustained production of a soluble IGF-I receptor by gutless adenovirus-transduced host cells protects from tumor growth in the liver. PMID: 23470563 Ref: Serotonin and the 5-HT7 receptor: the link between hepatocytes, IGF-1 and small intestinal neuroendocrine tumors. PMID: 23578138 Ref: Upregulation of T-cell factor-4 isoform-responsive target genes in hepatocellular carcinoma. PMID: 23651211 Ref: Serum insulin-like growth factor-I level is an independent predictor of recurrence and survival in early hepatocellular carcinoma: a prospective cohort study. PMID: 23757355 Ref: The insulin-like growth factor-1 and expression of its binding protein3 in chronic hepatitis C and hepatocellular carcinoma. PMID: 23784592 Ref: Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1. PMID: 23958494 Ref: The insulin-like growth factor-I receptor inhibitor picropodophyllin-induced selective apoptosis of hepatocellular carcinoma cell through a caspase-dependent mitochondrial pathway. PMID: 24406046 Ref: Differential expression of insulin-like growth factor 1 in human primary liver cancer. PMID: 24511663 Ref: [Igf-1 and its isoform expression in hepatic cell tumors and the surrounding tissue in mice liver carcinogenesis induced by diethylnitrozamine]. PMID: 25518553 |
Ref: Prediagnostic plasma testosterone, sex hormone-binding globulin, IGF-I and hepatocellular carcinoma: etiological factors or risk markers? PMID: 23801371 Ref: Clinical significance of serum circulating insulin-like growth factor-1 (IGF-1) mRNA in hepatocellular carcinoma. PMID: 24272080 Ref: Reductions in serum IGF-1 during aging impair health span. PMID: 24341939 Ref: Alterations in hepatic miRNA expression during negative energy balance in postpartum dairy cattle. PMID: 24428929 Ref: Management of endocrine disease: a clinical update on tumor-induced hypoglycemia. PMID: 24459236 Ref: Biochemical/metabolic changes associated with hepatocellular carcinoma development in mice. PMID: 24523022 Ref: Up-regulation of microRNA-190b plays a role for decreased IGF-1 that induces insulin resistance in human hepatocellular carcinoma. PMID: 24586785 Ref: Serum insulin-like growth factor-1 predicts disease progression and survival in patients with hepatocellular carcinoma who undergo transarterial chemoembolization. PMID: 24595361 Ref: Dairy products and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition. PMID: 24615266 Ref: Maintenance of stemness in oxaliplatin-resistant hepatocellular carcinoma is associated with increased autocrine of IGF1. PMID: 24632571 Ref: Association of IGF1R polymorphisms with the development of HBV-related hepatocellular carcinoma. PMID: 24758241 Ref: Antagonism of sorafenib and regorafenib actions by platelet factors in hepatocellular carcinoma cell lines. PMID: 24885890 Ref: An inducible hepatocellular carcinoma model for preclinical evaluation of antiangiogenic therapy in adult mice. PMID: 24906623 Ref: Expression levels of insulin-like growth factors and receptors in hepatocellular carcinoma: a retrospective study. PMID: 25052889 Ref: GSK3 protein positively regulates type I insulin-like growth factor receptor through forkhead transcription factors FOXO1/3/4. PMID: 25053419 Ref: The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets. PMID: 25225571 |
Ref: Identifying hepatocellular carcinoma-related genes and pathways by system biology analysis. PMID: 24744259 Ref: Anatomical Liver Resections Guided by 3-Dimensional Parenchymal Staining Using Fusion Indocyanine Green Fluorescence Imaging. PMID: 24887978 Ref: Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis. PMID: 25179284 Ref: Mechanistic and biological significance of DNA methyltransferase 1 upregulated by growth factors in human hepatocellular carcinoma. PMID: 25420499 Ref: PDCD5 transfection increases cisplatin sensitivity and decreases invasion in hepatic cancer cells. PMID: 