Primary Site >> Pancreatic Cancer

Gene >> HSP90AA1

Journal: J Exp Clin Cancer Res. 2000 Sep;19(3):329-34.
Title: Induction and membrane expression of heat shock proteins in heat-treated HPC-4 cells is correlated with increased resistance to LAK-mediated lysis.
Author: Vendetti, S|Cicconi, R|Piselli, P|Vismara, D|Cassol, M|Delpino, A
PMID: 11144526
Journal: J Nippon Med Sch. 2000 Jun;67(3):177-85.
Title: Overexpression and localization of heat shock proteins mRNA in pancreatic carcinoma.
Author: Ogata, M|Naito, Z|Tanaka, S|Moriyama, Y|Asano, G
PMID: 10851351
Journal: Clin Cancer Res. 2007 Nov 1;13(21):6459-68.
Title: Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotop
Author: Lang, Sven A|Moser, Christian|Gaumann, Andreas|Klein, Dagmar|Glockzin, Gabriel|Popp, Felix C|Dahlke, Marc H|Piso, Pompiliu|Schlitt, Hans J|Geissler, Edward K|Stoeltzing, Oliver
PMID: 17975158
Journal: Mol Carcinog. 2007 Jun;46(6):466-75.
Title: Potentiation of chemotherapeutics by the Hsp90 antagonist geldanamycin requires a steady serum condition.
Author: Burkitt, Michael|Magee, Conor|O'Connor, David|Campbell, Fiona|Cornford, Philip|Greenhalf, William
PMID: 17219417
Journal: Clin Cancer Res. 2008 Mar 15;14(6):1831-9.
Title: Synergistic antipancreatic tumor effect by simultaneously targeting hypoxic cancer cells with HSP90 inhibitor and glycolysis inhibitor.
Author: Cao, Xianhua|Bloomston, Mark|Zhang, Tao|Frankel, Wendy L|Jia, Guang|Wang, Bing|Hall, Nathan C|Koch, Regina M|Cheng, Hao|Knopp, Michael V|Sun, Duxin
PMID: 18347186
Journal: Mol Cancer Ther. 2008 Oct;7(10):3275-84.
Title: Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer.
Author: Song, Dongweon|Chaerkady, Raghothama|Tan, Aik Choon|Garcia-Garcia, Elena|Nalli, Anuradha|Suarez-Gauthier, Ana|Lopez-Rios, Fernando|Zhang, Xian Feng|Solomon, Anna|Tong, Jeffrey|Read, Margaret|Fritz, Christian|Jimeno, Antonio|Pandey, Akhilesh|Hidalgo, Manue
PMID: 18852131
Journal: Clin Cancer Res. 2008 Oct 15;14(20):6663-73.
Title: Phase I pharmacokinetic and pharmacodynamic study of LAQ824, a hydroxamate histone deacetylase inhibitor with a heat shock protein-90 inhibitory profile, in patients with advanced solid tumors.
Author: de Bono, Johann S|Kristeleit, Rebecca|Tolcher, Anthony|Fong, Peter|Pacey, Simon|Karavasilis, Vasilios|Mita, Monica|Shaw, Heather|Workman, Paul|Kaye, Stan|Rowinsky, Eric K|Aherne, Wynne|Atadja, Peter|Scott, Jeffrey W|Patnaik, Amita
PMID: 18927309
Journal: Biochem Pharmacol. 2010 Feb 15;79(4):542-51.
Title: Withaferin A targets heat shock protein 90 in pancreatic cancer cells.
Author: Yu, Yanke|Hamza, Adel|Zhang, Tao|Gu, Mancang|Zou, Peng|Newman, Bryan|Li, Yanyan|Gunatilaka, A A Leslie|Zhan, Chang-Guo|Sun, Duxin
PMID: 19769945
Journal: Oncol Rep. 2010 Jun;23(6):1709-14.
Title: HSP90 inhibitors induce desensitization of EGF receptor via p38 MAPK-mediated phosphorylation at Ser1046/1047 in human pancreatic cancer cells.
Author: Adachi, Seiji|Yasuda, Ichiro|Nakashima, Masanori|Yamauchi, Takahiro|Yamauchi, Junichi|Natsume, Hideo|Moriwaki, Hisataka|Kozawa, Osamu
PMID: 20428829
Journal: Mol Pharm. 2010 Oct 4;7(5):1576-84.
Title: MEK inhibition potentiates the activity of Hsp90 inhibitor 17-AAG against pancreatic cancer cells.
Author: Zhang, Tao|Li, Yanyan|Zhu, Zhenkun|Gu, Mancang|Newman, Bryan|Sun, Duxin
PMID: 20669973
Journal: J Mol Med (Berl). 2010 Dec;88(12):1243-53.
Title: Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.
