Literatures

Primary Site >> Pancreatic Cancer

Gene >> GLI1

1.
Journal:	Diabete Metab. 1976 Dec;2(4):165-9.
Title:	Secretion of immunoreactive insulin and glucagon in hamsters bearing a transplantable insuloma.
Author:	Dunbar, J C\|Walsh, M F\|Foa, P P
PMID:	190057

2.
Journal:	Neuroendocrinology. 1984 Jul;39(1):68-73.
Title:	Ontogeny of the neuroglandular system revealed with HPGRF 44 antibodies in human hypothalamus.
Author:	Bresson, J L\|Clavequin, M C\|Fellmann, D\|Bugnon, C
PMID:	6431308

3.
Journal:	Int J Oncol. 2005 Feb;26(2):545-9.
Title:	Identification and characterization of rat Desert hedgehog and Indian hedgehog genes in silico.
Author:	Katoh, Yuriko\|Katoh, Masaru
PMID:	15645142

4.
Journal:	Cancer Res. 2005 Mar 1;65(5):1619-26.
Title:	Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells.
Author:	Prasad, Nijaguna B\|Biankin, Andrew V\|Fukushima, Noriyoshi\|Maitra, Anirban\|Dhara, Surajit\|Elkahloun, Abdel G\|Hruban, Ralph H\|Goggins, Michael\|Leach, Steven D
PMID:	15753353

5.
Journal:	Mol Carcinog. 2005 Apr;42(4):183-92.
Title:	Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas.
Author:	Kayed, Hany\|Kleeff, Jorg\|Esposito, Irene\|Giese, Thomas\|Keleg, Shereen\|Giese, Nathalia\|Buchler, Markus W\|Friess, Helmut
PMID:	15754313

6.
Journal:	Cancer Biol Ther. 2005 Jul;4(7):728-33. Epub 2005 Jul 4.
Title:	Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms.
Author:	Martin, S T\|Sato, N\|Dhara, S\|Chang, R\|Hustinx, S R\|Abe, T\|Maitra, A\|Goggins, M
PMID:	15970691

7.
Journal:	Cancer Biol Ther. 2005 Oct;4(10):1050-4. Epub 2005 Oct 18.
Title:	Hedgehog signaling pathway and gastric cancer.
Author:	Katoh, Yuriko\|Katoh, Masaru
PMID:	16258256

8.
Journal:	Gene Ther. 2006 Nov;13(22):1587-94. Epub 2006 Jul 6.
Title:	Antisense Smo under the control of the PTCH1 promoter delivered by an adenoviral vector inhibits the growth of human pancreatic cancer.
Author:	Gao, J\|Li, Z\|Chen, Z\|Shao, J\|Zhang, L\|Xu, G\|Tu, Z\|Gong, Y
PMID:	16826192

9.
Journal:	Clin Cancer Res. 2006 Nov 1;12(21):6557-64.
Title:	Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells.
Author:	Tsuda, Naotake\|Ishiyama, Satoshi\|Li, Yufeng\|Ioannides, Constantin G\|Abbruzzese, James L\|Chang, David Z
PMID:	17085671

10.
Journal:	Cancer Res. 2007 Mar 1;67(5):2187-96.
Title:	Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers.
Author:	Feldmann, Georg\|Dhara, Surajit\|Fendrich, Volker\|Bedja, Djahida\|Beaty, Robert\|Mullendore, Michael\|Karikari, Collins\|Alvarez, Hector\|Iacobuzio-Donahue, Christine\|Jimeno, Antonio\|Gabrielson, Kathleen L\|Matsui, William\|Maitra, Anirban
PMID:	17332349

11.
Journal:	J Biol Chem. 2007 May 11;282(19):14048-55. Epub 2007 Mar 12.
Title:	Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells.
Author:	Ji, Zhenyu\|Mei, Fang C\|Xie, Jingwu\|Cheng, Xiaodong
PMID:	17353198

12.
Journal:	Pancreas. 2007 Apr;34(3):340-6.
Title:	Sonic hedgehog signaling pathway in pancreatic cystic neoplasms and ductal adenocarcinoma.
Author:	Liu, Maw-Sen\|Yang, Po-Yi\|Yeh, Ta-Sen
PMID:	17414057

13.
Journal:	Zhonghua Yi Xue Za Zhi. 2007 Mar 27;87(12):826-8.
Title:	[mRNA expression of GLI1 in pancreatic carcinoma and clinical significance thereof].
Author:	Guo, Jie-fang\|Li, Zhao-shen\|Jin, Zhen-dong\|Gao, Jun\|Gong, Yan-fang\|Jin, Jing\|Man, Xiao-hua
PMID:	17565866

14.
Journal:	Chembiochem. 2008 May 5;9(7):1082-92.
Title:	Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription.
Author:	Hosoya, Takahiro\|Arai, Midori A\|Koyano, Takashi\|Kowithayakorn, Thaworn\|Ishibashi, Masami
PMID:	18357592

15.
Journal:	Cancer Sci. 2008 Jul;99(7):1377-84.
Title:	Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation.
Author:	Nagai, Shuntaro\|Nakamura, Masafumi\|Yanai, Kosuke\|Wada, Junji\|Akiyoshi, Takashi\|Nakashima, Hiroshi\|Ohuchida, Kenoki\|Sato, Norihiro\|Tanaka, Masao\|Katano, Mitsuo
PMID:	18410405

16.
Journal:	Oncol Rep. 2008 May;19(5):1185-90.
Title:	Expression of Sonic hedgehog signaling pathway correlates with the tumorigenesis of intraductal papillary mucinous neoplasm of the pancreas.
Author:	Satoh, Kennichi\|Kanno, Atsushi\|Hamada, Shin\|Hirota, Morihisa\|Umino, Jun\|Masamune, Atsushi\|Egawa, Shinichi\|Motoi, Fuyuhiko\|Unno, Michiaki\|Shimosegawa, Tooru
PMID:	18425375

17.
Journal:	Gut. 2008 Oct;57(10):1420-30.
Title:	Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer.
Author:	Feldmann, G\|Habbe, N\|Dhara, S\|Bisht, S\|Alvarez, H\|Fendrich, V\|Beaty, R\|Mullendore, M\|Karikari, C\|Bardeesy, N\|Ouellette, M M\|Yu, W\|Maitra, A
PMID:	18515410

