Primary Site >> Stomach Cancer

Gene >> HSPA5

Journal: Cancer Res. 2001 Nov 15;61(22):8322-30.
Title: Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade.
Author: Song, M S|Park, Y K|Lee, J H|Park, K
PMID: 11719466
Journal: Mol Med. 2002 May;8(5):273-82.
Title: Trefoil factor 1 (TFF1/pS2) deficiency activates the unfolded protein response.
Author: Torres, Luis-Fernando|Karam, Sherif M|Wendling, Corinne|Chenard, Marie-Pierre|Kershenobich, David|Tomasetto, Catherine|Rio, Marie-Christine
PMID: 12359958
Journal: J Natl Cancer Inst. 2004 Sep 1;96(17):1300-10.
Title: Effect on tumor cells of blocking survival response to glucose deprivation.
Author: Park, Hae-Ryong|Tomida, Akihiro|Sato, Shigeo|Tsukumo, Yoshinori|Yun, Jisoo|Yamori, Takao|Hayakawa, Yoichi|Tsuruo, Takashi|Shin-ya, Kazuo
PMID: 15339968
Journal: Oncogene. 2006 Feb 16;25(7):1018-29.
Title: Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cells.
Author: Tsutsumi, S|Namba, T|Tanaka, K-I|Arai, Y|Ishihara, T|Aburaya, M|Mima, S|Hoshino, T|Mizushima, T
PMID: 16205636
Journal: Clin Exp Metastasis. 2006;23(7-8):401-10. Epub 2006 Dec 23.
Title: Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer.
Author: Zhang, Jun|Jiang, Yixing|Jia, Zhiliang|Li, Qiang|Gong, Weida|Wang, Liwei|Wei, Daoyan|Yao, James|Fang, Shengyun|Xie, Keping
PMID: 17187227
Journal: PLoS One. 2007 Oct 31;2(10):e1096.
Title: Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth.
Author: Sheu, Meei Ling|Liu, Shing Hwa|Lan, Keng Hsin
PMID: 17971859
Journal: Lab Invest. 2008 Apr;88(4):375-86.
Title: A new tumor-specific variant of GRP78 as target for antibody-based therapy.
Author: Rauschert, Nicole|Brandlein, Stephanie|Holzinger, Elisabeth|Hensel, Frank|Muller-Hermelink, Hans-Konrad|Vollmers, H Peter
PMID: 18268478
Journal: Hum Pathol. 2008 Jul;39(7):1042-9.
Title: Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas.
Author: Zheng, Hua-chuan|Takahashi, Hiroyuki|Li, Xiao-han|Hara, Takuo|Masuda, Shinji|Guan, Yi-fu|Takano, Yasuo
PMID: 18482745
Journal: J Antibiot (Tokyo). 2008 Jun;61(6):365-71.
Title: Efrapeptin J, a new down-regulator of the molecular chaperone GRP78 from a marine Tolypocladium sp.
Author: Hayakawa, Yoichi|Hattori, Yuki|Kawasaki, Takashi|Kanoh, Kaneo|Adachi, Kyoko|Shizuri, Yoshikazu|Shin-ya, Kazuo
PMID: 18667784
Journal: Cancer Lett. 2009 Feb 8;274(1):40-6.
Title: Inhibition of MEK blocks GRP78 up-regulation and enhances apoptosis induced by ER stress in gastric cancer cells.
Author: Zhang, Lin Jie|Chen, Si|Wu, Pin|Hu, Chun Song|Thorne, Rick F|Luo, Chang Ming|Hersey, Peter|Zhang, Xu Dong
PMID: 18829155
Journal: J Gastrointest Surg. 2009 Jun;13(6):1044-51.
Title: Effectiveness of HSV-tk suicide gene therapy driven by the Grp78 stress-inducible promoter in esophagogastric junction and gastric adenocarcinomas.
Author: Azatian, Armen|Yu, Hong|Dai, Wande|Schneiders, Fiona I|Botelho, Natalia K|Lord, Reginald V N
PMID: 19277794
Journal: Cancer Lett. 2010 Oct 1;296(1):123-31.
Title: Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells.
