Primary Site >> Esophagus Cancer

Gene >> HIF1A

Journal: Cancer Res. 2001 Mar 1;61(5):1830-2.
Title: Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy.
Author: Koukourakis, M I|Giatromanolaki, A|Skarlatos, J|Corti, L|Blandamura, S|Piazza, M|Gatter, K C|Harris, A L
PMID: 11280732
Journal: Int J Cancer. 2004 Jul 20;110(6):838-44.
Title: Pretreatment evaluation of combined HIF-1alpha, p53 and p21 expression is a useful and sensitive indicator of response to radiation and chemotherapy in esophageal cancer.
Author: Sohda, Makoto|Ishikawa, Hitoshi|Masuda, Norihiro|Kato, Hiroyuki|Miyazaki, Tatsuya|Nakajima, Masanobu|Fukuchi, Minoru|Manda, Ryokuhei|Fukai, Yasuyuki|Sakurai, Hideyuki|Kuwano, Hiroyuki
PMID: 15170665
Journal: Cancer Sci. 2005 Mar;96(3):176-82.
Title: Expression of hypoxia-inducible factor-1alpha in esophageal squamous cell carcinoma.
Author: Matsuyama, Tomokazu|Nakanishi, Kuniaki|Hayashi, Takuya|Yoshizumi, Yutaka|Aiko, Satoshi|Sugiura, Yoshiaki|Tanimoto, Takao|Uenoyama, Maki|Ozeki, Yuichi|Maehara, Tadaaki
PMID: 15771621
Journal: Pathobiology. 2005;72(4):179-85.
Title: Expression of p53 protein in esophageal squamous cell carcinoma: relation to hypoxia-inducible factor-1alpha, angiogenesis and apoptosis.
Author: Kimura, Shigeru|Kitadai, Yasuhiko|Kuwai, Toshio|Tanaka, Shinji|Hihara, Jun|Yoshida, Kazuhiro|Toge, Tetsuya|Chayama, Kazuaki
PMID: 16127293
Journal: Exp Mol Pathol. 2005 Apr;78(2):123-30.
Title: Correlation of hypoxia inducible factor-1alpha with lymphatic metastasis via vascular endothelial growth factor-C in human esophageal cancer.
Author: Katsuta, Miwako|Miyashita, Masao|Makino, Hiroshi|Nomura, Tsutomu|Shinji, Seiichi|Yamashita, Kiyohiko|Tajiri, Takashi|Kudo, Mitsuhiro|Ishiwata, Toshiyuki|Naito, Zenya
PMID: 15713437
Journal: Anticancer Res. 2006 Nov-Dec;26(6B):4505-9.
Title: HIF-1alpha mRNA is not associated with histopathological regression following neoadjuvant chemoradiation in esophageal cancer.
Author: Ling, Frederike C|Leimbach, Nadine|Baldus, Stephan E|Buechel, Sandra|Neiss, Susanne|Brabender, Jan|Drebber, Uta|Dienes, Hans P|Mueller, Rolf P|Hoelscher, Arnulf H|Schneider, Paul M
PMID: 17201171
Journal: J Thorac Cardiovasc Surg. 2007 Mar;133(3):763-9.
Title: Cytogenetic characterization and gene expression profiling in the rat reflux-induced esophageal tumor model.
Author: Bonde, Pramod|Sui, Guoping|Dhara, Surajit|Wang, Jiaai|Broor, Apoorv|Kim, Irene F|Wiley, John E|Marti, Guy|Duncan, Mark|Jaffee, Elizabeth|Montgomery, Elizabeth|Maitra, Anirban|Harmon, John W
PMID: 17320581
Journal: Zhonghua Zhong Liu Za Zhi. 2007 Sep;29(9):689-92.
Title: [Expression and biological significance of HPA and HIF-1alpha in human esophageal squamous cell carcinoma].
Author: Liu, Jia-Lin|Zhou, Bing-Juan|Zhang, Ying|Wu, Yan-Ping|Liu, Shu-Zhe|G A O, Wei-Min|Xue, Juan|Liu, Wei-Hua
PMID: 18246800
Journal: Zhonghua Yi Xue Za Zhi. 2008 Sep 16;88(35):2465-9.
