Primary Site >> Stomach Cancer

Gene >> HNF4A

Journal: Cell Adhes Commun. 1998;6(2-3):171-84.
Title: Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas.
Author: Berx, G|Nollet, F|van Roy, F
PMID: 9823469
Journal: Cell Growth Differ. 1999 Jun;10(6):369-76.
Title: Beta- and gamma-catenin mutations, but not E-cadherin inactivation, underlie T-cell factor/lymphoid enhancer factor transcriptional deregulation in gastric and pancreatic cancer.
Author: Caca, K|Kolligs, F T|Ji, X|Hayes, M|Qian, J|Yahanda, A|Rimm, D L|Costa, J|Fearon, E R
PMID: 10392898
Journal: Gastric Cancer. 2000 Dec;3(4):193-201.
Title: Clinical significance of disordered beta-catenin expression pattern in human gastric cancers.
Author: Utsunomiya, Takehiro|Doki, Yuichiro|Takemoto, Hiroyoshi|Shiozaki, Hitoshi|Yano, Masahiko|Inoue, Masatoshi|Yasuda, Takushi|Fujiwara, Yoshiyuki|Monden, Morito
PMID: 11984736
Journal: Tumour Biol. 2001 Mar-Apr;22(2):123-30.
Title: Mutational analysis of the beta-catenin gene in gastric carcinomas.
Author: Sasaki, Y|Morimoto, I|Kusano, M|Hosokawa, M|Itoh, F|Yanagihara, K|Imai, K|Tokino, T
PMID: 11125285
Journal: Oncology. 2001;61(2):156-61.
Title: Genetic alterations in the human Tcf-4 gene in Japanese patients with sporadic gastrointestinal cancers with microsatellite instability.
Author: Saeki, H|Tanaka, S|Tokunaga, E|Kawaguchi, H|Ikeda, Y|Maehara, Y|Sugimachi, K
PMID: 11528255
Journal: Int J Mol Med. 2001 Dec;8(6):611-5.
Title: Molecular cloning and characterization of LZIC, a novel gene encoding ICAT homologous protein with leucine zipper domain.
Author: Katoh, M
PMID: 11712074
Journal: Int J Oncol. 2002 May;20(5):977-82.
Title: Molecular cloning and characterization of WRCH2 on human chromosome 15q15.
Author: Katoh, Masaru
PMID: 11956592
Journal: Int J Oncol. 2002 May;20(5):993-8.
Title: Molecular cloning and characterization of Strabismus 2 (STB2).
Author: Katoh, Masaru
PMID: 11956595
Journal: Int J Mol Med. 2002 May;9(5):515-9.
Title: Frequent up-regulation of WNT5A mRNA in primary gastric cancer.
Author: Saitoh, Tetsuroh|Mine, Tetsuya|Katoh, Masaru
PMID: 11956659
Journal: Int J Mol Med. 2002 Sep;10(3):345-9.
Title: Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFalpha in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells.
Author: Saitoh, Tetsuroh|Katoh, Masaru
PMID: 12165812
Journal: Int J Oncol. 2002 Oct;21(4):895-900.
Title: Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer.
Author: Kirikoshi, Hiroyuki|Katoh, Masaru
PMID: 12239632
Journal: Jpn J Cancer Res. 2002 Nov;93(11):1213-20.
Title: Analysis of the beta-catenin/T cell factor signaling pathway in 36 gastrointestinal and liver cancer cells.
Author: Ikenoue, Tsuneo|Ijichi, Hideaki|Kato, Naoya|Kanai, Fumihiko|Masaki, Tsutomu|Rengifo, William|Okamoto, Makoto|Matsumura, Masayuki|Kawabe, Takao|Shiratori, Yasushi|Omata, Masao
PMID: 12460462
Journal: Digestion. 2002;66(3):131-44.
Title: Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis.
Author: Kolligs, Frank T|Bommer, Guido|Goke, Burkhard
PMID: 12481159
Journal: Ann Oncol. 2004 May;15(5):759-64.
Title: 5-Fluorouracil as protracted continuous intravenous infusion can be added to full-dose docetaxel (Taxotere)-cisplatin in advanced gastric carcinoma: a phase I-II trial.