Author: Huang, Xiaoli|Zhang, Zhihong|Jia, Li|Zhao, Yan|Zhang, Xuguang|Wu, Kun
PMID: 20435408
Journal: Oncol Rep. 2010 Apr;23(4):949-56.
Title: Proteomics-based identification of a tumor-associated antigen and its corresponding autoantibody in gastric cancer.
Author: Tsunemi, Soichiro|Nakanishi, Toyofumi|Fujita, Yoshihisa|Bouras, George|Miyamoto, Yoshiharu|Miyamoto, Akiko|Nomura, Eiji|Takubo, Takayuki|Tanigawa, Nobuhiko
PMID: 20204278
Journal: Histol Histopathol. 2010 Apr;25(4):445-52.
Title: The pathobiological behaviors and prognosis associated with Japanese gastric adenocarcinomas of pure WHO histological subtypes.
Author: Zheng, Hua-chuan|Zheng, Yu-shuang|Xia, Pu|Xu, Xiao-yan|Xing, Ya-nan|Takahashi, Hiroyuki|Guan, Yi-fu|Takano, Yasuo
PMID: 20183797
Journal: BMC Cancer. 2010 Jan 19;10:20.
Title: Grp78 promotes the invasion of hepatocellular carcinoma.
Author: Su, Rongjian|Li, Zhen|Li, Hongdan|Song, Huijuan|Bao, Cuifen|Wei, Jia|Cheng, Liufang
PMID: 20082722
Journal: Int J Oncol. 2011 Feb;38(2):375-83.
Title: Proteomics-based identification of a group of apoptosis-related proteins and biomarkers in gastric cancer.
Author: Bai, Zhigang|Ye, Yingjiang|Liang, Bin|Xu, Feng|Zhang, Hui|Zhang, Yanbin|Peng, Jiarou|Shen, Danhua|Cui, Zhirong|Zhang, Zhongtao|Wang, Shan
PMID: 21165559
Journal: Hepatogastroenterology. 2012 Nov-Dec;59(120):2377-84.
Title: Endoplasmic reticulum stress-mediated signaling pathway of gastric cancer apoptosis.
Author: Xu, Yu-Ying|You, Yan-Wen|Ren, Xiu-Hua|Ding, Yi|Cao, Jing|Zang, Wei-Dong|Feng, Ruo|Zhang, Qin-Xian
PMID: 22688017
Journal: Proteomics. 2012 Aug;12(15-16):2584-97.
Title: Targeting to overexpressed glucose-regulated protein 78 in gastric cancer discovered by 2D DIGE improves the diagnostic and therapeutic efficacy of micelles-mediated system.
Author: Cheng, Chun-Chia|Lu, Norman|Peng, Cheng-Liang|Chang, Chun-Chao|Mai, Fu-Der|Chen, Ling-Yun|Liao, Mei-Hsiu|Wang, Wen-Ming|Chang, Jungshan
PMID: 22778057
Journal: Br J Nutr. 2013 Feb 28;109(4):727-35.
Title: Crosstalk between endoplasmic reticulum stress and oxidative stress in apoptosis induced by alpha-tocopheryl succinate in human gastric carcinoma cells.
Author: Huang, Xiaoli|Li, Li|Zhang, Linyou|Zhang, Zhihong|Wang, Xiaolin|Zhang, Xuguang|Hou, Liying|Wu, Kun
PMID: 22676837
Journal: Lab Invest. 2013 Jan;93(1):112-22.
Title: The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner.
Author: Baird, Mhairi|Woon Ang, Pei|Clark, Ian|Bishop, Danial|Oshima, Masanobu|Cook, Matthew C|Hemmings, Christine|Takeishi, Shigeo|Worthley, Dan|Boussioutas, Alex|Wang, Timothy C|Taupin, Doug
PMID: 23108377
Journal: Int J Nanomedicine. 2013;8:1385-91.
Title: Novel targeted nuclear imaging agent for gastric cancer diagnosis: glucose-regulated protein 78 binding peptide-guided 111In-labeled polymeric micelles.
