Primary Site >> Colorectal Cancer

Gene >> HPGD

Journal: Cancer Res. 1997 Sep 1;57(17):3717-22.
Title: Enhancement of experimental colon cancer by genistein.
Author: Rao, C V|Wang, C X|Simi, B|Lubet, R|Kelloff, G|Steele, V|Reddy, B S
PMID: 9288778
Journal: Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17468-73. Epub 2004 Dec 1.
Title: 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers.
Author: Yan, Min|Rerko, Ronald M|Platzer, Petra|Dawson, Dawn|Willis, Joseph|Tong, Min|Lawrence, Earl|Lutterbaugh, James|Lu, Shilong|Willson, James K V|Luo, Guangbin|Hensold, Jack|Tai, Hsin-Hsiung|Wilson, Keith|Markowitz, Sanford D
PMID: 15574495
Journal: J Biol Chem. 2005 Feb 4;280(5):3217-23. Epub 2004 Nov 12.
Title: 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer.
Author: Backlund, Michael G|Mann, Jason R|Holla, Vijaykumar R|Buchanan, F Gregory|Tai, Hsin-Hsiung|Musiek, Erik S|Milne, Ginger L|Katkuri, Sharada|DuBois, Raymond N
PMID: 15542609
Journal: Cancer Res. 2006 Jul 1;66(13):6649-56.
Title: Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression.
Author: Mann, Jason R|Backlund, Michael G|Buchanan, F Gregory|Daikoku, Taki|Holla, Vijaykumar R|Rosenberg, Daniel W|Dey, Sudhansu K|DuBois, Raymond N
PMID: 16818638
Journal: Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12098-102. Epub 2006 Jul 31.
Title: 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.
Author: Myung, Seung-Jae|Rerko, Ronald M|Yan, Min|Platzer, Petra|Guda, Kishore|Dotson, Angela|Lawrence, Earl|Dannenberg, Andrew J|Lovgren, Alysia Kern|Luo, Guangbin|Pretlow, Theresa P|Newman, Robert A|Willis, Joseph|Dawson, Dawn|Markowitz, Sanford D
PMID: 16880406
Journal: Mol Carcinog. 2008 Jun;47(6):466-77.
Title: 15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice.
Author: Pham, Hung|Eibl, Guido|Vincenti, Romina|Chong, Benny|Tai, Hsin-Hsiung|Slice, Lee W
PMID: 18058808
Journal: Biochem Biophys Res Commun. 2008 Jul 18;372(1):249-53.
Title: Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice.
Author: Elander, N|Ungerback, J|Olsson, H|Uematsu, S|Akira, S|Soderkvist, P
PMID: 18485889
Journal: Korean J Gastroenterol. 2008 May;51(5):274-9.
Title: [Role of prostaglandins in colon cancer].
Author: Myung, Seung-Jae|Kim, In-Hwa
PMID: 18516010
Journal: Cancer Res. 2008 Jul 1;68(13):5040-8.
Title: 15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer.
Author: Huang, Guosheng|Eisenberg, Rosana|Yan, Min|Monti, Stefano|Lawrence, Earl|Fu, Pingfu|Walbroehl, Jaclyn|Lowenberg, Ester|Golub, Todd|Merchan, Jaime|Tenen, Daniel G|Markowitz, Sanford D|Halmos, Balazs
PMID: 18593902
Journal: Cancer Res. 2008 Nov 15;68(22):9331-7.
Title: Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer.
Author: Backlund, Michael G|Mann, Jason R|Holla, Vijaykumar R|Shi, Qiong|Daikoku, Takikoku|Dey, Sudhansu K|DuBois, Raymond N
PMID: 19010907
Journal: Cancer Invest. 2008 Nov;26(9):905-12.
Title: Suppression of invasive properties of colorectal carcinoma SW480 cells by 15-hydroxyprostaglandin dehydrogenase gene.
Author: Li, Meining|Xie, Jun|Cheng, Le|Chang, Bingmei|Wang, Ying|Lan, Xiaoqin|Zhang, Dong|Yin, Yunqin|Cheng, Niuliang
PMID: 19034772
Journal: Cancer Prev Res (Phila). 2008 Jul;1(2):93-9.