Author: Roth, A D|Maibach, R|Fazio, N|Sessa, C|Stupp, R|Morant, R|Herrmann, R|Borner, M M|Goldhirsch, A|de Braud, F
PMID: 15111343
Journal: Biochem Biophys Res Commun. 2005 Jun 17;331(4):1222-8.
Title: Inhibition of beta-catenin-mediated transactivation by flavanone in AGS gastric cancer cells.
Author: Park, Chi Hoon|Hahm, Eun Ryeong|Lee, Ju Hyung|Jung, Kyung Chae|Yang, Chul Hak
PMID: 15883006
Journal: Biochem Biophys Res Commun. 2005 Sep 30;335(3):771-6.
Title: Negative regulation of beta-catenin/Tcf signaling by naringenin in AGS gastric cancer cell.
Author: Lee, Ju Hyung|Park, Chi Hoon|Jung, Kyung Chae|Rhee, Ho Sung|Yang, Chul Hak
PMID: 16102728
Journal: Int J Mol Med. 2005 Sep;16(3):477-81.
Title: Comparative genomics on DKK2 and DKK4 orthologs.
Author: Katoh, Yuriko|Katoh, Masaru
PMID: 16077958
Journal: Int J Oncol. 2005 Apr;26(4):1135-9.
Title: Molecular evolution of Wnt2b orthologs.
Author: Katoh, Masaru
PMID: 15754012
Journal: Mol Cancer Ther. 2006 Nov;5(11):2861-71.
Title: Targeting the active beta-catenin pathway to treat cancer cells.
Author: Dvory-Sobol, Hadas|Sagiv, Eyal|Kazanov, Diana|Ben-Ze'ev, Avri|Arber, Nadir
PMID: 17121933
Journal: Cancer Chemother Pharmacol. 2007 Apr;59(5):631-6.
Title: A phase I study of paclitaxel, cisplatin, and fluorouracil (TCF) for advanced gastric cancer.
Author: Hara, Takuo|Omura, Kenji|Hirano, Makoto|Asada, Yasuyuki|Munemoto, Yoshinori|Sakamoto, Junichi
PMID: 16924496
Journal: Cancer. 2007 Jan 15;109(2):188-97.
Title: Suppression of gastric cancer cell growth by targeting the beta-catenin/T-cell factor pathway.
Author: Dvory-Sobol, Hadas|Sagiv, Eyal|Liberman, Eliezer|Kazanov, Diana|Arber, Nadir
PMID: 17149756
Journal: Oncogene. 2007 May 24;26(24):3511-20. Epub 2006 Dec 11.
Title: Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells.
Author: Aoki, K|Aoki, M|Sugai, M|Harada, N|Miyoshi, H|Tsukamoto, T|Mizoshita, T|Tatematsu, M|Seno, H|Chiba, T|Oshima, M|Hsieh, C-L|Taketo, M M
PMID: 17160019
Journal: Int J Mol Med. 2007 Mar;19(3):529-33.
Title: Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs.
Author: Katoh, Masuko|Katoh, Masaru
PMID: 17273804
Journal: APMIS. 2007 Feb;115(2):164-8.
Title: Genetic and epigenetic analysis of the EPHB2 gene in gastric cancers.
Author: Song, Jae Hwi|Kim, Chang Jae|Cho, Yong Gu|Kwak, Hyun Jung|Nam, Suk Woo|Yoo, Nam Jin|Lee, Jung Young|Park, Won Sang
PMID: 17295683
Journal: Pathol Int. 2007 Feb;57(2):82-90.
Title: Downregulated P1 promoter-driven hepatocyte nuclear factor-4alpha expression in human colorectal carcinoma is a new prognostic factor against liver metastasis.
Author: Oshima, Tomoko|Kawasaki, Takashi|Ohashi, Riuko|Hasegawa, Go|Jiang, Shuying|Umezu, Hajime|Aoyagi, Yutaka|Iwanari, Hiroko|Tanaka, Toshiya|Hamakubo, Takao|Kodama, Tatsuhiko|Naito, Makoto
PMID: 17300672
Journal: J Clin Oncol. 2007 Aug 1;25(22):3217-23.
