Primary Site >> Colorectal Cancer

Gene >> HAVCR2

Journal: Yonago Acta Med. 2012 Mar;55(1):1-9. Epub 2012 Mar 1.
Title: Upregulation of TIM-3 and PD-1 on CD4+ and CD8+ T Cells Associated with Dysfunction of Cell-Mediated Immunity after Colorectal Cancer Operation.
Author: Arai, Yosuke|Saito, Hiroaki|Ikeguchi, Masahide
PMID: 24031134
Journal: PLoS One. 2013;8(3):e58006.
Title: Tim-3 expression defines regulatory T cells in human tumors.
Author: Yan, Jing|Zhang, Yi|Zhang, Jing-Ping|Liang, Jing|Li, Lian|Zheng, Limin
PMID: 23526963
Journal: Nature. 2015 Jan 15;517(7534):386-90.
Title: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Author: Huang, Yu-Hwa|Zhu, Chen|Kondo, Yasuyuki|Anderson, Ana C|Gandhi, Amit|Russell, Andrew|Dougan, Stephanie K|Petersen, Britt-Sabina|Melum, Espen|Pertel, Thomas|Clayton, Kiera L|Raab, Monika|Chen, Qiang|Beauchemin, Nicole|Yazaki, Paul J|Pyzik, Michal|Ostrowski
PMID: 25363763
Journal: Oncoimmunology. 2015 Apr 2;4(3):e976052.
Title: An immunogenomic stratification of colorectal cancer: Implications for development of targeted immunotherapy.
Author: Lal, Neeraj|Beggs, Andrew D|Willcox, Benjamin E|Middleton, Gary W
PMID: 25949894
Journal: Oncotarget. 2015 Aug 21;6(24):20592-603.
Title: Circulating and tumor-infiltrating Tim-3 in patients with colorectal cancer.
Author: Xu, Benling|Yuan, Long|Gao, Quanli|Yuan, Peng|Zhao, Peng|Yuan, Huijuan|Fan, Huijie|Li, Tiepeng|Qin, Peng|Han, Lu|Fang, Weijia|Suo, Zhenhe
PMID: 26008981
Journal: Int J Clin Exp Pathol. 2015 Jul 1;8(7):8018-27. eCollection 2015.
Title: Up-regulation of Tim-3 is associated with poor prognosis of patients with colon cancer.
Author: Zhou, Encheng|Huang, Qing|Wang, Ji|Fang, Chengfeng|Yang, Leilei|Zhu, Min|Chen, Jianhui|Chen, Lihua|Dong, Milian
PMID: 26339368
Journal: Sci Rep. 2015 Oct 23;5:15659.
Title: Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer.
Author: Kang, Chiao-Wen|Dutta, Avijit|Chang, Li-Yuan|Mahalingam, Jayashri|Lin, Yung-Chang|Chiang, Jy-Ming|Hsu, Chen-Yu|Huang, Ching-Tai|Su, Wan-Ting|Chu, Yu-Yi|Lin, Chun-Yen
PMID: 26493689
Journal: Oncotarget. 2016 Jan 26;7(4):4522-30.
Title: Identification of TIM3 2'-fluoro oligonucleotide aptamer by HT-SELEX for cancer immunotherapy.
Author: Hervas-Stubbs, Sandra|Soldevilla, Mario M|Villanueva, Helena|Mancheno, Uxua|Bendandi, Maurizio|Pastor, Fernando
PMID: 26683225
Journal: J Immunother. 2016 May;39(4):171-80.
Title: Targeting PD-1 and Tim-3 Pathways to Reverse CD8 T-Cell Exhaustion and Enhance Ex Vivo T-Cell Responses to Autologous Dendritic/Tumor Vaccines.
Author: Liu, Jingwei|Zhang, Shurong|Hu, Yuefeng|Yang, Zhaomin|Li, Jingpo|Liu, Xuesong|Deng, Lijuan|Wang, Yue|Zhang, Xiaoyan|Jiang, Ting|Lu, Xu
PMID: 27070448
Journal: Oncol Res Treat. 2016;39(6):346-50.
Title: Immunotherapy of Colorectal Cancer.
Author: Jager, Dirk|Halama, Niels|Zornig, Inka|Klug, Paula|Krauss, Jurgen|Haag, Georg-Martin
PMID: 27259331
Journal: Oncoimmunology. 2016 Aug 3;5(9):e1211219.
Title: Tim-3 promotes tumor-promoting M2 macrophage polarization by binding to STAT1 and suppressing the STAT1-miR-155 signaling axis.
Author: Jiang, Xingwei|Zhou, Tingting|Xiao, Yan|Yu, Jiahui|Dou, Shuaijie|Chen, Guojiang|Wang, Renxi|Xiao, He|Hou, Chunmei|Wang, Wei|Shi, Qingzhu|Feng, Jiannan|Ma, Yuanfang|Shen, Beifen|Li, Yan|Han, Gencheng
PMID: 27757304
Journal: Neoplasma. 2017;64(1):101-107.
