Primary Site >> Colorectal Cancer

Gene >> HDAC2

Journal: Mol Cancer Ther. 2003 Apr;2(4):401-8.
Title: Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma.
Author: Kraker, Alan J|Mizzen, Craig A|Hartl, Brian G|Miin, Johnson|Allis, C David|Merriman, Ronald L
PMID: 12700284
Journal: Oncogene. 2004 Jul 8;23(31):5340-9.
Title: Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter.
Author: Yokota, Tomoya|Matsuzaki, Youichirou|Miyazawa, Kazuhiro|Zindy, Frederique|Roussel, Martine F|Sakai, Toshiyuki
PMID: 15107822
Journal: Cancer Cell. 2004 May;5(5):455-63.
Title: Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis.
Author: Zhu, Ping|Martin, Elke|Mengwasser, Jorg|Schlag, Peter|Janssen, Klaus-Peter|Gottlicher, Martin
PMID: 15144953
Journal: J Biol Chem. 2004 Jul 16;279(29):30358-68. Epub 2004 May 3.
Title: Requirement of histone deacetylase activity for signaling by STAT1.
Author: Klampfer, Lidija|Huang, Jie|Swaby, Laurie-Anne|Augenlicht, Leonard
PMID: 15123634
Journal: Cell Death Differ. 2005 Apr;12(4):395-404.
Title: Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1.
Author: Huang, B H|Laban, M|Leung, C H-W|Lee, L|Lee, C K|Salto-Tellez, M|Raju, G C|Hooi, S C
PMID: 15665816
Journal: Int J Cancer. 2005 Dec 10;117(5):800-6.
Title: Antibody response to a non-conserved C-terminal part of human histone deacetylase 3 in colon cancer patients.
Author: Shebzukhov, Yuriy V|Koroleva, Ekaterina P|Khlgatian, Svetlana V|Belousov, Pavel V|Kuz'mina, Ksenia E|Radko, Boris V|Longpre, Fanny|Lagarkova, Maria A|Kadachigova, Tatiana S|Gurova, Olga V|Meshcheryakov, Andrey A|Lichinitser, Mikhail R|Knuth, Alexander|Jag
PMID: 15981215
Journal: Anticancer Res. 2005 Nov-Dec;25(6B):4287-92.
Title: Expression analysis of a subset of coregulators and three nuclear receptors in human colorectal carcinoma.
Author: Giannini, Romina|Cavallini, Aldo
PMID: 16309230
Journal: J Biol Chem. 2006 May 12;281(19):13548-58. Epub 2006 Mar 13.
Title: Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer.
Author: Wilson, Andrew J|Byun, Do-Sun|Popova, Natalia|Murray, Lucas B|L'Italien, Kaitlin|Sowa, Yoshihiro|Arango, Diego|Velcich, Anna|Augenlicht, Leonard H|Mariadason, John M
PMID: 16533812
Journal: Mol Cancer Ther. 2006 May;5(5):1309-17.
Title: CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo.
Author: Buggy, Joseph J|Cao, Z Alexander|Bass, Kathryn E|Verner, Erik|Balasubramanian, Sriram|Liu, Liang|Schultz, Brian E|Young, Peter R|Dalrymple, Stacie A
PMID: 16731764
Journal: J Biol Chem. 2006 Aug 4;281(31):22062-72. Epub 2006 May 30.
Title: Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription.
Author: Majumder, Sarmila|Ghoshal, Kalpana|Datta, Jharna|Smith, David Spencer|Bai, Shoumei|Jacob, Samson T
PMID: 16735507
Journal: Mol Cancer Ther. 2006 Jul;5(7):1693-701.
Title: CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo.
Author: Cao, Z Alexander|Bass, Kathryn E|Balasubramanian, Sriram|Liu, Liang|Schultz, Brian|Verner, Erik|Dai, Yuqin|Molina, Rafael A|Davis, Jack R|Misialek, Shawn|Sendzik, Martin|Orr, Christine J|Leung, Ling|Callan, Ondine|Young, Peter|Dalrymple, Stacie A|Buggy, J
PMID: 16891455
Journal: BMC Cancer. 2006 Oct 4;6:236.
Title: Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells.
Author: Fuerer, Christophe|Homicsko, Krisztian|Lukashev, Alexander N|Pittet, Anne-Laure|Iggo, Richard D
PMID: 17020613
Journal: Gastroenterology. 2008 Nov;135(5):1654-1664.e2.