Title: Regulation of prostaglandin transporters in colorectal neoplasia.
Author: Holla, Vijaykumar R|Backlund, Michael G|Yang, Peying|Newman, Robert A|DuBois, Raymond N
PMID: 19138942
Journal: Arch Biochem Biophys. 2009 Jul 15;487(2):139-45.
Title: 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells.
Author: Chi, Xiuling|Freeman, Brittany Morgan|Tong, Min|Zhao, Yuhua|Tai, Hsin-Hsiung
PMID: 19501039
Journal: Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G559-66.
Title: Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes.
Author: Miyaki, Akira|Yang, Peiying|Tai, Hsin-Hsiung|Subbaramaiah, Kotha|Dannenberg, Andrew J
PMID: 19608733
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2009 Jul;12(4):371-3.
Title: [Study on radiation sensitivity of colorectal cancer cells using gene expression profile].
Author: Yang, Xiao-dong|Xing, Chun-gen|Gong, Wei|Zhou, Li-ying|Wu, Yong-you|Zhao, Kui
PMID: 19598022
Journal: J Immunol. 2009 Jun 15;182(12):7548-57.
Title: Altered expression of 15-hydroxyprostaglandin dehydrogenase in tumor-infiltrated CD11b myeloid cells: a mechanism for immune evasion in cancer.
Author: Eruslanov, Evgeniy|Kaliberov, Sergei|Daurkin, Irina|Kaliberova, Lyudmila|Buchsbaum, Donald|Vieweg, Johannes|Kusmartsev, Sergei
PMID: 19494278
Journal: Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9409-13.
Title: 15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors.
Author: Yan, Min|Myung, Seung-Jae|Fink, Stephen P|Lawrence, Earl|Lutterbaugh, James|Yang, Peiying|Zhou, Xiaohua|Liu, Danielle|Rerko, Ronald M|Willis, Joseph|Dawson, Dawn|Tai, Hsin-Hsiung|Barnholtz-Sloan, Jill S|Newman, Robert A|Bertagnolli, Monica M|Markowitz, Sa
PMID: 19470469
Journal: Pancreas. 2010 Apr;39(3):332-9.
Title: Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors.
Author: Pham, Hung|Chen, Monica|Li, Aihua|King, Jonathan|Angst, Eliane|Dawson, David W|Park, Jenny|Reber, Howard A|Hines, O Joe|Eibl, Guido
PMID: 19820419
Journal: Carcinogenesis. 2010 Mar;31(3):466-72.
Title: Polymorphisms in fatty-acid-metabolism-related genes are associated with colorectal cancer risk.
Author: Hoeft, Birgit|Linseisen, Jakob|Beckmann, Lars|Muller-Decker, Karin|Canzian, Federico|Husing, Anika|Kaaks, Rudolf|Vogel, Ulla|Jakobsen, Marianne U|Overvad, Kim|Hansen, Rikke D|Knuppel, Sven|Boeing, Heiner|Trichopoulou, Antonia|Koumantaki, Yvoni|Trichopoulo
PMID: 20042636
Journal: Int J Oncol. 2010 Feb;36(2):469-78.
Title: Receptor and enzyme expression for prostanoid metabolism in colorectal cancer related to tumor tissue PGE2.
Author: Gustafsson, Annika|Andersson, Marianne|Lagerstedt, Kristina|Lonnroth, Christina|Nordgren, Svante|Lundholm, Kent
PMID: 20043083
Journal: Yonsei Med J. 2010 Sep;51(5):692-9.
Title: Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer.
Author: Lim, Sung Chul|Cho, Hoon|Lee, Tae Bum|Choi, Cheol Hee|Min, Young Don|Kim, Sung Soo|Kim, Kyung Jong
PMID: 20635443
Journal: Carcinogenesis. 2011 Feb;32(2):190-6.
Title: Association of hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD) variants and colorectal cancer risk.
Author: Frank, Bernd|Hoeft, Birgit|Hoffmeister, Michael|Linseisen, Jakob|Breitling, Lutz P|Chang-Claude, Jenny|Brenner, Hermann|Nieters, Alexandra
PMID: 21047993
Journal: Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):37-40.
