Primary Site >> Liver Cancer
Gene >> GNMT
| 1. | |||||||||||
| Journal: | J Nutr. 1989 Apr;119(4):612-7. | ||||||||||
| Title: | Effect of dietary methyl group deficiency on one-carbon metabolism in rats. | ||||||||||
| Author: | Cook, R J|Horne, D W|Wagner, C | ||||||||||
| PMID: | 2703919 | ||||||||||
| 2. | |||||||||||
| Journal: | Int J Cancer. 1998 Mar 2;75(5):787-93. | ||||||||||
| Title: | Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma. | ||||||||||
| Author: | Chen, Y M|Shiu, J Y|Tzeng, S J|Shih, L S|Chen, Y J|Lui, W Y|Chen, P H | ||||||||||
| PMID: | 9495250 | ||||||||||
| 3. | |||||||||||
| Journal: | Genomics. 2000 May 15;66(1):43-7. | ||||||||||
| Title: | Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene. | ||||||||||
| Author: | Chen, Y M|Chen, L Y|Wong, F H|Lee, C M|Chang, T J|Yang-Feng, T L | ||||||||||
| PMID: | 10843803 | ||||||||||
| 4. | |||||||||||
| Journal: | Cancer Res. 2003 Feb 1;63(3):647-54. | ||||||||||
| Title: | Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer. | ||||||||||
| Author: | Tseng, Tzu-Ling|Shih, Yi-Ping|Huang, Yu-Chuen|Wang, Chung-Kwe|Chen, Pao-Huei|Chang, Jan-Gowth|Yeh, Kun-Tu|Chen, Yi-Ming Arthur|Buetow, Kenneth H | ||||||||||
| PMID: | 12566309 | ||||||||||
| 5. | |||||||||||
| Journal: | J Biomed Sci. 2003 Jan-Feb;10(1):87-97. | ||||||||||
| Title: | Characterization of reduced expression of glycine N-methyltransferase in cancerous hepatic tissues using two newly developed monoclonal antibodies. | ||||||||||
| Author: | Liu, Hsiao-Han|Chen, Kuan-Hsuan|Shih, Yi-Ping|Lui, Wing-Yiu|Wong, Fen-Hwa|Chen, Yi-Ming A | ||||||||||
| PMID: | 12566990 | ||||||||||
| 6. | |||||||||||
| Journal: | Cancer Res. 2004 May 15;64(10):3617-23. | ||||||||||
| Title: | Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway. | ||||||||||
| Author: | Chen, Shih-Yin|Lin, Jane-Ru Vivan|Darbha, Ramalakshmi|Lin, Pinpin|Liu, Tsung-Yun|Chen, Yi-Ming Arthur | ||||||||||
| PMID: | 15150120 | ||||||||||
| 7. | |||||||||||
| Journal: | Toxicol Appl Pharmacol. 2006 Jul 15;214(2):126-35. | ||||||||||
| Title: | Benzo[a]pyrene and glycine N-methyltransferse interactions: gene expression profiles of the liver detoxification pathway. | ||||||||||
| Author: | Lee, Cheng-Ming|Chen, Shih-Yin|Lee, Yuan-Chii G|Huang, Chi-Ying F|Chen, Yi-Ming Arthur | ||||||||||
| PMID: | 16545412 | ||||||||||
| 8. | |||||||||||
| Journal: | Clin Cancer Res. 2007 Mar 1;13(5):1412-20. | ||||||||||
| Title: | Haplotypes, loss of heterozygosity, and expression levels of glycine N-methyltransferase in prostate cancer. | ||||||||||
| Author: | Huang, Yu-Chuen|Lee, Cheng-Ming|Chen, Marcelo|Chung, Ming-Yi|Chang, Yen-Hwa|Huang, William Ji-Shian|Ho, Donald Ming-Tak|Pan, Chin-Chen|Wu, Tony T|Yang, Stone|Lin, Ming-Wei|Hsieh, Jer-Tsong|Chen, Yi-Ming Arthur | ||||||||||
| PMID: | 17332283 | ||||||||||
| 9. | |||||||||||
| Journal: | Hepatology. 2008 Apr;47(4):1191-9. | ||||||||||
| Title: | Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. | ||||||||||
