Primary Site >> Colorectal Cancer

Gene >> HDAC9

Journal: J Antibiot (Tokyo). 2000 Oct;53(10):1191-200.
Title: Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cells.
Author: Kim, Y B|Ki, S W|Yoshida, M|Horinouchi, S
PMID: 11132966
Journal: Biochem Biophys Res Commun. 2004 Apr 9;316(3):693-7.
Title: Modulation of angiogenesis-related protein synthesis by valproic acid.
Author: Zgouras, Dimitrios|Becker, Ute|Loitsch, Stefan|Stein, Jurgen
PMID: 15033455
Journal: Cancer Res. 2004 Aug 15;64(16):5767-74.
Title: A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.
Author: Myzak, Melinda C|Karplus, P Andrew|Chung, Fung-Lung|Dashwood, Roderick H
PMID: 15313918
Journal: Ann Oncol. 2004 Jul;15(7):1079-85.
Title: Solid tumors in patients treated for Hodgkin's disease: a report from the German Hodgkin Lymphoma Study Group.
Author: Behringer, K|Josting, A|Schiller, P|Eich, H T|Bredenfeld, H|Diehl, V|Engert, A
PMID: 15205202
Journal: Oncogene. 2004 Jul 8;23(31):5340-9.
Title: Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter.
Author: Yokota, Tomoya|Matsuzaki, Youichirou|Miyazawa, Kazuhiro|Zindy, Frederique|Roussel, Martine F|Sakai, Toshiyuki
PMID: 15107822
Journal: Biochem Biophys Res Commun. 2004 Apr 30;317(2):463-71.
Title: Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition.
Author: Tong, Xin|Yin, Lei|Giardina, Charles
PMID: 15063780
Journal: J Biol Chem. 2004 Jul 16;279(29):30358-68. Epub 2004 May 3.
Title: Requirement of histone deacetylase activity for signaling by STAT1.
Author: Klampfer, Lidija|Huang, Jie|Swaby, Laurie-Anne|Augenlicht, Leonard
PMID: 15123634
Journal: Biochem Pharmacol. 2005 Aug 1;70(3):394-406.
Title: HDAC inhibition prevents NF-kappa B activation by suppressing proteasome activity: down-regulation of proteasome subunit expression stabilizes I kappa B alpha.
Author: Place, Robert F|Noonan, Emily J|Giardina, Charles
PMID: 15950952
Journal: Carcinogenesis. 2006 Apr;27(4):811-9. Epub 2005 Nov 9.
Title: Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells.
Author: Myzak, Melinda C|Hardin, Karin|Wang, Rong|Dashwood, Roderick H|Ho, Emily
PMID: 16280330
Journal: FASEB J. 2006 Mar;20(3):506-8. Epub 2006 Jan 11.
Title: Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice.
Author: Myzak, Melinda C|Dashwood, W Mohaiza|Orner, Gayle A|Ho, Emily|Dashwood, Roderick H
PMID: 16407454
Journal: Mol Cancer Ther. 2006 Jul;5(7):1693-701.
Title: CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo.
Author: Cao, Z Alexander|Bass, Kathryn E|Balasubramanian, Sriram|Liu, Liang|Schultz, Brian|Verner, Erik|Dai, Yuqin|Molina, Rafael A|Davis, Jack R|Misialek, Shawn|Sendzik, Martin|Orr, Christine J|Leung, Ling|Callan, Ondine|Young, Peter|Dalrymple, Stacie A|Buggy, J
PMID: 16891455
Journal: Int J Cancer. 2007 Sep 1;121(5):1138-48.
Title: Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group.
Author: Beckers, Thomas|Burkhardt, Carmen|Wieland, Heike|Gimmnich, Petra|Ciossek, Thomas|Maier, Thomas|Sanders, Karl
PMID: 17455259
Journal: Anticancer Res. 2007 Mar-Apr;27(2):741-8.
Title: Induction of differentiation of colon cancer cells by combined inhibition of kinases and histone deacetylase.
Author: Lea, Michael A|Ibeh, Chinwe|Shah, Neel|Moyer, Mary P
PMID: 17465197
Journal: Cancer Res. 2007 Sep 15;67(18):8477-85.
Title: Histone deacetylase inhibitors induce cell death selectively in cells that harbor activated kRasV12: The role of signal transducers and activators of transcription 1 and p21.