Title: Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs).
Author: Tai, Hsin-Hsiung|Chi, Xiuling|Tong, Min
PMID: 21763448
Journal: J Korean Soc Coloproctol. 2012 Oct;28(5):253-8.
Title: Prognostic implication of 15-hydroxyprostaglandin dehydrogenase down-regulation in patients with colorectal cancer.
Author: Kang, Pil Sung|Kim, Jin Ha|Moon, Ok In|Lim, Sung Chul|Kim, Kyung Jong
PMID: 23185705
Journal: Br J Cancer. 2012 Oct 23;107(9):1514-7.
Title: beta-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?
Author: Smartt, H J M|Greenhough, A|Ordonez-Moran, P|Al-Kharusi, M|Collard, T J|Mariadason, J M|Huelsken, J|Williams, A C|Paraskeva, C
PMID: 23033009
Journal: Cancer Prev Res (Phila). 2012 Jun;5(6):855-63.
Title: A study of prostaglandin pathway genes and interactions with current nonsteroidal anti-inflammatory drug use in colorectal adenoma.
Author: Edwards, Todd L|Shrubsole, Martha J|Cai, Qiuyin|Li, Guoliang|Dai, Qi|Rex, Douglas K|Ulbright, Thomas M|Fu, Zhenming|Murff, Harvey J|Smalley, Walter|Ness, Reid|Zheng, Wei
PMID: 22551900
Journal: Gut. 2012 Sep;61(9):1306-14.
Title: beta-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells.
Author: Smartt, Helena J M|Greenhough, Alexander|Ordonez-Moran, Paloma|Talero, Elena|Cherry, Catherine A|Wallam, Catherine A|Parry, Lee|Al Kharusi, Manal|Roberts, Heather R|Mariadason, John M|Clarke, Alan R|Huelsken, Joerg|Williams, Ann C|Paraskeva, Chris
PMID: 22082586
Journal: Anticancer Res. 2012 Apr;32(4):1193-202.
Title: 5-aminosalicylic acid mediates expression of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase to suppress colorectal tumorigenesis.
Author: Miyoshi, Jun|Yajima, Tomoharu|Shimamura, Katsuyoshi|Matsuoka, Katsuyoshi|Okamoto, Susumu|Higuchi, Hajime|Funakoshi, Shinsuke|Takaishi, Hiromasa|Hibi, Toshifumi
PMID: 22493349
Journal: Eur J Cancer Prev. 2013 Sep;22(5):455-60.
Title: Effect of ginger root on cyclooxygenase-1 and 15-hydroxyprostaglandin dehydrogenase expression in colonic mucosa of humans at normal and increased risk for colorectal cancer.
Author: Jiang, Yan|Turgeon, Danielle K|Wright, Benjamin D|Sidahmed, Elkhansa|Ruffin, Mack T|Brenner, Dean E|Sen, Ananda|Zick, Suzanna M
PMID: 23222413
Journal: BMC Cancer. 2013 Feb 26;13:92.
Title: Regional differences in prostaglandin E(2) metabolism in human colorectal cancer liver metastases.
Author: Young, Alastair L|Chalmers, Claire R|Hawcroft, Gillian|Perry, Sarah L|Treanor, Darren|Toogood, Giles J|Jones, Pamela F|Hull, Mark A
PMID: 23442768
Journal: PLoS One. 2013 May 22;8(5):e64122.
Title: Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility.
Author: Thompson, Cheryl L|Fink, Stephen P|Lutterbaugh, James D|Elston, Robert C|Veigl, Martina L|Markowitz, Sanford D|Li, Li
PMID: 23717544
Journal: J Korean Med Sci. 2013 Aug;28(8):1154-60.
Title: 15-hydroxyprostaglandin dehydrogenase in colorectal mucosa as a potential biomarker for predicting colorectal neoplasms.
Author: Lee, Hyo Jeong|Yang, Dong-Hoon|Ryu, Yeon-Mi|Song, Miyeoun|Song, Ho June|Jung, Kee Wook|Kim, Kyung-Jo|Ye, Byong Duk|Byeon, Jeong-Sik|Choi, Eun Kyung|Yang, Suk-Kyun|Kim, Jin-Ho|Myung, Seung-Jae
PMID: 23960441
Journal: PLoS One. 2014 Apr 2;9(4):e92000.
