Primary Site >> Pancreatic Cancer
Gene >> HSPA5
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Ref: Identification of a neutrophil gelatinase-associated lipocalin mRNA in human pancreatic cancers using a modified signal sequence trap method. PMID: 9464512 |
Ref: Induction of endoplasmic reticulum-induced stress genes in Panc-1 pancreatic cancer cells is dependent on Sp proteins. PMID: 15760841 Ref: Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells. PMID: 16357160 |
Ref: Down-regulation of molecular chaperone 78-kd glucose-regulated protein/immunoglobulin-binding protein expression involved in enhancement of human RS cell mutability. PMID: 18192872 |
Ref: Proteomic characterisation of pancreatic islet beta-cells stimulated with pancreatic carcinoma cell conditioned medium. PMID: 19403515 Ref: BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing. PMID: 19483105 Ref: MALDI-ion mobility separation-mass spectrometry imaging of glucose-regulated protein 78 kDa (Grp78) in human formalin-fixed, paraffin-embedded pancreatic adenocarcinoma tissue sections. PMID: 19673544 Ref: Selective cytotoxicity of Ponciri Fructus against glucose-deprived PANC-1 human pancreatic cancer cells via blocking activation of GRP78. PMID: 19809193 |
Ref: Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein. PMID: 20145244 |
Ref: 2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion. PMID: 20593179 |
Ref: Cell intrinsic role of COX-2 in pancreatic cancer development. PMID: 22784710 |
Ref: MicroRNA-34b inhibits pancreatic cancer metastasis through repressing Smad3. PMID: 23305226 Ref: Involvement of endoplasmic reticulum stress in capsaicin-induced apoptosis of human pancreatic cancer cells. PMID: 23781265 Ref: Calix[6]arene bypasses human pancreatic cancer aggressiveness: downregulation of receptor tyrosine kinases and induction of cell death by reticulum stress and autophagy. PMID: 23872419 Ref: Effect of quercetin on apoptosis of PANC-1 cells. PMID: 24368982 |
Ref: Chemoprevention gene therapy (CGT) of pancreatic cancer using perillyl alcohol and a novel chimeric serotype cancer terminator virus. PMID: 24236457 Ref: The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. PMID: 24515801 Ref: Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells. PMID: 24699326 Ref: Proteomic analysis of solid pseudopapillary tumor of the pancreas reveals dysfunction of the endoplasmic reticulum protein processing pathway. PMID: 24997997 Ref: Androgen receptor signaling in hepatocellular carcinoma and pancreatic cancers. PMID: 25071315 Ref: Knockdown of glucose-regulated protein 78 enhances poly(ADP-ribose) polymerase cleavage in human pancreatic cancer cells exposed to endoplasmic reticulum stress. PMID: 25333575 |
Ref: GRP78 promotes the invasion of pancreatic cancer cells by FAK and JNK. PMID: 25218495 Ref: Isolation of a growth factor stress-induced pancreatic cancer sub-population: insight into changes due to micro-environment. PMID: 25770187 Ref: Small-Animal PET Imaging of Pancreatic Cancer Xenografts Using a 64Cu-Labeled Monoclonal Antibody, MAb159. PMID: 25908833 Ref: Changes in the Expression of Glucose-regulated Protein 78 in the Occurrence and Progression of Pancreatic Cancer in Mouse Models. PMID: 26149133 Ref: The combination of intravenous Reolysin and gemcitabine induces reovirus replication and endoplasmic reticular stress in a patient with KRAS-activated pancreatic cancer. PMID: 26156229 Ref: Exocrine pancreas ER stress is differentially induced by different fatty acids. PMID: 26433148 Ref: Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer. PMID: 26530532 |
Ref: Crude extract of Rheum palmatum L. Induces cell cycle arrest S phase and apoptosis through mitochondrial-dependent pathways in U-2 OS human osteosarcoma cells. PMID: 25689151 Ref: The Immunohistochemical Evaluation of Solid Pseudopapillary Tumors of the Pancreas and Pancreatic Neuroendocrine Tumors Reveals ERO1Lbeta as a New Biomarker. PMID: 26765469 Ref: Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell. PMID: 27015684 Ref: Bisdemethoxycurcumin exerts pro-apoptotic effects in human pancreatic adenocarcinoma cells through mitochondrial dysfunction and a GRP78-dependent pathway. PMID: 27845899 |
Ref: ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation. PMID: 27941872 Ref: Inhibition of Sp1 prevents ER homeostasis and causes cell death by lysosomal membrane permeabilization in pancreatic cancer. PMID: 28484232 Ref: Penfluridol induces endoplasmic reticulum stress leading to autophagy in pancreatic cancer. PMID: 28618969 Ref: Gemcitabine treatment induces endoplasmic reticular (ER) stress and subsequently upregulates urokinase plasminogen activator (uPA) to block mitochondrial-dependent apoptosis in Panc-1 cancer stem-like cells (CSCs). PMID: 28854261 Ref: Achiral Mannich-Base Curcumin Analogs Induce Unfolded Protein Response and Mitochondrial Membrane Depolarization in PANC-1 Cells. PMID: 28991167 Ref: Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP. PMID: 29137221 Ref: Identification of molecular mechanisms of glutamine in pancreatic cancer. PMID: 29163679 Ref: dTCApFs, a derivative of a novel human hormone peptide, induces apoptosis in cancer cells through a mechanism involving loss of Golgi function. PMID: 29285362 |
Ref: PRDM14 directly interacts with heat shock proteins HSP90alpha and glucose-regulated protein 78. PMID: 29178343 Ref: Design and Synthesis of Novel Reactive Oxygen Species Inducers for the Treatment of Pancreatic Ductal Adenocarcinoma. PMID: 29328656 Ref: A phase I clinical trial of dTCApFs, a derivative of a novel human hormone peptide, for the treatment of advanced/metastatic solid tumors. PMID: 29423221 Ref: GRP78-mediated antioxidant response and ABC transporter activity confers chemoresistance to pancreatic cancer cells. PMID: 29738634 Ref: 2-Deoxy-d-glucose increases GFAT1 phosphorylation resulting in endoplasmic reticulum-related apoptosis via disruption of protein N-glycosylation in pancreatic cancer cells. PMID: 29753740 Ref: Enzyme-treated Asparagus Extract Down-regulates Heat Shock Protein 27 of Pancreatic Cancer Cells. PMID: 29936456 Ref: Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer. PMID: 29986726 |