Author: Yadav, Vivek R|Sung, Bokyung|Prasad, Sahdeo|Kannappan, Ramaswamy|Cho, Sung-Gook|Liu, Mingyao|Chaturvedi, Madan M|Aggarwal, Bharat B
PMID: 20798912
Journal: BMC Cancer. 2010 Dec 3;10:668.
Title: Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition.
Author: Hackl, Christina|Lang, Sven A|Moser, Christian|Mori, Akira|Fichtner-Feigl, Stefan|Hellerbrand, Claus|Dietmeier, Wolfgang|Schlitt, Hans J|Geissler, Edward K|Stoeltzing, Oliver
PMID: 21129190
Journal: J Transl Med. 2011 Jan 14;9:8.
Title: Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent.
Author: Horibe, Tomohisa|Kohno, Masayuki|Haramoto, Mari|Ohara, Koji|Kawakami, Koji
PMID: 21235734
Journal: Proteomics. 2011 Dec;11(24):4638-47.
Title: Concomitant inhibition of HSP90, its mitochondrial localized homologue TRAP1 and HSP27 by green tea in pancreatic cancer HPAF-II cells.
Author: Zhang, Lifeng|Pang, Eric|Loo, Rachel R Ogorzalek|Rao, Jianyu|Go, Vay-Liang W|Loo, Joseph A|Lu, Qing-Yi
PMID: 22116673
Journal: Bioorg Med Chem. 2011 Dec 1;19(23):7151-7.
Title: Targeting pancreatic cancer with a G-quadruplex ligand.
Author: Gunaratnam, Mekala|de la Fuente, Maria|Hampel, Sonja M|Todd, Alan K|Reszka, Anthony P|Schatzlein, Andreas|Neidle, Stephen
PMID: 22041170
Journal: Nutr Cancer. 2011;63(7):1151-9.
Title: Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function.
Author: Li, Yanyan|Zhang, Tao|Schwartz, Steven J|Sun, Duxin
PMID: 21875325
Journal: Cancer Lett. 2011 Jul 28;306(2):180-9.
Title: RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation.
Author: Walsh, Naomi|Larkin, AnneMarie|Swan, Niall|Conlon, Kevin|Dowling, Paul|McDermott, Ray|Clynes, Martin
PMID: 21470770
Journal: J Pharmacol Exp Ther. 2011 Mar;336(3):874-80.
Title: Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells.
Author: Siegel, David|Shieh, Biehuoy|Yan, Chao|Kepa, Jadwiga K|Ross, David
PMID: 21156818
Journal: J Surg Res. 2012 Jul;176(1):147-53.
Title: Multiple kinase pathways involved in the different de novo sensitivity of pancreatic cancer cell lines to 17-AAG.
Author: Liu, Heping|Zhang, Ti|Chen, Rong|McConkey, David J|Ward, John F|Curley, Steven A
PMID: 22099584
Journal: Anticancer Res. 2012 Feb;32(2):427-37.
Title: Oncogenic MST1R activity in pancreatic and gastric cancer represents a valid target of HSP90 inhibitors.
Author: Moser, Christian|Lang, Sven A|Hackl, Christina|Zhang, Hong|Lundgren, Karen|Hong, Victor|McKenzie, Andres|Weber, Bernhard|Park, Jung S|Schlitt, Hans J|Geissler, Edward K|Jung, Young D|Stoeltzing, Oliver
PMID: 22287729
Journal: Anticancer Res. 2012 Jul;32(7):2551-61.
Title: Targeting HSP90 by the novel inhibitor NVP-AUY922 reduces growth and angiogenesis of pancreatic cancer.
Author: Moser, Christian|Lang, Sven A|Hackl, Christina|Wagner, Christine|Scheiffert, Eva|Schlitt, Hans J|Geissler, Edward K|Stoeltzing, Oliver
PMID: 22753713
Journal: Hum Mol Genet. 2012 Nov 1;21(21):4615-27.
Title: Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells.
Author: Giessrigl, Benedikt|Krieger, Sigurd|Rosner, Margit|Huttary, Nicole|Saiko, Philipp|Alami, Mouad|Messaoudi, Samir|Peyrat, Jean-Francois|Maciuk, Alexandre|Gollinger, Michaela|Kopf, Sabine|Kazlauskas, Egidijus|Mazal, Peter|Szekeres, Thomas|Hengstschlager, Mar
PMID: 22843495
Journal: Cancer Gene Ther. 2013 Dec;20(12):663-70.
Title: Heat-shock protein 90 inhibitors synergistically enhance melanoma differentiation-associated gene-7-mediated cell killing of human pancreatic carcinoma.