25436001 Ref: Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion. PMID: 25463538 Ref: Activation of IL6/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression. PMID: 25564572 Ref: Effect of hypoxia on hypoxia inducible factor-1alpha, insulin-like growth factor I and vascular endothelial growth factor expression in hepatocellular carcinoma HepG2 cells. PMID: 25663870 Ref: Predictive value of serum insulin-like growth factor-1 in hepatocellular carcinoma. PMID: 25684496 Ref: Gene expression analysis for evaluation of potential biomarkers in hepatocellular carcinoma. PMID: 25862856 Ref: Study of the effects of cyclooxygenase-2 inhibitor on the promotion of hepatic tumorigenesis in rats fed a high fat diet. PMID: 25941430 Ref: Daintain/AIF-1 accelerates the activation of insulin-like growth factor-1 receptor signaling pathway in HepG2 cells. PMID: 25998745 Ref: Regulation of Aspartyl-(Asparaginyl)-beta-Hydroxylase Protein Expression and Function by Phosphorylation in Hepatocellular Carcinoma Cells. PMID: 26029741 Ref: The Circulating IGF System in Hepatocellular Carcinoma: The Impact of Liver Status and Treatment. PMID: 26068014 Ref: Caveolin-1 Confers Resistance of Hepatoma Cells to Anoikis by Activating IGF-1 Pathway. PMID: 26138883 Ref: Down-regulated miR-28-5p in human hepatocellular carcinoma correlated with tumor proliferation and migration by targeting insulin-like growth factor-1 (IGF-1). PMID: 26160280 Ref: Resistance to multikinase inhibitor actions mediated by insulin like growth factor-1. PMID: 26329608 Ref: Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. PMID: 26409325 Ref: The effects of self-assembling peptide RADA16 hydrogel on malignant phenotype of human hepatocellular carcinoma cell. PMID: 26628972 Ref: MicroRNA-26a inhibits osteosarcoma cell proliferation by targeting IGF-1. PMID: 27468358 Ref: Type I insulin-like growth factor as a liver reserve assessment tool in hepatocellular carcinoma. PMID: 27508202 |
Ref: Activation of signal transduction pathways during hepatic oncogenesis. PMID: 26433160 Ref: MicroRNA-122 confers sorafenib resistance to hepatocellular carcinoma cells by targeting IGF-1R to regulate RAS/RAF/ERK signaling pathways. PMID: 26655273 Ref: Prognostic significance of serum insulin-like growth factor-1 in patients with hepatocellular carcinoma following transarterial chemoembolization. PMID: 26893654 Ref: Inflammation Promotes Expression of Stemness-Related Properties in HBV-Related Hepatocellular Carcinoma. PMID: 26919045 Ref: GRK2 overexpression inhibits IGF1-induced proliferation and migration of human hepatocellular carcinoma cells by downregulating EGR1. PMID: 26936374 Ref: Antitumor and biological investigation of doubly cyclometalated ruthenium(II) organometallics derived from benzimidazolyl derivatives. PMID: 26974823 Ref: Validation of a Preclinical Model of Diethylnitrosamine-Induced Hepatic Neoplasia in Yucatan Miniature Pigs. PMID: 27305144 Ref: Contradicting interplay between insulin-like growth factor-1 and miR-486-5p in primary NK cells and hepatoma cell lines with a contemporary inhibitory impact on HCC tumor progression. PMID: 27388576 Ref: Insulin-like growth factor-binding protein-3 inhibits IGF-1-induced proliferation of human hepatocellular carcinoma cells by controlling bFGF and PDGF autocrine/paracrine loops. PMID: 27521890 Ref: IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models. PMID: 27614046 Ref: Insulin-like growth factor-related components and the risk of liver cancer in a nested case-control study. PMID: 27662841 Ref: Bioinformatic identification of IGF1 as a hub gene in hepatocellular carcinoma (HCC) and in-vitro analysis of the chemosensitizing effect of miR-379 via suppressing the IGF1/IGF1R signaling pathway. PMID: 28051262 |
