Primary Site >> Pancreatic Cancer

Gene >> GNAS

Journal: Endocrinol Jpn. 1992 Jun;39(3):319-24.
Title: A pituitary specific point mutation of codon 201 of the Gs alpha gene in a pituitary adenoma of a patient with multiple endocrine neoplasia (MEN) type 1.
Author: Hosoi, E|Yokogoshi, Y|Hosoi, E|Yokoi, K|Sano, T|Saito, S
PMID: 1358601
Journal: Am J Surg Pathol. 2004 Oct;28(10):1371-8.
Title: Neuroendocrine secretory protein-55 (NESP-55) expression discriminates pancreatic endocrine tumors and pheochromocytomas from gastrointestinal and pulmonary carcinoids.
Author: Srivastava, Amitabh|Padilla, Osvaldo|Fischer-Colbrie, Reiner|Tischler, Arthur S|Dayal, Yogeshwar
PMID: 15371954
Journal: Gut. 2013 Jul;62(7):1024-33.
Title: Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts.
Author: Kanda, Mitsuro|Knight, Spencer|Topazian, Mark|Syngal, Sapna|Farrell, James|Lee, Jeffrey|Kamel, Ihab|Lennon, Anne Marie|Borges, Michael|Young, Angela|Fujiwara, Sho|Seike, Junro|Eshleman, James|Hruban, Ralph H|Canto, Marcia Irene|Goggins, Michael
PMID: 22859495
Journal: Br J Cancer. 2013 Mar 5;108(4):951-8.
Title: Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms.
Author: Nishikawa, G|Sekine, S|Ogawa, R|Matsubara, A|Mori, T|Taniguchi, H|Kushima, R|Hiraoka, N|Tsuta, K|Tsuda, H|Kanai, Y
PMID: 23403822
Journal: Pathology. 2013 Apr;45(3):286-304.
Title: Classification, morphology and molecular pathology of premalignant lesions of the pancreas.
Author: Cooper, Caroline L|O'Toole, Sandra A|Kench, James G
PMID: 23442735
Journal: Pathol Int. 2013 Mar;63(3):176-82.
Title: BCL10 as a useful marker for pancreatic acinar cell carcinoma, especially using endoscopic ultrasound cytology specimens.
Author: Hosoda, Waki|Sasaki, Eiichi|Murakami, Yoshiko|Yamao, Kenji|Shimizu, Yasuhiro|Yatabe, Yasushi
PMID: 23530562
Journal: Ann Surg. 2013 Jul;258(1):141-51.
Title: Intraductal papillary mucinous neoplasms of the pancreas with distinct pancreatic ductal adenocarcinomas are frequently of gastric subtype.
Author: Ideno, Noboru|Ohtsuka, Takao|Kono, Hiroshi|Fujiwara, Kenji|Oda, Yasunori|Aishima, Shinichi|Ito, Tetsuhide|Ishigami, Kousei|Tokunaga, Shoji|Ohuchida, Kenoki|Takahata, Shunichi|Nakamura, Masafumi|Mizumoto, Kazuhiro|Tanaka, Masao
PMID: 23532108
Journal: Ann Surg Oncol. 2013 Nov;20(12):3802-8.
Title: Clinicopathological correlates of activating GNAS mutations in intraductal papillary mucinous neoplasm (IPMN) of the pancreas.
Author: Molin, Marco Dal|Matthaei, Hanno|Wu, Jian|Blackford, Amanda|Debeljak, Marija|Rezaee, Neda|Wolfgang, Christopher L|Butturini, Giovanni|Salvia, Roberto|Bassi, Claudio|Goggins, Michael G|Kinzler, Kenneth W|Vogelstein, Bert|Eshleman, James R|Hruban, Ralph H|M
PMID: 23846778
Journal: Pathologe. 2013 Nov;34 Suppl 2:214-20.
Title: [Will molecular diagnostics become established in pancreatic pathology?].
Author: Sipos, B|Sperveslage, J
PMID: 24196616
Journal: J Pathol. 2014 Mar;232(4):428-35.
Title: Whole-exome sequencing of pancreatic neoplasms with acinar differentiation.
