Primary Site >> Liver Cancer
Gene >> HNF4A
| 1. | |||||||||||
| Journal: | Carcinogenesis. 1995 Jan;16(1):143-5. | ||||||||||
| Title: | The DNA binding activity of the liver transcription factors LFB1 (HNF1) and HNF4 varies coordinately in rat hepatocellular carcinoma. | ||||||||||
| Author: | Stumpf, H|Senkel, S|Rabes, H M|Ryffel, G U | ||||||||||
| PMID: | 7834800 | ||||||||||
| 2. | |||||||||||
| Journal: | J Virol. 1996 Jul;70(7):4714-23. | ||||||||||
| Title: | Cellular factors controlling the activity of woodchuck hepatitis virus enhancer II. | ||||||||||
| Author: | Ueda, K|Wei, Y|Ganem, D | ||||||||||
| PMID: | 8676498 | ||||||||||
| 3. | |||||||||||
| Journal: | Exp Cell Res. 1998 Jun 15;241(2):445-57. | ||||||||||
| Title: | Phenobarbital suppresses growth and accelerates restoration of differentiation markers of primary culture rat hepatocytes in the chemically defined hepatocyte growth medium containing hepatocyte growth factor and epidermal growth factor. | ||||||||||
| Author: | Miyazaki, M|Mars, W M|Runge, D|Kim, T H|Bowen, W C|Michalopoulos, G K | ||||||||||
| PMID: | 9637786 | ||||||||||
| 4. | |||||||||||
| Journal: | J Cell Sci. 2001 Mar;114(Pt 6):1205-12. | ||||||||||
| Title: | A common regulatory locus affects both HNF4/HNF1alpha pathway activation and sensitivity to LPS-mediated apoptosis in rat hepatoma cells. | ||||||||||
| Author: | Bulla, G A|Givens, E|Brown, S|Oladiran, B|Kraus, D | ||||||||||
| PMID: | 11228163 | ||||||||||
| 5. | |||||||||||
| Journal: | Genetika. 2001 Jun;37(6):803-10. | ||||||||||
| Title: | [Expression of tissue-specific genes with progression of mouse hepatocellular carcinoma]. | ||||||||||
| Author: | Varga, E V|Cheremnova, O A|Ovchinnikov, D A|Shapiguzov, A Iu|Kudriavtseva, E I|Morozova, O V|Engel'gardt, N V|Lazarevich, N L | ||||||||||
| PMID: | 11517767 | ||||||||||
| 6. | |||||||||||
| Journal: | Jpn J Cancer Res. 2002 Nov;93(11):1213-20. | ||||||||||
| Title: | Analysis of the beta-catenin/T cell factor signaling pathway in 36 gastrointestinal and liver cancer cells. | ||||||||||
| Author: | Ikenoue, Tsuneo|Ijichi, Hideaki|Kato, Naoya|Kanai, Fumihiko|Masaki, Tsutomu|Rengifo, William|Okamoto, Makoto|Matsumura, Masayuki|Kawabe, Takao|Shiratori, Yasushi|Omata, Masao | ||||||||||
| PMID: | 12460462 | ||||||||||
| 7. | |||||||||||
| Journal: | Digestion. 2002;66(3):131-44. | ||||||||||
| Title: | Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. | ||||||||||
| Author: | Kolligs, Frank T|Bommer, Guido|Goke, Burkhard | ||||||||||
| PMID: | 12481159 | ||||||||||
| 8. | |||||||||||
| Journal: | Hepatology. 2004 Apr;39(4):1038-47. | ||||||||||
| Title: | Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors. | ||||||||||
| Author: | Lazarevich, Natalia L|Cheremnova, Oksana A|Varga, Ekaterina V|Ovchinnikov, Dmitry A|Kudrjavtseva, Elena I|Morozova, Olga V|Fleishman, Daria I|Engelhardt, Natalia V|Duncan, Stephen A | ||||||||||
