Primary Site >> Colorectal Cancer

Gene >> HCAR2

Journal: Clin Exp Metastasis. 2004;21(1):79-85.
Title: p53 and HLA class-I expression are not down-regulated in colorectal cancer liver metastases.
Author: Menon, Anand G|Tollenaar, Rob A E M|van de Velde, Cornelis J H|Putter, Hein|Janssen-van Rhijn, Connie M|Keijzer, Rob|Fleuren, Gert Jan|Kuppen, Peter J K
PMID: 15065606
Journal: Cancer Res. 2009 Apr 1;69(7):2826-32.
Title: GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon.
Author: Thangaraju, Muthusamy|Cresci, Gail A|Liu, Kebin|Ananth, Sudha|Gnanaprakasam, Jaya P|Browning, Darren D|Mellinger, John D|Smith, Sylvia B|Digby, Gregory J|Lambert, Nevin A|Prasad, Puttur D|Ganapathy, Vadivel
PMID: 19276343
Journal: Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15;302(12):G1405-15.
Title: Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells.
Author: Zimmerman, Mary A|Singh, Nagendra|Martin, Pamela M|Thangaraju, Muthusamy|Ganapathy, Vadivel|Waller, Jennifer L|Shi, Huidong|Robertson, Keith D|Munn, David H|Liu, Kebin
PMID: 22517765
Journal: Cancer Res. 2014 Feb 15;74(4):1166-78.
Title: The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival.
Author: Elangovan, Selvakumar|Pathania, Rajneesh|Ramachandran, Sabarish|Ananth, Sudha|Padia, Ravi N|Lan, Ling|Singh, Nagendra|Martin, Pamela M|Hawthorn, Lesleyann|Prasad, Puttur D|Ganapathy, Vadivel|Thangaraju, Muthusamy
PMID: 24371223
Journal: Immunity. 2014 Jan 16;40(1):128-39.
Title: Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.
Author: Singh, Nagendra|Gurav, Ashish|Sivaprakasam, Sathish|Brady, Evan|Padia, Ravi|Shi, Huidong|Thangaraju, Muthusamy|Prasad, Puttur D|Manicassamy, Santhakumar|Munn, David H|Lee, Jeffrey R|Offermanns, Stefan|Ganapathy, Vadivel
PMID: 24412617
Journal: Immunity. 2014 Jan 16;40(1):8-10.
Title: GPR109a: the missing link between microbiome and good health?
Author: Jobin, Christian
PMID: 24439263
Journal: Cancer Immunol Res. 2015 Jul;3(7):795-805.
Title: IFNgamma Induces DNA Methylation-Silenced GPR109A Expression via pSTAT1/p300 and H3K18 Acetylation in Colon Cancer.
Author: Bardhan, Kankana|Paschall, Amy V|Yang, Dafeng|Chen, May R|Simon, Priscilla S|Bhutia, Yangzom D|Martin, Pamela M|Thangaraju, Muthusamy|Browning, Darren D|Ganapathy, Vadivel|Heaton, Christopher M|Gu, Keni|Lee, Jeffrey R|Liu, Kebin
PMID: 25735954
Journal: Neurochem Int. 2016 Oct;99:110-132.
Title: The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?
Author: Stilling, Roman M|van de Wouw, Marcel|Clarke, Gerard|Stanton, Catherine|Dinan, Timothy G|Cryan, John F
PMID: 27346602
Journal: FEMS Microbiol Lett. 2017 Mar 1;364(6). pii: 3045906.
Title: Effect of butyrate and Lactobacillus GG on a butyrate receptor and transporter during Campylobacter jejuni exposure.
Author: Cresci, Gail A M|Mayor, Paul C|Thompson, Stuart A
PMID: 28333199
Journal: Cancer Biol Ther. 2017 May 4;18(5):304-313.
Title: Ameliorative effects of pyrazinoic acid against oxidative and metabolic stress manifested in rats with dimethylhydrazine induced colonic carcinoma.
Author: Sahdev, Anil K|Raj, Vinit|Singh, Ashok K|Rai, Amit|Keshari, Amit K|De, Arnab|Samanta, Amalesh|Kumar, Umesh|Rawat, Atul|Kumar, Dinesh|Nath, Sneha|Prakash, Anand|Saha, Sudipta
PMID: 28358223