Author: Jiao, Yuchen|Yonescu, Raluca|Offerhaus, G Johan A|Klimstra, David S|Maitra, Anirban|Eshleman, James R|Herman, James G|Poh, Weijie|Pelosof, Lorraine|Wolfgang, Christopher L|Vogelstein, Bert|Kinzler, Kenneth W|Hruban, Ralph H|Papadopoulos, Nickolas|Wood, La
PMID: 24293293
Journal: JOP. 2014 Nov 28;15(6):581-6.
Title: Differential expression of GNAS and KRAS mutations in pancreatic cysts.
Author: Lee, Linda S|Doyle, Leona A|Houghton, Jeffrey|Sah, Sachin|Bellizzi, Andrew M|Szafranska-Schwarzbach, Anna E|Conner, James R|Kadiyala, Vivek|Suleiman, Shadeah L|Banks, Peter A|Andruss, Bernard F|Conwell, Darwin L
PMID: 25435574
Journal: Clin Transl Gastroenterol. 2014 Nov 13;5:e62.
Title: Mutant KRAS and GNAS DNA Concentrations in Secretin-Stimulated Pancreatic Fluid Collected from the Pancreatic Duct and the Duodenal Lumen.
Author: Sadakari, Yoshihiko|Kanda, Mitsuro|Maitani, Kosuke|Borges, Michael|Canto, Marcia I|Goggins, Michael
PMID: 25393586
Journal: Semin Diagn Pathol. 2014 Nov;31(6):452-66.
Title: Intraductal neoplasms of the pancreas.
Author: Kloppel, Gunter|Basturk, Olca|Schlitter, Anna Melissa|Konukiewitz, Bjorn|Esposito, Irene
PMID: 25282472
Journal: J Pathol. 2014 Jul;233(3):217-27.
Title: Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas.
Author: Amato, Eliana|Molin, Marco Dal|Mafficini, Andrea|Yu, Jun|Malleo, Giuseppe|Rusev, Borislav|Fassan, Matteo|Antonello, Davide|Sadakari, Yoshihiko|Castelli, Paola|Zamboni, Giuseppe|Maitra, Anirban|Salvia, Roberto|Hruban, Ralph H|Bassi, Claudio|Capelli, Paola|
PMID: 24604757
Journal: Diagn Pathol. 2014 Jan 20;9:11.
Title: Case report: Intraductal tubulopapillary neoplasm of the pancreas with unique clear cell phenotype.
Author: Ahls, Maria Gabriele|Niedergethmann, Marco|Dinter, Dietmar|Sauer, Christian|Luttges, Jutta|Post, Stefan|Marx, Alexander|Gaiser, Timo
PMID: 24443801
Journal: Am J Clin Pathol. 2014 Feb;141(2):168-80.
Title: Molecular genetics of pancreatic neoplasms and their morphologic correlates: an update on recent advances and potential diagnostic applications.
Author: Reid, Michelle D|Saka, Burcu|Balci, Serdar|Goldblum, Andrew S|Adsay, N Volkan
PMID: 24436263
Journal: Cancer Epidemiol Biomarkers Prev. 2014 Jan;23(1):98-106.
Title: Genes-environment interactions in obesity- and diabetes-associated pancreatic cancer: a GWAS data analysis.
Author: Tang, Hongwei|Wei, Peng|Duell, Eric J|Risch, Harvey A|Olson, Sara H|Bueno-de-Mesquita, H Bas|Gallinger, Steven|Holly, Elizabeth A|Petersen, Gloria M|Bracci, Paige M|McWilliams, Robert R|Jenab, Mazda|Riboli, Elio|Tjonneland, Anne|Boutron-Ruault, Marie Chri
PMID: 24136929
Journal: Expert Rev Mol Diagn. 2015 Mar;15(3):325-8.
Title: Activating mutations of GNAS and KRAS in cystic fluid can help detect intraductal papillary mucinous neoplasms of the pancreas.
Author: Frampton, Adam E|Stebbing, Justin|Gall, Tamara M H|Silver, Benjamin|Jiao, Long R|Krell, Jonathan
PMID: 25656048
Journal: Pathol Res Pract. 2015 Dec;211(12):1034-9.
Title: A case of MUC5AC-positive intraductal neoplasm of the pancreas classified as an intraductal tubulopapillary neoplasm?