| PMID: | 15057908 | ||||||||||
| 9. | |||||||||||
| Journal: | Mol Cancer Ther. 2006 Nov;5(11):2861-71. | ||||||||||
| Title: | Targeting the active beta-catenin pathway to treat cancer cells. | ||||||||||
| Author: | Dvory-Sobol, Hadas|Sagiv, Eyal|Kazanov, Diana|Ben-Ze'ev, Avri|Arber, Nadir | ||||||||||
| PMID: | 17121933 | ||||||||||
| 10. | |||||||||||
| Journal: | Int J Mol Med. 2007 Mar;19(3):529-33. | ||||||||||
| Title: | Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs. | ||||||||||
| Author: | Katoh, Masuko|Katoh, Masaru | ||||||||||
| PMID: | 17273804 | ||||||||||
| 11. | |||||||||||
| Journal: | Pathol Int. 2007 Feb;57(2):82-90. | ||||||||||
| Title: | Downregulated P1 promoter-driven hepatocyte nuclear factor-4alpha expression in human colorectal carcinoma is a new prognostic factor against liver metastasis. | ||||||||||
| Author: | Oshima, Tomoko|Kawasaki, Takashi|Ohashi, Riuko|Hasegawa, Go|Jiang, Shuying|Umezu, Hajime|Aoyagi, Yutaka|Iwanari, Hiroko|Tanaka, Toshiya|Hamakubo, Takao|Kodama, Tatsuhiko|Naito, Makoto | ||||||||||
| PMID: | 17300672 | ||||||||||
| 12. | |||||||||||
| Journal: | Biochemistry (Mosc). 2009 Apr;74(4):377-84. | ||||||||||
| Title: | Correlation between hepatocarcinogenic effect of estragole and its influence on glucocorticoid induction of liver-specific enzymes and activities of FOXA and HNF4 transcription factors in mouse and rat liver. | ||||||||||
| Author: | Kaledin, V I|Pakharukova, M Yu|Pivovarova, E N|Kropachev, K Yu|Baginskaya, N V|Vasilieva, E D|Ilnitskaya, S I|Nikitenko, E V|Kobzev, V F|Merkulova, T I | ||||||||||
| PMID: | 19463090 | ||||||||||
| 13. | |||||||||||
| Journal: | J Cell Mol Med. 2010 Mar;14(3):621-35. | ||||||||||
| Title: | URG11 promotes gastric cancer growth and invasion by activation of beta-catenin signalling pathway. | ||||||||||
| Author: | Du, Rui|Xia, Lin|Sun, Shiren|Lian, Zhaorui|Zou, Xue|Gao, Juan|Xie, Huahong|Fan, Rui|Song, Jiugang|Li, Xiaohua|Liu, Jie|Fan, Daiming | ||||||||||
| PMID: | 19413886 | ||||||||||
| 14. | |||||||||||
| Journal: | Stem Cells Dev. 2010 Aug;19(8):1277-84. | ||||||||||
| Title: | Human liver progenitor cell lines are readily established from non-tumorous tissue adjacent to hepatocellular carcinoma. | ||||||||||
| Author: | Zhang, Aibin|London, Roslyn|Schulz, Frederik Michael|Giguere-Simmonds, Philippe Wilfred Roger|Delriviere, Luc|Chandraratana, Harsha|Hardy, Kathy|Zheng, Shusen|Olynyk, John K|Yeoh, George | ||||||||||
| PMID: | 19874130 | ||||||||||
| 15. | |||||||||||
| Journal: | Biofizika. 2010 Mar-Apr;55(2):326-35. | ||||||||||
| Title: | [Effect of hepatocarcinogenicity of estragole on the glucocorticoid-mediated induction of liver-specific enzymes and the activity of the transcription factors FOXA and HNF4 in the liver of mouse and rat]. | ||||||||||
