Primary Site >> Colorectal Cancer

Gene >> GZMB

Journal: Science. 1992 Dec 11;258(5089):1795-8.
Title: Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice.
Author: Mizoguchi, H|O'Shea, J J|Longo, D L|Loeffler, C M|McVicar, D W|Ochoa, A C
PMID: 1465616
Journal: Gut. 1997 Jan;40(1):113-9.
Title: T cell receptor-zeta and granzyme B expression in mononuclear cell infiltrates in normal colon mucosa and colon carcinoma.
Author: Mulder, W M|Bloemena, E|Stukart, M J|Kummer, J A|Wagstaff, J|Scheper, R J
PMID: 9155587
Journal: Cancer Res. 1998 Aug 15;58(16):3491-4.
Title: CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer.
Author: Naito, Y|Saito, K|Shiiba, K|Ohuchi, A|Saigenji, K|Nagura, H|Ohtani, H
PMID: 9721846
Journal: Cancer Lett. 2002 Mar 28;177(2):163-72.
Title: The antiproliferative effects of biologically active isomers of conjugated linoleic acid on human colorectal and prostatic cancer cells.
Author: Palombo, John D|Ganguly, Aniruddha|Bistrian, Bruce R|Menard, Michael P
PMID: 11825663
Journal: N Engl J Med. 2005 Dec 22;353(25):2654-66.
Title: Effector memory T cells, early metastasis, and survival in colorectal cancer.
Author: Pages, Franck|Berger, Anne|Camus, Matthieu|Sanchez-Cabo, Fatima|Costes, Anne|Molidor, Robert|Mlecnik, Bernhard|Kirilovsky, Amos|Nilsson, Malin|Damotte, Diane|Meatchi, Tchao|Bruneval, Patrick|Cugnenc, Paul-Henri|Trajanoski, Zlatko|Fridman, Wolf-Herman|Galo
PMID: 16371631
Journal: J Pathol. 2006 Feb;208(3):381-7.
Title: Characterization of tumour-infiltrating lymphocytes and apoptosis in colitis-associated neoplasia: comparison with sporadic colorectal cancer.
Author: Michael-Robinson, J M|Pandeya, N|Walsh, M D|Biemer-Huttmann, A-E|Eri, R D|Buttenshaw, R L|Lincoln, D|Clouston, A D|Jass, J R|Radford-Smith, G L
PMID: 16315333
Journal: Cancer Biomark. 2006;2(1-2):61-8.
Title: Gene expression analysis of tumor infiltrating lymphocyte markers in endometrial cancers indicates no significant increases in those cases with microsatellite instability.
Author: Risinger, John I|Chandramouli, G V R|Maxwell, G Larry|Litzi, Tracy|Berchuck, Andrew|Umar, Asad
PMID: 17192060
Journal: Clin Cancer Res. 2007 May 1;13(9):2758-67.
Title: Targeted and untargeted CD137L fusion proteins for the immunotherapy of experimental solid tumors.
Author: Zhang, Nan|Sadun, Rebecca E|Arias, Robyn S|Flanagan, Meg L|Sachsman, Suzanne M|Nien, Yu-Chih|Khawli, Leslie A|Hu, Peisheng|Epstein, Alan L
PMID: 17460060
Journal: Gut. 2008 Jun;57(6):772-9. Epub 2007 Oct 26.
Title: High prevalence of Foxp3 and IL17 in MMR-proficient colorectal carcinomas.
Author: Le Gouvello, S|Bastuji-Garin, S|Aloulou, N|Mansour, H|Chaumette, M-T|Berrehar, F|Seikour, A|Charachon, A|Karoui, M|Leroy, K|Farcet, J-P|Sobhani, I
PMID: 17965063
Journal: Cancer Immun. 2008 Feb 29;8:5.
Title: Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tumor tissue infiltration of seemingly activated immune cells in colorectal cancer.
Author: Lonnroth, Christina|Andersson, Marianne|Arvidsson, Annette|Nordgren, Svante|Brevinge, Hans|Lagerstedt, Kristina|Lundholm, Kent
PMID: 18307280
Journal: Gastroenterology. 2008 Apr;134(4):998-1006.
Title: The specific immune response to tumor antigen CP1 and its correlation with improved survival in colon cancer patients.