Title: [Expression of hypoxia-inducible factor-1alpha and vessel endothelial growth factor in esophageal squamous cell carcinoma and clinico-pathological significance thereof].
Author: Yu, Zhen-Tao|Zhao, Hua-Feng|Shang, Xiao-Bin
PMID: 19080625
Journal: Oncol Rep. 2009 Jun;21(6):1489-94.
Title: Clinical significance of the gene expression profile in residual tumor cells after neoadjuvant chemo-radiotherapy for esophageal cancer.
Author: Tanaka, Koji|Otake, Kohhei|Mohri, Yasuhiko|Ohi, Masaki|Yokoe, Takeshi|Toiyama, Yuji|Miki, Chikao|Tonouchi, Hitoshi|Kusunoki, Masato
PMID: 19424628
Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2010 May;30(5):1037-40.
Title: [Effect of fractioned irradiation on HIF-1alpha and MDR1 expression in esophageal cancer cells].
Author: Gao, Rui|Zhang, Guang-jian|Fu, Jun-ke|Jin, Xin|Zhang, Ming-xin|Li, Fen
PMID: 20501388
Journal: Cell Physiol Biochem. 2010;26(6):849-58.
Title: Gensenoside Rg3 inhibits hypoxia-induced VEGF expression in human cancer cells.
Author: Chen, Qing-Jiang|Zhang, Ming-Zhi|Wang, Le-Xin
PMID: 21220916
Journal: J Surg Res. 2011 May 1;167(1):41-8.
Title: HIF-1alpha and VEGF are associated with disease progression in esophageal carcinoma.
Author: Takala, Heikki|Saarnio, Juha|Wiik, Heikki|Ohtonen, Pasi|Soini, Ylermi
PMID: 20451923
Journal: Anticancer Res. 2011 Jun;31(6):2351-9.
Title: Clinical significance of HIF-1alpha expression in patients with esophageal cancer treated with concurrent chemoradiotherapy.
Author: Ogawa, Kazuhiko|Chiba, Itaru|Morioka, Takamitsu|Shimoji, Hideaki|Tamaki, Wakana|Takamatsu, Reika|Nishimaki, Tadashi|Yoshimi, Naoki|Murayama, Sadayuki
PMID: 21737664
Journal: Cancer Biol Ther. 2011 Jun 1;11(11):981-7. Epub 2011 Jun 1.
Title: Inhibition of hypoxia inducible factor 1alpha expression suppresses the progression of esophageal squamous cell carcinoma.
Author: Zhu, Hong|Feng, Yadong|Zhang, Jie|Zhou, Xiqiao|Hao, Bo|Zhang, Guoxin|Shi, Ruihua
PMID: 21519196
Journal: Dis Esophagus. 2011 Sep;24(7):481-8.
Title: Various doses of fractioned irradiation modulates multidrug resistance 1 expression differently through hypoxia-inducible factor 1alpha in esophageal cancer cells.
Author: Zhang, G-J|Gao, R|Wang, J-S|Fu, J-K|Zhang, M-X|Jin, X
PMID: 21309917
Journal: Cell Biol Int. 2011 May;35(5):491-7.
Title: Effects of YC-1 targeting hypoxia-inducible factor 1 alpha in oesophageal squamous carcinoma cell line Eca109 cells.
Author: Feng, Yadong|Zhu, Hong|Ling, Tingsheng|Hao, Bo|Zhang, Guoxin|Shi, Ruihua
PMID: 20977428
Journal: Oncol Rep. 2012 Apr;27(4):940-6.
Title: Assessment of stanniocalcin-1 as a prognostic marker in human esophageal squamous cell carcinoma.
Author: Shirakawa, Mitsuhiro|Fujiwara, Yoshiyuki|Sugita, Yurika|Moon, Jeong-Ho|Takiguchi, Shuji|Nakajima, Kiyokazu|Miyata, Hiroshi|Yamasaki, Makoto|Mori, Masaki|Doki, Yuichiro
PMID: 22200953
Journal: Oncol Lett. 2012 Feb;3(2):287-292. Epub 2011 Nov 2.
Title: Early evaluation of the apoptotic index ratio is useful in predicting the efficacy of chemoradiotherapy in esophageal squamous cell carcinoma.