| Author: | Kaledin, V I|Pakharukova, M Iu|Pivovarova, E N|Kropachev, K Iu|Baginskaia, N V|Vasil'eva, E D|Il'nitskaia, S I|Nikitenko, E V|Kobzev, V F|Merkulova, T I | ||||||||||
| PMID: | 20429289 | ||||||||||
| 16. | |||||||||||
| Journal: | Mol Cancer. 2010 Jun 12;9:146. | ||||||||||
| Title: | Integrative and comparative genomics analysis of early hepatocellular carcinoma differentiated from liver regeneration in young and old. | ||||||||||
| Author: | Colak, Dilek|Chishti, Muhammad A|Al-Bakheet, Al-Bandary|Al-Qahtani, Ahmed|Shoukri, Mohamed M|Goyns, Malcolm H|Ozand, Pinar T|Quackenbush, John|Park, Ben H|Kaya, Namik | ||||||||||
| PMID: | 20540791 | ||||||||||
| 17. | |||||||||||
| Journal: | Int J Biochem Cell Biol. 2011 Feb;43(2):271-8. | ||||||||||
| Title: | Transcription dynamics in a physiological process: beta-catenin signaling directs liver metabolic zonation. | ||||||||||
| Author: | Torre, Cyril|Perret, Christine|Colnot, Sabine | ||||||||||
| PMID: | 19914393 | ||||||||||
| 18. | |||||||||||
| Journal: | Genes Chromosomes Cancer. 2011 Feb;50(2):122-35. | ||||||||||
| Title: | Sulfatase 1 and sulfatase 2 in hepatocellular carcinoma: associated signaling pathways, tumor phenotypes, and survival. | ||||||||||
| Author: | Yang, Ju Dong|Sun, Zhifu|Hu, Chunling|Lai, Jinping|Dove, Rebecca|Nakamura, Ikuo|Lee, Ju-Seog|Thorgeirsson, Snorri S|Kang, Koo Jeong|Chu, In-Sun|Roberts, Lewis R | ||||||||||
| PMID: | 21104785 | ||||||||||
| 19. | |||||||||||
| Journal: | Hepatology. 2011 Jun;53(6):2063-74. | ||||||||||
| Title: | The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4alpha. | ||||||||||
| Author: | Santangelo, Laura|Marchetti, Alessandra|Cicchini, Carla|Conigliaro, Alice|Conti, Beatrice|Mancone, Carmine|Bonzo, Jessica A|Gonzalez, Frank J|Alonzi, Tonino|Amicone, Laura|Tripodi, Marco | ||||||||||
| PMID: | 21384409 | ||||||||||
| 20. | |||||||||||
| Journal: | J Biol Chem. 2012 Mar 2;287(10):7345-56. | ||||||||||
| Title: | Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4alpha in adult mice. | ||||||||||
| Author: | Bonzo, Jessica A|Ferry, Christina H|Matsubara, Tsutomu|Kim, Jung-Hwan|Gonzalez, Frank J | ||||||||||
| PMID: | 22241473 | ||||||||||
| 21. | |||||||||||
| Journal: | Genome Res. 2013 May;23(5):800-11. | ||||||||||
| Title: | Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay. | ||||||||||
| Author: | Kheradpour, Pouya|Ernst, Jason|Melnikov, Alexandre|Rogov, Peter|Wang, Li|Zhang, Xiaolan|Alston, Jessica|Mikkelsen, Tarjei S|Kellis, Manolis | ||||||||||
| PMID: | 23512712 | ||||||||||
| 22. | |||||||||||
| Journal: | Mutagenesis. 2014 Jan;29(1):17-26. | ||||||||||
| Title: | Characterisation of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows conservation of regulating transcription factor networks. | ||||||||||