| Author: | Martinez-Chantar, M Luz|Vazquez-Chantada, Mercedes|Ariz, Usue|Martinez, Nuria|Varela, Marta|Luka, Zigmund|Capdevila, Antonieta|Rodriguez, Juan|Aransay, Ana M|Matthiesen, Rune|Yang, Heping|Calvisi, Diego F|Esteller, Manel|Fraga, Mario|Lu, Shelly C|Wagner, | ||||||||||
| PMID: | 18318442 | ||||||||||
| 10. | |||||||||||
| Journal: | J Gastroenterol Hepatol. 2008 Sep;23(9):1384-9. | ||||||||||
| Title: | Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma. | ||||||||||
| Author: | Huang, Yu-Chuen|Chen, Marcelo|Shyr, Yi-Ming|Su, Cheng-Hsi|Chen, Chi-Kuan|Li, Anna Fen-Yau|Ho, Donald Ming-Tak|Chen, Yi-Ming Arthur | ||||||||||
| PMID: | 18624901 | ||||||||||
| 11. | |||||||||||
| Journal: | Biochem Soc Trans. 2008 Oct;36(Pt 5):848-52. | ||||||||||
| Title: | S-adenosylmethionine and proliferation: new pathways, new targets. | ||||||||||
| Author: | Martinez-Lopez, Nuria|Varela-Rey, Marta|Ariz, Usue|Embade, Nieves|Vazquez-Chantada, Mercedes|Fernandez-Ramos, David|Gomez-Santos, Laura|Lu, Shelly C|Mato, Jose M|Martinez-Chantar, Maria L | ||||||||||
| PMID: | 18793149 | ||||||||||
| 12. | |||||||||||
| Journal: | Int J Cancer. 2009 Feb 15;124(4):816-26. | ||||||||||
| Title: | Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility. | ||||||||||
| Author: | Liao, Yi-Jen|Liu, Shih-Ping|Lee, Cheng-Ming|Yen, Chia-Hung|Chuang, Pei-Chun|Chen, Chia-Yen|Tsai, Ting-Fen|Huang, Shiu-Feng|Lee, Yan-Hwa Wu|Chen, Yi-Ming Arthur | ||||||||||
| PMID: | 19035462 | ||||||||||
| 13. | |||||||||||
| Journal: | Gene. 2009 Aug 15;443(1-2):151-7. | ||||||||||
| Title: | Characterization of the 5' regulatory region of the human Glycine N-methyltransferase gene. | ||||||||||
| Author: | Lee, Cheng-Ming|Shih, Yi-Ping|Wu, Cho-Han|Chen, Yi-Ming Arthur | ||||||||||
| PMID: | 19439180 | ||||||||||
| 14. | |||||||||||
| Journal: | Toxicol Appl Pharmacol. 2009 Jun 1;237(2):246; author reply 247. | ||||||||||
| Title: | Hepatocellular carcinoma in GNMT-/- mice. | ||||||||||
| Author: | Wagner, Conrad|Luka, Zigmund|Mato, Jose M | ||||||||||
| PMID: | 19345238 | ||||||||||
| 15. | |||||||||||
| Journal: | Mar Environ Res. 2010;69 Suppl:S74-6. | ||||||||||
| Title: | Benzo(a)pyrene induced glycine N-methyltransferase messenger RNA expression in Fundulus heteroclitus embryos. | ||||||||||
| Author: | Fang, Xiefan|Dong, Wu|Thornton, Cammi|Scheffler, Brian|Willett, Kristine L | ||||||||||
| PMID: | 19892394 | ||||||||||
| 16. | |||||||||||
| Journal: | Proteomics Clin Appl. 2010 Apr;4(4):394-406. | ||||||||||
| Title: | Deficiency of glycine N-methyltransferase results in deterioration of cellular defense to stress in mouse liver. | ||||||||||
| Author: | Liao, Yi-Jen|Chen, Kuan-Hsuan|Huang, Shiu-Feng|Chen, Tzu-Lang|Wang, Chung-Kwe|Chien, Chau-Heng|Tsai, Ting-Fen|Liu, Shih-Ping|Chen, Yi-Ming Arthur | ||||||||||
| PMID: | 21137059 | ||||||||||
| 17. | |||||||||||
| Journal: | Int J Cancer. 2011 Feb 1;128(3):511-23. | ||||||||||
| Title: | Higher susceptibility to aflatoxin B(1)-related hepatocellular carcinoma in glycine N-methyltransferase knockout mice. | ||||||||||
