Primary Site >> Pancreatic Cancer

Gene >> HSPA5

Journal: Cancer Lett. 1998 Jan 9;122(1-2):209-14.
Title: Identification of a neutrophil gelatinase-associated lipocalin mRNA in human pancreatic cancers using a modified signal sequence trap method.
Author: Furutani, M|Arii, S|Mizumoto, M|Kato, M|Imamura, M
PMID: 9464512
Journal: J Biol Chem. 2005 Apr 22;280(16):16508-13. Epub 2005 Mar 8.
Title: Induction of endoplasmic reticulum-induced stress genes in Panc-1 pancreatic cancer cells is dependent on Sp proteins.
Author: Abdelrahim, Maen|Liu, Shengxi|Safe, Stephen
PMID: 15760841
Journal: Cancer Res. 2005 Dec 15;65(24):11510-9.
Title: Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells.
Author: Nawrocki, Steffan T|Carew, Jennifer S|Dunner, Kenneth Jr|Boise, Lawrence H|Chiao, Paul J|Huang, Peng|Abbruzzese, James L|McConkey, David J
PMID: 16357160
Journal: Pancreas. 2008 Jan;36(1):e7-14.
Title: Down-regulation of molecular chaperone 78-kd glucose-regulated protein/immunoglobulin-binding protein expression involved in enhancement of human RS cell mutability.
Author: Hirano, Junko|Kita, Kazuko|Sugaya, Shigeru|Ichimura, Yoshinobu|Yamamori, Hideo|Nakajima, Nobuyuki|Suzuki, Nobuo
PMID: 18192872
Journal: J Clin Pathol. 2009 Sep;62(9):802-7.
Title: Proteomic characterisation of pancreatic islet beta-cells stimulated with pancreatic carcinoma cell conditioned medium.
Author: Song, G|Cui, Y|Zhong, N|Han, J
PMID: 19403515
Journal: Mol Pharmacol. 2009 Aug;76(2):327-41.
Title: BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing.
Author: Martin, Aditi Pandya|Park, Margaret A|Mitchell, Clint|Walker, Teneille|Rahmani, Mohamed|Thorburn, Andrew|Haussinger, Dieter|Reinehr, Roland|Grant, Steven|Dent, Paul
PMID: 19483105
Journal: J Proteome Res. 2009 Oct;8(10):4876-84.
Title: MALDI-ion mobility separation-mass spectrometry imaging of glucose-regulated protein 78 kDa (Grp78) in human formalin-fixed, paraffin-embedded pancreatic adenocarcinoma tissue sections.
Author: Djidja, Marie-Claude|Claude, Emmanuelle|Snel, Marten F|Scriven, Peter|Francese, Simona|Carolan, Vikki|Clench, Malcolm R
PMID: 19673544
Journal: Biosci Biotechnol Biochem. 2009 Oct;73(10):2167-71.
Title: Selective cytotoxicity of Ponciri Fructus against glucose-deprived PANC-1 human pancreatic cancer cells via blocking activation of GRP78.
Author: Cha, Mi-Ran|Yoon, Mi-young|Son, Eun-Soon|Park, Hae-Ryong
PMID: 19809193
Journal: J Biol Chem. 2010 Apr 2;285(14):10678-89.
Title: Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein.
Author: Venkataramani, Vivek|Rossner, Christian|Iffland, Lara|Schweyer, Stefan|Tamboli, Irfan Y|Walter, Jochen|Wirths, Oliver|Bayer, Thomas A
PMID: 20145244
Journal: Cancer Chemother Pharmacol. 2011 Apr;67(4):899-910.
Title: 2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion.
Author: Xi, Haibin|Kurtoglu, Metin|Liu, Huaping|Wangpaichitr, Medhi|You, Min|Liu, Xiongfei|Savaraj, Niramol|Lampidis, Theodore J
PMID: 20593179
Journal: Mol Cancer Ther. 2012 Oct;11(10):2127-37.
Title: Cell intrinsic role of COX-2 in pancreatic cancer development.