Author: Zhang, Z|Kawamura, K|Jiang, Y|Shingyoji, M|Ma, G|Li, Q|Hu, J|Qi, Y|Liu, H|Zhang, F|Kang, S|Shan, B|Wang, S|Chada, S|Tagawa, M
PMID: 24263157
Journal: Radiat Oncol. 2013 Feb 28;8:42.
Title: Increased radiosensitivity and radiothermosensitivity of human pancreatic MIA PaCa-2 and U251 glioblastoma cell lines treated with the novel Hsp90 inhibitor NVP-HSP990.
Author: Milanovic, Dusan|Firat, Elke|Grosu, Anca Ligia|Niedermann, Gabriele
PMID: 23448094
Journal: Pancreas. 2013 Apr;42(3):411-21.
Title: Molecular markers for novel therapeutic strategies in pancreatic endocrine tumors.
Author: Gilbert, Judith A|Adhikari, Laura J|Lloyd, Ricardo V|Halfdanarson, Thorvardur R|Muders, Michael H|Ames, Matthew M
PMID: 23211371
Journal: PLoS One. 2013;8(2):e57508.
Title: InterAKTions with FKBPs--mutational and pharmacological exploration.
Author: Fabian, Anne-Katrin|Marz, Andreas|Neimanis, Sonja|Biondi, Ricardo M|Kozany, Christian|Hausch, Felix
PMID: 23469007
Journal: Invest New Drugs. 2014 Feb;32(1):68-74.
Title: Structure-activity relationship (SAR) of withanolides to inhibit Hsp90 for its activity in pancreatic cancer cells.
Author: Gu, Mancang|Yu, Yanke|Gunaherath, G M Kamal B|Gunatilaka, A A Leslie|Li, Dapeng|Sun, Duxin
PMID: 23887853
Journal: Histol Histopathol. 2014 Apr;29(4):423-31.
Title: Melatonin influences pancreatic cancerogenesis.
Author: Jaworek, Jolanta|Leja-Szpak, Anna
PMID: 24258787
Journal: JOP. 2014 Mar 10;15(2):110-3.
Title: Novel agents for the treatment of pancreatic cancer.
Author: Brennan, Gregory T|Relias, Valerie|Saif, Muhammad Wasif
PMID: 24618430
Journal: Int J Biochem Cell Biol. 2014 Aug;53:224-36.
Title: Use of herbal medicines and natural products: an alternative approach to overcoming the apoptotic resistance of pancreatic cancer.
Author: Li, Lin|Leung, Po Sing
PMID: 24875648
Journal: Curr Cancer Drug Targets. 2014;14(7):671-83.
Title: Antiproliferative effect of HSP90 inhibitor Y306zh against pancreatic cancer is mediated by interruption of AKT and MAPK signaling pathways.
Author: Xue, Nina|Jin, Jing|Liu, Di|Yan, Rui|Zhang, Sen|Yu, Xiaoming|Chen, Xiaoguang
PMID: 25219422
Journal: Cancer Lett. 2015 Feb 28;357(2):557-65.
Title: Antiangiogenic effects of a novel synthetic curcumin analogue in pancreatic cancer.
Author: Nagaraju, Ganji Purnachandra|Zhu, Shijun|Ko, Jasmine E|Ashritha, Nakkana|Kandimalla, Ramesh|Snyder, James P|Shoji, Mamoru|El-Rayes, Bassel F
PMID: 25497868
Journal: Gan To Kagaku Ryoho. 2015 Feb;42(2):154-8.
Title: [Treatment with carbon-ion radiotherapy and its combinations -- basic biological studies and investigations at the National Institute of Radiological Sciences].
Author: Imai, Takashi
PMID: 25743134
Journal: Invest New Drugs. 2015 Aug;33(4):963-8.
Title: Phase II trial of gemcitabine and tanespimycin (17AAG) in metastatic pancreatic cancer: a Mayo Clinic Phase II Consortium study.
Author: Pedersen, Katrina S|Kim, George P|Foster, Nathan R|Wang-Gillam, Andrea|Erlichman, Charles|McWilliams, Robert R
PMID: 25952464
Journal: Int J Biol Macromol. 2015 Sep;80:253-9.
Title: Molecular docking study, synthesis and biological evaluation of Mannich bases as Hsp90 inhibitors.
Author: Gupta, Sayan Dutta|Bommaka, Manish Kumar|Mazaira, Gisela I|Galigniana, Mario D|Subrahmanyam, Chavali Venkata Satya|Gowrishankar, Naryanasamy Lachmana|Raghavendra, Nulgumnalli Manjunathaiah
PMID: 26116388
Journal: Eur J Cancer. 2016 Jan;52:109-19.
Title: Targeting the Janus-activated kinase-2-STAT3 signalling pathway in pancreatic cancer using the HSP90 inhibitor ganetespib.