Title: Docetaxel, cisplatin, and fluorouracil; docetaxel and cisplatin; and epirubicin, cisplatin, and fluorouracil as systemic treatment for advanced gastric carcinoma: a randomized phase II trial of the Swiss Group for Clinical Cancer Research.
Author: Roth, Arnaud D|Fazio, Nicola|Stupp, Roger|Falk, Stephen|Bernhard, Jurg|Saletti, Piercarlo|Koberle, Dieter|Borner, Markus M|Rufibach, Kaspar|Maibach, Rudolf|Wernli, Martin|Leslie, Martin|Glynne-Jones, Robert|Widmer, Lukas|Seymour, Matthew|de Braud, Filippo
PMID: 17664469
Journal: Clin Transl Oncol. 2009 Aug;11(8):518-25.
Title: Recommendations on current approach to gastric cancer.
Author: Rivera, Fernando|Carrato, Alfredo|Gravalos, Cristina|Pericay, Carles|Sastre, Javier|Aranda, Enrique
PMID: 19661026
Journal: Pathol Int. 2009 Jul;59(7):462-70.
Title: Immunohistochemical staining for P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha may complement mucin phenotype of differentiated-type early gastric carcinoma.
Author: Takano, Kabuto|Hasegawa, Go|Jiang, Shuying|Kurosaki, Isao|Hatakeyama, Katsuyoshi|Iwanari, Hiroko|Tanaka, Toshiya|Hamakubo, Takao|Kodama, Tatsuhiko|Naito, Makoto
PMID: 19563409
Journal: Oncogene. 2009 Feb 12;28(6):866-75.
Title: The aurora kinase A regulates GSK-3beta in gastric cancer cells.
Author: Dar, A A|Belkhiri, A|El-Rifai, W
PMID: 19060929
Journal: J Cell Mol Med. 2010 Mar;14(3):621-35.
Title: URG11 promotes gastric cancer growth and invasion by activation of beta-catenin signalling pathway.
Author: Du, Rui|Xia, Lin|Sun, Shiren|Lian, Zhaorui|Zou, Xue|Gao, Juan|Xie, Huahong|Fan, Rui|Song, Jiugang|Li, Xiaohua|Liu, Jie|Fan, Daiming
PMID: 19413886
Journal: Br J Cancer. 2010 Feb 2;102(3):475-81.
Title: Randomised, non-comparative phase II study of weekly docetaxel with cisplatin and 5-fluorouracil or with capecitabine in oesophagogastric cancer: the AGITG ATTAX trial.
Author: Tebbutt, N C|Cummins, M M|Sourjina, T|Strickland, A|Van Hazel, G|Ganju, V|Gibbs, D|Stockler, M|Gebski, V|Zalcberg, J
PMID: 20068567
Journal: World J Gastroenterol. 2010 Feb 21;16(7):868-74.
Title: Surgical outcome after docetaxel-based neoadjuvant chemotherapy in locally-advanced gastric cancer.
Author: Biffi, Roberto|Fazio, Nicola|Luca, Fabrizio|Chiappa, Antonio|Andreoni, Bruno|Zampino, Maria Giulia|Roth, Arnaud|Schuller, Jan Christian|Fiori, Giancarla|Orsi, Franco|Bonomo, Guido|Crosta, Cristiano|Huber, Olivier
PMID: 20143466
Journal: PLoS One. 2011 Apr 6;6(4):e18562.
Title: Wnt/beta-catenin signaling enhances cyclooxygenase-2 (COX2) transcriptional activity in gastric cancer cells.
Author: Nunez, Felipe|Bravo, Soraya|Cruzat, Fernando|Montecino, Martin|De Ferrari, Giancarlo V
PMID: 21494638
Journal: Clin Exp Metastasis. 2011 Dec;28(8):743-50.
Title: Galectin-3 germline variant at position 191 enhances nuclear accumulation and activation of beta-catenin in gastric cancer.
Author: Kim, Seok-Jun|Shin, Ji-Young|Cheong, Teak-Chin|Choi, Il-Ju|Lee, Yeon Su|Park, Seok Hee|Chun, Kyung-Hee
PMID: 21750908
Journal: PLoS One. 2012;7(1):e30185.