Author: Cheng, Chun-Chia|Huang, Chiung-Fang|Ho, Ai-Sheng|Peng, Cheng-Liang|Chang, Chun-Chao|Mai, Fu-Der|Chen, Ling-Yun|Luo, Tsai-Yueh|Chang, Jungshan
PMID: 23630420
Journal: Cancer Lett. 2013 Oct 10;339(2):247-59.
Title: A peptide derived from phage display library exhibits anti-tumor activity by targeting GRP78 in gastric cancer multidrug resistance cells.
Author: Kang, Jianqin|Zhao, Guohong|Lin, Tao|Tang, Shanhong|Xu, Guanghui|Hu, Sijun|Bi, Qian|Guo, Changcun|Sun, Li|Han, Shuang|Xu, Qian|Nie, Yongzhan|Wang, Biaoluo|Liang, Shuhui|Ding, Jie|Wu, Kaichun
PMID: 23792224
Journal: PLoS One. 2013 Nov 15;8(11):e81702.
Title: Mycophenolic acid inhibits migration and invasion of gastric cancer cells via multiple molecular pathways.
Author: Dun, Boying|Sharma, Ashok|Teng, Yong|Liu, Haitao|Purohit, Sharad|Xu, Heng|Zeng, Lingwen|She, Jin-Xiong
PMID: 24260584
Journal: Zhonghua Zhong Liu Za Zhi. 2013 Nov;35(11):837-42.
Title: [GRP78 expression in gastric cancer and its clinical significance].
Author: Yang, Lei|Yang, Shu-yun|Ji, Jian-mei|Cao, Yong-feng|Ji, Cong-fei|Ji, Jin-feng|Xu, Wei-wei|Wang, Jian-hong
PMID: 24447482
Journal: Int J Mol Med. 2014 Dec;34(6):1661-8.
Title: Tanshinone IIA inhibits human gastric carcinoma AGS cell growth by decreasing BiP, TCTP, Mcl1 and BclxL and increasing Bax and CHOP protein expression.
Author: Su, Chin-Cheng
PMID: 25270224
Journal: PLoS One. 2014 Jan 3;9(1):e84158.
Title: Discovery of tumor markers for gastric cancer by proteomics.
Author: Wu, Jeng-Yih|Cheng, Chun-Chia|Wang, Jaw-Yuan|Wu, Deng-Chyang|Hsieh, Jan-Sing|Lee, Shui-Cheng|Wang, Wen-Ming
PMID: 24404153
Journal: Arch Pharm Res. 2014 Jun;37(6):783-92.
Title: Ultrafine particles of Ulmus davidiana var. japonica induce apoptosis of gastric cancer cells via activation of caspase and endoplasmic reticulum stress.
Author: Ahn, Joungjwa|Lee, Jong Suk|Yang, Kyung Mi
PMID: 24395528
Journal: Exp Mol Pathol. 2014 Apr;96(2):235-41.
Title: Expression of GRP78 predicts taxane-based therapeutic resistance and recurrence of human gastric cancer.
Author: Yang, Lei|Yang, Shuyun|Liu, Jibin|Wang, Xiaolin|Ji, Jianmei|Cao, Yongfeng|Lu, Kun|Wang, Jianhong|Gao, Yong
PMID: 24602846
Journal: Oncol Lett. 2015 Mar;9(3):1181-1186.
Title: Decreased functional expression of Grp78 and Grp94 inhibits proliferation and attenuates apoptosis in a human gastric cancer cell line in vitro.
Author: Zhang, Xinchen|Zhang, Liying|Wang, Shu|Wu, Dequan|Yang, Weiliang
PMID: 25663878
Journal: BMC Cancer. 2015 May 6;15:358.
Title: Mechanism study of peptide GMBP1 and its receptor GRP78 in modulating gastric cancer MDR by iTRAQ-based proteomic analysis.
Author: Wang, Xiaojuan|Li, Yani|Xu, Guanghui|Liu, Muhan|Xue, Lin|Liu, Lijuan|Hu, Sijun|Zhang, Ying|Nie, Yongzhan|Liang, Shuhui|Wang, Biaoluo|Ding, Jie
PMID: 25943993
Journal: Oncotarget. 2015 Aug 14;6(23):19552-79.
