Primary Site >> Pancreatic Cancer

Gene >> GRP

Journal: Endocrinol Jpn. 1990 Dec;37(6):857-65.
Title: Effects of neuromedin B and GRP-10 on gastrin and insulin release from cultured tumor cells of a malignant gastrinoma.
Author: Kawai, K|Mukai, H|Yuzawa, K|Suzuki, S|Kuzuya, N|Fujii, K|Munekata, E|Yamashita, K
PMID: 2101791
Journal: Hum Cell. 1990 Mar;3(1):23-6.
Title: [Gut hormones with activity to modulate cellular growth].
Author: Yamaguchi, K
PMID: 2083220
Journal: Cancer Res. 1992 Jul 1;52(13):3726-32.
Title: Gastrin-releasing peptide: in vivo and in vitro growth effects on an acinar pancreatic carcinoma.
Author: Hajri, A|Balboni, G|Koenig, M|Garaud, J C|Damge, C
PMID: 1319829
Journal: Mol Carcinog. 1993;8(4):214-20.
Title: Effect of gastrin-releasing peptide on the pancreatic tumor cell line (Capan).
Author: Avis, I|Jett, M|Kasprzyk, P G|Cuttitta, F|Treston, A M|Maneckjee, R|Mulshine, J L
PMID: 8280369
Journal: Cancer Res. 1994 Feb 15;54(4):1035-41.
Title: Inhibitory effect of bombesin receptor antagonist RC-3095 on the growth of human pancreatic cancer cells in vivo and in vitro.
Author: Qin, Y|Ertl, T|Cai, R Z|Halmos, G|Schally, A V
PMID: 8313359
Journal: Int J Oncol. 1995 Jun;6(6):1165-72.
Title: New pseudononapeptide bombesin antagonists with C-terminal leu-psi(ch2n)tac-nh2 show high binding-affinity to bombesin/grp receptors on cfpac-1 human pancreatic-cancer cells.
Author: Cai, R|Qin, Y|Ertl, T|Schally, A
PMID: 21556653
Journal: Pancreas. 1996 Jan;12(1):25-35.
Title: Expression and characterization of gastrin-releasing peptide receptor in normal and cancerous pancreas.
Author: Hajri, A|Koenig, M|Balboni, G|Damge, C
PMID: 8927617
Journal: Int J Oncol. 1996 Sep;9(3):397-403.
Title: Effects of new bombesin antagonists given singly or in combination with a somatostatin analog on nitrosamine-induced pancreatic cancers in hamsters.
Author: Szepeshazi, K|Schally, A|Cai, R|Halmos, G|Groot, K
PMID: 21541526
Journal: Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):652-6.
Title: Design, synthesis, and in vitro evaluation of cytotoxic analogs of bombesin-like peptides containing doxorubicin or its intensely potent derivative, 2-pyrrolinodoxorubicin.
Author: Nagy, A|Armatis, P|Cai, R Z|Szepeshazi, K|Halmos, G|Schally, A V
PMID: 9012839
Journal: Eur J Pharmacol. 1998 Apr 17;347(1):77-86.
Title: Effect of the gastrin-releasing peptide antagonist BIM 26226 and lanreotide on an acinar pancreatic carcinoma.
Author: Damge, C|Hajri, A
PMID: 9650851
Journal: J Cancer Res Clin Oncol. 1999 Aug-Sep;125(8-9):444-52.
Title: Growth inhibition of experimental pancreatic cancers and sustained reduction in epidermal growth factor receptors during therapy with hormonal peptide analogs.
Author: Szepeshazi, K|Halmos, G|Schally, A V|Arencibia, J M|Groot, K|Vadillo-Buenfil, M|Rodriguez-Martin, E
PMID: 10480336
Journal: Br J Cancer. 2001 Apr 6;84(7):926-35.
Title: Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions.
Author: Murphy, L O|Cluck, M W|Lovas, S|Otvos, F|Murphy, R F|Schally, A V|Permert, J|Larsson, J|Knezetic, J A|Adrian, T E
PMID: 11286473
Journal: J Nucl Med. 2002 Dec;43(12):1650-6.
Title: Preclinical comparison of (111)In-labeled DTPA- or DOTA-bombesin analogs for receptor-targeted scintigraphy and radionuclide therapy.
Author: Breeman, Wouter A P|de Jong, Marion|Erion, Jack L|Bugaj, Joseph E|Srinivasan, Ananth|Bernard, Bert F|Kwekkeboom, Dik J|Visser, Theo J|Krenning, Eric P
PMID: 12468515
Journal: J Nucl Med. 2003 May;44(5):823-31.
