Primary Site >> Colorectal Cancer
Gene >> HPGD
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Ref: Enhancement of experimental colon cancer by genistein. PMID: 9288778 |
Ref: 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. PMID: 15574495 |
Ref: 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer. PMID: 15542609 |
Ref: Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression. PMID: 16818638 Ref: 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis. PMID: 16880406 |
Ref: 15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice. PMID: 18058808 Ref: Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice. PMID: 18485889 Ref: [Role of prostaglandins in colon cancer]. PMID: 18516010 Ref: 15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer. PMID: 18593902 Ref: Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. PMID: 19010907 Ref: Suppression of invasive properties of colorectal carcinoma SW480 cells by 15-hydroxyprostaglandin dehydrogenase gene. PMID: 19034772 Ref: Regulation of prostaglandin transporters in colorectal neoplasia. PMID: 19138942 |
Ref: 15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors. PMID: 19470469 Ref: Altered expression of 15-hydroxyprostaglandin dehydrogenase in tumor-infiltrated CD11b myeloid cells: a mechanism for immune evasion in cancer. PMID: 19494278 Ref: 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells. PMID: 19501039 Ref: [Study on radiation sensitivity of colorectal cancer cells using gene expression profile]. PMID: 19598022 Ref: Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes. PMID: 19608733 |
Ref: Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors. PMID: 19820419 Ref: Polymorphisms in fatty-acid-metabolism-related genes are associated with colorectal cancer risk. PMID: 20042636 Ref: Receptor and enzyme expression for prostanoid metabolism in colorectal cancer related to tumor tissue PGE2. PMID: 20043083 Ref: Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer. PMID: 20635443 |
Ref: Association of hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD) variants and colorectal cancer risk. PMID: 21047993 Ref: Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs). PMID: 21763448 |
Ref: beta-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells. PMID: 22082586 Ref: 5-aminosalicylic acid mediates expression of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase to suppress colorectal tumorigenesis. PMID: 22493349 Ref: A study of prostaglandin pathway genes and interactions with current nonsteroidal anti-inflammatory drug use in colorectal adenoma. PMID: 22551900 Ref: beta-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin? PMID: 23033009 Ref: Prognostic implication of 15-hydroxyprostaglandin dehydrogenase down-regulation in patients with colorectal cancer. PMID: 23185705 |
Ref: Effect of ginger root on cyclooxygenase-1 and 15-hydroxyprostaglandin dehydrogenase expression in colonic mucosa of humans at normal and increased risk for colorectal cancer. PMID: 23222413 Ref: Regional differences in prostaglandin E(2) metabolism in human colorectal cancer liver metastases. PMID: 23442768 Ref: Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility. PMID: 23717544 Ref: 15-hydroxyprostaglandin dehydrogenase in colorectal mucosa as a potential biomarker for predicting colorectal neoplasms. PMID: 23960441 |
Ref: Genetic variability in key genes in prostaglandin E2 pathway (COX-2, HPGD, ABCC4 and SLCO2A1) and their involvement in colorectal cancer development. PMID: 24694755 Ref: Role of 15-hydroxyprostaglandin dehydrogenase down-regulation on the prognosis of hepatocellular carcinoma. PMID: 24757656 Ref: Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD). PMID: 24760190 Ref: Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis. PMID: 24837432 Ref: Inactivating mutation in the prostaglandin transporter gene, SLCO2A1, associated with familial digital clubbing, colon neoplasia, and NSAID resistance. PMID: 24838973 |
Ref: Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs. PMID: 25503930 Ref: Identification of genes in ulcerative colitis associated colorectal cancer based on centrality analysis of co-expression network. PMID: 26278145 Ref: Biomarker-directed Targeted Therapy in Colorectal Cancer. PMID: 26609516 |
Ref: Endogenous conversion of omega-6 to omega-3 polyunsaturated fatty acids in fat-1 mice attenuated intestinal polyposis by either inhibiting COX-2/beta-catenin signaling or activating 15-PGDH/IL-18. PMID: 26650508 Ref: Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH and induces differentiation of colon cancer cells. PMID: 27522468 Ref: Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue. PMID: 27548026 Ref: The omega-3 polyunsaturated fatty acids prevented colitis-associated carcinogenesis through blocking dissociation of beta-catenin complex, inhibiting COX-2 through repressing NF-kappaB, and inducing 15-prostaglandin dehydrogenase. PMID: 27566583 |
Ref: Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice. PMID: 27864128 Ref: ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial. PMID: 28143522 Ref: Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer. PMID: 28320945 Ref: A potential anti-tumor effect of leukotriene C4 through the induction of 15-hydroxyprostaglandin dehydrogenase expression in colon cancer cells. PMID: 28402256 Ref: Integration of pharmacology, molecular pathology, and population data science to support precision gastrointestinal oncology. PMID: 29552640 |
Ref: Montelukast, a CysLT1 receptor antagonist, reduces colon cancer stemness and tumor burden in a mouse xenograft model of human colon cancer. PMID: 30144515 |