Primary Site >> Liver Cancer

Gene >> HNF1A

Journal: EMBO J. 1991 Jun;10(6):1435-43.
Title: LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia.
Author: De Simone, V|De Magistris, L|Lazzaro, D|Gerstner, J|Monaci, P|Nicosia, A|Cortese, R
PMID: 1673925
Journal: Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):272-6.
Title: Liver-specific expression of human insulin-like growth factor binding protein 1: functional role of transcription factor HNF1 in vivo.
Author: Babajko, S|Tronche, F|Groyer, A
PMID: 7678342
Journal: Growth Regul. 1993 Mar;3(1):17-20.
Title: Characterization of cis-acting elements and transacting factors involved in the tissue-specific and developmental regulation of IGFBP-1 gene expression.
Author: Babajko, S|Binoux, M|Groyer, A
PMID: 7683517
Journal: Carcinogenesis. 1995 Jan;16(1):143-5.
Title: The DNA binding activity of the liver transcription factors LFB1 (HNF1) and HNF4 varies coordinately in rat hepatocellular carcinoma.
Author: Stumpf, H|Senkel, S|Rabes, H M|Ryffel, G U
PMID: 7834800
Journal: J Virol. 1996 Jul;70(7):4714-23.
Title: Cellular factors controlling the activity of woodchuck hepatitis virus enhancer II.
Author: Ueda, K|Wei, Y|Ganem, D
PMID: 8676498
Journal: Eur J Biochem. 1996 Jun 1;238(2):400-9.
Title: trans-Acting factors, detoxication enzymes and hepatitis B virus replication in a novel set of human hepatoma cell lines.
Author: Le Jossic, C|Glaise, D|Corcos, L|Diot, C|Dezier, J F|Fautrel, A|Guguen-Guillouzo, C
PMID: 8681951
Journal: Nat Genet. 2002 Oct;32(2):312-5.
Title: Bi-allelic inactivation of TCF1 in hepatic adenomas.
Author: Bluteau, Olivier|Jeannot, Emmanuelle|Bioulac-Sage, Paulette|Marques, Juan Martin|Blanc, Jean-Frederic|Bui, Hung|Beaudoin, Jean-Christophe|Franco, Dominique|Balabaud, Charles|Laurent-Puig, Pierre|Zucman-Rossi, Jessica
PMID: 12355088
Journal: Gastroenterology. 2003 May;124(5):1311-4.
Title: Frequent mutations of hepatocyte nuclear factor 1 in colorectal cancer with microsatellite instability.
Author: Laurent-Puig, Pierre|Plomteux, Olivier|Bluteau, Olivier|Zinzindohoue, Franck|Jeannot, Emmanuelle|Dahan, Karin|Kartheuser, Alex|Chapusot, Caroline|Cugnenc, Paul-Henri|Zucman-Rossi, Jessica
PMID: 12730871
Journal: J Lipid Res. 2005 Sep;46(9):1868-76.
Title: Control of ACAT2 liver expression by HNF1.
Author: Pramfalk, Camilla|Davis, Matthew A|Eriksson, Mats|Rudel, Lawrence L|Parini, Paolo
PMID: 15961790
Journal: J Biol Chem. 2007 May 11;282(19):14437-46.
Title: HNF1alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP-1 and carbohydrate-response element-binding protein (ChREBP) activation.
Author: Rebouissou, Sandra|Imbeaud, Sandrine|Balabaud, Charles|Boulanger, Virginie|Bertrand-Michel, Justine|Terce, Francois|Auffray, Charles|Bioulac-Sage, Paulette|Zucman-Rossi, Jessica
PMID: 17379603
Journal: J Cell Mol Med. 2008 Dec;12(6B):2772-80.
Title: ZHX2 is a repressor of alpha-fetoprotein expression in human hepatoma cell lines.
Author: Shen, H|Luan, F|Liu, H|Gao, L|Liang, X|Zhang, L|Sun, W|Ma, C
PMID: 18194454
Journal: Oncogene. 2009 Oct 8;28(40):3526-36.
Title: Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties.
Author: Coulouarn, C|Factor, V M|Andersen, J B|Durkin, M E|Thorgeirsson, S S
PMID: 19617899
Journal: Biochemistry (Mosc). 2009 Apr;74(4):377-84.
Title: Correlation between hepatocarcinogenic effect of estragole and its influence on glucocorticoid induction of liver-specific enzymes and activities of FOXA and HNF4 transcription factors in mouse and rat liver.
Author: Kaledin, V I|Pakharukova, M Yu|Pivovarova, E N|Kropachev, K Yu|Baginskaya, N V|Vasilieva, E D|Ilnitskaya, S I|Nikitenko, E V|Kobzev, V F|Merkulova, T I
PMID: 19463090
Journal: J Biol Chem. 2009 May 15;284(20):13335-47.