Author: Klampfer, Lidija|Huang, Jie|Shirasawa, Senji|Sasazuki, Takehiko|Augenlicht, Leonard
PMID: 17875686
Journal: Int J Oncol. 2007 Dec;31(6):1391-402.
Title: Differential response of p53 and p21 on HDAC inhibitor-mediated apoptosis in HCT116 colon cancer cells in vitro and in vivo.
Author: Zopf, Steffen|Neureiter, Daniel|Bouralexis, Steve|Abt, Tobias|Glaser, Keith B|Okamoto, Kinya|Ganslmayer, Marion|Hahn, Eckhart G|Herold, Christoph|Ocker, Matthias
PMID: 17982666
Journal: Carcinogenesis. 2008 Sep;29(9):1816-24.
Title: Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter.
Author: Nian, Hui|Delage, Barbara|Pinto, John T|Dashwood, Roderick H
PMID: 18628250
Journal: Epigenetics. 2008 Jan-Feb;3(1):28-37. Epub 2008 Feb 15.
Title: HDACs and HDAC inhibitors in colon cancer.
Author: Mariadason, John M
PMID: 18326939
Journal: Autoimmunity. 2009 Feb;42(2):120-5.
Title: Decreased levels of autoantibody against histone deacetylase 3 in patients with systemic sclerosis.
Author: Kuwatsuka, Yutaka|Ogawa, Fumihide|Iwata, Yohei|Komura, Kazuhiro|Muroi, Eiji|Hara, Toshihide|Takenaka, Motoi|Shimizu, Kazuhiro|Hasegawa, Minoru|Fujimoto, Manabu|Sato, Shinichi
PMID: 19021012
Journal: Cancer Biol Ther. 2009 May;8(9):782-91. Epub 2009 May 9.
Title: Modulation of thymidilate synthase and p53 expression by HDAC inhibitor vorinostat resulted in synergistic antitumor effect in combination with 5FU or raltitrexed.
Author: Di Gennaro, Elena|Bruzzese, Francesca|Pepe, Stefano|Leone, Alessandra|Delrio, Paolo|Subbarayan, Pochi R|Avallone, Antonio|Budillon, Alfredo
PMID: 19270508
Journal: Anticancer Drugs. 2009 Jun;20(5):321-33.
Title: Acquired vorinostat resistance shows partial cross-resistance to 'second-generation' HDAC inhibitors and correlates with loss of histone acetylation and apoptosis but not with altered HDAC and HAT activities.
Author: Dedes, Konstantin J|Dedes, Ioannis|Imesch, Patrick|von Bueren, Andre O|Fink, Daniel|Fedier, Andre
PMID: 19322073
Journal: Biochem Pharmacol. 2009 Sep 1;78(5):486-94.
Title: A novel delta-lactam-based histone deacetylase inhibitor, KBH-A42, induces cell cycle arrest and apoptosis in colon cancer cells.
Author: Kang, Moo Rim|Kang, Jong Soon|Han, Sang-Bae|Kim, Jang Hyun|Kim, Dong-Myung|Lee, Kiho|Lee, Chang Woo|Lee, Ki Hoon|Lee, Chul Ho|Han, Gyoonhee|Kang, Jong Seong|Kim, Hwan Mook|Park, Song-Kyu
PMID: 19445901
Journal: Carcinogenesis. 2009 Aug;30(8):1416-23.
Title: Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells.
Author: Nian, Hui|Bisson, William H|Dashwood, Wan-Mohaiza|Pinto, John T|Dashwood, Roderick H
PMID: 19528666
Journal: Int J Oncol. 2009 Sep;35(3):631-40.
Title: MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells.
Author: Imesch, Patrick|Dedes, Konstantin J|Furlato, Michele|Fink, Daniel|Fedier, Andre
PMID: 19639184
Journal: Biochem Biophys Res Commun. 2010 Feb 5;392(2):190-5.
Title: A novel histone deacetylase inhibitor Chidamide induces apoptosis of human colon cancer cells.
Author: Liu, Lin|Chen, Baoan|Qin, Shukui|Li, Suyi|He, Xiangming|Qiu, Shaomin|Zhao, Wei|Zhao, Hong
PMID: 20060381
Journal: Cancer Res. 2010 Jan 15;70(2):646-54.