Author: Liu, Fang-Fang|Dong, Xue-Yuan|Pang, Xue-Wen|Xing, Qiao|Wang, Hong-Cheng|Zhang, Hua-Gang|Li, Yan|Yin, Yan-Hui|Fant, Michael|Ye, Ying-Jiang|Shen, Dan-Hua|Zhang, Yu|Wang, Shan|Chen, Wei-Feng
PMID: 18395081
Journal: J Gastroenterol. 2008;43(7):576-80.
Title: Primary CD56+ NK/T-cell lymphoma of the rectum accompanied with refractory ulcerative colitis.
Author: Kakimoto, Kazuki|Inoue, Takuya|Nishikawa, Takashi|Ishida, Kumi|Kawakami, Ken|Kuramoto, Takanori|Abe, Yosuke|Morita, Eijiro|Murano, Naoko|Toshina, Ken|Murano, Mitsuyuki|Umegaki, Eiji|Egashira, Yutaro|Okuda, Junji|Tanigawa, Nobuhiko|Hirata, Ichiro|Katsu, Ke
PMID: 18648746
Journal: Mol Biotechnol. 2009 Mar;41(3):236-46.
Title: Comparison of caspase genes for the induction of apoptosis following gene delivery.
Author: Zhang, Xiujuan|Turner, Curlicia|Godbey, W T
PMID: 19067254
Journal: World J Gastroenterol. 2009 Dec 21;15(47):5898-906.
Title: Invasive front of colorectal cancer: dynamic interface of pro-/anti-tumor factors.
Author: Zlobec, Inti|Lugli, Alessandro
PMID: 20014453
Journal: BMC Cancer. 2009 Jun 15;9:184.
Title: Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas.
Author: Nielsen, Maartje|de Miranda, Noel F C C|van Puijenbroek, Marjo|Jordanova, Ekaterina S|Middeldorp, Anneke|van Wezel, Tom|van Eijk, Ronald|Tops, Carli M J|Vasen, Hans F A|Hes, Frederik J|Morreau, Hans
PMID: 19527492
Journal: Cancer Immun. 2009 Feb 19;9:1.
Title: The localization and density of immune cells in primary tumors of human metastatic colorectal cancer shows an association with response to chemotherapy.
Author: Halama, Niels|Michel, Sara|Kloor, Matthias|Zoernig, Inka|Pommerencke, Thora|von Knebel Doeberitz, Magnus|Schirmacher, Peter|Weitz, Jurgen|Grabe, Niels|Jager, Dirk
PMID: 19226101
Journal: BMC Immunol. 2010 Apr 12;11:19.
Title: Tumor infiltrating lymphocytes: an intriguing player in the survival of colorectal cancer patients.
Author: Deschoolmeester, Vanessa|Baay, Marc|Van Marck, Eric|Weyler, Joost|Vermeulen, Peter|Lardon, Filip|Vermorken, Jan B
PMID: 20385003
Journal: Anal Quant Cytol Histol. 2010 Dec;32(6):333-40.
Title: Quantification of prognostic immune cell markers in colorectal cancer using whole slide imaging tumor maps.
Author: Halama, Niels|Zoernig, Inka|Spille, Anna|Michel, Sara|Kloor, Matthias|Grauling-Halama, Silke|Westphal, Kathi|Schirmacher, Peter|Jager, Dirk|Grabe, Niels
PMID: 21456345
Journal: Cancer Res. 2011 Feb 15;71(4):1263-71.
Title: Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer.
Author: Tosolini, Marie|Kirilovsky, Amos|Mlecnik, Bernhard|Fredriksen, Tessa|Mauger, Stephanie|Bindea, Gabriela|Berger, Anne|Bruneval, Patrick|Fridman, Wolf-Herman|Pages, Franck|Galon, Jerome
PMID: 21303976
Journal: Cancer Res. 2011 Sep 1;71(17):5670-7.
Title: Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy.
Author: Halama, Niels|Michel, Sara|Kloor, Matthias|Zoernig, Inka|Benner, Axel|Spille, Anna|Pommerencke, Thora|von Knebel, Doeberitz Magnus|Folprecht, Gunnar|Luber, Birgit|Feyen, Nadine|Martens, Uwe M|Beckhove, Philipp|Gnjatic, Sacha|Schirmacher, Peter|Herpel, Est
PMID: 21846824
Journal: Clin Cancer Res. 2012 Mar 1;18(5):1237-45.