Title: Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular carcinoma.
Author: Yu, Hai-Tao|Yu, Miao|Li, Chang-Yan|Zhan, Yi-Qun|Xu, Wang-Xiang|Li, Yong-Hui|Li, Wei|Wang, Zhi-Dong|Ge, Chang-Hui|Yang, Xiao-Ming
PMID: 19304666
Journal: Hepatology. 2010 Feb;51(2):557-66.
Title: Loss of hepatocyte nuclear factor 1alpha function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis.
Author: Pelletier, Laura|Rebouissou, Sandra|Paris, Alain|Rathahao-Paris, Estelle|Perdu, Elisabeth|Bioulac-Sage, Paulette|Imbeaud, Sandrine|Zucman-Rossi, Jessica
PMID: 20041408
Journal: Am J Transl Res. 2010 Jan 23;2(1):105-18.
Title: Molecular genetics of hepatocellular neoplasia.
Author: Jain, Shilpa|Singhal, Shashideep|Lee, Peng|Xu, Ruliang
PMID: 20182587
Journal: Dig Surg. 2010;27(1):39-45.
Title: Subtype classification of hepatocellular adenoma.
Author: Bioulac-Sage, Paulette|Balabaud, Charles|Zucman-Rossi, Jessica
PMID: 20357450
Journal: Biofizika. 2010 Mar-Apr;55(2):326-35.
Title: [Effect of hepatocarcinogenicity of estragole on the glucocorticoid-mediated induction of liver-specific enzymes and the activity of the transcription factors FOXA and HNF4 in the liver of mouse and rat].
Author: Kaledin, V I|Pakharukova, M Iu|Pivovarova, E N|Kropachev, K Iu|Baginskaia, N V|Vasil'eva, E D|Il'nitskaia, S I|Nikitenko, E V|Kobzev, V F|Merkulova, T I
PMID: 20429289
Journal: Radiology. 2011 Mar;258(3):673-93.
Title: Recent advances in cytogenetics and molecular biology of adult hepatocellular tumors: implications for imaging and management.
Author: Shanbhogue, Alampady K|Prasad, Srinivasa R|Takahashi, Naoki|Vikram, Raghunandan|Sahani, Dushyant V
PMID: 21339346
Journal: Semin Liver Dis. 2011 Feb;31(1):91-103.
Title: Revisiting the pathology of resected benign hepatocellular nodules using new immunohistochemical markers.
Author: Bioulac-Sage, Paulette|Cubel, Gaelle|Balabaud, Charles|Zucman-Rossi, Jessica
PMID: 21344354
Journal: BMC Cancer. 2011 Oct 5;11:427.
Title: HNF1alpha inhibition triggers epithelial-mesenchymal transition in human liver cancer cell lines.
Author: Pelletier, Laura|Rebouissou, Sandra|Vignjevic, Danijela|Bioulac-Sage, Paulette|Zucman-Rossi, Jessica
PMID: 21975049
Journal: Hepatology. 2012 Jan;55(1):98-107.
Title: MicroRNA-194 is a target of transcription factor 1 (Tcf1, HNF1alpha) in adult liver and controls expression of frizzled-6.
Author: Krutzfeldt, Jan|Rosch, Nora|Hausser, Jean|Manoharan, Muthiah|Zavolan, Mihaela|Stoffel, Markus
PMID: 21887698
Journal: Gastroenterology. 2013 May;144(5):888-902.
Title: Hepatocellular benign tumors-from molecular classification to personalized clinical care.
Author: Nault, Jean-Charles|Bioulac-Sage, Paulette|Zucman-Rossi, Jessica
PMID: 23485860
Journal: J Hepatol. 2013 Oct;59(4):904-7.
Title: Primary hepatocellular neoplasms in a MODY3 family with a novel HNF1A germline mutation.
Author: Willson, J S B|Godwin, T D|Wiggins, G A R|Guilford, P J|McCall, J L
PMID: 23707370
Journal: Int J Hepatol. 2013;2013:253261.
Title: Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context.
Author: Bioulac-Sage, Paulette|Sempoux, Christine|Possenti, Laurent|Frulio, Nora|Laumonier, Herve|Laurent, Christophe|Chiche, Laurence|Frederic Blanc, Jean|Saric, Jean|Trillaud, Herve|Le Bail, Brigitte|Balabaud, Charles
PMID: 23691330
Journal: Int J Hepatol. 2013;2013:398308.
Title: Histological and immunohistochemical revision of hepatocellular adenomas: a learning experience.
Author: Fonseca, S|Hoton, D|Dardenne, S|Annet, L|Hubert, C|Godecharles, S|Jouret-Mourin, A|Reding, R|Otte, J B|Rahier, J|Gigot, J F|Sempoux, C
PMID: 23533787
Journal: Liver Transpl. 2013 Mar;19(3):336-45.
