Primary Site >> Colorectal Cancer
Gene >> HDAC2
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Ref: Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma. PMID: 12700284 |
Ref: Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter. PMID: 15107822 Ref: Requirement of histone deacetylase activity for signaling by STAT1. PMID: 15123634 Ref: Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis. PMID: 15144953 |
Ref: Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1. PMID: 15665816 Ref: Antibody response to a non-conserved C-terminal part of human histone deacetylase 3 in colon cancer patients. PMID: 15981215 Ref: Expression analysis of a subset of coregulators and three nuclear receptors in human colorectal carcinoma. PMID: 16309230 |
Ref: Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer. PMID: 16533812 Ref: CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo. PMID: 16731764 Ref: Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription. PMID: 16735507 Ref: CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo. PMID: 16891455 Ref: Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells. PMID: 17020613 |
Ref: HDAC3 overexpression and colon cancer cell proliferation and differentiation. PMID: 17849419 Ref: Transforming pathways unleashed by a HDAC2 mutation in human cancer. PMID: 18264134 Ref: HDAC2 deficiency sensitizes colon cancer cells to TNFalpha-induced apoptosis through inhibition of NF-kappaB activity. PMID: 18314102 Ref: Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. PMID: 18347167 Ref: An inactivating mutation in HDAC2 leads to dysregulation of apoptosis mediated by APAF1. PMID: 18834886 Ref: Making sense of HDAC2 mutations in colon cancer. PMID: 18851967 Ref: Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. PMID: 19010907 |
Ref: Decreased levels of autoantibody against histone deacetylase 3 in patients with systemic sclerosis. PMID: 19021012 Ref: Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma. PMID: 19057998 Ref: 15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells. PMID: 19198625 Ref: Histone deacetylase inhibitors suppress thymidylate synthase gene expression and synergize with the fluoropyrimidines in colon cancer cells. PMID: 19384949 Ref: Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer. PMID: 19787250 |
Ref: HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability. PMID: 19881542 Ref: Chemopreventive agent 3,3'-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases. PMID: 20068155 |
Ref: HDAC2 and TXNL1 distinguish aneuploid from diploid colorectal cancers. PMID: 21290163 |
Ref: SAHA inhibits the growth of colon tumors by decreasing histone deacetylase and the expression of cyclin D1 and survivin. PMID: 22270866 Ref: Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer. PMID: 22719182 Ref: Mechanism and stereoselectivity of HDAC I inhibition by (R)-9-hydroxystearic acid in colon cancer. PMID: 22814230 |
Ref: Kaempferol, a new nutrition-derived pan-inhibitor of human histone deacetylases. PMID: 23159065 Ref: Protocatechualdehyde possesses anti-cancer activity through downregulating cyclin D1 and HDAC2 in human colorectal cancer cells. PMID: 23159608 Ref: Patchouli alcohol, an essential oil of Pogostemon cablin, exhibits anti-tumorigenic activity in human colorectal cancer cells. PMID: 23602914 Ref: HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure. PMID: 23724067 Ref: Dietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis. PMID: 24067901 Ref: Black raspberries protectively regulate methylation of Wnt pathway genes in precancerous colon tissue. PMID: 24129635 |
Ref: Chemopreventive effects of an HDAC2-selective inhibitor on rat colon carcinogenesis and APCmin/+ mouse intestinal tumorigenesis. PMID: 24218540 Ref: Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells. PMID: 24766560 Ref: The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer. PMID: 24919179 Ref: Overexpression of histone deacetylases in cancer cells is controlled by interplay of transcription factors and epigenetic modulators. PMID: 24948597 Ref: The contribution of activating transcription factor 3 to apoptosis of human colorectal cancer cells by protocatechualdehyde, a naturally occurring phenolic compound. PMID: 25447816 |
Ref: Nuclear expression of histone deacetylases and their histone modifications predicts clinical outcome in colorectal cancer. PMID: 25307864 Ref: Trichostatin A, a histone deacetylase inhibitor, reverses epithelial-mesenchymal transition in colorectal cancer SW480 and prostate cancer PC3 cells. PMID: 25434997 Ref: Microsatellite instability: an update. PMID: 25701956 Ref: Sumoylation of HDAC2 promotes NF-kappaB-dependent gene expression. PMID: 25704882 Ref: Regulation of VDR Expression in Apc-Mutant Mice, Human Colon Cancers and Adenomas. PMID: 25873367 Ref: Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells. PMID: 26309122 Ref: HDAC1 and HDAC2 independently predict mortality in hepatocellular carcinoma by a competing risk regression model in a Southeast Asian population. PMID: 26352599 Ref: Radiation-induced modulation of immunogenic genes in tumor cells is regulated by both histone deacetylases and DNA methyltransferases. PMID: 26458736 |
Ref: Chidamide and 5-flurouracil show a synergistic antitumor effect on human colon cancer xenografts in nude mice. PMID: 26774139 Ref: Histone deacetylase 2 regulates doxorubicin (Dox) sensitivity of colorectal cancer cells by targeting ABCB1 transcription. PMID: 26846508 Ref: Histone modifiers and marks define heterogeneous groups of colorectal carcinomas and affect responses to HDAC inhibitors in vitro. PMID: 27152243 Ref: Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer. PMID: 27283986 |
Ref: Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study. PMID: 28415009 Ref: MicroRNA-455 suppresses the oncogenic function of HDAC2 in human colorectal cancer. PMID: 28538837 |
Ref: Repurposing of sodium valproate in colon cancer associated with diabetes mellitus: Role of HDAC inhibition. PMID: 29852291 Ref: Anti-Tumor Effects of Paeoniflorin on Epithelial-To-Mesenchymal Transition in Human Colorectal Cancer Cells. PMID: 30208371 |