Title: Chemopreventive agent 3,3'-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases.
Author: Li, Yongming|Li, Xia|Guo, Bin
PMID: 20068155
Journal: Lancet Oncol. 2010 May;11(5):459-64.
Title: Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study.
Author: Ree, Anne Hansen|Dueland, Svein|Folkvord, Sigurd|Hole, Knut H|Seierstad, Therese|Johansen, Marianne|Abrahamsen, Torveig W|Flatmark, Kjersti
PMID: 20378407
Journal: Bioorg Med Chem. 2010 Jun 1;18(11):3925-33.
Title: New orally bioavailable 2-aminobenzamide-type histone deacetylase inhibitor possessing a (2-hydroxyethyl)(4-(thiophen-2-yl)benzyl)amino group.
Author: Kiyokawa, Shingo|Hirata, Yoshiyuki|Nagaoka, Yasuo|Shibano, Makio|Taniguchi, Masahiko|Yasuda, Masahide|Baba, Kimiye|Uesato, Shinichi
PMID: 20452226
Journal: Clin Exp Pharmacol Physiol. 2010 Sep;37(9):905-11.
Title: Structure-activity relationship of butyrate analogues on apoptosis, proliferation and histone deacetylase activity in HCT-116 human colorectal cancer cells.
Author: Ooi, Cheng Cheng|Good, Norm M|Williams, Desmond B|Lewanowitsch, Tanya|Cosgrove, Leah J|Lockett, Trevor J|Head, Richard J
PMID: 20497425
Journal: J Chromatogr A. 2011 Jun 24;1218(25):3862-75.
Title: Efficient organic monoliths prepared by gamma-radiation induced polymerization in the evaluation of histone deacetylase inhibitors by capillary(nano)-high performance liquid chromatography and ion trap mass spectrometry.
Author: Badaloni, Elena|Barbarino, Marcella|Cabri, Walter|D'Acquarica, Ilaria|Forte, Michela|Gasparrini, Francesco|Giorgi, Fabrizio|Pierini, Marco|Simone, Patrizia|Ursini, Ornella|Villani, Claudio
PMID: 21561626
Journal: Biochim Biophys Acta. 2012 Feb;1820(2):104-15.
Title: Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells.
Author: Hsu, Ya-Fen|Sheu, Joen-Rong|Lin, Chien-Huang|Yang, De-Shin|Hsiao, George|Ou, George|Chiu, Pei-Ting|Huang, Yu-Han|Kuo, Wen-Hsin|Hsu, Ming-Jen
PMID: 22155142
Journal: Cell Death Differ. 2012 Aug;19(8):1317-27.
Title: Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis.
Author: Kerr, E|Holohan, C|McLaughlin, K M|Majkut, J|Dolan, S|Redmond, K|Riley, J|McLaughlin, K|Stasik, I|Crudden, M|Van Schaeybroeck, S|Fenning, C|O'Connor, R|Kiely, P|Sgobba, M|Haigh, D|Johnston, P G|Longley, D B
PMID: 22322857
Journal: PLoS One. 2012;7(2):e31729.
Title: Induction of sodium/iodide symporter (NIS) expression and radioiodine uptake in non-thyroid cancer cells.
Author: Liu, Zhi|Xing, Mingzhao
PMID: 22359623
Journal: Mol Carcinog. 2012 Feb;51(2):174-84.
Title: Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells.
Author: Xiong, Hua|Du, Wan|Zhang, Yan-Jie|Hong, Jie|Su, Wen-Yu|Tang, Jie-Ting|Wang, Ying-Chao|Lu, Rong|Fang, Jing-Yuan
PMID: 21520296
Journal: Br J Nutr. 2013 Jun 28;109(12):2117-25.
Title: The Australian fruit Illawarra plum (Podocarpus elatus Endl., Podocarpaceae) inhibits telomerase, increases histone deacetylase activity and decreases proliferation of colon cancer cells.
Author: Symonds, Erin L|Konczak, Izabela|Fenech, Michael
PMID: 23069328
Journal: Cell Oncol (Dordr). 2013 Apr;36(2):155-67.
Title: Epigenetic control of HNF-4alpha in colon carcinoma cells affects MUC4 expression and malignancy.
Author: Algamas-Dimantov, Anna|Yehuda-Shnaidman, Einav|Peri, Irena|Schwartz, Betty
PMID: 23307400
Journal: J Nutr Metab. 2013;2013:821082.