Title: ING5 suppresses proliferation, apoptosis, migration and invasion, and induces autophagy and differentiation of gastric cancer cells: a good marker for carcinogenesis and subsequent progression.
Author: Gou, Wen-feng|Shen, Dao-fu|Yang, Xue-feng|Zhao, Shuang|Liu, Yun-peng|Sun, Hong-zhi|Su, Rong-Jian|Luo, Jun-sheng|Zheng, Hua-chuan
PMID: 25980581
Journal: Cancer Res. 2015 Aug 1;75(15):3087-97.
Title: KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78.
Author: Kang, Jin Muk|Park, Sujin|Kim, Staci Jakyong|Kim, Hyojung|Lee, Bona|Kim, Junil|Park, Jinah|Kim, Shin Tae|Yang, Han-Kwang|Kim, Woo Ho|Kim, Seong-Jin
PMID: 26045166
Journal: Oncotarget. 2015 Aug 14;6(23):19685-705.
Title: BTG1 expression correlates with pathogenesis, aggressive behaviors and prognosis of gastric cancer: a potential target for gene therapy.
Author: Zheng, Hua-chuan|Li, Jing|Shen, Dao-fu|Yang, Xue-feng|Zhao, Shuang|Wu, Ya-zhou|Takano, Yasuo|Sun, Hong-zhi|Su, Rong-jian|Luo, Jun-sheng|Gou, Wen-feng
PMID: 26050197
Journal: Oncol Lett. 2015 May;9(5):2393-2397.
Title: 3,3'-diindolylmethane potentiates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of gastric cancer cells.
Author: Ye, Yang|Miao, Shuhan|Wang, Yan|Zhou, Jianwei|Lu, Rongzhu
PMID: 26137077
Journal: Biochem Pharmacol. 2016 Mar 15;104:8-18.
Title: Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis.
Author: Zhang, Bin|Han, Hongyan|Fu, Shilong|Yang, Ping|Gu, Zhenlun|Zhou, Quansheng|Cao, Zhifei
PMID: 26774454
Journal: Nutr Cancer. 2016;68(2):267-79.
Title: Grifola frondosa Glycoprotein GFG-3a Arrests S phase, Alters Proteome, and Induces Apoptosis in Human Gastric Cancer Cells.
Author: Cui, Fengjie|Zan, Xinyi|Li, Yunhong|Sun, Wenjing|Yang, Yan|Ping, Lifeng
PMID: 27040446
Journal: Am J Cancer Res. 2016 May 1;6(5):924-36. eCollection 2016.
Title: Recombinant Newcastle disease virus (rL-RVG) triggers autophagy and apoptosis in gastric carcinoma cells by inducing ER stress.
Author: Bu, Xuefeng|Zhao, Yinghai|Zhang, Zhijian|Wang, Mubin|Li, Mi|Yan, Yulan
PMID: 27293989
Journal: Molecules. 2016 Jul 14;21(7). pii: molecules21070914.
Title: Nobiletin Induces Protective Autophagy Accompanied by ER-Stress Mediated Apoptosis in Human Gastric Cancer SNU-16 Cells.
Author: Moon, Jeong Yong|Cho, Somi Kim
PMID: 27428937
Journal: Mol Carcinog. 2017 Jan;56(1):218-231.
Title: E platinum, a newly synthesized platinum compound, induces apoptosis through ROS-triggered ER stress in gastric carcinoma cells.
Author: Wang, Xiaoping|Guo, Qinglong|Tao, Lei|Zhao, Li|Chen, Yan|An, Teng|Chen, Zhen|Fu, Rong
PMID: 27061377
Journal: Cell Death Dis. 2017 Oct 26;8(10):e3144.
Title: Plasminogen kringle 5 suppresses gastric cancer via regulating HIF-1alpha and GRP78.
Author: Fang, Shuhuan|Hong, Honghai|Li, Lei|He, Dan|Xu, Zumin|Zuo, Shaoyuan|Han, Jing|Wu, Qiyuan|Dai, Zhiyu|Cai, Weibin|Ma, Jianxing|Shao, Chunkui|Gao, Guoquan|Yang, Xia
PMID: 29072683
Journal: Oncotarget. 2017 Aug 18;8(42):73017-73028.