| Author: | Liu, Shih-Ping|Li, Ying-Shiuan|Lee, Cheng-Ming|Yen, Chia-Hung|Liao, Yi-Jen|Huang, Shiu-Feng|Chien, Chau-Heng|Chen, Yi-Ming Arthur | ||||||||||
| PMID: | 20473876 | ||||||||||
| 18. | |||||||||||
| Journal: | J Hepatol. 2011 May;54(5):939-47. | ||||||||||
| Title: | Aberrant CpG island hypermethylation in dysplastic nodules and early HCC of hepatitis B virus-related human multistep hepatocarcinogenesis. | ||||||||||
| Author: | Um, Tae-Hee|Kim, Haeryoung|Oh, Bong-Kyeong|Kim, Myoung Soo|Kim, Kyung Sik|Jung, Guhung|Park, Young Nyun | ||||||||||
| PMID: | 21145824 | ||||||||||
| 19. | |||||||||||
| Journal: | J Nutr. 2011 May;141(5):777-82. | ||||||||||
| Title: | Glycine-N methyltransferase expression in HepG2 cells is involved in methyl group homeostasis by regulating transmethylation kinetics and DNA methylation. | ||||||||||
| Author: | Wang, Yi-Cheng|Tang, Feng-Yao|Chen, Shih-Yin|Chen, Yi-Ming|Chiang, En-Pei Isabel | ||||||||||
| PMID: | 21411609 | ||||||||||
| 20. | |||||||||||
| Journal: | Mol Med. 2012 Mar 30;18:286-96. | ||||||||||
| Title: | Functional characterization of glycine N-methyltransferase and its interactive protein DEPDC6/DEPTOR in hepatocellular carcinoma. | ||||||||||
| Author: | Yen, Chia-Hung|Lu, Yao-Cheng|Li, Chung-Hsien|Lee, Cheng-Ming|Chen, Chia-Yen|Cheng, Ming-Yuan|Huang, Shiu-Feng|Chen, Kuen-Feng|Cheng, Ann-Lii|Liao, Li-Ying|Lee, Yan-Hwa Wu|Chen, Yi-Ming Arthur | ||||||||||
| PMID: | 22160218 | ||||||||||
| 21. | |||||||||||
| Journal: | Physiol Rev. 2012 Oct;92(4):1515-42. | ||||||||||
| Title: | S-adenosylmethionine in liver health, injury, and cancer. | ||||||||||
| Author: | Lu, Shelly C|Mato, Jose M | ||||||||||
| PMID: | 23073625 | ||||||||||
| 22. | |||||||||||
| Journal: | Gastroenterology. 2012 Sep;143(3):787-798.e13. | ||||||||||
| Title: | Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1. | ||||||||||
| Author: | Martinez-Lopez, Nuria|Garcia-Rodriguez, Juan L|Varela-Rey, Marta|Gutierrez, Virginia|Fernandez-Ramos, David|Beraza, Naiara|Aransay, Ana M|Schlangen, Karin|Lozano, Juan Jose|Aspichueta, Patricia|Luka, Zigmund|Wagner, Conrad|Evert, Matthias|Calvisi, Diego F | ||||||||||
| PMID: | 22687285 | ||||||||||
| 23. | |||||||||||
| Journal: | Hepatology. 2012 Aug;56(2):747-59. | ||||||||||
| Title: | Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase. | ||||||||||
| Author: | Gomez-Santos, Laura|Luka, Zigmund|Wagner, Conrad|Fernandez-Alvarez, Sara|Lu, Shelly C|Mato, Jose M|Martinez-Chantar, Maria L|Beraza, Naiara | ||||||||||
| PMID: | 22392635 | ||||||||||
| 24. | |||||||||||
| Journal: | Mol Med. 2012 May 9;18:412-22. | ||||||||||
| Title: | Glycine N-methyltransferase deficiency affects Niemann-Pick type C2 protein stability and regulates hepatic cholesterol homeostasis. | ||||||||||
| Author: | Liao, Yi-Jen|Chen, Tzu-Lang|Lee, Tzong-Shyuan|Wang, Hsiang-An|Wang, Chung-Kwe|Liao, Li-Ying|Liu, Ren-Shyan|Huang, Shiu-Feng|Chen, Yi-Ming Arthur | ||||||||||