Author: Hill, Reginald|Li, Yunfeng|Tran, Linh M|Dry, Sarah|Calvopina, Joseph Hargan|Garcia, Alejandro|Kim, Christine|Wang, Ying|Donahue, Timothy R|Herschman, Harvey R|Wu, Hong
PMID: 22784710
Journal: Evid Based Complement Alternat Med. 2013;2013:629750.
Title: Involvement of endoplasmic reticulum stress in capsaicin-induced apoptosis of human pancreatic cancer cells.
Author: Lin, Shengzhang|Zhang, Jianhong|Chen, Hui|Chen, Kangjie|Lai, Fuji|Luo, Jiang|Wang, Zhaohong|Bu, Heqi|Zhang, Riyuan|Li, Honghai|Tong, Hongfei
PMID: 23781265
Journal: J Korean Surg Soc. 2013 Dec;85(6):249-60.
Title: Effect of quercetin on apoptosis of PANC-1 cells.
Author: Lee, Joo Hyun|Lee, Han-Beom|Jung, Gum O|Oh, Jung Taek|Park, Dong Eun|Chae, Kwon Mook
PMID: 24368982
Journal: Biochim Biophys Acta. 2013 Dec;1833(12):2856-65.
Title: Calix[6]arene bypasses human pancreatic cancer aggressiveness: downregulation of receptor tyrosine kinases and induction of cell death by reticulum stress and autophagy.
Author: Pelizzaro-Rocha, Karin Juliane|de Jesus, Marcelo Bispo|Ruela-de-Sousa, Roberta Regina|Nakamura, Celso Vataru|Reis, Fabiano Souza|de Fatima, Angelo|Ferreira-Halder, Carmen Verissima
PMID: 23872419
Journal: Curr Mol Med. 2013 May;13(4):467-78.
Title: MicroRNA-34b inhibits pancreatic cancer metastasis through repressing Smad3.
Author: Liu, C|Cheng, H|Shi, S|Cui, X|Yang, J|Chen, L|Cen, P|Cai, X|Lu, Y|Wu, C|Yao, W|Qin, Y|Liu, L|Long, J|Xu, J|Li, M|Yu, X
PMID: 23305226
Journal: Curr Mol Med. 2014 Jan;14(1):125-40.
Title: Chemoprevention gene therapy (CGT) of pancreatic cancer using perillyl alcohol and a novel chimeric serotype cancer terminator virus.
Author: Sarkar, S|Azab, B|Quinn, B A|Shen, X|Dent, P|Klibanov, A L|Emdad, L|Das, S K|Sarkar, D|Fisher, P B
PMID: 24236457
Journal: Mol Cancer Res. 2014 Apr;12(4):527-538.
Title: The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells.
Author: Lee, Syng-Ook|Jin, Un-Ho|Kang, Jeong Han|Kim, Sang Bae|Guthrie, Aaron S|Sreevalsan, Sandeep|Lee, Ju-Seog|Safe, Stephen
PMID: 24515801
Journal: Am J Physiol Gastrointest Liver Physiol. 2014 Jun 1;306(11):G1011-20.
Title: Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells.
Author: Mujumdar, Nameeta|Banerjee, Sulagna|Chen, Zhiyu|Sangwan, Veena|Chugh, Rohit|Dudeja, Vikas|Yamamoto, Masato|Vickers, Selwyn M|Saluja, Ashok K
PMID: 24699326
Journal: Mol Cell Proteomics. 2014 Oct;13(10):2593-603.
Title: Proteomic analysis of solid pseudopapillary tumor of the pancreas reveals dysfunction of the endoplasmic reticulum protein processing pathway.
Author: Zhu, Yi|Xu, Hong|Chen, Hao|Xie, Junjie|Shi, Minmin|Shen, Baiyong|Deng, Xiaxing|Liu, Chao|Zhan, Xi|Peng, Chenghong
PMID: 24997997
Journal: World J Gastroenterol. 2014 Jul 28;20(28):9229-36.