Author: Muraki, Takashi|Uehara, Takeshi|Sano, Kenji|Oota, Hiroyoshi|Yoshizawa, Akihiko|Asaka, Shiho|Tateishi, Ayako|Otsuki, Toshiaki|Shingu, Kunihiko|Matoba, Hisanori|Kobayashi, Shota|Ichimata, Shojiro|Watanabe, Takayuki|Itou, Tetsuya|Tanaka, Eiji
PMID: 26586167
Journal: Am J Surg Pathol. 2015 Dec;39(12):1730-41.
Title: A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Author: Basturk, Olca|Hong, Seung-Mo|Wood, Laura D|Adsay, N Volkan|Albores-Saavedra, Jorge|Biankin, Andrew V|Brosens, Lodewijk A A|Fukushima, Noriyoshi|Goggins, Michael|Hruban, Ralph H|Kato, Yo|Klimstra, David S|Kloppel, Gunter|Krasinskas, Alyssa|Longnecker, Dani
PMID: 26559377
Journal: Gastroenterology. 2015 Nov;149(6):1501-10.
Title: A combination of molecular markers and clinical features improve the classification of pancreatic cysts.
Author: Springer, Simeon|Wang, Yuxuan|Dal Molin, Marco|Masica, David L|Jiao, Yuchen|Kinde, Isaac|Blackford, Amanda|Raman, Siva P|Wolfgang, Christopher L|Tomita, Tyler|Niknafs, Noushin|Douville, Christopher|Ptak, Janine|Dobbyn, Lisa|Allen, Peter J|Klimstra, David
PMID: 26253305
Journal: Cancer Genet. 2015 Jul-Aug;208(7-8):374-81.
Title: Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines.
Author: Boora, Ganesh K|Kanwar, Rahul|Kulkarni, Amit A|Pleticha, Josef|Ames, Matthew|Schroth, Gary|Beutler, Andreas S|Banck, Michaela S
PMID: 26087898
Journal: Virchows Arch. 2015 Jun;466(6):665-74.
Title: GNAS mutation is a frequent event in pancreatic intraductal papillary mucinous neoplasms and associated adenocarcinomas.
Author: Hosoda, Waki|Sasaki, Eiichi|Murakami, Yoshiko|Yamao, Kenji|Shimizu, Yasuhiro|Yatabe, Yasushi
PMID: 25796395
Journal: Mod Pathol. 2015 Feb;28(2):261-7.
Title: Clinicopathological significance of somatic RNF43 mutation and aberrant expression of ring finger protein 43 in intraductal papillary mucinous neoplasms of the pancreas.
Author: Sakamoto, Hitomi|Kuboki, Yuko|Hatori, Takashi|Yamamoto, Masakazu|Sugiyama, Masanori|Shibata, Noriyuki|Shimizu, Kyoko|Shiratori, Keiko|Furukawa, Toru
PMID: 25081753
Journal: Hepatol Res. 2016 Jun;46(7):713-8.
Title: Intraductal tubulopapillary neoplasm of the bile duct: A case report and review of the published work.
Author: Nakagawa, Takashi|Arisaka, Yoshifumi|Ajiki, Tetsuo|Fujikura, Kohei|Masuda, Atsuhiro|Takenaka, Mamoru|Shiomi, Hideyuki|Okabe, Yoshihiro|Fukumoto, Takumi|Ku, Yonson|Azuma, Takeshi|Zen, Yoh
PMID: 26459784
Journal: Hum Pathol. 2016 Feb;48:117-21.
Title: Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia.
Author: Ma, Changqing|Gocke, Christopher D|Hruban, Ralph H|Belchis, Deborah A
PMID: 26626780
Journal: Pancreas. 2016 Jul;45(6):915-8.
Title: Tracking the Clonal Evolution of Adenosquamous Carcinoma, a Rare Variant of Intraductal Papillary Mucinous Neoplasm of the Pancreas.
Author: Matsuzaka, Suguru|Karasaki, Hidenori|Ono, Yusuke|Ogata, Munehiko|Oikawa, Kensuke|Tamakawa, Susumu|Chiba, Shin-Ichi|Muraki, Miho|Yokochi, Tomoki|Funakoshi, Hiroshi|Kono, Toru|Nagashima, Kazuo|Mizukami, Yusuke
PMID: 27295533
Journal: Gastroenterology. 2016 Aug;151(2):267-70.