18.
Journal:	Mol Cancer Ther. 2008 Sep;7(9):2725-35.
Title:	An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.
Author:	Feldmann, Georg\|Fendrich, Volker\|McGovern, Karen\|Bedja, Djahida\|Bisht, Savita\|Alvarez, Hector\|Koorstra, Jan-Bart M\|Habbe, Nils\|Karikari, Collins\|Mullendore, Michael\|Gabrielson, Kathleen L\|Sharma, Rajni\|Matsui, William\|Maitra, Anirban
PMID:	18790753

19.
Journal:	Cancer Res. 2008 Oct 1;68(19):7723-9.
Title:	SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of suppressor-of-fused in pancreatic cancer cell.
Author:	Kasai, Kenji\|Inaguma, Shingo\|Yoneyama, Akiko\|Yoshikawa, Kazuhiro\|Ikeda, Hiroshi
PMID:	18829525

20.
Journal:	Bioorg Med Chem. 2008 Nov 1;16(21):9420-4.
Title:	Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana.
Author:	Arai, Midori A\|Tateno, Chikashi\|Hosoya, Takahiro\|Koyano, Takashi\|Kowithayakorn, Thaworn\|Ishibashi, Masami
PMID:	18842418

21.
Journal:	Cancer Lett. 2009 Jan 18;273(2):266-72.
Title:	Cathepsin B is a target of Hedgehog signaling in pancreatic cancer.
Author:	Hwang, Jin-Hyeok\|Lee, Sang Hyub\|Lee, Kwang Hyuck\|Lee, Keung Youp\|Kim, Haeryoung\|Ryu, Ji Kon\|Yoon, Yong Bum\|Kim, Yong-Tae
PMID:	19004543

22.
Journal:	Pancreatology. 2009;9(1-2):116-26.
Title:	The expression pattern of PDX-1, SHH, Patched and Gli-1 is associated with pathological and clinical features in human pancreatic cancer.
Author:	Quint, Karl\|Stintzing, Sebastian\|Alinger, Beate\|Hauser-Kronberger, Cornelia\|Dietze, Otto\|Gahr, Susanne\|Hahn, Eckhart G\|Ocker, Matthias\|Neureiter, Daniel
PMID:	19077462

23.
Journal:	Genes Dev. 2009 Jan 1;23(1):24-36.
Title:	GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.
Author:	Nolan-Stevaux, Olivier\|Lau, Janet\|Truitt, Morgan L\|Chu, Gerald C\|Hebrok, Matthias\|Fernandez-Zapico, Martin E\|Hanahan, Douglas
PMID:	19136624

24.
Journal:	Int J Oncol. 2009 Jul;35(1):187-92.
Title:	Integrative genomic analyses on GLI1: positive regulation of GLI1 by Hedgehog-GLI, TGFbeta-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals.
Author:	Katoh, Yuriko\|Katoh, Masaru
PMID:	19513567

25.
Journal:	J Carcinog. 2009;8:13.
Title:	Gli1 maintains cell survival by up-regulating IGFBP6 and Bcl-2 through promoter regions in parallel manner in pancreatic cancer cells.
Author:	Xu, Xuan-Fu\|Guo, Chuan-Yong\|Liu, Jun\|Yang, Wen-Juan\|Xia, Yu-Jing\|Xu, Ling\|Yu, Yong-Chun\|Wang, Xing-Peng
PMID:	19736394

26.
Journal:	Curr Mol Med. 2009 Sep;9(7):873-86.
Title:	Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.
Author:	Katoh, Y\|Katoh, M
PMID:	19860666

27.
Journal:	Mol Biosyst. 2010 Jan;6(1):44-54.
Title:	Small-molecule modulators of the Sonic Hedgehog signaling pathway.
Author:	Stanton, Benjamin Z\|Peng, Lee F
PMID:	20024066

28.
Journal:	Int J Oncol. 2010 Feb;36(2):415-20.
Title:	Integrative genomic analyses of CXCR4: transcriptional regulation of CXCR4 based on TGFbeta, Nodal, Activin signaling and POU5F1, FOXA2, FOXC2, FOXH1, SOX17, and GFI1 transcription factors.
Author:	Katoh, Masuko\|Katoh, Masaru
PMID:	20043076

29.
Journal:	PLoS One. 2010 Jan 21;5(1):e8824.
Title:	Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells.
Author:	Nakamura, Kazumasa\|Sasajima, Junpei\|Mizukami, Yusuke\|Sugiyama, Yoshiaki\|Yamazaki, Madoka\|Fujii, Rie\|Kawamoto, Toru\|Koizumi, Kazuya\|Sato, Kazuya\|Fujiya, Mikihiro\|Sasaki, Katsunori\|Tanno, Satoshi\|Okumura, Toshikatsu\|Shimizu, Norihiko\|Kawabe, Jun-ichi\|Karasa
PMID:	20098680

30.
Journal:	Clin Cancer Res. 2010 Mar 15;16(6):1781-9.
Title:	Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts.
Author:	Walter, Kimberly\|Omura, Noriyuki\|Hong, Seung-Mo\|Griffith, Margaret\|Vincent, Audrey\|Borges, Michael\|Goggins, Michael
PMID:	20215540

31.
Journal:	Cancer Biol Ther. 2010 Nov 1;10(9):893-902.
Title:	Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer.
Author:	Steg, Adam\|Amm, Hope M\|Novak, Zdenek\|Frost, Andra R\|Johnson, Martin R
PMID:	20814245

32.
Journal:	Oncogene. 2011 Feb 10;30(6):714-23.
Title:	GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin.
Author:	Inaguma, S\|Kasai, K\|Ikeda, H
PMID:	20972463

33.
Journal:	Org Biomol Chem. 2011 Feb 21;9(4):1133-9.
Title:	New hedgehog/GLI-signaling inhibitors from Adenium obesum.
Author:	Arai, Midori A\|Tateno, Chikashi\|Koyano, Takashi\|Kowithayakorn, Thaworn\|Kawabe, Seiichiro\|Ishibashi, Masami
PMID:	21170436

34.
Journal:	J Biol Chem. 2011 Apr 8;286(14):11960-9.
Title:	Structural analysis of the cancer-specific promoter in mesothelin and in other genes overexpressed in cancers.
Author:	Ren, Yunzhao R\|Patel, Kalpesh\|Paun, Bogdan C\|Kern, Scott E
PMID:	21288909