| Author: | Rieswijk, Linda|Lizarraga, Daneida|Brauers, Karen J J|Kleinjans, Jos C S|van Delft, Joost H M | ||||||||||
| PMID: | 24280081 | ||||||||||
| 23. | |||||||||||
| Journal: | PLoS One. 2014 Dec 19;9(12):e114263. | ||||||||||
| Title: | Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers. | ||||||||||
| Author: | Shiraishi, Yuichi|Fujimoto, Akihiro|Furuta, Mayuko|Tanaka, Hiroko|Chiba, Ken-ichi|Boroevich, Keith A|Abe, Tetsuo|Kawakami, Yoshiiku|Ueno, Masaki|Gotoh, Kunihito|Ariizumi, Shun-ichi|Shibuya, Tetsuo|Nakano, Kaoru|Sasaki, Aya|Maejima, Kazuhiro|Kitada, Rina|H | ||||||||||
| PMID: | 25526364 | ||||||||||
| 24. | |||||||||||
| Journal: | Hepatology. 2014 Nov;60(5):1674-85. | ||||||||||
| Title: | Gd-EOB-DTPA-enhanced magnetic resonance imaging and alpha-fetoprotein predict prognosis of early-stage hepatocellular carcinoma. | ||||||||||
| Author: | Yamashita, Taro|Kitao, Azusa|Matsui, Osamu|Hayashi, Takehiro|Nio, Kouki|Kondo, Mitsumasa|Ohno, Naoki|Miyati, Tosiaki|Okada, Hikari|Yamashita, Tatsuya|Mizukoshi, Eishiro|Honda, Masao|Nakanuma, Yasuni|Takamura, Hiroyuki|Ohta, Tetsuo|Nakamoto, Yasunari|Yamam | ||||||||||
| PMID: | 24700365 | ||||||||||
| 25. | |||||||||||
| Journal: | Proteomics. 2015 Jun;15(11):1793-800. | ||||||||||
| Title: | Transcriptome and proteome of human hepatocellular carcinoma reveal shared metastatic pathways with significant genes. | ||||||||||
| Author: | Shen, Huali|Zhong, Fan|Zhang, Yang|Yu, Hongxiu|Liu, Yinkun|Qin, Lunxiu|He, Fuchu|Tang, Zhaoyou|Yang, Pengyuan | ||||||||||
| PMID: | 25652264 | ||||||||||
| 26. | |||||||||||
| Journal: | Cell Rep. 2015 Mar 10. pii: S2211-1247(15)00173-4. | ||||||||||
| Title: | YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression. | ||||||||||
| Author: | Fitamant, Julien|Kottakis, Filippos|Benhamouche, Samira|Tian, Helen S|Chuvin, Nicolas|Parachoniak, Christine A|Nagle, Julia M|Perera, Rushika M|Lapouge, Marjorie|Deshpande, Vikram|Zhu, Andrew X|Lai, Albert|Min, Bosun|Hoshida, Yujin|Avruch, Joseph|Sia, Dan | ||||||||||
| PMID: | 25772357 | ||||||||||
| 27. | |||||||||||
| Journal: | PLoS One. 2015 May 20;10(5):e0124544. | ||||||||||
| Title: | Integrative genomic signatures of hepatocellular carcinoma derived from nonalcoholic Fatty liver disease. | ||||||||||
| Author: | Frades, Itziar|Andreasson, Erik|Mato, Jose Maria|Alexandersson, Erik|Matthiesen, Rune|Martinez-Chantar, Maria Luz | ||||||||||
| PMID: | 25993042 | ||||||||||
| 28. | |||||||||||
| Journal: | Oncotarget. 2016 May 17;7(20):28903-13. | ||||||||||
| Title: | Increased liver carcinogenesis and enrichment of stem cell properties in livers of Dickkopf 2 (Dkk2) deleted mice. | ||||||||||
| Author: | Maass, Thorsten|Marquardt, Jens|Lee, Ju-Seog|Krupp, Markus|Scholz-Kreisel, Peter|Mogler, Carolin|Schirmacher, Peter|Muller, Martina|Westphal, Heiner|Galle, Peter R|Teufel, Andreas | ||||||||||