Title: Detection of Hot-Spot Mutations in Circulating Cell-Free DNA From Patients With Intraductal Papillary Mucinous Neoplasms of the Pancreas.
Author: Berger, Andreas W|Schwerdel, Daniel|Costa, Ivan G|Hackert, Thilo|Strobel, Oliver|Lam, Sandra|Barth, Thomas F|Schroppel, Bernd|Meining, Alexander|Buchler, Markus W|Zenke, Martin|Hermann, Patrick C|Seufferlein, Thomas|Kleger, Alexander
PMID: 27343369
Journal: Asian Pac J Trop Med. 2016 Dec;9(12):1218-1221.
Title: EUS for pancreatic cystic neoplasms: The roadmap to the future is much more than just a few shades of gray.
Author: Kirtane, Tejas|Bhutani, Manoop S
PMID: 27955751
Journal: Gastrointest Endosc. 2017 Dec;86(6):1152-1156.e2.
Title: Using an endoscopic distal cap to collect pancreatic fluid from the ampulla (with video).
Author: Suenaga, Masaya|Sadakari, Yoshihiko|Almario, Jose Alejandro|Borges, Michael|Lennon, Anne-Marie|Shin, Eun-Ji|Canto, Marcia Irene|Goggins, Michael
PMID: 28259593
Journal: J Gastrointest Oncol. 2017 Feb;8(1):164-172.
Title: Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis.
Author: Borazanci, Erkut|Millis, Sherri Z|Kimbrough, Jeffery|Doll, Nancy|Von Hoff, Daniel|Ramanathan, Ramesh K
PMID: 28280620
Journal: Gene. 2017 Aug 20;625:72-77.
Title: Integrated clinicopathological features and gene microarray analysis of pancreatic neuroendocrine tumors.
Author: Zhou, Huaqiang|Chen, Qinchang|Tan, Wulin|Qiu, Zeting|Li, Si|Song, Yiyan|Gao, Shaowei
PMID: 28479381
Journal: Pituitary. 2017 Oct;20(5):509-514.
Title: Cross-sectional prevalence of pancreatic cystic lesions in patients with acromegaly, a single-center experience.
Author: Odake, Yukiko|Fukuoka, Hidenori|Yamamoto, Masaaki|Arisaka, Yoshifumi|Konishi, Junya|Yoshida, Kenichi|Matsumoto, Ryusaku|Bando, Hironori|Suda, Kentaro|Nishizawa, Hitoshi|Iguchi, Genzo|Yamada, Shozo|Ogawa, Wataru|Takahashi, Yutaka
PMID: 28540626
Journal: Chirurg. 2017 Nov;88(11):913-917.
Title: [Resection of main duct and mixed type IPMN >/=5 mm].
Author: Ceyhan, G O|Scheufele, F|Friess, H
PMID: 28842734
Journal: Nat Cell Biol. 2018 Jul;20(7):740-741.
Title: GNAS shifts metabolism in pancreatic cancer.
Author: Hollstein, Pablo E|Shaw, Reuben J
PMID: 29941928
Journal: Nat Cell Biol. 2018 Jul;20(7):811-822.
Title: Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
Author: Patra, Krushna C|Kato, Yasutaka|Mizukami, Yusuke|Widholz, Sebastian|Boukhali, Myriam|Revenco, Iulia|Grossman, Elizabeth A|Ji, Fei|Sadreyev, Ruslan I|Liss, Andrew S|Screaton, Robert A|Sakamoto, Kei|Ryan, David P|Mino-Kenudson, Mari|Castillo, Carlos Fernand
PMID: 29941929
Journal: Surg Case Rep. 2018 Aug 16;4(1):96.
Title: Intrapancreatic recurrence of intraductal tubulopapillary neoplasm (ITPN) 16 years after the initial surgery for noninvasive ITPN: a case report.
Author: Saeki, Kiyoshi|Miyasaka, Yoshihiro|Ohishi, Yoshihiro|Yamamoto, Takeo|Matsuda, Ryota|Mochidome, Naoki|Mori, Yasuhisa|Nakata, Kohei|Ohtsuka, Takao|Ishigami, Kousei|Minoda, Yosuke|Koga, Yutaka|Oda, Yoshinao|Nakamura, Masafumi
PMID: 30116990