35.
Journal:	Clin Cancer Res. 2011 Apr 15;17(8):2502-11.
Title:	Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.
Author:	LoRusso, Patricia M\|Rudin, Charles M\|Reddy, Josina C\|Tibes, Raoul\|Weiss, Glen J\|Borad, Mitesh J\|Hann, Christine L\|Brahmer, Julie R\|Chang, Ilsung\|Darbonne, Walter C\|Graham, Richard A\|Zerivitz, Kenn L\|Low, Jennifer A\|Von Hoff, Daniel D
PMID:	21300762

36.
Journal:	Cancer Sci. 2011 Jun;102(6):1144-50.
Title:	Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer.
Author:	Onishi, Hideya\|Kai, Masaya\|Odate, Seiichi\|Iwasaki, Hironori\|Morifuji, Yoshihiro\|Ogino, Toshitatsu\|Morisaki, Takafumi\|Nakashima, Yutaka\|Katano, Mitsuo
PMID:	21338440

37.
Journal:	PLoS One. 2011 Apr 11;6(4):e18434.
Title:	Identification of RegIV as a novel GLI1 target gene in human pancreatic cancer.
Author:	Wang, Feng\|Xu, Ling\|Guo, Chuanyong\|Ke, Aiwu\|Hu, Guoyong\|Xu, Xuanfu\|Mo, Wenhui\|Yang, Lijuan\|Huang, Yinshi\|He, Shanshan\|Wang, Xingpeng
PMID:	21494603

38.
Journal:	Swiss Med Wkly. 2011 May 31;141:w13208.
Title:	Cyclopamine reverts acquired chemoresistance and down-regulates cancer stem cell markers in pancreatic cancer cell lines.
Author:	Yao, Jie\|An, Yong\|Wie, Ji-shu\|Ji, Zhen-ling\|Lu, Zi-peng\|Wu, Jun-li\|Jiang, Kui-rong\|Chen, Ping\|Xu, Ze-kuan\|Miao, Yi
PMID:	21630164

39.
Journal:	J Biol Chem. 2011 Sep 2;286(35):30714-22.
Title:	The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened.
Author:	Douglas, Andrew E\|Heim, Jennifer A\|Shen, Feng\|Almada, Luciana L\|Riobo, Natalia A\|Fernandez-Zapico, Martin E\|Manning, David R
PMID:	21757753

40.
Journal:	PLoS One. 2011;6(8):e23383.
Title:	Holoclone forming cells from pancreatic cancer cells enrich tumor initiating cells and represent a novel model for study of cancer stem cells.
Author:	Tan, Lei\|Sui, Xin\|Deng, Hongkui\|Ding, Mingxiao
PMID:	21826251

41.
Journal:	PLoS One. 2011;6(11):e27306.
Title:	Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms.
Author:	Singh, Brahma N\|Fu, Junsheng\|Srivastava, Rakesh K\|Shankar, Sharmila
PMID:	22087285

42.
Journal:	PLoS One. 2011;6(11):e27684.
Title:	Expression of DNMT1 and DNMT3a are regulated by GLI1 in human pancreatic cancer.
Author:	He, ShanShan\|Wang, Feng\|Yang, LiJuan\|Guo, ChuanYong\|Wan, Rong\|Ke, AiWu\|Xu, Ling\|Hu, GuoYong\|Xu, XuanFu\|Shen, Jie\|Wang, XingPeng
PMID:	22110720

43.
Journal:	PLoS One. 2011;6(12):e27941.
Title:	Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish.
Author:	Jung, In Hye\|Jung, Dawoon E\|Park, Young Nyun\|Song, Si Young\|Park, Seung Woo
PMID:	22164219

44.
Journal:	Pancreatology. 2011;11(6):601-9.
Title:	Resveratrol inhibits proliferation and induces apoptosis through the hedgehog signaling pathway in pancreatic cancer cell.
Author:	Mo, Wenhui\|Xu, Xuanfu\|Xu, Ling\|Wang, Feng\|Ke, Aiwu\|Wang, Xingpeng\|Guo, Chuanyong
PMID:	22301921

45.
Journal:	Int J Cancer. 2012 Jul 1;131(1):30-40.
Title:	Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics.
Author:	Tang, Su-Ni\|Fu, Junsheng\|Nall, Dara\|Rodova, Mariana\|Shankar, Sharmila\|Srivastava, Rakesh K
PMID:	21796625

46.
Journal:	Mol Cancer Ther. 2012 Jan;11(1):165-73.
Title:	A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists.
Author:	Chenna, Venugopal\|Hu, Chaoxin\|Pramanik, Dipankar\|Aftab, Blake T\|Karikari, Collins\|Campbell, Nathaniel R\|Hong, Seung-Mo\|Zhao, Ming\|Rudek, Michelle A\|Khan, Saeed R\|Rudin, Charles M\|Maitra, Anirban
PMID:	22027695

47.
Journal:	Pancreas. 2012 Mar;41(2):222-9.
Title:	Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas.
Author:	Bahra, Marcus\|Kamphues, Carsten\|Boas-Knoop, Sabine\|Lippert, Steffen\|Esendik, Ulrike\|Schuller, Ulrich\|Hartmann, Wolfgang\|Waha, Andreas\|Neuhaus, Peter\|Heppner, Frank\|Pietsch, Torsten\|Koch, Arend
PMID:	22076568

48.
Journal:	Cancer Res. 2012 Jan 1;72(1):88-99.
Title:	GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells.
Author:	Joost, Simon\|Almada, Luciana L\|Rohnalter, Verena\|Holz, Philipp S\|Vrabel, Anne M\|Fernandez-Barrena, Maite G\|McWilliams, Robert R\|Krause, Michael\|Fernandez-Zapico, Martin E\|Lauth, Matthias
PMID:	22086851

49.
Journal:	Cancer Lett. 2012 Sep 28;322(2):169-76.
Title:	SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial-mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway.
Author:	Li, Xuqi\|Ma, Qingyong\|Xu, Qinhong\|Liu, Han\|Lei, Jianjun\|Duan, Wanxing\|Bhat, Kruttika\|Wang, Fengfei\|Wu, Erxi\|Wang, Zheng
PMID:	22450749

50.
Journal:	Cancer Sci. 2012 Jul;103(7):1272-9.
Title:	Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer.
Author:	Onishi, Hideya\|Morifuji, Yoshihiro\|Kai, Masaya\|Suyama, Kumi\|Iwasaki, Hironori\|Katano, Mitsuo
PMID:	22486854