Title: Androgen receptor signaling in hepatocellular carcinoma and pancreatic cancers.
Author: Kanda, Tatsuo|Jiang, Xia|Yokosuka, Osamu
PMID: 25071315
Journal: Oncol Rep. 2014 Dec;32(6):2343-8.
Title: Knockdown of glucose-regulated protein 78 enhances poly(ADP-ribose) polymerase cleavage in human pancreatic cancer cells exposed to endoplasmic reticulum stress.
Author: Jiang, Xia|Kanda, Tatsuo|Nakamoto, Shingo|Haga, Yuki|Sasaki, Reina|Nakamura, Masato|Wu, Shuang|Mikata, Rintaro|Yokosuka, Osamu
PMID: 25333575
Journal: J Nucl Med. 2015 Jun;56(6):908-13.
Title: Small-Animal PET Imaging of Pancreatic Cancer Xenografts Using a 64Cu-Labeled Monoclonal Antibody, MAb159.
Author: Wang, Hui|Li, Dan|Liu, Shuanglong|Liu, Ren|Yuan, Hong|Krasnoperov, Valery|Shan, Hong|Conti, Peter S|Gill, Parkash S|Li, Zibo
PMID: 25908833
Journal: Sci Rep. 2015 Nov 4;5:16067.
Title: Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer.
Author: Niu, Zheyu|Wang, Mengyi|Zhou, Li|Yao, Lutian|Liao, Quan|Zhao, Yupei
PMID: 26530532
Journal: Exp Cell Res. 2015 Dec 10;339(2):397-406.
Title: Exocrine pancreas ER stress is differentially induced by different fatty acids.
Author: Danino, Hila|Ben-Dror, Karin|Birk, Ruth
PMID: 26433148
Journal: BMC Cancer. 2015 Jul 10;15:513.
Title: The combination of intravenous Reolysin and gemcitabine induces reovirus replication and endoplasmic reticular stress in a patient with KRAS-activated pancreatic cancer.
Author: Mahalingam, Devalingam|Patel, Sukeshi|Nuovo, Gerard|Gill, George|Selvaggi, Giovanni|Coffey, Matt|Nawrocki, Steffan T
PMID: 26156229
Journal: Cancer Genomics Proteomics. 2015 Mar-Apr;12(2):49-55.
Title: Isolation of a growth factor stress-induced pancreatic cancer sub-population: insight into changes due to micro-environment.
Author: Baron, Byron|Kitagawa, Takao|Nakamura, Kazuyuki|Kuramitsu, Yasuhiro
PMID: 25770187
Journal: Mol Cell Biochem. 2015 Jan;398(1-2):55-62.
Title: GRP78 promotes the invasion of pancreatic cancer cells by FAK and JNK.
Author: Yuan, X P|Dong, Ming|Li, Xin|Zhou, J P
PMID: 25218495
Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2015 Jun;37(3):259-63.
Title: Changes in the Expression of Glucose-regulated Protein 78 in the Occurrence and Progression of Pancreatic Cancer in Mouse Models.
Author: Niu, Zhe-Yu|Liu, Qiao-Fei|Wang, Meng-Yi|Zhou, Li|Yao, Lu-Tian|Liao, Quan|Zhao, Yu-Pei
PMID: 26149133
Journal: Environ Toxicol. 2016 Aug;31(8):957-69.
Title: Crude extract of Rheum palmatum L. Induces cell cycle arrest S phase and apoptosis through mitochondrial-dependent pathways in U-2 OS human osteosarcoma cells.
Author: Lin, Chin-Chung|Lee, Ming-Huei|Lin, Ju-Hwa|Lin, Meng-Liang|Chueh, Fu-Shin|Yu, Chien-Chih|Lin, Jing-Pin|Chou, Yu-Cheng|Hsu, Shu-Chun|Chung, Jing-Gung
PMID: 25689151
Journal: Medicine (Baltimore). 2016 Jan;95(2):e2509.