Title: S100A6 protein negatively regulates CacyBP/SIP-mediated inhibition of gastric cancer cell proliferation and tumorigenesis.
Author: Ning, Xiaoxuan|Sun, Shiren|Zhang, Kun|Liang, Jie|Chuai, Yucai|Li, Yuan|Wang, Xiaoming
PMID: 22295074
Journal: FEBS Lett. 2013 Jul 11;587(14):2105-11.
Title: FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C-myc.
Author: Qinyu, Li|Long, Cui|Zhen-dong, Du|Min-min, Shi|Wei-ze, Wu|Wei-ping, Yang|Cheng-hong, Peng
PMID: 23714368
Journal: Carcinogenesis. 2013 Dec;34(12):2861-9.
Title: GPR48, a poor prognostic factor, promotes tumor metastasis and activates beta-catenin/TCF signaling in colorectal cancer.
Author: Wu, Jinhua|Xie, Na|Xie, Ke|Zeng, Jun|Cheng, Lin|Lei, Yunlong|Liu, Yuan|Song, Linhong|Dong, Dandan|Chen, Yi|Zeng, Rui|Nice, Edouard C|Huang, Canhua|Wei, Yuquan
PMID: 23803691
Journal: J Pathol. 2014 Nov;234(3):302-15.
Title: Odd-skipped related 1 is a novel tumour suppressor gene and a potential prognostic biomarker in gastric cancer.
Author: Otani, Koji|Dong, Yujuan|Li, Xiaoxing|Lu, Jing|Zhang, Ning|Xu, Lixia|Go, Minnie Y Y|Ng, Enders K W|Arakawa, Tetsuo|Chan, Francis K L|Sung, Joseph J Y|Yu, Jun
PMID: 24931004
Journal: Virchows Arch. 2014 Jun;464(6):673-9.
Title: HNF4A immunohistochemistry facilitates distinction between primary and metastatic breast and gastric carcinoma.
Author: van der Post, R S|Bult, P|Vogelaar, I P|Ligtenberg, M J L|Hoogerbrugge, N|van Krieken, J H
PMID: 24711169
Journal: Oncogene. 2014 Oct 9;33(41):4941-51.
Title: PATHOME: an algorithm for accurately detecting differentially expressed subpathways.
Author: Nam, S|Chang, H R|Kim, K-T|Kook, M-C|Hong, D|Kwon, C H|Jung, H R|Park, H S|Powis, G|Liang, H|Park, T|Kim, Y H
PMID: 24681952
Journal: Nucleic Acids Res. 2014 Mar;42(5):2988-98.
Title: Glycogen synthase kinase 3 beta inhibits microRNA-183-96-182 cluster via the beta-Catenin/TCF/LEF-1 pathway in gastric cancer cells.
Author: Tang, Xiaoli|Zheng, Dong|Hu, Ping|Zeng, Zongyue|Li, Ming|Tucker, Lynne|Monahan, Renee|Resnick, Murray B|Liu, Manran|Ramratnam, Bharat
PMID: 24335145
Journal: Mol Carcinog. 2014 Sep;53(9):736-43.
Title: Prolyl hydroxylase 3 inhibited the tumorigenecity of gastric cancer cells.
Author: Cui, Lei|Qu, Jianguo|Dang, Shengchun|Mao, Zhengfa|Wang, Xuqing|Fan, Xin|Sun, Kang|Zhang, Jianxin
PMID: 23533015
Journal: Gut. 2015 May;64(5):707-19.
Title: Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development.
Author: Chia, Na-Yu|Deng, Niantao|Das, Kakoli|Huang, Dachuan|Hu, Longyu|Zhu, Yansong|Lim, Kiat Hon|Lee, Ming-Hui|Wu, Jeanie|Sam, Xin Xiu|Tan, Gek San|Wan, Wei Keat|Yu, Willie|Gan, Anna|Tan, Angie Lay Keng|Tay, Su-Ting|Soo, Khee Chee|Wong, Wai Keong|Dominguez, Lou
PMID: 25053715
Journal: Oncotarget. 2015 Jun 30;6(18):16168-82.
Title: Intelectin 1 suppresses tumor progression and is associated with improved survival in gastric cancer.