51.
Journal:	Pancreatology. 2012 Jan-Feb;12(1):8-15.
Title:	Direct histological processing of EUS biopsies enables rapid molecular biomarker analysis for interventional pancreatic cancer trials.
Author:	Brais, Rebecca J\|Davies, Susan E\|O'Donovan, Maria\|Simpson, Ben W\|Cook, Natalie\|Darbonne, Walter C\|Chilcott, Sian\|Lolkema, Martijn P\|Neesse, Albrecht\|Lockley, Michelle\|Corrie, Pippa G\|Jodrell, Duncan I\|Praseedom, Raaj K\|Huguet, Emmanuel L\|Jah, Asif\|Jamieso
PMID:	22487467

52.
Journal:	Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):E1038-47.
Title:	The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis.
Author:	Rajurkar, Mihir\|De Jesus-Monge, Wilfredo E\|Driscoll, David R\|Appleman, Victoria A\|Huang, He\|Cotton, Jennifer L\|Klimstra, David S\|Zhu, Lihua J\|Simin, Karl\|Xu, Lan\|McMahon, Andrew P\|Lewis, Brian C\|Mao, Junhao
PMID:	22493246

53.
Journal:	Pancreas. 2012 Oct;41(7):1019-28.
Title:	Plasma Shh levels reduced in pancreatic cancer patients.
Author:	El-Zaatari, Mohamad\|Daignault, Stephanie\|Tessier, Art\|Kelsey, Gail\|Travnikar, Lisa A\|Cantu, Esperanza F\|Lee, Jamie\|Plonka, Caitlyn M\|Simeone, Diane M\|Anderson, Michelle A\|Merchant, Juanita L
PMID:	22513293

54.
Journal:	Cancer Res. 2012 Jul 15;72(14):3702-3; author reply 3704-5.
Title:	GLI1 modulates EMT in pancreatic cancer--letter.
Author:	Inaguma, Shingo\|Kasai, Kenji\|Hashimoto, Mitsuyoshi\|Ikeda, Hiroshi
PMID:	22761339

55.
Journal:	Mol Cancer Res. 2012 Sep;10(9):1147-57. Epub 2012 Aug 2.
Title:	Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer.
Author:	Hwang, Rosa F\|Moore, Todd T\|Hattersley, Maureen Mertens\|Scarpitti, Meghan\|Yang, Bin\|Devereaux, Erik\|Ramachandran, Vijaya\|Arumugam, Thiruvengadam\|Ji, Baoan\|Logsdon, Craig D\|Brown, Jeffrey L\|Godin, Robert
PMID:	22859707

56.
Journal:	PLoS One. 2012;7(8):e43119.
Title:	Genome-wide screening reveals an EMT molecular network mediated by Sonic hedgehog-Gli1 signaling in pancreatic cancer cells.
Author:	Xu, Xuanfu\|Zhou, Yingqun\|Xie, Chuangao\|Wei, Shu-mei\|Gan, Huizhong\|He, Shengli\|Wang, Fan\|Xu, Ling\|Lu, Jie\|Dai, Weiqi\|He, Lei\|Chen, Ping\|Wang, Xingpeng\|Guo, Chuanyong
PMID:	22900095

57.
Journal:	Zhonghua Yi Xue Za Zhi. 2012 Jul 10;92(26):1849-53.
Title:	[Effects and mechanisms of combined suppression of epidermal growth factor receptor and hedgehog signaling on proliferation in pancreatic cancer cells].
Author:	Qin, Chang-fu\|Tian, Xiao-dong\|Hao, Kun\|Yang, Yin-mo
PMID:	22944238

58.
Journal:	PLoS One. 2012;7(9):e46083.
Title:	Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal.
Author:	Rodova, Mariana\|Fu, Junsheng\|Watkins, Dara Nall\|Srivastava, Rakesh K\|Shankar, Sharmila
PMID:	23029396

59.
Journal:	Mol Cell Biochem. 2013 Jan;373(1-2):217-27.
Title:	Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway.
Author:	Li, Shih-Hui\|Fu, Junsheng\|Watkins, Dara Nall\|Srivastava, Rakesh K\|Shankar, Sharmila
PMID:	23129257

60.
Journal:	Cancer Lett. 2013 Feb 28;329(2):228-35.
Title:	MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2.
Author:	An, Yong\|Cai, Baobao\|Chen, Jianmin\|Lv, Nan\|Yao, Jie\|Xue, Xiaofeng\|Tu, Min\|Tang, Dong\|Wei, Jishu\|Jiang, Kuirong\|Wu, Junli\|Li, Qiang\|Gao, Wentao\|Miao, Yi
PMID:	23178452

61.
Journal:	Cancer Lett. 2013 Mar 1;330(1):22-32.
Title:	GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft.
Author:	Fu, Junsheng\|Rodova, Mariana\|Roy, Sanjit K\|Sharma, Jay\|Singh, Karan P\|Srivastava, Rakesh K\|Shankar, Sharmila
PMID:	23200667

62.
Journal:	Drug Metab Dispos. 2013 Apr;41(4):727-34.
Title:	Pharmacokinetic and pharmacodynamic modeling of hedgehog inhibitor TAK-441 for the inhibition of Gli1 messenger RNA expression and antitumor efficacy in xenografted tumor model mice.
Author:	Kogame, Akifumi\|Tagawa, Yoshihiko\|Shibata, Sachio\|Tojo, Hideaki\|Miyamoto, Maki\|Tohyama, Kimio\|Kondo, Takahiro\|Prakash, Shimoga\|Shyu, Wen Chyi\|Asahi, Satoru
PMID:	23298863

63.
Journal:	J Biol Chem. 2013 Apr 26;288(17):11786-94.
Title:	Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation.
Author:	Mills, Lisa D\|Zhang, Yaqing\|Marler, Ronald J\|Herreros-Villanueva, Marta\|Zhang, Lizhi\|Almada, Luciana L\|Couch, Fergus\|Wetmore, Cynthia\|Pasca di Magliano, Marina\|Fernandez-Zapico, Martin E
PMID:	23482563

64.
Journal:	Oncol Rep. 2013 Jun;29(6):2401-7.
Title:	Curcumin reverses the epithelial-mesenchymal transition of pancreatic cancer cells by inhibiting the Hedgehog signaling pathway.
Author:	Sun, Xiao-Dong\|Liu, Xing-E\|Huang, Dong-Sheng
PMID:	23563640