Title: Novel series of 111In-labeled bombesin analogs as potential radiopharmaceuticals for specific targeting of gastrin-releasing peptide receptors expressed on human prostate cancer cells.
Author: Hoffman, Timothy J|Gali, Hariprasad|Smith, C Jeffrey|Sieckman, Gary L|Hayes, Donald L|Owen, Nellie K|Volkert, Wynn A
PMID: 12732685
Journal: Cancer Res. 2003 Jul 15;63(14):4082-8.
Title: Radiochemical investigations of gastrin-releasing peptide receptor-specific [(99m)Tc(X)(CO)3-Dpr-Ser-Ser-Ser-Gln-Trp-Ala-Val-Gly-His-Leu-Met-(NH2)] in PC-3, tumor-bearing, rodent models: syntheses, radiolabeling, and in vitro/in vivo studies where Dpr = 2
Author: Smith, C Jeffrey|Sieckman, Gary L|Owen, Nellie K|Hayes, Donald L|Mazuru, Dana G|Kannan, Raghuraman|Volkert, Wynn A|Hoffman, Timothy J
PMID: 12874010
Journal: Nucl Med Biol. 2003 Feb;30(2):101-9.
Title: Radiochemical investigations of 177Lu-DOTA-8-Aoc-BBN[7-14]NH2: an in vitro/in vivo assessment of the targeting ability of this new radiopharmaceutical for PC-3 human prostate cancer cells.
Author: Smith, C Jeffrey|Gali, Hariprasad|Sieckman, Gary L|Hayes, Donald L|Owen, Nellie K|Mazuru, Dana G|Volkert, Wynn A|Hoffman, Timothy J
PMID: 12623108
Journal: Bioconjug Chem. 2003 Jan-Feb;14(1):93-102.
Title: Radiochemical investigations of (99m)Tc-N(3)S-X-BBN[7-14]NH(2): an in vitro/in vivo structure-activity relationship study where X = 0-, 3-, 5-, 8-, and 11-carbon tethering moieties.
Author: Smith, C Jeffrey|Gali, Hariprasad|Sieckman, Gary L|Higginbotham, Chris|Volkert, Wynn A|Hoffman, Timothy J
PMID: 12526698
Journal: Anticancer Res. 2003 Jan-Feb;23(1A):63-70.
Title: Radiochemical investigations of [188Re(H2O)(CO)3-diaminopropionic acid-SSS-bombesin(7-14)NH2]: syntheses, radiolabeling and in vitro/in vivo GRP receptor targeting studies.
Author: Smith, C Jeffrey|Sieckman, Gary L|Owen, Nellie K|Hayes, Donald L|Mazuru, Dana G|Volkert, Wynn A|Hoffman, Timothy J
PMID: 12680195
Journal:
Title: 3-Cyano-4-[(18)F]fluoro-benzoyl-Ala(SO3H)-Ala(SO3H)-Ava-Gln-Trp-Ala-Val-NMeGly-Hi s-Sta-Leu-NH2
Author: Leung, Kam
PMID: 21882401
Journal:
Title: (64)Cu-1,4,7-Triazacyclononane-1,4-7-triacetic acid-8-aminooctanoic acid-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
Author: Leung, Kam
PMID: 20641895
Journal:
Title: [(18)F]Fluorobenzyl-bombesin[7-14]-c(RGDyK)
Author: Leung, Kam
PMID: 20641919
Journal:
Title: Bombesin peptide conjugated-cross-linked iron oxide-Cy5.5
Author:
PMID: 20641922
Journal:
Title: (99m)Tc identical withNitrido(diphosphine)-Cys-beta-Ala-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
Author: Leung, Kam
PMID: 20641947
Journal:
Title: (111)In-Diethylenetriamine pentaacetic acid-QKYGNQWAVGHLM-NH2
Author: Leung, Kam
PMID: 20642008
Journal:
Title: (68)Ga-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta- Leu-NH2
Author: Leung, Kam
PMID: 21563331
Journal:
Title: (111)In-DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta -Leu-NH2
Author: Leung, Kam
PMID: 21563332
Journal:
Title: (68)Ga-1,4,7-Triazacyclononane-1,4-diacetic acid-8-aminooctanoic acid-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
Author: Leung, Kam
PMID: 23057095
Journal:
Title: (111)In-1,4,7,10-Tetraazacyclododecane-1,4,7,10-triacetic acid-8-aminooctanoic acid-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
Author: Leung, Kam
PMID: 23057096
Journal:
Title: Al(18)F-1,4,7-Triazacyclononane-1,4,7-diacetic acid-8-aminooctanoic acid-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
Author: Leung, Kam
PMID: 23057097
Journal:
Title: (64)Cu-1,4,7-Triazacyclononane-1,4-diacetic acid-c(RGDyK)-Glu-6-aminohexanoic acid-bombesin[7-14]NH2
Author: Leung, Kam
PMID: 23166957
Journal:
Title: (99m)Tc-Hydrazinonicotinyl(tricine)(TPPTS)-Glu-c(RGDyK)-bombesin[7-14]NH2
Author: Leung, Kam
PMID: 23166958
Journal:
Title: (99m)Tc-(Hydrazinonicotinic acid-beta-Ala-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2)(tricine)(TPPTS)
Author: Leung, Kam
PMID: 20641678
Journal:
Title: (86)Y-DOTA-[Pro(1),Tyr(4)]-Bombesin[1-14]
Author: Cheng, Kenneth T.|Lewis, Jason S.|Biddlecombe, Grainne B.