Author: Sobajima, Jun|Kumamoto, Kensuke|Haga, Norihiro|Tamaru, Junichi|Takahashi, Takeo|Miyazaki, Tatsuya|Ishida, Hideyuki
PMID: 22740896
Journal: Acta Med Okayama. 2012;66(5):399-407.
Title: HIF-1alpha contributes to hypoxia-induced invasion and metastasis of esophageal carcinoma via inhibiting E-cadherin and promoting MMP-2 expression.
Author: Jing, Shao-Wu|Wang, Ya-Di|Kuroda, Masahiro|Su, Jing-Wei|Sun, Guo-Gui|Liu, Qing|Cheng, Yun-Jie|Yang, Cong-Rong
PMID: 23093058
Journal: Thorac Cancer. 2013 Aug;4(3):312-317.
Title: Metastasis associated protein 1 correlates with Hypoxia inducible-factor 1 alpha expression and lymphangiogenesis in esophageal cancer.
Author: Guo, Xufeng|Chen, Yongbing|Fang, Wentao|Yang, Wentao|Shi, Li|Zhu, Rongying
PMID: 28920244
Journal: Cancer Biol Ther. 2013 Nov;14(11):1068-73.
Title: Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1alpha in vitro and in vivo.
Author: Yang, Xi|Yang, Baixia|Cai, Jing|Zhang, Chi|Zhang, Qu|Xu, Liping|Qin, Qin|Zhu, Hongcheng|Ma, Jianxin|Tao, Guangzhou|Cheng, Hongyan|Sun, Xinchen
PMID: 24025355
Journal: Cancer Biol Ther. 2013 Mar;14(3):230-6.
Title: Antiproliferative effect of a novel mTOR inhibitor temsirolimus contributes to the prolonged survival of orthotopic esophageal cancer-bearing mice.
Author: Nishikawa, Toshio|Takaoka, Munenori|Ohara, Toshiaki|Tomono, Yasuko|Hao, Huifang|Bao, Xiaohong|Fukazawa, Takuya|Wang, Zhigang|Sakurama, Kazufumi|Fujiwara, Yasuhiro|Motoki, Takayuki|Shirakawa, Yasuhiro|Yamatsuji, Tomoki|Tanaka, Noriaki|Fujiwara, Toshiyoshi|
PMID: 23291985
Journal: Dis Esophagus. 2013 Jan;26(1):75-83.
Title: Hypoxia suppresses E-cadherin and enhances matrix metalloproteinase-2 expression favoring esophageal carcinoma migration and invasion via hypoxia inducible factor-1 alpha activation.
Author: Jing, S-w|Wang, Y-d|Chen, L-Q|Sang, M-x|Zheng, M-m|Sun, G-g|Liu, Q|Cheng, Y-j|Yang, C-r
PMID: 22340517
Journal: Histol Histopathol. 2013 Oct;28(10):1361-8.
Title: Primary tumor vascularity in esophagus cancer. CD34 and HIF1-alpha expression correlate with tumor progression.
Author: Goscinski, Mariusz Adam|Nesland, Jahn Marthin|Giercksky, Karl-Erik|Dhakal, Hari Prasad
PMID: 23653235
Journal: Dis Esophagus. 2014 Sep-Oct;27(7):685-92.
Title: Blockage of Nrf2 suppresses the migration and invasion of esophageal squamous cell carcinoma cells in hypoxic microenvironment.
Author: Shen, H|Yang, Y|Xia, S|Rao, B|Zhang, J|Wang, J
PMID: 24028437
Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jun;34(6):798-801.
Title: [Amphotericin B suppresses migration and invasion of esophageal carcinoma Eca109 cells in hypoxic microenvironment by down-regulating hypoxia-inducible factor-1alpha activity].
Author: Kang, Qiangqiang|Tang, Min|Hou, Yanli|Duan, Liqun|Chen, Xingyue|Shu, Jin|Wu, Furong|Wang, Ying|Li, Shaolin
PMID: 24968833
Journal: Tumour Biol. 2014 Oct;35(10):9793-9.
Title: STAT3 inhibitor NSC74859 radiosensitizes esophageal cancer via the downregulation of HIF-1alpha.