Title: The Immunohistochemical Evaluation of Solid Pseudopapillary Tumors of the Pancreas and Pancreatic Neuroendocrine Tumors Reveals ERO1Lbeta as a New Biomarker.
Author: Xie, Junjie|Zhu, Yi|Chen, Hao|Shi, Minmin|Gu, Jiangning|Zhang, Jiaqiang|Shen, Baiyong|Deng, Xiaxing|Zhan, Xi|Peng, Chenghong
PMID: 26765469
Journal: Mol Cell Biochem. 2016 Apr;415(1-2):119-31.
Title: Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell.
Author: Morais, Katia L P|Pacheco, Mario Thiego Fernandes|Berra, Carolina Maria|Bosch, Rosemary V|Sciani, Juliana Mozer|Chammas, Roger|de Freitas Saito, Renata|Iqbal, Asif|Chudzinski-Tavassi, Ana Marisa
PMID: 27015684
Journal: Oncotarget. 2016 Dec 13;7(50):83641-83656.
Title: Bisdemethoxycurcumin exerts pro-apoptotic effects in human pancreatic adenocarcinoma cells through mitochondrial dysfunction and a GRP78-dependent pathway.
Author: Yang, Haopeng|Fan, Shengjun|An, Yu|Wang, Xin|Pan, Yan|Xiaokaiti, Yilixiati|Duan, Jianhui|Li, Xin|Tie, Lu|Ye, Min|Li, Xuejun
PMID: 27845899
Journal: Int J Mol Sci. 2017 Oct 7;18(10). pii: ijms18102105.
Title: Achiral Mannich-Base Curcumin Analogs Induce Unfolded Protein Response and Mitochondrial Membrane Depolarization in PANC-1 Cells.
Author: Szebeni, Gabor J|Balazs, Arpad|Madarasz, Ildiko|Pocz, Gabor|Ayaydin, Ferhan|Kanizsai, Ivan|Fajka-Boja, Roberta|Alfoldi, Robert|Hackler, Laszlo Jr|Puskas, Laszlo G
PMID: 28991167
Journal: Mol Clin Oncol. 2017 Dec;7(6):991-999.
Title: dTCApFs, a derivative of a novel human hormone peptide, induces apoptosis in cancer cells through a mechanism involving loss of Golgi function.
Author: Ohana, Joel|Sandler, Uziel|Kass, Gideon|Stemmer, Salomon M|Devary, Yoram
PMID: 29285362
Journal: Oncol Lett. 2017 Dec;14(6):6395-6402.
Title: Identification of molecular mechanisms of glutamine in pancreatic cancer.
Author: Jia, Zhen-Yi|Shen, Tong-Yi|Jiang, Wei|Qin, Huan-Long
PMID: 29163679
Journal: Oncotarget. 2017 Sep 12;8(47):81776-81793.
Title: Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP.
Author: Lev, Avital|Lulla, Amriti R|Wagner, Jessica|Ralff, Marie D|Kiehl, Joshua B|Zhou, Yan|Benes, Cyril H|Prabhu, Varun V|Oster, Wolfgang|Astsaturov, Igor|Dicker, David T|El-Deiry, Wafik S
PMID: 29137221
Journal: PLoS One. 2017 Aug 30;12(8):e0184110.
Title: Gemcitabine treatment induces endoplasmic reticular (ER) stress and subsequently upregulates urokinase plasminogen activator (uPA) to block mitochondrial-dependent apoptosis in Panc-1 cancer stem-like cells (CSCs).
Author: Wang, Li|Zhang, Yi|Wang, Weiguo|Zhu, Yunjie|Chen, Yang|Tian, Bole
PMID: 28854261
Journal: Tumour Biol. 2017 Jun;39(6):1010428317705517.
Title: Penfluridol induces endoplasmic reticulum stress leading to autophagy in pancreatic cancer.
Author: Ranjan, Alok|German, Nadezhda|Mikelis, Constantinos|Srivenugopal, Kalkunte|Srivastava, Sanjay K
PMID: 28618969
Journal: Sci Rep. 2017 May 8;7(1):1564.