Title: The meta and bioinformatics analysis of GRP78 expression in gastric cancer.
Author: Zheng, Hua-Chuan|Gong, Bao-Cheng|Zhao, Shuang
PMID: 29069845
Journal: Mol Med Rep. 2017 Dec;16(6):8329-8334.
Title: GRP78 positively regulates estrogenstimulated cell growth mediated by ERalpha36 in gastric cancer cells.
Author: Fu, Zhengqi|Wang, Xuming|Zhou, Hongyan|Li, Yan|Chen, Ying|Wang, Zhaoyi|Liu, Lijiang
PMID: 28983626
Journal: Cancer Biomark. 2017 Sep 7;20(3):273-281.
Title: Prognostic role of BiP/GRP78 expression as ER stress in patients with gastric adenocarcinoma.
Author: Ogawa, Hiroomi|Kaira, Kyoichi|Takahashi, Kengo|Shimizu, Akira|Altan, Bolag|Yoshinari, Daisuke|Asao, Takayuki|Oyama, Tetsunari
PMID: 28854502
Journal: Cancer Res. 2017 Apr 15;77(8):1968-1982.
Title: Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation.
Author: Qian, Yun|Wong, Chi Chun|Xu, Jiaying|Chen, Huarong|Zhang, Yanquan|Kang, Wei|Wang, Hua|Zhang, Li|Li, Weilin|Chu, Eagle S H|Go, Minnie Y Y|Chiu, Philip W Y|Ng, Enders K W|Chan, Francis K L|Sung, Joseph J Y|Si, Jianmin|Yu, Jun
PMID: 28202509
Journal: Oncol Res. 2017 May 24;25(5):799-808.
Title: Oxysterol-Binding Protein-Related Protein 8 Inhibits Gastric Cancer Growth Through Induction of ER Stress, Inhibition of Wnt Signaling, and Activation of Apoptosis.
Author: Guo, Xiaohe|Zhang, Lanfang|Fan, Yingying|Zhang, Dezhong|Qin, Lei|Dong, Shuping|Li, Guangyan
PMID: 27983927
Journal: Oncol Lett. 2018 May;15(5):6087-6093.
Title: Endoplasmic reticulum chaperone glucose-regulated protein 78 in gastric cancer: An emerging biomarker.
Author: Wang, Yan|Wang, Jian-Hong|Zhang, Xun-Lei|Wang, Xiao-Li|Yang, Lei
PMID: 29616092
Journal: J Cell Biochem. 2018 Aug;119(8):6723-6731.
Title: Hyperbaric oxygen treatment sensitizes gastric cancer cells to melatonin-induced apoptosis through multiple pathways.
Author: Wei, Xiang|Qi, Yinliang|Jia, Ning|Zhou, Qing|Zhang, Sumei|Wang, Yuan
PMID: 29665051
Journal: Oncol Lett. 2018 Jun;15(6):10031-10036.
Title: Estrogen receptor-alpha36-mediated rapid estrogen signaling regulates 78 kDa glucose-regulated protein expression in gastric carcinoma cells.
Author: Fu, Zhengqi|Wang, Xuming|Wang, Zhaoyi|Liu, Lijiang
PMID: 29805694
Journal: Nutr Cancer. 2018 Oct 1:1-13.
Title: Induction of ER Stress-Mediated Apoptosis by the Major Component 5,7,4'-Trimethoxyflavone Isolated from Kaempferia parviflora Tea Infusion.
Author: Kim, Hyeonji|Moon, Jeong Yong|Burapan, Supawadee|Han, Jaehong|Cho, Somi Kim
PMID: 30273054
Journal: Cell Death Dis. 2018 Oct 19;9(11):1070.
Title: MicroRNA-495-3p inhibits multidrug resistance by modulating autophagy through GRP78/mTOR axis in gastric cancer.
Author: Chen, Sheng|Wu, Jian|Jiao, Kai|Wu, Qiong|Ma, Jiaojiao|Chen, Di|Kang, Jianqin|Zhao, Guodong|Shi, Yongquan|Fan, Daiming|Zhao, Guohong
PMID: 30341283