Title: Infiltration of Lynch colorectal cancers by activated immune cells associates with early staging of the primary tumor and absence of lymph node metastases.
Author: de Miranda, Noel F C C|Goudkade, Danny|Jordanova, Ekaterina S|Tops, Carli M J|Hes, Frederik J|Vasen, Hans F A|van Wezel, Tom|Morreau, Hans
PMID: 22261803
Journal: Oncoimmunology. 2012 Aug 1;1(5):593-599.
Title: Sequential metastases of colorectal cancer: Immunophenotypes and spatial distributions of infiltrating immune cells in relation to time and treatments.
Author: Keim, Sophia|Zoernig, Inka|Spille, Anna|Lahrmann, Bernd|Brand, Karsten|Herpel, Esther|Grabe, Niels|Jager, Dirk|Halama, Niels
PMID: 22934251
Journal: J Transl Med. 2013 Oct 20;11:262.
Title: Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer, and colorectal cancer.
Author: Peng, Yun-Peng|Zhu, Yi|Zhang, Jing-Jing|Xu, Ze-Kuan|Qian, Zhu-Yin|Dai, Cun-Cai|Jiang, Kui-Rong|Wu, Jun-Li|Gao, Wen-Tao|Li, Qiang|Du, Qing|Miao, Yi
PMID: 24138752
Journal: Int Immunopharmacol. 2013 Jan;15(1):6-14.
Title: The effect of phloretin on human gammadelta T cells killing colon cancer SW-1116 cells.
Author: Zhu, Sheng-Ping|Liu, Gang|Wu, Xiao-Ting|Chen, Fu-Xing|Liu, Jun-Quan|Zhou, Zhong-Hai|Zhang, Jian-Fu|Fei, Su-Juan
PMID: 23174508
Journal: World J Gastroenterol. 2014 May 7;20(17):4994-9.
Title: Clinical and histopathological correlations of fecal calprotectin release in colorectal carcinoma.
Author: Lehmann, Frank Serge|Trapani, Francesca|Fueglistaler, Ida|Terracciano, Luigi Maria|von Flue, Markus|Cathomas, Gieri|Zettl, Andreas|Benkert, Pascal|Oertli, Daniel|Beglinger, Christoph
PMID: 24803811
Journal: J Cancer Res Ther. 2014 Jul-Sep;10(3):587-90.
Title: Granzyme B gene polymorphisms, colorectal cancer risk, and metastasis.
Author: Mhaidat, Nizar M|Al-azzam, Sayer I|Alzoubi, Karem H|Khabour, Omar F|Gharaibeh, Baraa F
PMID: 25313744
Journal: Oncotarget. 2015 Feb 20;6(5):2981-91.
Title: Active secretion of CXCL10 and CCL5 from colorectal cancer microenvironments associates with GranzymeB+ CD8+ T-cell infiltration.
Author: Zumwalt, Timothy J|Arnold, Mildred|Goel, Ajay|Boland, C Richard
PMID: 25671296
Journal: J Immunol. 2015 Oct 1;195(7):3472-81.
Title: Human Mucosa-Associated Invariant T Cells Accumulate in Colon Adenocarcinomas but Produce Reduced Amounts of IFN-gamma.
Author: Sundstrom, Patrik|Ahlmanner, Filip|Akeus, Paulina|Sundquist, Malin|Alsen, Samuel|Yrlid, Ulf|Borjesson, Lars|Sjoling, Asa|Gustavsson, Bengt|Wong, S B Justin|Quiding-Jarbrink, Marianne
PMID: 26297765
Journal: Oncoimmunology. 2015 May 29;4(12):e1050574.
Title: Absence of myeloperoxidase and CD8 positive cells in colorectal cancer infiltrates identifies patients with severe prognosis.
Author: Daster, Silvio|Eppenberger-Castori, Serenella|Hirt, Christian|Soysal, Savas D|Delko, Tarik|Nebiker, Christian A|Weixler, Benjamin|Amicarella, Francesca|Iezzi, Giandomenica|Governa, Valeria|Padovan, Elisabetta|Mele, Valentina|Sconocchia, Giuseppe|Heberer,
PMID: 26587320
Journal: Ann Surg Oncol. 2016 Feb;23 Suppl 2:S257-65.