Title: Hepatocyte nuclear factor 1beta is a novel prognostic marker independent of the Milan criteria in transplantable hepatocellular carcinoma: a retrospective analysis based on tissue microarrays.
Author: Shim, Ju Hyun|Lee, Han Chu|Han, Seungbong|Kang, Hyo Jeong|Yu, Eunsil|Lee, Sung-Gyu
PMID: 23203386
Journal: J Hepatol. 2013 Feb;58(2):350-7.
Title: Molecular characterization of hepatocellular adenomas developed in patients with glycogen storage disease type I.
Author: Calderaro, Julien|Labrune, Philippe|Morcrette, Guillaume|Rebouissou, Sandra|Franco, Dominique|Prevot, Sophie|Quaglia, Alberto|Bedossa, Pierre|Libbrecht, Louis|Terracciano, Luigi|Smit, G Peter A|Bioulac-Sage, Paulette|Zucman-Rossi, Jessica
PMID: 23046672
Journal: Genome Res. 2013 May;23(5):800-11.
Title: Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay.
Author: Kheradpour, Pouya|Ernst, Jason|Melnikov, Alexandre|Rogov, Peter|Wang, Li|Zhang, Xiaolan|Alston, Jessica|Mikkelsen, Tarjei S|Kellis, Manolis
PMID: 23512712
Journal: World J Gastroenterol. 2014 Dec 14;20(46):17541-51.
Title: Significance of downregulation of liver fatty acid-binding protein in hepatocellular carcinoma.
Author: Inoue, Masafumi|Takahashi, Yoshihisa|Fujii, Takeshi|Kitagawa, Masanobu|Fukusato, Toshio
PMID: 25516669
Journal: Toxicology. 2015 Oct 2;336:99-112.
Title: Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR).
Author: Oshida, Keiyu|Vasani, Naresh|Thomas, Russell S|Applegate, Dawn|Gonzalez, Frank J|Aleksunes, Lauren M|Klaassen, Curtis D|Corton, J Christopher
PMID: 26215100
Journal: Liver Int. 2016 Nov;36(11):1668-1676.
Title: Liver biopsy for diagnosis of presumed benign hepatocellular lesions lacking magnetic resonance imaging diagnostic features of focal nodular hyperplasia.
Author: Sannier, Aurelie|Cazejust, Julien|Lequoy, Marie|Cervera, Pascale|Scatton, Olivier|Rosmorduc, Olivier|Wendum, Dominique
PMID: 26969817
Journal: Hum Pathol. 2016 Apr;50:135-9.
Title: Expression of liver fatty acid binding protein in hepatocellular carcinoma.
Author: Cho, Soo-Jin|Ferrell, Linda D|Gill, Ryan M
PMID: 26997447
Journal: Oncotarget. 2016 Jun 21;7(25):38440-38450.
Title: Validation of a multi-omics strategy for prioritizing personalized candidate driver genes
Author: Liang, Li|Song, Liting|Yang, Yi|Tian, Ling|Li, Xiaoyuan|Wu, Songfeng|Huang, Wenxun|Ren, Hong|Tang, Ni|Ding, Keyue
PMID: 27469031
Journal: Folia Biol (Praha). 2017;63(5-6):202-208.
Title: Comparison of Subtypes of Hepatocellular Adenoma to Hepatocellular Carcinoma and Non-Neoplastic Liver Tissue in Terms of PTEN Expression.
Author: Szparecki, G|Ilczuk, T|Gabzdyl, N|Gornicka, B
PMID: 29687774
Journal: Case Rep Gastroenterol. 2017 Oct 30;11(3):637-642.
Title: Hepatocyte Nuclear Factor 1alpha-Mutated Hepatocellular Adenomas: An Atypical Presentation.
Author: Sousa, Camila Maria Neves|Gadelha, Patricia Maria Miranda|Cartaxo, Rafaella de Sousa|Pedrosa, George Washington Holanda|Honorio, Rodrigo Schuler|Lima, Jose Milton de Castro|Coelho, Gustavo Rego|Coelho, Clovis Rego
PMID: 29282384
Journal: J Hepatol. 2017 Nov;67(5):1074-1083.
Title: Molecular classification of hepatocellular adenoma in clinical practice.
Author: Nault, Jean-Charles|Paradis, Valerie|Cherqui, Daniel|Vilgrain, Valerie|Zucman-Rossi, Jessica
PMID: 28733222
Journal: Gastroenterology. 2017 Mar;152(4):880-894.e6.
Title: Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.
