Primary Site >> Pancreatic Cancer
Gene >> HSP90AA1
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Ref: Overexpression and localization of heat shock proteins mRNA in pancreatic carcinoma. PMID: 10851351 Ref: Induction and membrane expression of heat shock proteins in heat-treated HPC-4 cells is correlated with increased resistance to LAK-mediated lysis. PMID: 11144526 |
Ref: Potentiation of chemotherapeutics by the Hsp90 antagonist geldanamycin requires a steady serum condition. PMID: 17219417 Ref: Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotop PMID: 17975158 |
Ref: Synergistic antipancreatic tumor effect by simultaneously targeting hypoxic cancer cells with HSP90 inhibitor and glycolysis inhibitor. PMID: 18347186 Ref: Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer. PMID: 18852131 Ref: Phase I pharmacokinetic and pharmacodynamic study of LAQ824, a hydroxamate histone deacetylase inhibitor with a heat shock protein-90 inhibitory profile, in patients with advanced solid tumors. PMID: 18927309 |
Ref: Withaferin A targets heat shock protein 90 in pancreatic cancer cells. PMID: 19769945 Ref: HSP90 inhibitors induce desensitization of EGF receptor via p38 MAPK-mediated phosphorylation at Ser1046/1047 in human pancreatic cancer cells. PMID: 20428829 Ref: MEK inhibition potentiates the activity of Hsp90 inhibitor 17-AAG against pancreatic cancer cells. PMID: 20669973 Ref: Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor. PMID: 20798912 Ref: Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition. PMID: 21129190 |
Ref: Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells. PMID: 21156818 Ref: Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent. PMID: 21235734 Ref: RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation. PMID: 21470770 Ref: Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function. PMID: 21875325 Ref: Targeting pancreatic cancer with a G-quadruplex ligand. PMID: 22041170 Ref: Concomitant inhibition of HSP90, its mitochondrial localized homologue TRAP1 and HSP27 by green tea in pancreatic cancer HPAF-II cells. PMID: 22116673 |
Ref: Multiple kinase pathways involved in the different de novo sensitivity of pancreatic cancer cell lines to 17-AAG. PMID: 22099584 Ref: Oncogenic MST1R activity in pancreatic and gastric cancer represents a valid target of HSP90 inhibitors. PMID: 22287729 Ref: Targeting HSP90 by the novel inhibitor NVP-AUY922 reduces growth and angiogenesis of pancreatic cancer. PMID: 22753713 Ref: Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells. PMID: 22843495 |
Ref: Molecular markers for novel therapeutic strategies in pancreatic endocrine tumors. PMID: 23211371 Ref: Increased radiosensitivity and radiothermosensitivity of human pancreatic MIA PaCa-2 and U251 glioblastoma cell lines treated with the novel Hsp90 inhibitor NVP-HSP990. PMID: 23448094 Ref: InterAKTions with FKBPs--mutational and pharmacological exploration. PMID: 23469007 Ref: Heat-shock protein 90 inhibitors synergistically enhance melanoma differentiation-associated gene-7-mediated cell killing of human pancreatic carcinoma. PMID: 24263157 |
Ref: Structure-activity relationship (SAR) of withanolides to inhibit Hsp90 for its activity in pancreatic cancer cells. PMID: 23887853 Ref: Melatonin influences pancreatic cancerogenesis. PMID: 24258787 Ref: Novel agents for the treatment of pancreatic cancer. PMID: 24618430 Ref: Use of herbal medicines and natural products: an alternative approach to overcoming the apoptotic resistance of pancreatic cancer. PMID: 24875648 Ref: Antiproliferative effect of HSP90 inhibitor Y306zh against pancreatic cancer is mediated by interruption of AKT and MAPK signaling pathways. PMID: 25219422 |
Ref: Antiangiogenic effects of a novel synthetic curcumin analogue in pancreatic cancer. PMID: 25497868 Ref: [Treatment with carbon-ion radiotherapy and its combinations -- basic biological studies and investigations at the National Institute of Radiological Sciences]. PMID: 25743134 Ref: Phase II trial of gemcitabine and tanespimycin (17AAG) in metastatic pancreatic cancer: a Mayo Clinic Phase II Consortium study. PMID: 25952464 Ref: Molecular docking study, synthesis and biological evaluation of Mannich bases as Hsp90 inhibitors. PMID: 26116388 |
Ref: Targeting the Janus-activated kinase-2-STAT3 signalling pathway in pancreatic cancer using the HSP90 inhibitor ganetespib. PMID: 26682870 Ref: A phase II study of the HSP90 inhibitor AUY922 in chemotherapy refractory advanced pancreatic cancer. PMID: 27422303 Ref: Dual mode of cancer cell destruction for pancreatic cancer therapy using Hsp90 inhibitor loaded polymeric nano magnetic formulation. PMID: 27469073 Ref: [Pancreatic acinar neoplasms : Comparative molecular characterization]. PMID: 27807633 |
Ref: Targeted delivery of chemotherapy using HSP90 inhibitor drug conjugates is highly active against pancreatic cancer models. PMID: 27779106 Ref: HSP90 is a promising target in gemcitabine and 5-fluorouracil resistant pancreatic cancer. PMID: 27878398 Ref: Epigenetic effects of inhibition of heat shock protein 90 (HSP90) in human pancreatic and colon cancer. PMID: 28583846 Ref: Inhibiting heat shock protein 90 and the ubiquitin-proteasome pathway impairs metabolic homeostasis and leads to cell death in human pancreatic cancer cells. PMID: 28841232 Ref: Clinical significance and prospective molecular mechanism of MALAT1 in pancreatic cancer exploration: a comprehensive study based on the GeneChip, GEO, Oncomine, and TCGA databases. PMID: 28860807 |
Ref: PRDM14 directly interacts with heat shock proteins HSP90alpha and glucose-regulated protein 78. PMID: 29178343 Ref: PET imaging of Hsp90 expression in pancreatic cancer using a new (64)Cu-labeled dimeric Sansalvamide A decapeptide. PMID: 29691700 Ref: Inhibition of pancreatic cancer Panc1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK. PMID: 29758193 |