Title: An inactivating mutation in HDAC2 leads to dysregulation of apoptosis mediated by APAF1.
Author: Hanigan, Christin L|Van Engeland, Manon|De Bruine, Adriaan P|Wouters, Kim A|Weijenberg, Matty P|Eshleman, James R|Herman, James G
PMID: 18834886
Journal: Cancer Res. 2008 Nov 15;68(22):9331-7.
Title: Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer.
Author: Backlund, Michael G|Mann, Jason R|Holla, Vijaykumar R|Shi, Qiong|Daikoku, Takikoku|Dey, Sudhansu K|DuBois, Raymond N
PMID: 19010907
Journal: Gastroenterology. 2008 Nov;135(5):1457-9.
Title: Making sense of HDAC2 mutations in colon cancer.
Author: Mariadason, John M
PMID: 18851967
Journal: Clin Cancer Res. 2008 Mar 15;14(6):1669-77.
Title: Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo.
Author: Weichert, Wilko|Roske, Annika|Niesporek, Silvia|Noske, Aurelia|Buckendahl, Ann-Christin|Dietel, Manfred|Gekeler, Volker|Boehm, Markus|Beckers, Thomas|Denkert, Carsten
PMID: 18347167
Journal: Exp Cell Res. 2008 Apr 15;314(7):1507-18.
Title: HDAC2 deficiency sensitizes colon cancer cells to TNFalpha-induced apoptosis through inhibition of NF-kappaB activity.
Author: Kaler, Pawan|Sasazuki, Takehiko|Shirasawa, Senji|Augenlicht, Leonard|Klampfer, Lidija
PMID: 18314102
Journal: Oncogene. 2008 Jun 26;27(28):4008-12.
Title: Transforming pathways unleashed by a HDAC2 mutation in human cancer.
Author: Ropero, S|Ballestar, E|Alaminos, M|Arango, D|Schwartz, S Jr|Esteller, M
PMID: 18264134
Journal: Mol Carcinog. 2008 Feb;47(2):137-47.
Title: HDAC3 overexpression and colon cancer cell proliferation and differentiation.
Author: Spurling, Colleen C|Godman, Cassandra A|Noonan, Emily J|Rasmussen, Theodore P|Rosenberg, Daniel W|Giardina, Charles
PMID: 17849419
Journal: Autoimmunity. 2009 Feb;42(2):120-5.
Title: Decreased levels of autoantibody against histone deacetylase 3 in patients with systemic sclerosis.
Author: Kuwatsuka, Yutaka|Ogawa, Fumihide|Iwata, Yohei|Komura, Kazuhiro|Muroi, Eiji|Hara, Toshihide|Takenaka, Motoi|Shimizu, Kazuhiro|Hasegawa, Minoru|Fujimoto, Manabu|Sato, Shinichi
PMID: 19021012
Journal: Dig Dis Sci. 2009 Oct;54(10):2109-17.
Title: Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma.
Author: Ashktorab, Hassan|Belgrave, Kevin|Hosseinkhah, Fatemeh|Brim, Hassan|Nouraie, Mehdi|Takkikto, Mikiko|Hewitt, Steve|Lee, Edward L|Dashwood, R H|Smoot, Duane
PMID: 19057998
Journal: Oncogene. 2009 Mar 26;28(12):1496-505.
Title: 15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells.
Author: Zuo, X|Morris, J S|Broaddus, R|Shureiqi, I
PMID: 19198625
Journal: Int J Cancer. 2009 Jul 15;125(2):463-73.
Title: Histone deacetylase inhibitors suppress thymidylate synthase gene expression and synergize with the fluoropyrimidines in colon cancer cells.
Author: Fazzone, William|Wilson, Peter M|Labonte, Melissa J|Lenz, Heinz-Josef|Ladner, Robert D
PMID: 19384949
Journal: Int J Oncol. 2009 Nov;35(5):977-82.
Title: Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer.
Author: Kawaguchi, Makiko|Banno, Kouji|Yanokura, Megumi|Kobayashi, Yusuke|Kishimi, Arisa|Ogawa, Seiji|Kisu, Iori|Nomura, Hiroyuki|Hirasawa, Akira|Susumu, Nobuyuki|Aoki, Daisuke
PMID: 19787250
Journal: Oncogene. 2010 Jan 14;29(2):305-12.
Title: HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability.
Author: Krishnan, M|Singh, A B|Smith, J J|Sharma, A|Chen, X|Eschrich, S|Yeatman, T J|Beauchamp, R D|Dhawan, P
PMID: 19881542
Journal: Cancer Res. 2010 Jan 15;70(2):646-54.