Author: Nagaraju, Ganji Purnachandra|Mezina, Anya|Shaib, Walid L|Landry, Jerome|El-Rayes, Bassel F
PMID: 26682870
Journal: Pathologe. 2016 Nov;37(Suppl 2):191-195.
Title: [Pancreatic acinar neoplasms : Comparative molecular characterization].
Author: Bergmann, F
PMID: 27807633
Journal: Int J Pharm. 2016 Sep 10;511(1):648-658.
Title: Dual mode of cancer cell destruction for pancreatic cancer therapy using Hsp90 inhibitor loaded polymeric nano magnetic formulation.
Author: Rochani, Ankit K|Balasubramanian, Sivakumar|Ravindran Girija, Aswathy|Raveendran, Sreejith|Borah, Ankita|Nagaoka, Yutaka|Nakajima, Yoshikata|Maekawa, Toru|Kumar, D Sakthi
PMID: 27469073
Journal: Cancer Chemother Pharmacol. 2016 Sep;78(3):541-5.
Title: A phase II study of the HSP90 inhibitor AUY922 in chemotherapy refractory advanced pancreatic cancer.
Author: Renouf, D J|Hedley, D|Krzyzanowska, M K|Schmuck, M|Wang, L|Moore, M J
PMID: 27422303
Journal: Oncotarget. 2017 Jan 17;8(3):4399-4409.
Title: Targeted delivery of chemotherapy using HSP90 inhibitor drug conjugates is highly active against pancreatic cancer models.
Author: Bobrov, Egor|Skobeleva, Natalia|Restifo, Diana|Beglyarova, Natalya|Cai, Kathy Q|Handorf, Elizabeth|Campbell, Kerry|Proia, David A|Khazak, Vladimir|Golemis, Erica A|Astsaturov, Igor
PMID: 27779106
Journal: Apoptosis. 2017 Mar;22(3):369-380.
Title: HSP90 is a promising target in gemcitabine and 5-fluorouracil resistant pancreatic cancer.
Author: Ghadban, Tarik|Dibbern, Judith L|Reeh, Matthias|Miro, Jameel T|Tsui, Tung Y|Wellner, Ulrich|Izbicki, Jakob R|Gungor, Cenap|Vashist, Yogesh K
PMID: 27878398
Journal: Cancer Lett. 2017 Aug 28;402:110-116.
Title: Epigenetic effects of inhibition of heat shock protein 90 (HSP90) in human pancreatic and colon cancer.
Author: Nagaraju, Ganji Purnachandra|Wu, Christina|Merchant, Neha|Chen, Zhengjia|Lesinski, Gregory B|El-Rayes, Bassel F
PMID: 28583846
Journal: Cancer. 2017 Dec 15;123(24):4924-4933.
Title: Inhibiting heat shock protein 90 and the ubiquitin-proteasome pathway impairs metabolic homeostasis and leads to cell death in human pancreatic cancer cells.
Author: Belalcazar, Astrid|Shaib, Walid L|Farren, Matthew R|Zhang, Chao|Chen, Zhengjia|Yang, Lily|Lesinski, Gregory B|El-Rayes, Bassel F|Nagaraju, Ganji Purnachandra
PMID: 28841232
Journal: Onco Targets Ther. 2017 Aug 10;10:3991-4005.
Title: Clinical significance and prospective molecular mechanism of MALAT1 in pancreatic cancer exploration: a comprehensive study based on the GeneChip, GEO, Oncomine, and TCGA databases.
Author: Xie, Zu-Cheng|Dang, Yi-Wu|Wei, Dan-Ming|Chen, Peng|Tang, Rui-Xue|Huang, Qian|Liu, Jiang-Hua|Luo, Dian-Zhong
PMID: 28860807
Journal: Cancer Sci. 2018 Feb;109(2):373-383.
Title: PRDM14 directly interacts with heat shock proteins HSP90alpha and glucose-regulated protein 78.
Author: Moriya, Chiharu|Taniguchi, Hiroaki|Nagatoishi, Satoru|Igarashi, Hisayoshi|Tsumoto, Kouhei|Imai, Kohzoh
PMID: 29178343
Journal: Amino Acids. 2018 Jul;50(7):897-907.
Title: PET imaging of Hsp90 expression in pancreatic cancer using a new (64)Cu-labeled dimeric Sansalvamide A decapeptide.
Author: Wang, Xiaohui|Zhang, Jun|Wu, Hubing|Li, Yumin|Conti, Peter S|Chen, Kai
PMID: 29691700
Journal: Biochem Biophys Res Commun. 2018 Jun 27;501(3):751-757.
Title: Inhibition of pancreatic cancer Panc1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK.
Author: Jin, Un-Ho|Karki, Keshav|Kim, Sang-Bae|Safe, Stephen
PMID: 29758193