PMID: 20641773
Journal: Cancer Biother Radiopharm. 2004 Apr;19(2):219-29.
Title: Gastrin-releasing peptide (GRP) analogues for cancer imaging.
Author: Varvarigou, Alexandra|Bouziotis, Penelope|Zikos, Christos|Scopinaro, Francesco|De Vincentis, Giuseppe
PMID: 15186603
Journal: J Clin Gastroenterol. 2004 Oct;38(9):834-5.
Title: A small cell carcinoma of the pancreas with a high level of serum ProGRP.
Author: Matsubayashi, Hiroyuki|Fujiwara, Shinichi|Kobayashi, Yuka|Iiri, Takao|Mitra, Anirban|Goggins, Michael|Hruban, Ralph H|Moriyasu, Fuminori
PMID: 15365423
Journal:
Title: Alexa Fluor 680-glycylglycylglycine-bombesin[7-14]NH2 peptide
Author: Cheng, Kenneth T.|Smith, Charles J.|Ma, Lixin|Yu, Ping|Hoffman, Timothy J.
PMID: 20641271
Journal:
Title: (99m)Tc-Ethylenenediamine-N,N'-diacetic acid/hydrazinonicotinamide[Lys(3)]-bombesin
Author: Cheng, Kenneth T.|Ferro-Flores, Guillermina|Arteaga de Murphy, Consuelo
PMID: 20641296
Journal:
Title: [(18)F]Fluorobenzyl-PEG3-Glu-c(RGDyK)-bombesin[7-14]
Author: Leung, Kam
PMID: 20641311
Journal:
Title: [(111)In-Diethylenetriamine pentaacetic acid-ACMpip(5),Tha(6),betaAla(11),Tha(13),NIe(14)]bombesin(5-14)
Author: Cheng, Kenneth T.
PMID: 20641369
Journal:
Title: (111)In-DOTA-Gly-benzoyl-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2
Author: Leung, Kam
PMID: 20641535
Journal:
Title: [(111)In-1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid-Pro(1),Tyr(4)]Bombesin
Author: Cheng, Kenneth T.
PMID: 20641605
Journal:
Title: (64)Cu-1,4,7-Triazacyclononane-1,4-7-triacetic acid-Glu-c(RGDyK)-bombesin[7-14]
Author: Leung, Kam
PMID: 20641630
Journal:
Title: (64)Cu-1,4,7-Triazacyclononane-1,4-diacetate-8-aminooctanoic acid-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
Author: Leung, Kam
PMID: 20641703
Journal:
Title: (68)Ga-1,4,7-Triazacyclononane-1,4-7-triacetic acid-Glu-c(RGDyK)-bombesin[7-14]
Author: Leung, Kam
PMID: 20641746
Journal:
Title: (64)Cu-DOTA-[Pro(1),Tyr(4)]-Bombesin[1-14]
Author: Cheng, Kenneth T.|Lewis, Jason S.|Biddlecombe, Grainne B.
PMID: 20641835
Journal:
Title: [(111)In-Diethylenetriaminepentaacetic acid-Pro(1),Tyr(4)]bombesin
Author: Cheng, Kenneth T.
PMID: 20641503
Journal: Pancreas. 2005 Oct;31(3):275-82.