Title: Chemopreventive agent 3,3'-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases.
Author: Li, Yongming|Li, Xia|Guo, Bin
PMID: 20068155
Journal: Cell Mol Life Sci. 2011 Oct;68(19):3261-74.
Title: HDAC2 and TXNL1 distinguish aneuploid from diploid colorectal cancers.
Author: Gemoll, Timo|Roblick, Uwe J|Szymczak, Silke|Braunschweig, Till|Becker, Susanne|Igl, Bernd-Wolfgang|Bruch, Hans-Peter|Ziegler, Andreas|Hellman, Ulf|Difilippantonio, Michael J|Ried, Thomas|Jornvall, Hans|Auer, Gert|Habermann, Jens K
PMID: 21290163
Journal: Biochim Biophys Acta. 2012 Oct;1821(10):1334-40.
Title: Mechanism and stereoselectivity of HDAC I inhibition by (R)-9-hydroxystearic acid in colon cancer.
Author: Parolin, Carola|Calonghi, Natalia|Presta, Enrica|Boga, Carla|Caruana, Paolo|Naldi, Marina|Andrisano, Vincenza|Masotti, Lanfranco|Sartor, Giorgio
PMID: 22814230
Journal: World J Gastroenterol. 2012 Jun 14;18(22):2745-55.
Title: Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer.
Author: Yamamoto, Hiroyuki|Adachi, Yasushi|Taniguchi, Hiroaki|Kunimoto, Hiroaki|Nosho, Katsuhiko|Suzuki, Hiromu|Shinomura, Yasuhisa
PMID: 22719182
Journal: Pathol Oncol Res. 2012 Jul;18(3):713-20.
Title: SAHA inhibits the growth of colon tumors by decreasing histone deacetylase and the expression of cyclin D1 and survivin.
Author: Jin, Jong-Shiaw|Tsao, Tang-Yi|Sun, Pei-Chang|Yu, Cheng-Ping|Tzao, Ching
PMID: 22270866
Journal: J Nutr Biochem. 2013 Jun;24(6):977-85.
Title: Kaempferol, a new nutrition-derived pan-inhibitor of human histone deacetylases.
Author: Berger, Alexander|Venturelli, Sascha|Kallnischkies, Mascha|Bocker, Alexander|Busch, Christian|Weiland, Timo|Noor, Seema|Leischner, Christian|Weiss, Thomas S|Lauer, Ulrich M|Bischoff, Stephan C|Bitzer, Michael
PMID: 23159065
Journal: Biochem Biophys Res Commun. 2013 Jan 4;430(1):381-6.
Title: Protocatechualdehyde possesses anti-cancer activity through downregulating cyclin D1 and HDAC2 in human colorectal cancer cells.
Author: Jeong, Jin Boo|Lee, Seong-Ho
PMID: 23159608
Journal: Int Immunopharmacol. 2013 Jun;16(2):184-90.
Title: Patchouli alcohol, an essential oil of Pogostemon cablin, exhibits anti-tumorigenic activity in human colorectal cancer cells.
Author: Jeong, Jin Boo|Choi, Jieun|Lou, Zhiyuan|Jiang, Xiaojing|Lee, Seong-Ho
PMID: 23602914
Journal: PLoS One. 2013 May 28;8(5):e64600.
Title: HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure.
Author: Stypula-Cyrus, Yolanda|Damania, Dhwanil|Kunte, Dhananjay P|Cruz, Mart Dela|Subramanian, Hariharan|Roy, Hemant K|Backman, Vadim
PMID: 23724067
Journal: Carcinogenesis. 2013 Dec;34(12):2842-50.
Title: Dietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis.
Author: Wang, Li-Shu|Kuo, Chieh-Ti|Stoner, Kristen|Yearsley, Martha|Oshima, Kiyoko|Yu, Jianhua|Huang, Tim H-M|Rosenberg, Daniel|Peiffer, Dan|Stoner, Gary|Huang, Yi-Wen
PMID: 24067901
Journal: Cancer Prev Res (Phila). 2013 Dec;6(12):1317-27.
Title: Black raspberries protectively regulate methylation of Wnt pathway genes in precancerous colon tissue.
Author: Wang, Li-Shu|Kuo, Chieh-Ti|Huang, Tim H-M|Yearsley, Martha|Oshima, Kiyoko|Stoner, Gary D|Yu, Jianhua|Lechner, John F|Huang, Yi-Wen
PMID: 24129635
Journal: J Pharmacol Exp Ther. 2014 Jan;348(1):59-68.