Title: Down-regulated expression of Tim-3 promotes invasion and metastasis of colorectal cancer cells.
Author: Sun, Q Y|Qu, C H|Liu, J Q|Zhang, P|Yao, J
PMID: 27881010
Journal: Mol Med Rep. 2017 Jun;15(6):3810-3818.
Title: Preoperative Tim3 expression on peripheral NK cells is correlated with pathologic TNM staging in colorectal cancer.
Author: Wang, Yang|Sun, Jintang|Gao, Wenjuan|Song, Bingfeng|Shao, Qianqian|Zhao, Lei|Zhang, Yun|Wang, Qingjie|Zhang, Yun|Qu, Xun
PMID: 28440449
Journal: Int Immunopharmacol. 2017 Feb;43:210-218.
Title: Co-expression of TIM-3 and CEACAM1 promotes T cell exhaustion in colorectal cancer patients.
Author: Zhang, Yang|Cai, Pengcheng|Li, Lei|Shi, Liang|Chang, Panpan|Liang, Tao|Yang, Qianqian|Liu, Yang|Wang, Lin|Hu, Lihua
PMID: 28038383
Journal: Mol Med Rep. 2017 Feb;15(2):689-695.
Title: Tim-3 is upregulated in human colorectal carcinoma and associated with tumor progression.
Author: Yu, Muming|Lu, Bin|Liu, Yancun|Me, Ying|Wang, Lijun|Zhang, Peng
PMID: 28035413
Journal: J Cancer. 2018 Jan 1;9(2):239-249.
Title: Early and Partial Reduction in CD4(+)Foxp3(+) Regulatory T Cells during Colitis-Associated Colon Cancer Induces CD4(+) and CD8(+) T Cell Activation Inhibiting Tumorigenesis.
Author: Olguin, Jonadab E|Medina-Andrade, Itzel|Molina, Emmanuel|Vazquez, Armando|Pacheco-Fernandez, Thalia|Saavedra, Rafael|Perez-Plasencia, Carlos|Chirino, Yolanda I|Vaca-Paniagua, Felipe|Arias-Romero, Luis E|Gutierrez-Cirlos, Emma B|Leon-Cabrera, Sonia A|Rodri
PMID: 29344269
Journal: Hum Immunol. 2018 Jun;79(6):446-452.
Title: CD8(+)CXCR5(+) T cells in tumor-draining lymph nodes are highly activated and predict better prognosis in colorectal cancer.
Author: E, Jifu|Yan, Feihu|Kang, Zhengchun|Zhu, Liangliang|Xing, Junjie|Yu, Enda
PMID: 29544815
Journal: Ann Surg Oncol. 2018 Aug;25(8):2323-2331.
Title: Cytolytic Activity Score to Assess Anticancer Immunity in Colorectal Cancer.
Author: Narayanan, Sumana|Kawaguchi, Tsutomu|Yan, Li|Peng, Xuan|Qi, Qianya|Takabe, Kazuaki
PMID: 29770915
Journal: Oncoimmunology. 2018 Apr 25;7(7):e1448332.
Title: Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer.
Author: Zhou, Guoying|Noordam, Lisanne|Sprengers, Dave|Doukas, Michail|Boor, Patrick P C|van Beek, Adriaan A|Erkens, Remco|Mancham, Shanta|Grunhagen, Dirk|Menon, Anand G|Lange, Johan F|Burger, Pim J W A|Brandt, Alexandra|Galjart, Boris|Verhoef, Cornelis|Kwekkeboo
PMID: 29900067
Journal: Clin Exp Pharmacol Physiol. 2018 Oct;45(10):1002-1009.
Title: Co-expression of LAG3 and TIM3 identifies a potent Treg population that suppresses macrophage functions in colorectal cancer patients.
Author: Ma, Qiang|Liu, Junning|Wu, Guoliang|Teng, Mujian|Wang, Shaoxuan|Cui, Meng|Li, Yuantao
PMID: 29905955
Journal: Oncol Lett. 2018 Jul;16(1):1059-1066.
Title: Downregulated Tim-3 expression is responsible for the incidence and development of colorectal cancer.
Author: Zhang, Ping|Wang, Yan|Liu, Xue-Rong|Hong, Shi-Ru|Yao, Jian
PMID: 29963183
Journal: Clin Epigenetics. 2018 Aug 6;10(1):104.
Title: DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer.
Author: Sasidharan Nair, Varun|Toor, Salman M|Taha, Rowaida Z|Shaath, Hibah|Elkord, Eyad
PMID: 30081950
Journal: Cancer Manag Res. 2018 Sep 17;10:3569-3577.
Title: Low tumor purity is associated with poor prognosis, heavy mutation burden, and intense immune phenotype in colon cancer.
Author: Mao, Yihao|Feng, Qingyang|Zheng, Peng|Yang, Liangliang|Liu, Tianyu|Xu, Yuqiu|Zhu, Dexiang|Chang, Wenju|Ji, Meiling|Ren, Li|Wei, Ye|He, Guodong|Xu, Jianmin
PMID: 30271205