| PMID: | 22183894 | ||||||||||
| 25. | |||||||||||
| Journal: | Cell Oncol (Dordr). 2012 Jun;35(3):163-73. | ||||||||||
| Title: | An expression signature of phenotypic resistance to hepatocellular carcinoma identified by cross-species gene expression analysis. | ||||||||||
| Author: | Frau, Maddalena|Simile, Maria M|Tomasi, Maria L|Demartis, Maria I|Daino, Lucia|Seddaiu, Maria A|Brozzetti, Stefania|Feo, Claudio F|Massarelli, Giovanni|Solinas, Giuliana|Feo, Francesco|Lee, Ju-Seog|Pascale, Rosa M | ||||||||||
| PMID: | 22434528 | ||||||||||
| 26. | |||||||||||
| Journal: | Toxicol Appl Pharmacol. 2013 Jan 1;266(1):67-75. | ||||||||||
| Title: | The multi-functional roles of GNMT in toxicology and cancer. | ||||||||||
| Author: | Yen, Chia-Hung|Lin, Yu-Ting|Chen, Heng-Li|Chen, Shih-Yin|Chen, Yi-Ming Arthur | ||||||||||
| PMID: | 23147572 | ||||||||||
| 27. | |||||||||||
| Journal: | J Mol Med (Berl). 2013 Aug;91(8):939-50. | ||||||||||
| Title: | A DNA methylation signature associated with the epigenetic repression of glycine N-methyltransferase in human hepatocellular carcinoma. | ||||||||||
| Author: | Huidobro, Covadonga|Torano, Estela G|Fernandez, Agustin F|Urdinguio, Rocio G|Rodriguez, Ramon M|Ferrero, Cecilia|Martinez-Camblor, Pablo|Boix, Loreto|Bruix, Jordi|Garcia-Rodriguez, Juan Luis|Varela-Rey, Marta|Mato, Jose Maria|Martinez-Chantar, Maria Luz|F | ||||||||||
| PMID: | 23475283 | ||||||||||
| 28. | |||||||||||
| Journal: | Anticancer Res. 2013 Jun;33(6):2763-9. | ||||||||||
| Title: | Identification of FKBP11 as a biomarker for hepatocellular carcinoma. | ||||||||||
| Author: | Lin, I-Yin|Yen, Chia-Hung|Liao, Yi-Jen|Lin, Sey-En|Ma, Hon-Ping|Chan, Yu-Jiun|Chen, Yi-Ming A | ||||||||||
| PMID: | 23749938 | ||||||||||
| 29. | |||||||||||
| Journal: | Int J Cancer. 2014 Feb 15;134(4):799-810. | ||||||||||
| Title: | A novel role of the tumor suppressor GNMT in cellular defense against DNA damage. | ||||||||||
| Author: | Wang, Yi-Cheng|Lin, Wei-Li|Lin, Yan-Jun|Tang, Feng-Yao|Chen, Yi-Ming|Chiang, En-Pei Isabel | ||||||||||
| PMID: | 23922098 | ||||||||||
| 30. | |||||||||||
| Journal: | Mol Med. 2015 Mar 24;20:684-96. | ||||||||||
| Title: | Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis. | ||||||||||
| Author: | Li, Chung-Hsien|Lin, Ming-Hong|Chu, Shih-Han|Tu, Pang-Hsien|Fang, Cheng-Chieh|Yen, Chia-Hung|Liang, Peir-In|Huang, Jason C|Su, Yu-Chia|Sytwu, Huey-Kang|Chen, Yi-Ming Arthur | ||||||||||
| PMID: | 25535034 | ||||||||||
| 31. | |||||||||||
| Journal: | Lab Invest. 2015 Feb;95(2):223-36. | ||||||||||
| Title: | TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency. | ||||||||||
| Author: | Fernandez-Alvarez, Sara|Gutierrez-de Juan, Virginia|Zubiete-Franco, Imanol|Barbier-Torres, Lucia|Lahoz, Agustin|Pares, Albert|Luka, Zigmund|Wagner, Conrad|Lu, Shelly C|Mato, Jose M|Martinez-Chantar, Maria L|Beraza, Naiara | ||||||||||
| PMID: | 25531568 | ||||||||||
| 32. | |||||||||||
| Journal: | Int J Mol Sci. 2016 May 4;17(5). pii: ijms17050669. | ||||||||||