Title: Chemopreventive effects of an HDAC2-selective inhibitor on rat colon carcinogenesis and APCmin/+ mouse intestinal tumorigenesis.
Author: Ravillah, Durgadevi|Mohammed, Altaf|Qian, Li|Brewer, Misty|Zhang, Yuting|Biddick, Laura|Steele, Vernon E|Rao, Chinthalapally V
PMID: 24218540
Journal: J Med Chem. 2014 May 22;57(10):4009-22.
Title: Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells.
Author: Lee, Hsueh-Yun|Tsai, An-Chi|Chen, Mei-Chuan|Shen, Po-Jung|Cheng, Yun-Ching|Kuo, Ching-Chuan|Pan, Shiow-Lin|Liu, Yi-Min|Liu, Jin-Fen|Yeh, Teng-Kuang|Wang, Jing-Chi|Chang, Chi-Yen|Chang, Jang-Yang|Liou, Jing-Ping
PMID: 24766560
Journal: Cancer Biol Ther. 2014 Sep;15(9):1198-207.
Title: The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer.
Author: Wang, Jian|Elahi, Abul|Ajidahun, Abidemi|Clark, Whalen|Hernandez, Jonathan|Achille, Alex|Hao, Ji-hui|Seto, Edward|Shibata, David
PMID: 24919179
Journal: FASEB J. 2014 Oct;28(10):4265-79.
Title: Overexpression of histone deacetylases in cancer cells is controlled by interplay of transcription factors and epigenetic modulators.
Author: Yang, Hui|Salz, Tal|Zajac-Kaye, Maria|Liao, Daiqing|Huang, Suming|Qiu, Yi
PMID: 24948597
Journal: Arch Biochem Biophys. 2014 Dec 15;564:203-10.
Title: The contribution of activating transcription factor 3 to apoptosis of human colorectal cancer cells by protocatechualdehyde, a naturally occurring phenolic compound.
Author: Lee, Jeong Rak|Lee, Man Hyo|Eo, Hyun Ji|Park, Gwang Hun|Song, Hun Min|Kim, Mi Kyoung|Lee, Jin Wook|Jeong, Jin Boo
PMID: 25447816
Journal: Arch Toxicol. 2015 Jun;89(6):899-921.
Title: Microsatellite instability: an update.
Author: Yamamoto, Hiroyuki|Imai, Kohzoh
PMID: 25701956
Journal: Int J Oncol. 2015 Dec;47(6):2264-75.
Title: Radiation-induced modulation of immunogenic genes in tumor cells is regulated by both histone deacetylases and DNA methyltransferases.
Author: Cacan, Ercan|Greer, Susanna F|Garnett-Benson, Charlie
PMID: 26458736
Journal: Oncol Rep. 2015 Nov;34(5):2238-50.
Title: HDAC1 and HDAC2 independently predict mortality in hepatocellular carcinoma by a competing risk regression model in a Southeast Asian population.
Author: Ler, Ser Yeng|Leung, Carol Ho Wing|Khin, Lay Wai|Lu, Guo-Dong|Salto-Tellez, Manuel|Hartman, Mikael|Iau, Philip Tsau Choong|Yap, Celestial T|Hooi, Shing Chuan
PMID: 26352599
Journal: Org Biomol Chem. 2015 Oct 28;13(40):10226-35.
Title: Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells.
Author: Liu, Yi-Min|Lee, Hsueh-Yun|Lai, Mei-Jung|Pan, Shiow-Lin|Huang, Hsiang-Ling|Kuo, Fei-Chiao|Chen, Mei-Chuan|Liou, Jing-Ping
PMID: 26309122
Journal: Cancer Prev Res (Phila). 2015 May;8(5):387-99.
Title: Regulation of VDR Expression in Apc-Mutant Mice, Human Colon Cancers and Adenomas.
Author: Giardina, Charles|Nakanishi, Masako|Khan, Awaad|Kuratnik, Anton|Xu, Wanli|Brenner, Bruce|Rosenberg, Daniel W
PMID: 25873367
Journal: Oncotarget. 2015 Mar 30;6(9):7123-35.
Title: Sumoylation of HDAC2 promotes NF-kappaB-dependent gene expression.