| PMID: | 25826080 | ||||||||||
| 29. | |||||||||||
| Journal: | J Virol. 2016 Jan 20;90(7):3530-42. | ||||||||||
| Title: | Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx. | ||||||||||
| Author: | Kouwaki, Takahisa|Okamoto, Toru|Ito, Ayano|Sugiyama, Yukari|Yamashita, Kazuo|Suzuki, Tatsuya|Kusakabe, Shinji|Hirano, Junki|Fukuhara, Takasuke|Yamashita, Atsuya|Saito, Kazunobu|Okuzaki, Daisuke|Watashi, Koichi|Sugiyama, Masaya|Yoshio, Sachiyo|Standley, Da | ||||||||||
| PMID: | 26792738 | ||||||||||
| 30. | |||||||||||
| Journal: | Int J Cancer. 2016 Oct 1;139(7):1586-97. | ||||||||||
| Title: | Integrative functional genomic delineation of the cascades of transcriptional changes involved in hepatocellular carcinoma progression. | ||||||||||
| Author: | Ramesh, Vignesh|Ganesan, Kumaresan | ||||||||||
| PMID: | 27194100 | ||||||||||
| 31. | |||||||||||
| Journal: | Ann Hepatol. 2016 Jul-Aug;15(4):568-76. | ||||||||||
| Title: | CUL4B, NEDD4, and UGT1As involve in the TGF-beta signalling in hepatocellular carcinoma. | ||||||||||
| Author: | Qu, Zhaowei|Li, Di|Xu, Haitao|Zhang, Rujia|Li, Bing|Sun, Chengming|Dong, Wei|Zhang, Yubao | ||||||||||
| PMID: | 27236156 | ||||||||||
| 32. | |||||||||||
| Journal: | BMC Genomics. 2017 Jun 5;18(1):439. | ||||||||||
| Title: | Uncovering the transcriptomic and epigenomic landscape of nicotinic receptor genes in non-neuronal tissues. | ||||||||||
| Author: | Zhang, Bo|Madden, Pamela|Gu, Junchen|Xing, Xiaoyun|Sankar, Savita|Flynn, Jennifer|Kroll, Kristen|Wang, Ting | ||||||||||
| PMID: | 28583088 | ||||||||||
| 33. | |||||||||||
| Journal: | Cell Death Dis. 2017 Jul 20;8(7):e2944. | ||||||||||
| Title: | Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression. | ||||||||||
| Author: | Wei, Libin|Dai, Yuanyuan|Zhou, Yuxin|He, Zihao|Yao, Jingyue|Zhao, Li|Guo, Qinglong|Yang, Lin | ||||||||||
| PMID: | 28726775 | ||||||||||
| 34. | |||||||||||
| Journal: | J Biol Chem. 2017 Jun 23;292(25):10574-10585. | ||||||||||
| Title: | An HNF4alpha-microRNA-194/192 signaling axis maintains hepatic cell function. | ||||||||||
| Author: | Morimoto, Aoi|Kannari, Mana|Tsuchida, Yuichi|Sasaki, Shota|Saito, Chinatsu|Matsuta, Tsuyoshi|Maeda, Tsukasa|Akiyama, Megumi|Nakamura, Takahiro|Sakaguchi, Masakiyo|Nameki, Nobukazu|Gonzalez, Frank J|Inoue, Yusuke | ||||||||||
| PMID: | 28465351 | ||||||||||
| 35. | |||||||||||
| Journal: | Oncogene. 2017 Apr 6;36(14):2030-2044. | ||||||||||
| Title: | A pre-neoplastic epigenetic field defect in HCV-infected liver at transcription factor binding sites and polycomb targets. | ||||||||||
| Author: | Wijetunga, N A|Pascual, M|Tozour, J|Delahaye, F|Alani, M|Adeyeye, M|Wolkoff, A W|Verma, A|Greally, J M | ||||||||||
| PMID: | 27721404 | ||||||||||
| 36. | |||||||||||