Author: Zhang, Chi|Yang, Xi|Zhang, Qu|Guo, Qing|He, Jia|Qin, Qin|Zhu, Hongcheng|Liu, Jia|Zhan, Liangliang|Lu, Jing|Liu, Zheming|Xu, Liping|Ma, Jianxin|Dai, Shengbin|Cheng, Hongyan|Sun, Xinchen
PMID: 24981247
Journal: World J Gastroenterol. 2014 Dec 21;20(47):17894-904.
Title: HIF-1alpha induces VE-cadherin expression and modulates vasculogenic mimicry in esophageal carcinoma cells.
Author: Tang, Na-Na|Zhu, Hong|Zhang, Hong-Jie|Zhang, Wei-Feng|Jin, Hai-Lin|Wang, Lu|Wang, Pin|He, Gui-Jun|Hao, Bo|Shi, Rui-Hua
PMID: 25548487
Journal: Biomed Pharmacother. 2015 Feb;69:260-6.
Title: Metformin enhances radiation response of ECa109 cells through activation of ATM and AMPK.
Author: Feng, Tingting|Li, Lei|Ling, Sunbin|Fan, Ning|Fang, Meiyu|Zhang, Haiquan|Fang, Xin|Lan, Wen|Hou, Zhaoyuan|Meng, QingChun|Jin, Di|Xu, Fei|Li, Yan
PMID: 25661368
Journal: Mol Med Rep. 2015 Nov;12(5):7419-24.
Title: Upregulation of extracellular matrix metalloproteinase inducer promotes hypoxia-induced epithelial-mesenchymal transition in esophageal cancer.
Author: Wu, Xiaopeng|Qiao, Bin|Liu, Qin|Zhang, Weiguo
PMID: 26458866
Journal: Cancer Chemother Pharmacol. 2015 Dec;76(6):1199-207.
Title: Oxygen carrier YQ23 can enhance the chemotherapeutic drug responses of chemoresistant esophageal tumor xenografts.
Author: Lee, Nikki P|Chan, Kin Tak|Choi, Mei Yuk|Lam, Ho Yu|Tung, Lai Nar|Tzang, Fei Chuen|Han, Heron|Lam, Ian P Y|Kwok, Sui Yi|Lau, Sze Hang|Man, Cornelia|Tong, Daniel K|Wong, Bing L|Law, Simon
PMID: 26553104
Journal: Cell Biol Int. 2016 Nov;40(11):1187-1194.
Title: VEGF expression is regulated by HIF-1alpha and ARNT in 3D KYSE-70, esophageal cancer cell spheroids.
Author: Terashima, Jun|Sampei, Satoko|Iidzuka, Mei|Ohsakama, Ayumi|Tachikawa, Chie|Satoh, Junya|Kudo, Kenzo|Habano, Wataru|Ozawa, Shogo
PMID: 27542820
Journal: Oncol Lett. 2016 Dec;12(6):4671-4676.
Title: Improved sensitization effect of sunitinib in cancer cells of the esophagus under hypoxic microenviroment.
Author: Ding, Yu-Qiong|Qin, Qin|Yang, Yan|Sun, Xin-Chen|Yang, Xi|Zhu, Hong-Cheng|Chen, Xiao-Chen|Zhang, Hao|Yang, Yue-Hua|Gao, Lei|Luo, Ju-Dong|Zhou, Xi-Fa
PMID: 28105174
Journal: Int J Oncol. 2016 Nov;49(5):1859-1869.
Title: Valproic acid inhibits irradiation-induced epithelial-mesenchymal transition and stem cell-like characteristics in esophageal squamous cell carcinoma.
Author: Kanamoto, Ayako|Ninomiya, Itasu|Harada, Shinichi|Tsukada, Tomoya|Okamoto, Koichi|Nakanuma, Shinichi|Sakai, Seisho|Makino, Isamu|Kinoshita, Jun|Hayashi, Hironori|Oyama, Katsunobu|Miyashita, Tomoharu|Tajima, Hidehiro|Takamura, Hiroyuki|Fushida, Sachio|Ohta,
PMID: 27826618
Journal: World J Gastroenterol. 2016 May 28;22(20):4868-80.
Title: Wortmannin influences hypoxia-inducible factor-1 alpha expression and glycolysis in esophageal carcinoma cells.