Title: Genetic variability in key genes in prostaglandin E2 pathway (COX-2, HPGD, ABCC4 and SLCO2A1) and their involvement in colorectal cancer development.
Author: Pereira, Carina|Queiros, Sara|Galaghar, Ana|Sousa, Hugo|Pimentel-Nunes, Pedro|Brandao, Catarina|Moreira-Dias, Luis|Medeiros, Rui|Dinis-Ribeiro, Mario
PMID: 24694755
Journal: Clin Mol Hepatol. 2014 Mar;20(1):28-37.
Title: Role of 15-hydroxyprostaglandin dehydrogenase down-regulation on the prognosis of hepatocellular carcinoma.
Author: Yang, Jee Eun|Park, Eunji|Lee, Hyo Jeong|Kang, Hyo Jeong|Kim, Kang Mo|Yu, Eunsil|Lee, Danbi|Shim, Ju Hyun|Lim, Young-Suk|Lee, Han Chu|Chung, Young-Hwa|Lee, Yung Sang
PMID: 24757656
Journal: Sci Transl Med. 2014 Apr 23;6(233):233re2.
Title: Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD).
Author: Fink, Stephen P|Yamauchi, Mai|Nishihara, Reiko|Jung, Seungyoun|Kuchiba, Aya|Wu, Kana|Cho, Eunyoung|Giovannucci, Edward|Fuchs, Charles S|Ogino, Shuji|Markowitz, Sanford D|Chan, Andrew T
PMID: 24760190
Journal: J Clin Invest. 2014 Jun;124(6):2472-82.
Title: Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.
Author: Choi, Sung Hee|Kim, Byung-Gyu|Robinson, Janet|Fink, Steve|Yan, Min|Sporn, Michael B|Markowitz, Sanford D|Letterio, John J
PMID: 24837432
Journal: Cancer Prev Res (Phila). 2014 Aug;7(8):805-12.
Title: Inactivating mutation in the prostaglandin transporter gene, SLCO2A1, associated with familial digital clubbing, colon neoplasia, and NSAID resistance.
Author: Guda, Kishore|Fink, Stephen P|Milne, Ginger L|Molyneaux, Neil|Ravi, Lakshmeswari|Lewis, Susan M|Dannenberg, Andrew J|Montgomery, Courtney G|Zhang, Shulin|Willis, Joseph|Wiesner, Georgia L|Markowitz, Sanford D
PMID: 24838973
Journal: Neoplasma. 2015;62(5):756-64.
Title: Identification of genes in ulcerative colitis associated colorectal cancer based on centrality analysis of co-expression network.
Author: Zhu, J|Li, C|Ji, W
PMID: 26278145
Journal: J Dig Cancer Rep. 2015 Jun;3(1):5-10.
Title: Biomarker-directed Targeted Therapy in Colorectal Cancer.
Author: Carethers, John M
PMID: 26609516
Journal: Carcinogenesis. 2015 Feb;36(2):291-8.
Title: Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs.
Author: Fink, Stephen P|Dawson, Dawn M|Zhang, Yongyou|Kresak, Adam|Lawrence, Earl G|Yang, Peiying|Chen, Yanwen|Barnholtz-Sloan, Jill S|Willis, Joseph E|Kopelovich, Levy|Markowitz, Sanford D
PMID: 25503930
Journal: Int J Cancer. 2016 May 1;138(9):2247-56.
Title: Endogenous conversion of omega-6 to omega-3 polyunsaturated fatty acids in fat-1 mice attenuated intestinal polyposis by either inhibiting COX-2/beta-catenin signaling or activating 15-PGDH/IL-18.
Author: Han, Young-Min|Park, Jong-Min|Cha, Ji-Young|Jeong, Migyeong|Go, Eun-Jin|Hahm, Ki Baik
PMID: 26650508
Journal: Mol Oncol. 2016 Nov;10(9):1415-1429.
Title: Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH and induces differentiation of colon cancer cells.