Title: Inhibition of growth of experimental human and hamster pancreatic cancers in vivo by a targeted cytotoxic bombesin analog.
Author: Szepeshazi, Karoly|Schally, Andrew V|Nagy, Attila|Halmos, Gabor
PMID: 16163060
Journal: J Nucl Med. 2005 Apr;46(4):691-9.
Title: GRP receptor-targeted PET of a rat pancreas carcinoma xenograft in nude mice with a 68Ga-labeled bombesin(6-14) analog.
Author: Schuhmacher, Jochen|Zhang, Hanwen|Doll, Josef|Macke, Helmut R|Matys, Ronald|Hauser, Harald|Henze, Marcus|Haberkorn, Uwe|Eisenhut, Michael
PMID: 15809493
Journal: Mol Imaging. 2007 May-Jun;6(3):171-80.
Title: In vitro and in vivo evaluation of Alexa Fluor 680-bombesin[7-14]NH2 peptide conjugate, a high-affinity fluorescent probe with high selectivity for the gastrin-releasing peptide receptor.
Author: Ma, Lixin|Yu, Ping|Veerendra, Bhadrasetty|Rold, Tammy L|Retzloff, Lauren|Prasanphanich, Adam|Sieckman, Gary|Hoffman, Timothy J|Volkert, Wynn A|Smith, Charles J
PMID: 17532883
Journal: Bioconjug Chem. 2007 Sep-Oct;18(5):1516-20.
Title: Radiolabeling of bombesin-like peptide with 99mTc: 99mTc-litorin and biodistribution in rats.
Author: Durkan, Kubra|Lambrecht, Fatma Yurt|Unak, Perihan
PMID: 17760415
Journal: Nucl Med Commun. 2008 Aug;29(8):741-7.
Title: Targeted imaging of gastrin-releasing peptide receptors with 99mTc-EDDA/HYNIC-[Lys3]-bombesin: biokinetics and dosimetry in women.
Author: Santos-Cuevas, Clara L|Ferro-Flores, Guillermina|Arteaga de Murphy, Consuelo|Pichardo-Romero, Pablo A
PMID: 18753829
Journal: Bioconjug Chem. 2009 Jun;20(6):1171-8.
Title: In vitro and in vivo metabolism of Lu-AMBA, a GRP-receptor binding compound, and the synthesis and characterization of its metabolites.
Author: Linder, Karen E|Metcalfe, Edmund|Arunachalam, Thangavel|Chen, Jianqing|Eaton, Stephen M|Feng, Weiwei|Fan, Hong|Raju, Natarajan|Cagnolini, Aldo|Lantry, Laura E|Nunn, Adrian D|Swenson, Rolf E
PMID: 19480415
Journal: J Med Chem. 2009 Jul 23;52(14):4234-46.
Title: Structural assessment and biological evaluation of two N3S bombesin derivatives.
Author: Gourni, Eleni|Bouziotis, Penelope|Benaki, Dimitra|Loudos, George|Xanthopoulos, Stavros|Paravatou-Petsotas, Maria|Mavri-Vavagianni, Maria|Pelecanou, Maria|Archimandritis, Spyros C|Varvarigou, Alexandra D
PMID: 19522464
Journal: Curr Drug Deliv. 2011 Jan;8(1):11-25.
Title: Use of analogs of peptide hormones conjugated to cytotoxic radicals for chemotherapy targeted to receptors on tumors.
Author: Schally, Andrew V|Engel, Jorg B|Emons, Gunter|Block, Norman L|Pinski, Jacek
PMID: 21034424
Journal: Braz J Med Biol Res. 2015 Oct;48(10):923-8.
Title: Evaluation of (99m)Tc-HYNIC-betaAla-Bombesin(7-14) as an agent for pancreas tumor detection in mice.
Author: Carlesso, F N|Fuscaldi, L L|Araujo, R S|Teixeira, C S|Oliveira, M C|Fernandes, S O A|Cassali, G D|Reis, D C|Barros, A L B|Cardoso, V N
PMID: 26445336
Journal: Nat Commun. 2018 Feb 8;9(1):556.
Title: Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
Author: Klein, Alison P|Wolpin, Brian M|Risch, Harvey A|Stolzenberg-Solomon, Rachael Z|Mocci, Evelina|Zhang, Mingfeng|Canzian, Federico|Childs, Erica J|Hoskins, Jason W|Jermusyk, Ashley|Zhong, Jun|Chen, Fei|Albanes, Demetrius|Andreotti, Gabriella|Arslan, Alan A|B
PMID: 29422604