Title: Plant polyphenols and oxidative metabolites of the herbal alkenylbenzene methyleugenol suppress histone deacetylase activity in human colon carcinoma cells.
Author: Groh, Isabel Anna Maria|Chen, Chen|Luske, Claudia|Cartus, Alexander Thomas|Esselen, Melanie
PMID: 23476753
Journal: Cancer Epidemiol Biomarkers Prev. 2013 Jul;22(7):1219-26.
Title: Genome-wide association study identifies possible genetic risk factors for colorectal adenomas.
Author: Edwards, Todd L|Shrubsole, Martha J|Cai, Qiuyin|Li, Guoliang|Dai, Qi|Rex, Douglas K|Ulbright, Thomas M|Fu, Zhenming|Delahanty, Ryan H|Murff, Harvey J|Smalley, Walter|Ness, Reid M|Zheng, Wei
PMID: 23677573
Journal: Int J Oncol. 2013 Dec;43(6):1907-14.
Title: Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity.
Author: Kang, Kyoung Ah|Piao, Mei Jing|Kim, Ki Cheon|Zheng, Jian|Yao, Cheng Wen|Cha, Ji Won|Kim, Hye Sun|Kim, Dong Hyun|Bae, Suk Chul|Hyun, Jin Won
PMID: 24100442
Journal: J Magn Reson Imaging. 2014 Sep;40(3):715-22.
Title: Dynamic contrast enhanced-MRI in rectal cancer: Inter- and intraobserver reproducibility and the effect of slice selection on pharmacokinetic analysis.
Author: Hotker, Andreas M|Schmidtmann, Irene|Oberholzer, Katja|Duber, Christoph
PMID: 24127204
Journal: Biochem Cell Biol. 2014 Apr;92(2):85-93.
Title: Cell differentiation along multiple pathways accompanied by changes in histone acetylation status.
Author: Legartova, Sona|Kozubek, Stanislav|Franek, Michal|Zdrahal, Zbynek|Lochmanova, Gabriela|Martinet, Nadine|Bartova, Eva
PMID: 24697692
Journal: Autophagy. 2014 Aug;10(8):1403-14.
Title: Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors.
Author: Mahalingam, Devalingam|Mita, Monica|Sarantopoulos, John|Wood, Leslie|Amaravadi, Ravi K|Davis, Lisa E|Mita, Alain C|Curiel, Tyler J|Espitia, Claudia M|Nawrocki, Steffan T|Giles, Francis J|Carew, Jennifer S
PMID: 24991835
Journal: Oncol Rep. 2015 May;33(5):2299-308.
Title: HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells.
Author: Ji, Meiying|Lee, Eun Jeoung|Kim, Ki Bae|Kim, Yangmi|Sung, Rohyun|Lee, Sang-Jeon|Kim, Don Soo|Park, Seon Mee
PMID: 25813246
Journal: Clin Epigenetics. 2015 Sep 18;7:102.
Title: Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon.
Author: Rajendran, Praveen|Dashwood, Wan-Mohaiza|Li, Li|Kang, Yuki|Kim, Eunah|Johnson, Gavin|Fischer, Kay A|Lohr, Christiane V|Williams, David E|Ho, Emily|Yamamoto, Masayuki|Lieberman, David A|Dashwood, Roderick H
PMID: 26388957
Journal: Biomolecules. 2015 Aug 28;5(3):2035-55.
Title: Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells.
Author: Sobolewski, Cyril|Sanduja, Sandhya|Blanco, Fernando F|Hu, Liangyan|Dixon, Dan A
PMID: 26343742
Journal: Exp Cell Res. 2015 Jun 10;334(2):323-36.
Title: Caveolin-1 is transcribed from a hypermethylated promoter to mediate colonocyte differentiation and apoptosis.
Author: Dasgupta, Nirmalya|Kumar Thakur, Bhupesh|Ta, Atri|Das, Santasabuj
PMID: 25842166
Journal: Mol Carcinog. 2015 Nov;54(11):1513-20.
Title: The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses.
Author: Dickinson, Sally E|Rusche, Jadrian J|Bec, Sergiu L|Horn, David J|Janda, Jaroslav|Rim, So Hyun|Smith, Catharine L|Bowden, G Timothy
PMID: 25307283
Journal: Eur J Med Chem. 2016 Apr 13;112:99-105.