Author: Mehdawi, Lubna M|Prasad, Chandra Prakash|Ehrnstrom, Roy|Andersson, Tommy|Sjolander, Anita
PMID: 27522468
Journal: Nutr Cancer. 2016 Oct;68(7):1192-201.
Title: Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue.
Author: Sidahmed, ElKhansa|Sen, Ananda|Ren, Jianwei|Patel, Arsh|Turgeon, D Kim|Ruffin, Mack T|Brenner, Dean E|Djuric, Zora
PMID: 27548026
Journal: Oncotarget. 2016 Sep 27;7(39):63583-63595.
Title: The omega-3 polyunsaturated fatty acids prevented colitis-associated carcinogenesis through blocking dissociation of beta-catenin complex, inhibiting COX-2 through repressing NF-kappaB, and inducing 15-prostaglandin dehydrogenase.
Author: Han, Young-Min|Jeong, Migyeung|Park, Jong-Min|Kim, Mi-Young|Go, Eun-Jin|Cha, Ji Young|Kim, Kyung Jo|Hahm, Ki Baik
PMID: 27566583
Journal: Gastroenterology. 2017 Feb;152(3):616-630.
Title: Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice.
Author: Kim, Han-Byul|Kim, Minchul|Park, Young-Soo|Park, Intae|Kim, Tackhoon|Yang, Sung-Yeun|Cho, Charles J|Hwang, DaeHee|Jung, Jin-Hak|Markowitz, Sanford D|Hwang, Sung Wook|Yang, Suk-Kyun|Lim, Dae-Sik|Myung, Seung-Jae
PMID: 27864128
Journal: Trials. 2017 Feb 1;18(1):50.
Title: ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial.
Author: Drew, David A|Chin, Samantha M|Gilpin, Katherine K|Parziale, Melanie|Pond, Emily|Schuck, Madeline M|Stewart, Kathleen|Flagg, Meaghan|Rawlings, Crystal A|Backman, Vadim|Carolan, Peter J|Chung, Daniel C|Colizzo, Francis P 3rd|Freedman, Matthew|Gala, Manish|
PMID: 28143522
Journal: Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2852-E2861.
Title: Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer.
Author: Li, Cunxi|Singh, Bhuminder|Graves-Deal, Ramona|Ma, Haiting|Starchenko, Alina|Fry, William H|Lu, Yuanyuan|Wang, Yang|Bogatcheva, Galina|Khan, Mohseen P|Milne, Ginger L|Zhao, Shilin|Ayers, Gregory Daniel|Li, Nenggan|Hu, Huaying|Washington, Mary Kay|Yeatman,
PMID: 28320945
Journal: Oncotarget. 2017 May 23;8(21):35033-35047.
Title: A potential anti-tumor effect of leukotriene C4 through the induction of 15-hydroxyprostaglandin dehydrogenase expression in colon cancer cells.
Author: Mehdawi, Lubna M|Satapathy, Shakti Ranjan|Gustafsson, Annika|Lundholm, Kent|Alvarado-Kristensson, Maria|Sjolander, Anita
PMID: 28402256
Journal: NPJ Precis Oncol. 2017;1.
Title: Integration of pharmacology, molecular pathology, and population data science to support precision gastrointestinal oncology.
Author: Ogino, Shuji|Jhun, Iny|Mata, Douglas A|Soong, Thing Rinda|Hamada, Tsuyoshi|Liu, Li|Nishihara, Reiko|Giannakis, Marios|Cao, Yin|Manson, JoAnn E|Nowak, Jonathan A|Chan, Andrew T
PMID: 29552640
Journal: Cancer Lett. 2018 Nov 28;437:13-24.
Title: Montelukast, a CysLT1 receptor antagonist, reduces colon cancer stemness and tumor burden in a mouse xenograft model of human colon cancer.
Author: Bellamkonda, Kishan|Satapathy, Shakti Ranjan|Douglas, Desiree|Chandrashekar, Naveenkumar|Selvanesan, Benson Chellakkan|Liu, Minghui|Savari, Sayeh|Jonsson, Gunilla|Sjolander, Anita
PMID: 30144515