Primary Site >> Colorectal Cancer
Gene >> HDAC9
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Ref: Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cells. PMID: 11132966 |
Ref: Modulation of angiogenesis-related protein synthesis by valproic acid. PMID: 15033455 Ref: Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. PMID: 15063780 Ref: Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter. PMID: 15107822 Ref: Requirement of histone deacetylase activity for signaling by STAT1. PMID: 15123634 Ref: Solid tumors in patients treated for Hodgkin's disease: a report from the German Hodgkin Lymphoma Study Group. PMID: 15205202 Ref: A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. PMID: 15313918 |
Ref: HDAC inhibition prevents NF-kappa B activation by suppressing proteasome activity: down-regulation of proteasome subunit expression stabilizes I kappa B alpha. PMID: 15950952 |
Ref: Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. PMID: 16280330 Ref: Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. PMID: 16407454 Ref: CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo. PMID: 16891455 |
Ref: Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. PMID: 17455259 Ref: Induction of differentiation of colon cancer cells by combined inhibition of kinases and histone deacetylase. PMID: 17465197 Ref: Histone deacetylase inhibitors induce cell death selectively in cells that harbor activated kRasV12: The role of signal transducers and activators of transcription 1 and p21. PMID: 17875686 Ref: Differential response of p53 and p21 on HDAC inhibitor-mediated apoptosis in HCT116 colon cancer cells in vitro and in vivo. PMID: 17982666 |
Ref: HDACs and HDAC inhibitors in colon cancer. PMID: 18326939 Ref: Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter. PMID: 18628250 |
Ref: Decreased levels of autoantibody against histone deacetylase 3 in patients with systemic sclerosis. PMID: 19021012 Ref: Modulation of thymidilate synthase and p53 expression by HDAC inhibitor vorinostat resulted in synergistic antitumor effect in combination with 5FU or raltitrexed. PMID: 19270508 Ref: Acquired vorinostat resistance shows partial cross-resistance to 'second-generation' HDAC inhibitors and correlates with loss of histone acetylation and apoptosis but not with altered HDAC and HAT activities. PMID: 19322073 Ref: A novel delta-lactam-based histone deacetylase inhibitor, KBH-A42, induces cell cycle arrest and apoptosis in colon cancer cells. PMID: 19445901 Ref: Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells. PMID: 19528666 Ref: MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells. PMID: 19639184 |
Ref: A novel histone deacetylase inhibitor Chidamide induces apoptosis of human colon cancer cells. PMID: 20060381 Ref: Chemopreventive agent 3,3'-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases. PMID: 20068155 Ref: Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study. PMID: 20378407 Ref: New orally bioavailable 2-aminobenzamide-type histone deacetylase inhibitor possessing a (2-hydroxyethyl)(4-(thiophen-2-yl)benzyl)amino group. PMID: 20452226 Ref: Structure-activity relationship of butyrate analogues on apoptosis, proliferation and histone deacetylase activity in HCT-116 human colorectal cancer cells. PMID: 20497425 |
Ref: Efficient organic monoliths prepared by gamma-radiation induced polymerization in the evaluation of histone deacetylase inhibitors by capillary(nano)-high performance liquid chromatography and ion trap mass spectrometry. PMID: 21561626 |
Ref: Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells. PMID: 21520296 Ref: Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells. PMID: 22155142 Ref: Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis. PMID: 22322857 Ref: Induction of sodium/iodide symporter (NIS) expression and radioiodine uptake in non-thyroid cancer cells. PMID: 22359623 |
Ref: The Australian fruit Illawarra plum (Podocarpus elatus Endl., Podocarpaceae) inhibits telomerase, increases histone deacetylase activity and decreases proliferation of colon cancer cells. PMID: 23069328 Ref: Epigenetic control of HNF-4alpha in colon carcinoma cells affects MUC4 expression and malignancy. PMID: 23307400 Ref: Plant polyphenols and oxidative metabolites of the herbal alkenylbenzene methyleugenol suppress histone deacetylase activity in human colon carcinoma cells. PMID: 23476753 Ref: Genome-wide association study identifies possible genetic risk factors for colorectal adenomas. PMID: 23677573 Ref: Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity. PMID: 24100442 |
Ref: Dynamic contrast enhanced-MRI in rectal cancer: Inter- and intraobserver reproducibility and the effect of slice selection on pharmacokinetic analysis. PMID: 24127204 Ref: Cell differentiation along multiple pathways accompanied by changes in histone acetylation status. PMID: 24697692 Ref: Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors. PMID: 24991835 |
Ref: The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses. PMID: 25307283 Ref: HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells. PMID: 25813246 Ref: Caveolin-1 is transcribed from a hypermethylated promoter to mediate colonocyte differentiation and apoptosis. PMID: 25842166 Ref: Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells. PMID: 26343742 Ref: Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon. PMID: 26388957 |
Ref: Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity. PMID: 26890116 Ref: An appraisal of cinnamyl sulfonamide hydroxamate derivatives (HDAC inhibitors) for anti-cancer, anti-angiogenic and anti-metastatic activities in human cancer cells. PMID: 27163855 Ref: Association of Common Susceptibility Variants of Pancreatic Cancer in Higher-Risk Patients: A PACGENE Study. PMID: 27197284 Ref: Acetylation modification regulates GRP78 secretion in colon cancer cells. PMID: 27460191 Ref: Combination of the histone deacetylase inhibitor depsipeptide and 5-fluorouracil upregulates major histocompatibility complex class II and p21 genes and activates caspase-3/7 in human colon cancer HCT-116 cells. PMID: 27509880 |
Ref: A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis. PMID: 28107195 Ref: Naturally occurring benzoic acid derivatives retard cancer cell growth by inhibiting histone deacetylases (HDAC). PMID: 28506198 |
Ref: Mechanisms for the Inhibition of Colon Cancer Cells by Sulforaphane through Epigenetic Modulation of MicroRNA-21 and Human Telomerase Reverse Transcriptase (hTERT) Down-regulation. PMID: 28176652 Ref: Deregulated expression of HDAC3 in colorectal cancer and its clinical significance. PMID: 29558042 Ref: Repurposing of sodium valproate in colon cancer associated with diabetes mellitus: Role of HDAC inhibition. PMID: 29852291 |