Author: Li, Dan|Zhao, Xiang|Xiao, Yong|Mei, Hong|Pu, Jiarui|Xiang, Xuan|Jiao, Wanju|Song, Huajie|Qu, Hongxia|Huang, Kai|Zheng, Liduan|Tong, Qiangsong
PMID: 25965823
Journal: Diagn Pathol. 2015 Jul 28;10:128.
Title: The significance of NTR1 expression and its correlation with beta-catenin and EGFR in gastric cancer.
Author: Zhou, Zhiyi|Xie, Jiaming|Cai, Ying|Yang, Shudong|Chen, Ying|Wu, HaoRong
PMID: 26215716
Journal: Gut. 2016 Jan;65(1):19-32.
Title: HNF4alpha is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer.
Author: Chang, Hae Ryung|Nam, Seungyoon|Kook, Myeong-Cherl|Kim, Kyung-Tae|Liu, Xiuping|Yao, Hui|Jung, Hae Rim|Lemos, Robert Jr|Seo, Hye Hyun|Park, Hee Seo|Gim, Youme|Hong, Dongwan|Huh, Iksoo|Kim, Young-Woo|Tan, Dongfeng|Liu, Chang-Gong|Powis, Garth|Park, Taesung|
PMID: 25410163
Journal: Gut. 2016 Jun;65(6):914-24.
Title: miR-30-HNF4gamma and miR-194-NR2F2 regulatory networks contribute to the upregulation of metaplasia markers in the stomach.
Author: Sousa, Josane F|Nam, Ki Taek|Petersen, Christine P|Lee, Hyuk-Joon|Yang, Han-Kwang|Kim, Woo Ho|Goldenring, James R
PMID: 25800782
Journal: Oncotarget. 2016 Mar 8;7(10):11349-63.
Title: Mutual amplification of HNF4alpha and IL-1R1 composes an inflammatory circuit in Helicobacter pylori associated gastric carcinogenesis.
Author: Ma, Lin|Zeng, Jiping|Guo, Qing|Liang, Xiuming|Shen, Li|Li, Shuyan|Sun, Yundong|Li, Wenjuan|Liu, Shili|Yu, Han|Chen, Chunyan|Jia, Jihui
PMID: 26870992
Journal: Oncotarget. 2016 Mar 1;7(9):10650-62.
Title: The expression of presenilin 1 enhances carcinogenesis and metastasis in gastric cancer.
Author: Li, Ping|Lin, Xi|Zhang, Jun-Rong|Li, Yun|Lu, Jun|Huang, Fei-Chao|Zheng, Chao-Hui|Xie, Jian-Wei|Wang, Jia-Bin|Huang, Chang-Ming
PMID: 26872378
Journal: Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311(2):G267-75.
Title: Hepatocyte nuclear factor 4alpha is required for cell differentiation and homeostasis in the adult mouse gastric epithelium.
Author: Moore, Benjamin D|Khurana, Shradha S|Huh, Won Jae|Mills, Jason C
PMID: 27340127
Journal: Diagn Pathol. 2017 Jun 5;12(1):43.
Title: HNF4A expression as a potential diagnostic tool to discriminate primary gastric cancer from breast cancer metastasis in a Brazilian cohort.
Author: Juca, Patricia Chaves de Freitas Campos|Correa, Stephany|Vignal, Giselle Maria|Accioly, Maria Theresa de Souza|Lustosa, Suzana Angelica Silva|Abdelhay, Eliana|Matos, Delcio
PMID: 28583188
Journal: Biochem Biophys Rep. 2018 Feb 12;13:141-146.
Title: Gastric cancer biomarkers; A systems biology approach.
Author: Saberi Anvar, Mohammad|Minuchehr, Zarrin|Shahlaei, Mohsen|Kheitan, Samira
PMID: 29556568
Journal: Int J Mol Med. 2018 Aug;42(2):713-725.
Title: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review).
Author: Katoh, Masaru
PMID: 29786110
Journal: Am J Cancer Res. 2018 Jun 1;8(6):932-943. eCollection 2018.
Title: VGLL4 is a transcriptional cofactor acting as a novel tumor suppressor via interacting with TEADs.
Author: Deng, Xiaochong|Fang, Lin
PMID: 30034932