Ref: The role of extracellular vesicles in mediating progression, metastasis and potential treatment of hepatocellular carcinoma. PMID: 27713136 Ref: Validation of a Modified Child-Turcotte-Pugh Classification System Utilizing Insulin-Like Growth Factor-1 for Patients with Hepatocellular Carcinoma in an HBV Endemic Area. PMID: 28107416 Ref: Production of insulin-like growth factor-II in hepatocellular carcinoma with recurrent hypoglycemia: a case report. PMID: 28163291 Ref: Serum Insulin-Like Growth Factor-1 (IGF-1): a Novel Prognostic Factor for Early Recurrence of Hepatocellular Carcinoma (HCC). PMID: 28182337 Ref: Type 2 Diabetes and Hepatocellular Carcinoma: Risk Factors and Pathogenesis. PMID: 28290049 Ref: Cell surface GRP78 facilitates hepatoma cells proliferation and migration by activating IGF-IR. PMID: 28389416 Ref: IL-37 induces autophagy in hepatocellular carcinoma cells by inhibiting the PI3K/AKT/mTOR pathway. PMID: 28433890 Ref: Pro-IGF2-induced hypoglycaemia associated with hepatocellular carcinoma. PMID: 28567293 Ref: B lymphocytes repress hepatic tumorigenesis but not development in Hras12V transgenic mice. PMID: 28580661 Ref: Co-targeting of IGF1R/mTOR pathway by miR-497 and miR-99a impairs hepatocellular carcinoma development. PMID: 28624790 Ref: The Role of Growth Hormone and Insulin-Like Growth Factor-I in the Liver. PMID: 28678199 Ref: Classifier of cross talk genes predicts the prognosis of hepatocellular carcinoma. PMID: 28713927 Ref: [Circular RNA CircHIPK3 Promotes NCI-H1299 and NCI-H2170 Cell Proliferation through miR-379 and its Target IGF1]. PMID: 28738961 Ref: MiR-615-5p depresses natural killer cells cytotoxicity through repressing IGF-1R in hepatocellular carcinoma patients. PMID: 28747084 Ref: The type I insulin-like growth factor regulates the liver stromal response to metastatic colon carcinoma cells. PMID: 28881729 Ref: Glypican-3 induces oncogenicity by preventing IGF-1R degradation, a process that can be blocked by Grb10. PMID: 29113314 Ref: Serum insulin-like growth factor-1 and its binding protein 3 as prognostic factors for the incidence, progression, and outcome of hepatocellular carcinoma: a systematic review and meta-analysis. PMID: 29113370 Ref: Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP. PMID: 29137221 Ref: IGF-1 induces the epithelial-mesenchymal transition via Stat5 in hepatocellular carcinoma. PMID: 29340101 |
Ref: Strong enhancement by IGF1-R antagonists of hepatocellular carcinoma cell migration inhibition by Sorafenib and/or vitamin K1. PMID: 29470830 Ref: MicroRNA-190b regulates lipid metabolism and insulin sensitivity by targeting IGF-1 and ADAMTS9 in non-alcoholic fatty liver disease. PMID: 29575055 Ref: Preoperative Serum Insulin-Like Growth Factor 1 Level as a Prognostic Factor in Patients Undergoing Hepatic Resection for Hepatocellular Carcinoma. PMID: 29638204 Ref: Insulin-Like Growth Factor (IGF) System in Liver Diseases. PMID: 29702590 Ref: Decreased expression of microRNA-223 promotes cell proliferation in hepatocellular carcinoma cells via the insulin-like growth factor-1 signaling pathway. PMID: 29725374 Ref: Hepatitis B virus suppresses the secretion of insulin-like growth factor binding protein 1 to facilitate anti-apoptotic IGF-1 effects in HepG2 cells. PMID: 29981339 Ref: Insulin-like growth factor-1 induces epithelial-mesenchymal transition in hepatocellular carcinoma by activating survivin. PMID: 29989646 Ref: Downregulation of lncRNA OGFRP1 inhibits hepatocellular carcinoma progression by AKT/mTOR and Wnt/beta-catenin signaling pathways. PMID: 29997441 Ref: Validation of insulin-like growth factor-1 as a prognostic parameter in patients with hepatocellular carcinoma in a European cohort. PMID: 30064393 Ref: A circRNA-miRNA-mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma. PMID: 30092792 Ref: Bioinformatics identification of crucial genes and pathways associated with hepatocellular carcinoma. PMID: 30341252 |