Title: Abdominal Infection Suppresses the Number and Activity of Intrahepatic Natural Killer Cells and Promotes Tumor Growth in a Murine Liver Metastasis Model.
Author: Matsumoto, Yusuke|Tsujimoto, Hironori|Ono, Satoshi|Shinomiya, Nariyoshi|Miyazaki, Hiromi|Hiraki, Shuichi|Takahata, Risa|Yoshida, Kazumichi|Saitoh, Daizoh|Yamori, Takao|Yamamoto, Junji|Hase, Kazuo
PMID: 25752891
Journal: Acta Biomater. 2016 Mar;33:142-52.
Title: Targeted intracellular protein delivery based on hyaluronic acid-green tea catechin nanogels.
Author: Liang, Kun|Ng, Shengyong|Lee, Fan|Lim, Jaehong|Chung, Joo Eun|Lee, Su Seong|Kurisawa, Motoichi
PMID: 26785145
Journal: PLoS One. 2016 Jun 16;11(6):e0156660.
Title: Decreased Anti-Tumor Cytotoxic Immunity among Microsatellite-Stable Colon Cancers from African Americans.
Author: Basa, Ranor C B|Davies, Vince|Li, Xiaoxiao|Murali, Bhavya|Shah, Jinel|Yang, Bing|Li, Shi|Khan, Mohammad W|Tian, Mengxi|Tejada, Ruth|Hassan, Avan|Washington, Allen Jr|Mukherjee, Bhramar|Carethers, John M|McGuire, Kathleen L
PMID: 27310868
Journal: Cancer Immunol Res. 2016 Sep 2;4(9):766-78.
Title: Gp96-Ig/Costimulator (OX40L, ICOSL, or 4-1BBL) Combination Vaccine Improves T-cell Priming and Enhances Immunity, Memory, and Tumor Elimination.
Author: Fromm, George|de Silva, Suresh|Giffin, Louise|Xu, Xin|Rose, Jason|Schreiber, Taylor H
PMID: 27364122
Journal: Oncotarget. 2016 Nov 15;7(46):76274-76290.
Title: Clinical relevance of circulating mucosal-associated invariant T cell levels and their anti-cancer activity in patients with mucosal-associated cancer.
Author: Won, Eun Jeong|Ju, Jae Kyun|Cho, Young-Nan|Jin, Hye-Mi|Park, Ki-Jeong|Kim, Tae-Jong|Kwon, Yong-Soo|Kee, Hae Jin|Kim, Jung-Chul|Kee, Seung-Jung|Park, Yong-Wook
PMID: 27517754
Journal: Oncoimmunology. 2016 Apr 29;5(7):e1177690.
Title: CD169 identifies an activated CD8(+) T cell subset in regional lymph nodes that predicts favorable prognosis in colorectal cancer patients.
Author: Zhang, Jiali|Xu, Jing|Zhang, Rong-Xin|Zhang, Yi|Ou, Qing-Jian|Li, Jin-Qing|Jiang, Ze-Zhou|Wu, Xiao-Jun|Fang, Yu-Jing|Zheng, Limin
PMID: 27622027
Journal: Oncotarget. 2017 Jan 31;8(5):7586-7597.
Title: T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice.
Author: Liu, Wen|Guo, Wenjie|Shen, Lihong|Chen, Zhen|Luo, Qiong|Luo, Xiaolin|Feng, GenSheng|Shu, Yongqian|Gu, Yanhong|Xu, Qiang|Sun, Yang
PMID: 27935860
Journal: Oncotarget. 2017 Jun 9;8(33):54775-54787.
Title: Tumor location impacts immune response in mouse models of colon cancer.
Author: Zhao, Xianda|Li, Lihua|Starr, Timothy K|Subramanian, Subbaya
PMID: 28903381
Journal: Oncoimmunology. 2017 Feb 6;6(4):e1288330.
Title: Digital analysis and epigenetic regulation of the signature of rejection in colorectal cancer.
Author: Koelzer, Viktor H|Sokol, Lena|Zahnd, Stefan|Christe, Lucine|Dawson, Heather|Berger, Martin D|Inderbitzin, Daniel|Zlobec, Inti|Lugli, Alessandro
PMID: 28507795
Journal: Oncoimmunology. 2016 Dec 7;6(1):e1261776.
Title: Deficiency of the immunostimulatory cytokine IL-21 promotes intestinal neoplasia via dysregulation of the Th1/Th17 axis.