| Title: | Identification of 1,2,3,4,6-Penta-O-galloyl-beta-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma. | ||||||||||
| Author: | Kant, Rajni|Yen, Chia-Hung|Lu, Chung-Kuang|Lin, Ying-Chi|Li, Jih-Heng|Chen, Yi-Ming Arthur | ||||||||||
| PMID: | 27153064 | ||||||||||
| 33. | |||||||||||
| Journal: | J Biomed Sci. 2016 Oct 4;23(1):69. | ||||||||||
| Title: | Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver. | ||||||||||
| Author: | Liao, Yi-Jen|Lee, Tzong-Shyuan|Twu, Yuh-Ching|Hsu, Shih-Ming|Yang, Ching-Ping|Wang, Chung-Kwe|Liang, Yu-Chih|Chen, Yi-Ming Arthur | ||||||||||
| PMID: | 27716281 | ||||||||||
| 34. | |||||||||||
| Journal: | Int J Cancer. 2017 May 15;140(10):2284-2297. | ||||||||||
| Title: | Characterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma. | ||||||||||
| Author: | Li, Chung-Hsien|Yen, Chia-Hung|Chen, Yen-Fu|Lee, Kuo-Jui|Fang, Cheng-Chieh|Zhang, Xian|Lai, Chih-Chung|Huang, Shiu-Feng|Lin, Hui-Kuan|Arthur Chen, Yi-Ming | ||||||||||
| PMID: | 28205209 | ||||||||||
| 35. | |||||||||||
| Journal: | J Biol Chem. 2018 Jul 27;293(30):11944-11954. | ||||||||||
| Title: | Glycine N-methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates. | ||||||||||
| Author: | Hughey, Curtis C|Trefts, Elijah|Bracy, Deanna P|James, Freyja D|Donahue, E Patrick|Wasserman, David H | ||||||||||
| PMID: | 29891549 | ||||||||||
| 36. | |||||||||||
| Journal: | Sci Rep. 2018 Aug 16;8(1):12284. | ||||||||||
| Title: | MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma. | ||||||||||
| Author: | Hung, Jung-Hsien|Li, Chung-Hsien|Yeh, Ching-Hua|Huang, Pin-Cheng|Fang, Cheng-Chieh|Chen, Yen-Fu|Lee, Kuo-Jui|Chou, Chih-Hung|Cheng, Hsin-Yun|Huang, Hsien-Da|Chen, Marcelo|Tsai, Ting-Fen|Lin, Anya Maan-Yuh|Yen, Chia-Hung|Tsou, Ann-Ping|Tyan, Yu-Chang|Chen, | ||||||||||
| PMID: | 30115977 | ||||||||||
| 37. | |||||||||||
| Journal: | PLoS One. 2018 Aug 23;13(8):e0202524. | ||||||||||
| Title: | Signature molecules expressed differentially in a liver disease stage-specific manner by HIV-1 and HCV co-infection. | ||||||||||
| Author: | Whitmill, Amanda|Kim, Seongcheol|Rojas, Vivian|Gulraiz, Fahad|Afreen, Kazi|Jain, Mamta|Singh, Meharvan|Park, In-Woo | ||||||||||
| PMID: | 30138348 | ||||||||||
| 38. | |||||||||||
| Journal: | Sci Rep. 2018 Sep 14;8(1):13802. | ||||||||||
| Title: | AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage. | ||||||||||
| Author: | Fang, Cheng-Chieh|Wu, Ching-Fen|Liao, Yi-Jen|Huang, Shiu-Feng|Chen, Marcelo|Chen, Yi-Ming Arthur | ||||||||||
| PMID: | 30217986 | ||||||||||
| 39. | |||||||||||
| Journal: | Cell Death Dis. 2018 Sep 20;9(10):958. | ||||||||||
| Title: | MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis. | ||||||||||
| Author: | Fernandez-Ramos, David|Fernandez-Tussy, Pablo|Lopitz-Otsoa, Fernando|Gutierrez-de-Juan, Virginia|Navasa, Nicolas|Barbier-Torres, Lucia|Zubiete-Franco, Imanol|Simon, Jorge|Fernandez, Agustin F|Arbelaiz, Ander|Aransay, Ana M|Lavin, Jose Luis|Beraza, Naiara| | ||||||||||
| PMID: | 30237481 | ||||||||||