| Journal: | J Gastroenterol Hepatol. 2018 Apr 19. | ||||||||||
| Title: | Insights into the etiology-associated gene regulatory networks in hepatocellular carcinoma from The Cancer Genome Atlas. | ||||||||||
| Author: | Seshachalam, Veerabrahma Pratap|Sekar, Karthik|Hui, Kam M | ||||||||||
| PMID: | 29672926 | ||||||||||
| 37. | |||||||||||
| Journal: | Int J Mol Med. 2018 Aug;42(2):713-725. | ||||||||||
| Title: | Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). | ||||||||||
| Author: | Katoh, Masaru | ||||||||||
| PMID: | 29786110 | ||||||||||
| 38. | |||||||||||
| Journal: | Oncotarget. 2018 May 25;9(40):26144-26156. | ||||||||||
| Title: | Loss-of-function mutations in Zn-finger DNA-binding domain of HNF4A cause aberrant transcriptional regulation in liver cancer. | ||||||||||
| Author: | Taniguchi, Hiroaki|Fujimoto, Akihiro|Kono, Hidetoshi|Furuta, Mayuko|Fujita, Masashi|Nakagawa, Hidewaki | ||||||||||
| PMID: | 29899848 | ||||||||||
| 39. | |||||||||||
| Journal: | Nucleic Acids Res. 2018 Sep 28;46(17):8832-8847. | ||||||||||
| Title: | Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis. | ||||||||||
| Author: | Lee, Ying-Ying|Mok, Myth Ts|Kang, Wei|Yang, Weiqin|Tang, Wenshu|Wu, Feng|Xu, Liangliang|Yan, Mingfei|Yu, Zhuo|Lee, Sau-Dan|Tong, Joanna H M|Cheung, Yue-Sun|Lai, Paul B S|Yu, Dae-Yeul|Wang, Qianben|Wong, Grace L H|Chan, Andrew M|Yip, Kevin Y|To, Ka-Fai|Che | ||||||||||
| PMID: | 29992318 | ||||||||||
| 40. | |||||||||||
| Journal: | J Cell Biochem. 2018 Sep 7. | ||||||||||
| Title: | Novel mechanisms of regulation of the expression and transcriptional activity of hepatocyte nuclear factor 4alpha. | ||||||||||
| Author: | Guo, Shangdong|Lu, Hong | ||||||||||
| PMID: | 30191603 | ||||||||||
| 41. | |||||||||||
| Journal: | Cancer Sci. 2018 Sep 16. | ||||||||||
| Title: | Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors. | ||||||||||
| Author: | Takashima, Yasuo|Horisawa, Kenichi|Udono, Miyako|Ohkawa, Yasuyuki|Suzuki, Atsushi | ||||||||||
| PMID: | 30220099 | ||||||||||
| 42. | |||||||||||
| Journal: | Mol Cell Biol. 2018 Sep 17. pii: MCB.00213-18. | ||||||||||
| Title: | Induction of hepatic metabolic functions by a novel variant of hepatocyte nuclear factor 4gamma. | ||||||||||
| Author: | Sasaki, Shota|Urabe, Mizuho|Maeda, Tsukasa|Suzuki, Junko|Irie, Ryota|Suzuki, Masanori|Tomaru, Yasuhiro|Sakaguchi, Masakiyo|Gonzalez, Frank J|Inoue, Yusuke | ||||||||||
| PMID: | 30224520 | ||||||||||
| 43. | |||||||||||
| Journal: | Cell Death Dis. 2018 Oct 25;9(11):1091. | ||||||||||
| Title: | circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma. | ||||||||||
| Author: | Zhang, Xiao|Xu, Yanfeng|Qian, Zijun|Zheng, Weisheng|Wu, Qi|Chen, Yan|Zhu, Guoqing|Liu, Ya|Bian, Zhixuan|Xu, Wen|Zhang, Yue|Sun, Fenyong|Pan, Qiuhui|Wang, Jiayi|Du, Lutao|Yu, Yongchun | ||||||||||
| PMID: | 30361504 | ||||||||||