Title: Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.
Author: Cincinelli, Raffaella|Zwick, Vincent|Musso, Loana|Zuco, Valentina|De Cesare, Michelandrea|Zunino, Franco|Simoes-Pires, Claudia|Nurisso, Alessandra|Giannini, Giuseppe|Cuendet, Muriel|Dallavalle, Sabrina
PMID: 26890116
Journal: Chem Biol Interact. 2016 Jun 25;253:112-24.
Title: An appraisal of cinnamyl sulfonamide hydroxamate derivatives (HDAC inhibitors) for anti-cancer, anti-angiogenic and anti-metastatic activities in human cancer cells.
Author: Reddy, Neetinkumar D|Shoja, M H|Biswas, Subhankar|Nayak, Pawan G|Kumar, Nitesh|Rao, C Mallikarjuna
PMID: 27163855
Journal: Cancer Epidemiol Biomarkers Prev. 2016 Jul;25(7):1185-91.
Title: Association of Common Susceptibility Variants of Pancreatic Cancer in Higher-Risk Patients: A PACGENE Study.
Author: Childs, Erica J|Chaffee, Kari G|Gallinger, Steven|Syngal, Sapna|Schwartz, Ann G|Cote, Michele L|Bondy, Melissa L|Hruban, Ralph H|Chanock, Stephen J|Hoover, Robert N|Fuchs, Charles S|Rider, David N|Amundadottir, Laufey T|Stolzenberg-Solomon, Rachael|Wolpin
PMID: 27197284
Journal: Sci Rep. 2016 Jul 27;6:30406.
Title: Acetylation modification regulates GRP78 secretion in colon cancer cells.
Author: Li, Zongwei|Zhuang, Ming|Zhang, Lichao|Zheng, Xingnan|Yang, Peng|Li, Zhuoyu
PMID: 27460191
Journal: Oncol Rep. 2016 Oct;36(4):1875-85.
Title: Combination of the histone deacetylase inhibitor depsipeptide and 5-fluorouracil upregulates major histocompatibility complex class II and p21 genes and activates caspase-3/7 in human colon cancer HCT-116 cells.
Author: Okada, Kouji|Hakata, Shuko|Terashima, Jun|Gamou, Toshie|Habano, Wataru|Ozawa, Shogo
PMID: 27509880
Journal: Oncotarget. 2017 Feb 28;8(9):14748-14758.
Title: A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis.
Author: Zhu, Bing-Yan|Shang, Bo-Yang|Du, Yue|Li, Yi|Li, Liang|Xu, Xian-Dong|Zhen, Yong-Su
PMID: 28107195
Journal: Cancer Biol Ther. 2017 Jul 3;18(7):492-504.
Title: Naturally occurring benzoic acid derivatives retard cancer cell growth by inhibiting histone deacetylases (HDAC).
Author: Anantharaju, Preethi G|Reddy, Bandi Deepa|Padukudru, Mahesh A|Kumari Chitturi, Ch M|Vimalambike, Manjunath G|Madhunapantula, SubbaRao V
PMID: 28506198
Journal: Curr Cancer Drug Targets. 2018;18(1):97-106.
Title: Mechanisms for the Inhibition of Colon Cancer Cells by Sulforaphane through Epigenetic Modulation of MicroRNA-21 and Human Telomerase Reverse Transcriptase (hTERT) Down-regulation.
Author: Martin, Samantha L|Kala, Rishabh|Tollefsbol, Trygve O
PMID: 28176652
Journal: Adv Clin Exp Med. 2018 Mar;27(3):305-311.
Title: Deregulated expression of HDAC3 in colorectal cancer and its clinical significance.
Author: Nemati, Masoumeh|Ajami, Naser|Estiar, Mehrdad Asghari|Rezapour, Saleheh|Gavgani, Reyhaneh Ravanbakhsh|Hashemzadeh, Shahryar|Kafil, Hossein Samadi|Sakhinia, Ebrahim
PMID: 29558042
Journal: Eur J Pharm Sci. 2018 May 28;121:188-199.
Title: Repurposing of sodium valproate in colon cancer associated with diabetes mellitus: Role of HDAC inhibition.
Author: Patel, Mayur M|Patel, Bhoomika M
PMID: 29852291