Author: Shapiro, Mia|Nandi, Bisweswar|Gonzalez, Gabriel|Prabhala, Rao H|Mashimo, Hiroshi|Huang, Qin|Frank, Natasha Y|Munshi, Nikhil C|Gold, Jason S
PMID: 28197386
Journal: Cancer Epidemiol Biomarkers Prev. 2017 Apr;26(4):622-631.
Title: Cytotoxic T Cells and Granzyme B Associated with Improved Colorectal Cancer Survival in a Prospective Cohort of Older Women.
Author: Prizment, Anna E|Vierkant, Robert A|Smyrk, Thomas C|Tillmans, Lori S|Nelson, Heather H|Lynch, Charles F|Pengo, Thomas|Thibodeau, Stephen N|Church, Timothy R|Cerhan, James R|Anderson, Kristin E|Limburg, Paul J
PMID: 27979806
Journal: Hum Vaccin Immunother. 2018 Jan 2;14(1):140-145.
Title: Sequential administration of MVA-based vaccines and PD-1/PD-L1-blocking antibodies confers measurable benefits on tumor growth and survival: Preclinical studies with MVA-betaGal and MVA-MUC1 (TG4010) in a murine tumor model.
Author: Remy-Ziller, Christelle|Thioudellet, Christine|Hortelano, Julie|Gantzer, Murielle|Nourtier, Virginie|Claudepierre, Marie-Christine|Sansas, Benoit|Preville, Xavier|Bendjama, Kaidre|Quemeneur, Eric|Rittner, Karola
PMID: 28925793
Journal: Exp Cell Res. 2018 Jan 1;362(1):63-71.
Title: Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human gammadeltaT cells against colon cancer.
Author: Chen, Yong-Qiang|Zheng, Lu|Aldarouish, Mohanad|Zhou, Zhong-Hai|Pan, Ning|Liu, Jun-Quan|Chen, Fu-Xing|Wang, Li-Xin
PMID: 29104081
Journal: Oncoimmunology. 2017 Nov 7;7(2):e1393133.
Title: Neoadjuvant radiochemotherapy decreases the total amount of tumor infiltrating lymphocytes, but increases the number of CD8+/Granzyme B+ (GrzB) cytotoxic T-cells in rectal cancer.
Author: Jarosch, Armin|Sommer, Ulrich|Bogner, Andreas|Reissfelder, Christoph|Weitz, Jurgen|Krause, Mechthild|Folprecht, Gunnar|Baretton, Gustavo B|Aust, Daniela E
PMID: 29308324
Journal: Hum Immunol. 2018 Jun;79(6):446-452.
Title: CD8(+)CXCR5(+) T cells in tumor-draining lymph nodes are highly activated and predict better prognosis in colorectal cancer.
Author: E, Jifu|Yan, Feihu|Kang, Zhengchun|Zhu, Liangliang|Xing, Junjie|Yu, Enda
PMID: 29544815
Journal: Cent Eur J Immunol. 2018;43(1):26-32.
Title: Functional activity of natural killer cells in biological fluids in patients with colorectal and ovarian cancers.
Author: Yunusova, Natalia V|Stakheyeva, Marina N|Molchanov, Sergey V|Afanas'ev, Sergey G|Tsydenova, Anastasia A|Kolomiets, Larisa A|Cherdyntseva, Nadejda V
PMID: 29736145
Journal: Anticancer Res. 2018 Jul;38(7):4159-4167.
Title: The Impact of Immune Interaction on the Metastatic Infiltration of Colorectal Carcinoma to Lymph Nodes.
Author: Vycital, Ondrej|Dubova, Magdalena|Palek, Richard|Hosek, Petr|Branzovsky, Jindrich|Treska, Vladislav|Daum, Ondrej|Liska, Vaclav
PMID: 29970545
Journal: Cancer Immunol Res. 2018 Sep 18. pii: 2326-6066.CIR-17-0443.
Title: Stromal cell PD-L1 inhibits CD8+ T-cell antitumor immune responses and promotes colon cancer.
Author: O'Malley, Grace|Treacy, Oliver|Lynch, Kevin|Naicker, Serika D|Leonard, Niamh A|Lohan, Paul|Dunne, Philip D|Ritter, Thomas|Egan, Laurence John|Ryan, Aideen E
PMID: 30228206