Author: Zeng, Ling|Zhou, Hai-Yun|Tang, Na-Na|Zhang, Wei-Feng|He, Gui-Jun|Hao, Bo|Feng, Ya-Dong|Zhu, Hong
PMID: 27239113
Journal: PLoS One. 2016 Jan 5;11(1):e0145807.
Title: Tenascin-C, a Prognostic Determinant of Esophageal Squamous Cell Carcinoma.
Author: Yang, Zhao-Ting|Yeo, So-Young|Yin, Yong-Xue|Lin, Zhen-Hua|Lee, Hak-Min|Xuan, Yan-Hua|Cui, Yan|Kim, Seok-Hyung
PMID: 26731558
Journal: Onco Targets Ther. 2017 Apr 7;10:2025-2031.
Title: Expression and significance of GRHL2 in esophageal cancer.
Author: Shao, Chengcheng|Ji, Chushu|Wang, Xiaoqiu|Hu, Bing
PMID: 28435293
Journal: Mol Med Rep. 2017 Aug;16(2):2107-2112.
Title: Hypoxia inducible factor-1alpha regulates autophagy via the p27-E2F1 signaling pathway.
Author: Wang, Pan|Long, Meijing|Zhang, Shijie|Cheng, Zhenyun|Zhao, Xin|He, Fucheng|Liu, Hongchun|Ming, Liang
PMID: 28627618
Journal: Methods. 2017 Jul 10. pii: S1046-2023(16)30312-7.
Title: Hypoxia and hypoxia response-associated molecular markers in esophageal cancer: A systematic review.
Author: Peerlings, Jurgen|Van De Voorde, Lien|Mitea, Cristina|Larue, Ruben|Yaromina, Ala|Sandeleanu, Sebastian|Spiegelberg, Linda|Dubois, Ludwig|Lambin, Philippe|Mottaghy, Felix M
PMID: 28705470
Journal: J Cancer. 2018 Jan 1;9(1):32-40.
Title: Efficacy of Shikonin against Esophageal Cancer Cells and its possible mechanisms in vitro and in vivo.
Author: Tang, Jian-Cai|Zhao, Jia|Long, Feng|Chen, Jian-Ye|Mu, Bo|Jiang, Zhen|Ren, Yonggan|Yang, Jian
PMID: 29290767
Journal: Oncol Lett. 2018 Mar;15(3):3870-3875.
Title: Brucea javanica seed oil enhances the radiosensitivity of esophageal cancer by inhibiting hypoxia-inducible factor 1alpha, in vitro and in vivo.
Author: Pan, Peng|Yang, Bai-Xia|Ge, Xiao-Lin
PMID: 29456736
Journal: J Enzyme Inhib Med Chem. 2018 Dec;33(1):1024-1033.
Title: CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target.
Author: Drenckhan, Astrid|Freytag, Morton|Supuran, Claudiu T|Sauter, Guido|Izbicki, Jakob R|Gros, Stephanie J
PMID: 29865880
Journal: J Exp Clin Cancer Res. 2018 Aug 6;37(1):183.
Title: ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis.
Author: Ma, Sai|Lu, Chen-Chen|Yang, Li-Yan|Wang, Juan-Juan|Wang, Bo-Shi|Cai, Hong-Qing|Hao, Jia-Jie|Xu, Xin|Cai, Yan|Zhang, Yu|Wang, Ming-Rong
PMID: 30081903
Journal: Cell Physiol Biochem. 2018;48(5):2035-2045.
Title: Dihydroartemisinin Increases the Sensitivity of Photodynamic Therapy Via NF-kappaB/HIF-1alpha/VEGF Pathway in Esophageal Cancer Cell in vitro and in vivo.
Author: Li, Yanjing|Sui, Hong|Jiang, Cailing|Li, Shumin|Han, Yu|Huang, Peng|Du, Xiaoxue|Du, Jingwen|Bai, Yuxian
PMID: 30099443
Journal: J Cell Biochem. 2018 Sep 11.
Title: Knockdown of USP28 enhances the radiosensitivity of esophageal cancer cells via the c-Myc/hypoxia-inducible factor-1 alpha pathway.
Author: Weili, Zhang|Zhikun, Liu|Jianmin, Wang|Qingbao, Tian
PMID: 30206969