65.
Journal:	Cancer Lett. 2013 Sep 1;337(2):210-7.
Title:	Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice.
Author:	Zhao, Min\|Tang, Su-Ni\|Marsh, Justin L\|Shankar, Sharmila\|Srivastava, Rakesh K
PMID:	23684930

66.
Journal:	PLoS One. 2013 Jun 10;8(6):e65403.
Title:	Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1.
Author:	Gotschel, Frank\|Berg, Daniela\|Gruber, Wolfgang\|Bender, Christian\|Eberl, Markus\|Friedel, Myriam\|Sonntag, Johanna\|Rungeler, Elena\|Hache, Hendrik\|Wierling, Christoph\|Nietfeld, Wilfried\|Lehrach, Hans\|Frischauf, Annemarie\|Schwartz-Albiez, Reinhard\|Aberger, Fri
PMID:	23762360

67.
Journal:	Mol Cancer. 2013 Jun 20;12:66.
Title:	Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner.
Author:	Lei, Jianjun\|Ma, Jiguang\|Ma, Qingyong\|Li, Xuqi\|Liu, Han\|Xu, Qinhong\|Duan, Wanxing\|Sun, Qing\|Xu, Jun\|Wu, Zheng\|Wu, Erxi
PMID:	23786654

68.
Journal:	Cancer Lett. 2013 Oct 10;339(2):185-94.
Title:	Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo.
Author:	Guo, Jiefang\|Gao, Jun\|Li, Zhaoshen\|Gong, Yanfang\|Man, Xiaohua\|Jin, Jing\|Wu, Hongyu
PMID:	23791879

69.
Journal:	Hepatogastroenterology. 2013 Jul-Aug;60(125):1169-73.
Title:	Inhibiting K-ras signaling reserves the epithelial-mesenchymal transition of pancreatic cancer cells and its mechanisms.
Author:	Liu, Xing-E\|Sun, Xiao-Do
PMID:	23803380

70.
Journal:	Oncology. 2013;85(2):86-94.
Title:	Nuclear expression of glioma-associated oncogene homolog 1 and nuclear factor-kappaB is associated with a poor prognosis of pancreatic cancer.
Author:	Yang, Shih-Hung\|Hsu, Chih-Hung\|Lee, Jen-Chieh\|Tien, Yu-Wen\|Kuo, Sung-Hsin\|Cheng, Ann-Lii
PMID:	23860225

71.
Journal:	PLoS One. 2013 Jul 23;8(7):e69132.
Title:	Structural and logical analysis of a comprehensive hedgehog signaling pathway to identify alternative drug targets for glioma, colon and pancreatic cancer.
Author:	Chowdhury, Saikat\|Pradhan, Rachana N\|Sarkar, Ram Rup
PMID:	23935937

72.
Journal:	Onco Targets Ther. 2013 Aug 19;6:1129-38.
Title:	Arsenic trioxide inhibits viability of pancreatic cancer stem cells in culture and in a xenograft model via binding to SHH-Gli.
Author:	Han, Jin-Bin\|Sang, Feng\|Chang, Jin-Jia\|Hua, Yong-Qiang\|Shi, Wei-Dong\|Tang, Li-Hua\|Liu, Lu-Ming
PMID:	23990729

73.
Journal:	Cancer Res. 2013 Dec 15;73(24):7313-23.
Title:	GLI1 interferes with the DNA mismatch repair system in pancreatic cancer through BHLHE41-mediated suppression of MLH1.
Author:	Inaguma, Shingo\|Riku, Miho\|Hashimoto, Mitsuyoshi\|Murakami, Hideki\|Saga, Shinsuke\|Ikeda, Hiroshi\|Kasai, Kenji
PMID:	24165159

74.
Journal:	Zhonghua Wai Ke Za Zhi. 2013 Oct;51(10):916-21.
Title:	[Correlation between Gli1 expression and clinicopathological significance in human pancreatic cancer].
Author:	Sheng, Wei-wei\|Dong, Ming\|Zhou, Jian-ping\|Liu, Qing-feng\|Li, Xin\|Dong, Qi
PMID:	24433772

75.
Journal:	Histopathology. 2014 Mar;64(4):523-35.
Title:	The clinicopathological significance and relationship of Gli1, MDM2 and p53 expression in resectable pancreatic cancer.
Author:	Sheng, Weiwei\|Dong, Ming\|Zhou, Jianping\|Li, Xin\|Liu, Qingfeng\|Dong, Qi\|Li, Feng
PMID:	24289472

76.
Journal:	Biochem Biophys Res Commun. 2014 Apr 11;446(3):669-74.
Title:	Metabolites in vertebrate Hedgehog signaling.
Author:	Roberg-Larsen, Hanne\|Strand, Martin Frank\|Krauss, Stefan\|Wilson, Steven Ray
PMID:	24486313

77.
Journal:	Cancer Lett. 2014 May 28;347(1):129-38.
Title:	alpha-Mangostin inhibits hypoxia-driven ROS-induced PSC activation and pancreatic cancer cell invasion.
Author:	Lei, Jianjun\|Huo, Xiongwei\|Duan, Wanxing\|Xu, Qinhong\|Li, Rong\|Ma, Jiguang\|Li, Xuqi\|Han, Liang\|Li, Wei\|Sun, Hao\|Wu, Erxi\|Ma, Qingyong
PMID:	24513179

78.
Journal:	Cancer Chemother Pharmacol. 2014 Apr;73(4):711-9.
Title:	Perifosine inhibits S6K1-Gli1 signaling and enhances gemcitabine-induced anti-pancreatic cancer efficiency.
Author:	Xin, Ying\|Shen, Xiang-di\|Cheng, Long\|Hong, De-fei\|Chen, Bin
PMID:	24519751

79.
Journal:	J Pathol. 2014 Jun;233(2):196-208.
Title:	Suppression of Hedgehog signalling promotes pro-tumourigenic integrin expression and function.
Author:	Moutasim, Karwan A\|Mellows, Toby\|Mellone, Massimiliano\|Lopez, Marie-Antoinette\|Tod, Joanne\|Kiely, Philip C\|Sapienza, Karen\|Greco, Azzura\|Neill, Graham W\|Violette, Shelia\|Weinreb, Paul H\|Marshall, John F\|Ottensmeier, Christian H\|Sayan, A Emre\|Jenei, Veroni
PMID:	24573955

