Primary Site >> Liver Cancer
Gene >> HNF4A
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Ref: The DNA binding activity of the liver transcription factors LFB1 (HNF1) and HNF4 varies coordinately in rat hepatocellular carcinoma. PMID: 7834800 |
Ref: Cellular factors controlling the activity of woodchuck hepatitis virus enhancer II. PMID: 8676498 |
Ref: Phenobarbital suppresses growth and accelerates restoration of differentiation markers of primary culture rat hepatocytes in the chemically defined hepatocyte growth medium containing hepatocyte growth factor and epidermal growth factor. PMID: 9637786 |
Ref: A common regulatory locus affects both HNF4/HNF1alpha pathway activation and sensitivity to LPS-mediated apoptosis in rat hepatoma cells. PMID: 11228163 Ref: [Expression of tissue-specific genes with progression of mouse hepatocellular carcinoma]. PMID: 11517767 |
Ref: Analysis of the beta-catenin/T cell factor signaling pathway in 36 gastrointestinal and liver cancer cells. PMID: 12460462 Ref: Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. PMID: 12481159 |
Ref: Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors. PMID: 15057908 |
Ref: Targeting the active beta-catenin pathway to treat cancer cells. PMID: 17121933 |
Ref: Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs. PMID: 17273804 Ref: Downregulated P1 promoter-driven hepatocyte nuclear factor-4alpha expression in human colorectal carcinoma is a new prognostic factor against liver metastasis. PMID: 17300672 |
Ref: Correlation between hepatocarcinogenic effect of estragole and its influence on glucocorticoid induction of liver-specific enzymes and activities of FOXA and HNF4 transcription factors in mouse and rat liver. PMID: 19463090 |
Ref: URG11 promotes gastric cancer growth and invasion by activation of beta-catenin signalling pathway. PMID: 19413886 Ref: Human liver progenitor cell lines are readily established from non-tumorous tissue adjacent to hepatocellular carcinoma. PMID: 19874130 Ref: [Effect of hepatocarcinogenicity of estragole on the glucocorticoid-mediated induction of liver-specific enzymes and the activity of the transcription factors FOXA and HNF4 in the liver of mouse and rat]. PMID: 20429289 Ref: Integrative and comparative genomics analysis of early hepatocellular carcinoma differentiated from liver regeneration in young and old. PMID: 20540791 |
Ref: Transcription dynamics in a physiological process: beta-catenin signaling directs liver metabolic zonation. PMID: 19914393 Ref: Sulfatase 1 and sulfatase 2 in hepatocellular carcinoma: associated signaling pathways, tumor phenotypes, and survival. PMID: 21104785 Ref: The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4alpha. PMID: 21384409 |
Ref: Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4alpha in adult mice. PMID: 22241473 |
Ref: Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay. PMID: 23512712 |
Ref: Characterisation of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows conservation of regulating transcription factor networks. PMID: 24280081 Ref: Gd-EOB-DTPA-enhanced magnetic resonance imaging and alpha-fetoprotein predict prognosis of early-stage hepatocellular carcinoma. PMID: 24700365 Ref: Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers. PMID: 25526364 |
Ref: Transcriptome and proteome of human hepatocellular carcinoma reveal shared metastatic pathways with significant genes. PMID: 25652264 Ref: YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression. PMID: 25772357 Ref: Integrative genomic signatures of hepatocellular carcinoma derived from nonalcoholic Fatty liver disease. PMID: 25993042 |
Ref: Increased liver carcinogenesis and enrichment of stem cell properties in livers of Dickkopf 2 (Dkk2) deleted mice. PMID: 25826080 Ref: Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx. PMID: 26792738 Ref: Integrative functional genomic delineation of the cascades of transcriptional changes involved in hepatocellular carcinoma progression. PMID: 27194100 Ref: CUL4B, NEDD4, and UGT1As involve in the TGF-beta signalling in hepatocellular carcinoma. PMID: 27236156 |
Ref: A pre-neoplastic epigenetic field defect in HCV-infected liver at transcription factor binding sites and polycomb targets. PMID: 27721404 Ref: An HNF4alpha-microRNA-194/192 signaling axis maintains hepatic cell function. PMID: 28465351 Ref: Uncovering the transcriptomic and epigenomic landscape of nicotinic receptor genes in non-neuronal tissues. PMID: 28583088 Ref: Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression. PMID: 28726775 |
Ref: Insights into the etiology-associated gene regulatory networks in hepatocellular carcinoma from The Cancer Genome Atlas. PMID: 29672926 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: Loss-of-function mutations in Zn-finger DNA-binding domain of HNF4A cause aberrant transcriptional regulation in liver cancer. PMID: 29899848 Ref: Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis. PMID: 29992318 Ref: Novel mechanisms of regulation of the expression and transcriptional activity of hepatocyte nuclear factor 4alpha. PMID: 30191603 Ref: Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors. PMID: 30220099 Ref: Induction of hepatic metabolic functions by a novel variant of hepatocyte nuclear factor 4gamma. PMID: 30224520 Ref: circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma. PMID: 30361504 |