Primary Site >> Colorectal Cancer
Gene >> HAVCR2
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Ref: Upregulation of TIM-3 and PD-1 on CD4+ and CD8+ T Cells Associated with Dysfunction of Cell-Mediated Immunity after Colorectal Cancer Operation. PMID: 24031134 |
Ref: Tim-3 expression defines regulatory T cells in human tumors. PMID: 23526963 |
Ref: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. PMID: 25363763 Ref: An immunogenomic stratification of colorectal cancer: Implications for development of targeted immunotherapy. PMID: 25949894 Ref: Circulating and tumor-infiltrating Tim-3 in patients with colorectal cancer. PMID: 26008981 Ref: Up-regulation of Tim-3 is associated with poor prognosis of patients with colon cancer. PMID: 26339368 Ref: Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer. PMID: 26493689 |
Ref: Identification of TIM3 2'-fluoro oligonucleotide aptamer by HT-SELEX for cancer immunotherapy. PMID: 26683225 Ref: Targeting PD-1 and Tim-3 Pathways to Reverse CD8 T-Cell Exhaustion and Enhance Ex Vivo T-Cell Responses to Autologous Dendritic/Tumor Vaccines. PMID: 27070448 Ref: Immunotherapy of Colorectal Cancer. PMID: 27259331 Ref: Tim-3 promotes tumor-promoting M2 macrophage polarization by binding to STAT1 and suppressing the STAT1-miR-155 signaling axis. PMID: 27757304 |
Ref: Down-regulated expression of Tim-3 promotes invasion and metastasis of colorectal cancer cells. PMID: 27881010 Ref: Tim-3 is upregulated in human colorectal carcinoma and associated with tumor progression. PMID: 28035413 Ref: Co-expression of TIM-3 and CEACAM1 promotes T cell exhaustion in colorectal cancer patients. PMID: 28038383 Ref: Preoperative Tim3 expression on peripheral NK cells is correlated with pathologic TNM staging in colorectal cancer. PMID: 28440449 |
Ref: Early and Partial Reduction in CD4(+)Foxp3(+) Regulatory T Cells during Colitis-Associated Colon Cancer Induces CD4(+) and CD8(+) T Cell Activation Inhibiting Tumorigenesis. PMID: 29344269 Ref: CD8(+)CXCR5(+) T cells in tumor-draining lymph nodes are highly activated and predict better prognosis in colorectal cancer. PMID: 29544815 Ref: Cytolytic Activity Score to Assess Anticancer Immunity in Colorectal Cancer. PMID: 29770915 Ref: Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer. PMID: 29900067 Ref: Co-expression of LAG3 and TIM3 identifies a potent Treg population that suppresses macrophage functions in colorectal cancer patients. PMID: 29905955 Ref: Downregulated Tim-3 expression is responsible for the incidence and development of colorectal cancer. PMID: 29963183 Ref: DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer. PMID: 30081950 Ref: Low tumor purity is associated with poor prognosis, heavy mutation burden, and intense immune phenotype in colon cancer. PMID: 30271205 |