80.
Journal:	Curr Cancer Drug Targets. 2014;14(5):446-57.
Title:	The Activation of beta1-integrin by Type I Collagen Coupling with the Hedgehog Pathway Promotes the Epithelial-Mesenchymal Transition in Pancreatic Cancer.
Author:	Duan, Wanxing\|Ma, Jiguang\|Ma, Qingyong\|Xu, Qinhong\|Lei, Jianjun\|Han, Liang\|Li, Xuqi\|Wang, Zheng\|Wu, Zheng\|Lv, Shifang\|Ma, Zhenhua\|Liu, Mouzhu\|Wang, Fengfei\|Wu, Erxi
PMID:	24720337

81.
Journal:	J Biol Chem. 2014 Jun 6;289(23):16516-25.
Title:	Inactivation of the transcription factor GLI1 accelerates pancreatic cancer progression.
Author:	Mills, Lisa D\|Zhang, Lizhi\|Marler, Ronald\|Svingen, Phyllis\|Fernandez-Barrena, Maite G\|Dave, Maneesh\|Bamlet, William\|McWilliams, Robert R\|Petersen, Gloria M\|Faubion, William\|Fernandez-Zapico, Martin E
PMID:	24737325

82.
Journal:	World J Gastroenterol. 2014 Apr 28;20(16):4712-7.
Title:	Sonic hedgehog expression in a rat model of chronic pancreatitis.
Author:	Wang, Luo-Wei\|Lin, Han\|Lu, Yi\|Xia, Wei\|Gao, Jun\|Li, Zhao-Shen
PMID:	24782623

83.
Journal:	Nutr Cancer. 2014;66(5):896-903.
Title:	Copolymeric micelles for delivery of EGCG and cyclopamine to pancreatic cancer cells.
Author:	Sun, Liming\|Zhang, Chenlu\|Li, Ping
PMID:	24798568

84.
Journal:	PLoS One. 2014 Jul 29;9(7):e96441.
Title:	Sonic hedgehog-Gli1 signaling pathway regulates the epithelial mesenchymal transition (EMT) by mediating a new target gene, S100A4, in pancreatic cancer cells.
Author:	Xu, Xuanfu\|Su, Bin\|Xie, Chuangao\|Wei, Shumei\|Zhou, Yingqun\|Liu, Hua\|Dai, Weiqi\|Cheng, Ping\|Wang, Fan\|Xu, Xiaorong\|Guo, Chuanyong
PMID:	25072505

85.
Journal:	J Biol Chem. 2014 Oct 3;289(40):27727-43.
Title:	The transcription factor GLI1 modulates the inflammatory response during pancreatic tissue remodeling.
Author:	Mathew, Esha\|Collins, Meredith A\|Fernandez-Barrena, Maite G\|Holtz, Alexander M\|Yan, Wei\|Hogan, James O\|Tata, Zachary\|Allen, Benjamin L\|Fernandez-Zapico, Martin E\|di Magliano, Marina Pasca
PMID:	25104358

86.
Journal:	Oncogenesis. 2014 Aug 11;3:e112.
Title:	The Yes-associated protein controls the cell density regulation of Hedgehog signaling.
Author:	Tariki, M\|Dhanyamraju, P K\|Fendrich, V\|Borggrefe, T\|Feldmann, G\|Lauth, M
PMID:	25111861

87.
Journal:	Int J Clin Exp Pathol. 2014 Jun 15;7(7):4531-8. eCollection 2014.
Title:	Expression of Gli1 and Wnt2B correlates with progression and clinical outcome of pancreatic cancer.
Author:	Jiang, Hua\|Li, Fengru\|He, Chengzhi\|Wang, Xuebin\|Li, Qingqing\|Gao, Hengjun
PMID:	25120849

88.
Journal:	Zhonghua Wai Ke Za Zhi. 2014 Jul;52(7):518-22.
Title:	[The role of Gli1 in the invasion and migration of pancreatic cancer cells].
Author:	Sheng, Weiwei\|Dong, Ming\|Zhou, Jianping\|Liu, Qingfeng\|Li, Xin\|Dong, Qi
PMID:	25262609

89.
Journal:	Clin Cancer Res. 2014 Dec 1;20(23):5937-5945.
Title:	Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma.
Author:	Kim, Edward J\|Sahai, Vaibhav\|Abel, Ethan V\|Griffith, Kent A\|Greenson, Joel K\|Takebe, Naoko\|Khan, Gazala N\|Blau, John L\|Craig, Ronald\|Balis, Ulysses G\|Zalupski, Mark M\|Simeone, Diane M
PMID:	25278454

90.
Journal:	Clin Cancer Res. 2015 Mar 1;21(5):1002-9.
Title:	Phase I dose-escalation trial of the oral investigational Hedgehog signaling pathway inhibitor TAK-441 in patients with advanced solid tumors.
Author:	Goldman, Jonathan\|Eckhardt, S Gail\|Borad, Mitesh J\|Curtis, Kelly K\|Hidalgo, Manuel\|Calvo, Emiliano\|Ryan, David P\|Wirth, Lori J\|Parikh, Asit\|Partyka, James\|Faessel, Helene\|Gangolli, Esha\|Stewart, Sally\|Rosen, Lee S\|Bowles, Daniel W
PMID:	25501576

91.
Journal:	Nanoscale. 2015 Feb 14;7(6):2609-24.
Title:	Biodegradable polymeric micelles encapsulated JK184 suppress tumor growth through inhibiting Hedgehog signaling pathway.
Author:	Zhang, Nannan\|Liu, Shichang\|Wang, Ning\|Deng, Senyi\|Song, Linjiang\|Wu, Qinjie\|Liu, Lei\|Su, Weijun\|Wei, Yuquan\|Xie, Yongmei\|Gong, Changyang
PMID:	25581613

92.
Journal:	Asian Pac J Cancer Prev. 2015;16(2):437-42.
Title:	Establishment of a pancreatic cancer stem cell model using the SW1990 human pancreatic cancer cell line in nude mice.
Author:	Pan, Yan\|Gao, Song\|Hua, Yong-Qiang\|Liu, Lu-Ming
PMID:	25684468

93.
Journal:	Mol Pharm. 2015 Jun 1;12(6):2093-100.
Title:	Cyclopamine-loaded core-cross-linked polymeric micelles enhance radiation response in pancreatic cancer and pancreatic stellate cells.
Author:	Zhao, Jun\|Wu, Chunhui\|Abbruzzese, James\|Hwang, Rosa F\|Li, Chun
PMID:	25936695