Author: Wagner, Tobias|Kiweler, Nicole|Wolff, Katharina|Knauer, Shirley K|Brandl, Andre|Hemmerich, Peter|Dannenberg, Jan-Hermen|Heinzel, Thorsten|Schneider, Gunter|Kramer, Oliver H
PMID: 25704882
Journal: Biochem Biophys Res Commun. 2015 Jan 2;456(1):320-6.
Title: Trichostatin A, a histone deacetylase inhibitor, reverses epithelial-mesenchymal transition in colorectal cancer SW480 and prostate cancer PC3 cells.
Author: Wang, Xiaoxiong|Xu, Jun|Wang, Hao|Wu, Long|Yuan, Weiqi|Du, Jun|Cai, Shaohui
PMID: 25434997
Journal: Histopathology. 2015 Jan;66(2):270-82.
Title: Nuclear expression of histone deacetylases and their histone modifications predicts clinical outcome in colorectal cancer.
Author: Benard, Anne|Goossens-Beumer, Ines J|van Hoesel, Anneke Q|Horati, Hamed|de Graaf, Wouter|Putter, Hein|Zeestraten, Eliane C M|Liefers, Gerrit-Jan|van de Velde, Cornelis J H|Kuppen, Peter J K
PMID: 25307864
Journal: Neoplasma. 2016;63(2):193-200.
Title: Chidamide and 5-flurouracil show a synergistic antitumor effect on human colon cancer xenografts in nude mice.
Author: Liu, L|Qiu, S|Liu, Y|Liu, Z|Zheng, Y|Su, X|Chen, B|Chen, H
PMID: 26774139
Journal: Cancer Chemother Pharmacol. 2016 Mar;77(3):613-21.
Title: Histone deacetylase 2 regulates doxorubicin (Dox) sensitivity of colorectal cancer cells by targeting ABCB1 transcription.
Author: Ye, Pingjiang|Xing, Haibo|Lou, Fang|Wang, Kaifeng|Pan, Qin|Zhou, Xiaoyun|Gong, Liu|Li, Da
PMID: 26846508
Journal: Am J Cancer Res. 2016 Feb 15;6(3):664-76. eCollection 2016.
Title: Histone modifiers and marks define heterogeneous groups of colorectal carcinomas and affect responses to HDAC inhibitors in vitro.
Author: Lutz, Lisa|Fitzner, Ingrid Coutino|Ahrens, Theresa|Geissler, Anna-Lena|Makowiec, Frank|Hopt, Ulrich T|Bogatyreva, Lioudmila|Hauschke, Dieter|Werner, Martin|Lassmann, Silke
PMID: 27152243
Journal: Oncotarget. 2016 Jul 12;7(28):44505-44521.
Title: Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer.
Author: Alzoubi, Samer|Brody, Leigh|Rahman, Sunniyat|Mahul-Mellier, Anne-Laure|Mercado, Nicolas|Ito, Kazuhiro|El-Bahrawy, Mona|Silver, Andrew|Boobis, Alan|Bell, Jimmy D|Hajji, Nabil
PMID: 27283986
Journal: Eur J Med Chem. 2017 Jul 7;134:185-206.
Title: Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study.
Author: Li, Xiaoyang|Zhang, Yingjie|Jiang, Yuqi|Wu, Jingde|Inks, Elizabeth S|Chou, C James|Gao, Shuai|Hou, Jinning|Ding, Qinge|Li, Jingyao|Wang, Xue|Huang, Yongxue|Xu, Wenfang
PMID: 28415009
Journal: Braz J Med Biol Res. 2017 May 18;50(6):e6103.
Title: MicroRNA-455 suppresses the oncogenic function of HDAC2 in human colorectal cancer.
Author: Mao, Q D|Zhang, W|Zhao, K|Cao, B|Yuan, H|Wei, L Z|Song, M Q|Liu, X S
PMID: 28538837
Journal: Eur J Pharm Sci. 2018 May 28;121:188-199.
Title: Repurposing of sodium valproate in colon cancer associated with diabetes mellitus: Role of HDAC inhibition.
Author: Patel, Mayur M|Patel, Bhoomika M
PMID: 29852291
Journal: Med Sci Monit. 2018 Sep 12;24:6405-6413.
Title: Anti-Tumor Effects of Paeoniflorin on Epithelial-To-Mesenchymal Transition in Human Colorectal Cancer Cells.
Author: Zhang, Jia-Wei|Li, Li-Xin|Wu, Wei-Zhong|Pan, Ting-Jia|Yang, Zhao-Shuo|Yang, Yun-Ke
PMID: 30208371