Author: Nault, Jean-Charles|Couchy, Gabrielle|Balabaud, Charles|Morcrette, Guillaume|Caruso, Stefano|Blanc, Jean-Frederic|Bacq, Yannick|Calderaro, Julien|Paradis, Valerie|Ramos, Jeanne|Scoazec, Jean-Yves|Gnemmi, Viviane|Sturm, Nathalie|Guettier, Catherine|Fabre,
PMID: 27939373
Journal: Biochem Biophys Res Commun. 2018 Jan 1;495(1):86-91.
Title: p.Q511L mutation of HNF1alpha in hepatocellular carcinoma suppresses the transcriptional activity and the anti-tumor effect of HNF1alpha.
Author: Ding, Chen-Hong|Deng, Long-Fei|Chen, Fei|Ding, Kai|Chen, Wan-Sheng|Xie, Wei-Fen|Zhang, Xin
PMID: 29101032
Journal: Mol Cancer. 2018 Feb 21;17(1):63.
Title: The HNF1alpha-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1.
Author: Ding, Chen-Hong|Yin, Chuan|Chen, Shi-Jie|Wen, Liang-Zhi|Ding, Kai|Lei, Shu-Juan|Liu, Jin-Pei|Wang, Jian|Chen, Kai-Xian|Jiang, Hua-Liang|Zhang, Xin|Luo, Cheng|Xie, Wei-Fen
PMID: 29466992
Journal: J Gastroenterol Hepatol. 2018 Apr 19.
Title: Insights into the etiology-associated gene regulatory networks in hepatocellular carcinoma from The Cancer Genome Atlas.
Author: Seshachalam, Veerabrahma Pratap|Sekar, Karthik|Hui, Kam M
PMID: 29672926
Journal: Oncotarget. 2018 May 25;9(40):26144-26156.
Title: Loss-of-function mutations in Zn-finger DNA-binding domain of HNF4A cause aberrant transcriptional regulation in liver cancer.
Author: Taniguchi, Hiroaki|Fujimoto, Akihiro|Kono, Hidetoshi|Furuta, Mayuko|Fujita, Masashi|Nakagawa, Hidewaki
PMID: 29899848
Journal: Nucleic Acids Res. 2018 Sep 28;46(17):8832-8847.
Title: Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.
Author: Lee, Ying-Ying|Mok, Myth Ts|Kang, Wei|Yang, Weiqin|Tang, Wenshu|Wu, Feng|Xu, Liangliang|Yan, Mingfei|Yu, Zhuo|Lee, Sau-Dan|Tong, Joanna H M|Cheung, Yue-Sun|Lai, Paul B S|Yu, Dae-Yeul|Wang, Qianben|Wong, Grace L H|Chan, Andrew M|Yip, Kevin Y|To, Ka-Fai|Che
PMID: 29992318
Journal: Hum Pathol. 2018 Aug 16. pii: S0046-8177(18)30308-3.
Title: Somatic HNF1A mutations in the malignant transformation of hepatocellular adenomas: a retrospective analysis of data from MSK-IMPACT and TCGA.
Author: Hechtman, Jaclyn F|Abou Alfa, Ghassan K|Stadler, Zsofia K|Mandelker, Diana L|Roehrl, Michael H A|Zehir, Ahmet|Vakiani, Efsevia|Middha, Sumit|Klimstra, David S|Shia, Jinru
PMID: 30121369
Journal: J Diabetes Res. 2018 Aug 1;2018:7842064.
Title: Lower Circulating miR-122 Level in Patients with HNF1A Variant-Induced Diabetes Compared with Type 2 Diabetes.
Author: Huang, Xiuting|Gong, Siqian|Ma, Yumin|Cai, Xiaoling|Zhou, Lingli|Luo, Yingying|Li, Meng|Liu, Wei|Zhang, Simin|Zhang, Xiuying|Ren, Qian|Zhu, Yu|Zhou, Xianghai|Zhang, Rui|Chen, Ling|Gao, Xueying|Zhang, Fang|Wang, Yanai|Han, Xueyao|Ji, Linong
PMID: 30155490
Journal: J Cell Biochem. 2018 Sep 7.
Title: Novel mechanisms of regulation of the expression and transcriptional activity of hepatocyte nuclear factor 4alpha.
Author: Guo, Shangdong|Lu, Hong
PMID: 30191603
Journal: Cancer Sci. 2018 Sep 16.
Title: Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors.
Author: Takashima, Yasuo|Horisawa, Kenichi|Udono, Miyako|Ohkawa, Yasuyuki|Suzuki, Atsushi
PMID: 30220099
Journal: Hepat Oncol. 2018 Apr 9;5(1):HEP04.
Title: Molecular classification of hepatocellular adenomas: impact on clinical practice.
Author: Vedie, Anne-Laure|Sutter, Olivier|Ziol, Marianne|Nault, Jean-Charles
PMID: 30302195