94.
Journal:	Surgery. 2015 Jul;158(1):211-24.
Title:	Gli1 promotes transforming growth factor-beta1- and epidermal growth factor-induced epithelial to mesenchymal transition in pancreatic cancer cells.
Author:	Liu, Qingfeng\|Sheng, Weiwei\|Dong, Ming\|Dong, Xiaoshen\|Dong, Qi\|Li, Feng
PMID:	25979438

95.
Journal:	Nanomedicine. 2015 Nov;11(8):2061-70.
Title:	Anthothecol-encapsulated PLGA nanoparticles inhibit pancreatic cancer stem cell growth by modulating sonic hedgehog pathway.
Author:	Verma, Raj Kumar\|Yu, Wei\|Singh, Surya Pratap\|Shankar, Sharmila\|Srivastava, Rakesh K
PMID:	26199979

96.
Journal:	Oncotarget. 2015 Sep 29;6(29):27661-73.
Title:	Crocetinic acid inhibits hedgehog signaling to inhibit pancreatic cancer stem cells.
Author:	Rangarajan, Parthasarathy\|Subramaniam, Dharmalingam\|Paul, Santanu\|Kwatra, Deep\|Palaniyandi, Kanagaraj\|Islam, Shamima\|Harihar, Sitaram\|Ramalingam, Satish\|Gutheil, William\|Putty, Sandeep\|Pradhan, Rohan\|Padhye, Subhash\|Welch, Danny R\|Anant, Shrikant\|Dhar, An
PMID:	26317547

97.
Journal:	Pancreas. 2015 Nov;44(8):1252-8.
Title:	Sonic Hedgehog-GLI Family Zinc Finger 1 Signaling Pathway Promotes the Growth and Migration of Pancreatic Cancer Cells by Regulating the Transcription of Eukaryotic Translation Initiation Factor 5A2.
Author:	Xu, Xuanfu\|Liu, Hua\|Zhang, Hui\|Dai, Weiqi\|Guo, Chuanyong\|Xie, Chuangao\|Wei, Shumei\|He, Shengli\|Xu, Xiaorong
PMID:	26465952

98.
Journal:	Pharmacogn Mag. 2015 Oct-Dec;11(44):690-7.
Title:	Phenolic alkaloids from Menispermum dauricum inhibits BxPC-3 pancreatic cancer cells by blocking of Hedgehog signaling pathway.
Author:	Zhou, Zhong-Guang\|Zhang, Chao-Ying\|Fei, Hong-Xin\|Zhong, Li-Li\|Bai, Yun
PMID:	26600712

99.
Journal:	Cancer Lett. 2016 Feb 28;371(2):143-50.
Title:	Hypoxia but not normoxia promotes Smoothened transcription through upregulation of RBPJ and Mastermind-like 3 in pancreatic cancer.
Author:	Onishi, Hideya\|Yamasaki, Akio\|Kawamoto, Makoto\|Imaizumi, Akira\|Katano, Mitsuo
PMID:	26655998

100.
Journal:	Mol Med Rep. 2016 Feb;13(2):1434-40.
Title:	Reduced proliferation and increased apoptosis of the SGC7901 gastric cancer cell line on exposure to GDC0449.
Author:	Wu, Chuanqing\|Cheng, Ji\|Hu, Shaobo\|Deng, Rui\|Muangu, Yamba Willy\|Shi, Liang\|Wu, Ke\|Zhang, Peng\|Chang, Weilong\|Wang, Guobin\|Tao, Kaixiong
PMID:	26676867

101.
Journal:	Eur J Cancer. 2016 Jan;52:188-96.
Title:	Nicotine induces self-renewal of pancreatic cancer stem cells via neurotransmitter-driven activation of sonic hedgehog signalling.
Author:	Al-Wadei, Mohammed H\|Banerjee, Jheelam\|Al-Wadei, Hussein A N\|Schuller, Hildegard M
PMID:	26689865

102.
Journal:	Oncol Rep. 2016 Mar;35(3):1718-26.
Title:	Resveratrol inhibits hypoxia-driven ROS-induced invasive and migratory ability of pancreatic cancer cells via suppression of the Hedgehog signaling pathway.
Author:	Li, Wei\|Cao, Lei\|Chen, Xin\|Lei, Jianjun\|Ma, Qingyong
PMID:	26707376

103.
Journal:	Tumour Biol. 2016 Jul;37(7):9943-50.
Title:	SHh-Gli1 signaling pathway promotes cell survival by mediating baculoviral IAP repeat-containing 3 (BIRC3) gene in pancreatic cancer cells.
Author:	Gan, Huizhong\|Liu, Hua\|Zhang, Hui\|Li, Yueyue\|Xu, Xiaorong\|Xu, Xuanfu\|Xu, Jianming
PMID:	26815504

104.
Journal:	Oncol Rep. 2016 Jun;35(6):3728-34.
Title:	Curcumin inhibits hypoxia-induced epithelialmesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway.
Author:	Cao, Lei\|Xiao, Xue\|Lei, Jianjun\|Duan, Wanxing\|Ma, Qingyong\|Li, Wei
PMID:	27035865

105.
Journal:	Clin Cancer Res. 2016 Aug 15;22(16):4259-70.
Title:	Regulation of GLI Underlies a Role for BET Bromodomains in Pancreatic Cancer Growth and the Tumor Microenvironment.
Author:	Huang, Yinshi\|Nahar, Sabikun\|Nakagawa, Akifumi\|Fernandez-Barrena, Maite G\|Mertz, Jennifer A\|Bryant, Barbara M\|Adams, Curtis E\|Mino-Kenudson, Mari\|Von Alt, Kate N\|Chang, Kevin\|Conery, Andrew R\|Hatton, Charlie\|Sims, Robert J 3rd\|Fernandez-Zapico, Martin E\|W
PMID:	27169995

106.
Journal:	Mol Cancer. 2016 Jun 27;15(1):49.
Title:	Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition.
Author:	Miyazaki, Yumi\|Matsubara, Shyuichirou\|Ding, Qiang\|Tsukasa, Koichiro\|Yoshimitsu, Makoto\|Kosai, Ken-Ichiro\|Takao, Sonshin
PMID:	27349387

107.
Journal:	Oncol Lett. 2016 Oct;12(4):2912-2917.
Title:	A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cells.
Author:	Lee, Hwa Jin\|Wu, Qian\|Li, Hua\|Bae, Gyu-Un\|Kim, An Keun\|Ryu, Jae-Ha
PMID:	27698879