Title: Inhibition of Sp1 prevents ER homeostasis and causes cell death by lysosomal membrane permeabilization in pancreatic cancer.
Author: Dauer, Patricia|Gupta, Vineet K|McGinn, Olivia|Nomura, Alice|Sharma, Nikita S|Arora, Nivedita|Giri, Bhuwan|Dudeja, Vikas|Saluja, Ashok K|Banerjee, Sulagna
PMID: 28484232
Journal: Oncogene. 2017 Jun 1;36(22):3094-3103.
Title: ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation.
Author: Dumartin, L|Alrawashdeh, W|Trabulo, S M|Radon, T P|Steiger, K|Feakins, R M|di Magliano, M P|Heeschen, C|Esposito, I|Lemoine, N R|Crnogorac-Jurcevic, T
PMID: 27941872
Journal: Cancer Sci. 2018 Feb;109(2):373-383.
Title: PRDM14 directly interacts with heat shock proteins HSP90alpha and glucose-regulated protein 78.
Author: Moriya, Chiharu|Taniguchi, Hiroaki|Nagatoishi, Satoru|Igarashi, Hisayoshi|Tsumoto, Kouhei|Imai, Kohzoh
PMID: 29178343
Journal: J Med Chem. 2018 Feb 22;61(4):1576-1594.
Title: Design and Synthesis of Novel Reactive Oxygen Species Inducers for the Treatment of Pancreatic Ductal Adenocarcinoma.
Author: Kuang, Yuting|Sechi, Mario|Nurra, Salvatore|Ljungman, Mats|Neamati, Nouri
PMID: 29328656
Journal: Mol Clin Oncol. 2018 Jan;8(1):22-29.
Title: A phase I clinical trial of dTCApFs, a derivative of a novel human hormone peptide, for the treatment of advanced/metastatic solid tumors.
Author: Stemmer, Salomon M|Benjaminov, Ofer|Silverman, Michael H|Sandler, Uziel|Purim, Ofer|Sender, Naomi|Meir, Chen|Oren-Apoteker, Pnina|Ohana, Joel|Devary, Yoram
PMID: 29423221
Journal: Mol Oncol. 2018 Sep;12(9):1498-1512.
Title: GRP78-mediated antioxidant response and ABC transporter activity confers chemoresistance to pancreatic cancer cells.
Author: Dauer, Patricia|Sharma, Nikita S|Gupta, Vineet K|Nomura, Alice|Dudeja, Vikas|Saluja, Ashok|Banerjee, Sulagna
PMID: 29738634
Journal: Biochem Biophys Res Commun. 2018 Jun 27;501(3):668-673.
Title: 2-Deoxy-d-glucose increases GFAT1 phosphorylation resulting in endoplasmic reticulum-related apoptosis via disruption of protein N-glycosylation in pancreatic cancer cells.
Author: Ishino, Kousuke|Kudo, Mitsuhiro|Peng, Wei-Xia|Kure, Shoko|Kawahara, Kiyoko|Teduka, Kiyoshi|Kawamoto, Yoko|Kitamura, Taeko|Fujii, Takenori|Yamamoto, Tetsushi|Wada, Ryuichi|Naito, Zenya
PMID: 29753740
Journal: In Vivo. 2018 Jul-Aug;32(4):759-763.
Title: Enzyme-treated Asparagus Extract Down-regulates Heat Shock Protein 27 of Pancreatic Cancer Cells.
Author: Shimada, Takuya|Nanimoto, Yuta|Baron, Byron|Kitagawa, Takao|Tokuda, Kazuhiro|Kuramitsu, Yasuhiro
PMID: 29936456
Journal: J Transl Med. 2018 Jul 9;16(1):190.
Title: Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer.
Author: Thakur, Prakash C|Miller-Ocuin, Jennifer L|Nguyen, Khanh|Matsuda, Rina|Singhi, Aatur D|Zeh, Herbert J|Bahary, Nathan
PMID: 29986726