108.
Journal:	Tumour Biol. 2016 Oct 12. pii: 10.1007/s13277-016-5461-8.
Title:	Ski modulate the characteristics of pancreatic cancer stem cells via regulating sonic hedgehog signaling pathway.
Author:	Song, Libin\|Chen, Xiangyuan\|Gao, Song\|Zhang, Chenyue\|Qu, Chao\|Wang, Peng\|Liu, Luming
PMID:	27734340

109.
Journal:	Pathol Int. 2016 Dec;66(12):653-660.
Title:	GLI1, a master regulator of the hallmark of pancreatic cancer.
Author:	Kasai, Kenji
PMID:	27862693

110.
Journal:	Biotechnol Appl Biochem. 2017 Mar;64(2):165-173.
Title:	Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells.
Author:	Huang, Chi-Cheng\|Lin, Chien-Min\|Huang, Yan-Jiun\|Wei, Li\|Ting, Lei-Li\|Kuo, Chia-Chun\|Hsu, Cheyu\|Chiou, Jeng-Fong\|Wu, Alexander T H\|Lee, Wei-Hwa
PMID:	26400206

111.
Journal:	Oncotarget. 2017 Feb 14;8(7):10891-10904.
Title:	Gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathway.
Author:	Subramani, Ramadevi\|Gonzalez, Elizabeth\|Nandy, Sushmita Bose\|Arumugam, Arunkumar\|Camacho, Fernando\|Medel, Joshua\|Alabi, Damilola\|Lakshmanaswamy, Rajkumar
PMID:	26988754

112.
Journal:	J Cell Biochem. 2017 Mar;118(3):499-509.
Title:	Inhibition of Pancreatic Cancer Cell-Induced Paracrine Hedgehog Signaling by Liver X Receptor Agonists and Oxy16, a Naturally Occurring Oxysterol.
Author:	Wang, Feng\|Stappenbeck, Frank\|Matsui, William\|Parhami, Farhad
PMID:	27490478

113.
Journal:	Int J Oncol. 2017 Jan;50(1):121-128.
Title:	Prometastatic mechanisms of CAF-mediated EMT regulation in pancreatic cancer cells.
Author:	Shan, Tao\|Chen, Shuo\|Chen, Xi\|Lin, Wan Run\|Li, Wei\|Ma, Jiancang\|Wu, Tao\|Ji, Hong\|Li, Yiming\|Cui, Xijuan\|Kang, Ya'an
PMID:	27878234

114.
Journal:	Arch Pharm Res. 2017 Apr;40(4):509-517.
Title:	Diarylheptanoids suppress proliferation of pancreatic cancer PANC-1 cells through modulating shh-Gli-FoxM1 pathway.
Author:	Dong, Guang-Zhi\|Jeong, Ji Hye\|Lee, Yu-Ih\|Lee, So Yoon\|Zhao, Hui-Yuan\|Jeon, Raok\|Lee, Hwa Jin\|Ryu, Jae-Ha
PMID:	28258481

115.
Journal:	Mol Med Rep. 2017 Apr;15(4):1461-1470.
Title:	Sclareolide enhances gemcitabineinduced cell death through mediating the NICD and Gli1 pathways in gemcitabineresistant human pancreatic cancer.
Author:	Chen, Sheng\|Wang, Ye\|Zhang, Wen-Long\|Dong, Mao-Sheng\|Zhang, Jian-Hua
PMID:	28259943

116.
Journal:	Sci Rep. 2017 May 10;7(1):1665.
Title:	Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer.
Author:	Kumar, Vinod\|Chaudhary, Amit Kumar\|Dong, Yuxiang\|Zhong, Haizhen A\|Mondal, Goutam\|Lin, Feng\|Kumar, Virender\|Mahato, Ram I
PMID:	28490735

117.
Journal:	Exp Ther Med. 2017 May;13(5):2529-2536.
Title:	Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines.
Author:	Wu, Chuanqing\|Hu, Shaobo\|Cheng, Ji\|Wang, Guobin\|Tao, Kaixiong
PMID:	28565875

118.
Journal:	Biomaterials. 2017 Nov;144:105-118.
Title:	Terminating the criminal collaboration in pancreatic cancer: Nanoparticle-based synergistic therapy for overcoming fibroblast-induced drug resistance.
Author:	Wang, Liying\|Liu, Xiangrui\|Zhou, Quan\|Sui, Meihua\|Lu, Zipeng\|Zhou, Zhuxian\|Tang, Jianbin\|Miao, Yi\|Zheng, Min\|Wang, Weilin\|Shen, Youqing
PMID:	28837958

119.
Journal:	Carcinogenesis. 2017 Oct 1;38(10):1047-1056.
Title:	Sanguinarine inhibits pancreatic cancer stem cell characteristics by inducing oxidative stress and suppressing sonic hedgehog-Gli-Nanog pathway.
Author:	Ma, Yiming\|Yu, Wei\|Shrivastava, Anju\|Alemi, Farzad\|Lankachandra, Kamani\|Srivastava, Rakesh K\|Shankar, Sharmila
PMID:	28968696

120.
Journal:	Cancer Lett. 2018 Apr 10;419:103-115.
Title:	Palmatine suppresses glutamine-mediated interaction between pancreatic cancer and stellate cells through simultaneous inhibition of survivin and COL1A1.
Author:	Chakravarthy, Divya\|Munoz, Amanda R\|Su, Angel\|Hwang, Rosa F\|Keppler, Brian R\|Chan, Daniel E\|Halff, Glenn\|Ghosh, Rita\|Kumar, Addanki P
PMID:	29414301

121.
Journal:	Int J Oncol. 2018 Sep 26.
Title:	Overexpression of Gremlin 1 by sonic hedgehog signaling promotes pancreatic cancer progression.
Author:	Yu, Yongtian\|Cheng, Liang\|Yan, Bin\|Zhou, Cancan\|Qian, Weikun\|Xiao, Ying\|Qin, Tao\|Cao, Junyu\|Han, Liang\|Ma, Qingyong\|Ma, Jiguang
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122.
Journal:	Oncogene. 2018 Oct 31. pii: 10.1038/s41388-018-0553-0.
Title:	The role of GLI-SOX2 signaling axis for gemcitabine resistance in pancreatic cancer.
Author:	Jia, Yanfei\|Gu, Dongsheng\|Wan, Jun\|Yu, Beiqin\|Zhang, Xiaoli\|Chiorean, E Gabriela\|Wang, Yunshan\|Xie, Jingwu
PMID:	30382189