Primary Site >> Pancreatic Cancer
Gene >> GLI1
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Ref: Secretion of immunoreactive insulin and glucagon in hamsters bearing a transplantable insuloma. PMID: 190057 |
Ref: Ontogeny of the neuroglandular system revealed with HPGRF 44 antibodies in human hypothalamus. PMID: 6431308 |
Ref: Identification and characterization of rat Desert hedgehog and Indian hedgehog genes in silico. PMID: 15645142 Ref: Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells. PMID: 15753353 Ref: Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas. PMID: 15754313 Ref: Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms. PMID: 15970691 Ref: Hedgehog signaling pathway and gastric cancer. PMID: 16258256 |
Ref: Antisense Smo under the control of the PTCH1 promoter delivered by an adenoviral vector inhibits the growth of human pancreatic cancer. PMID: 16826192 Ref: Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells. PMID: 17085671 |
Ref: Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. PMID: 17332349 Ref: Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. PMID: 17353198 Ref: Sonic hedgehog signaling pathway in pancreatic cystic neoplasms and ductal adenocarcinoma. PMID: 17414057 Ref: [mRNA expression of GLI1 in pancreatic carcinoma and clinical significance thereof]. PMID: 17565866 |
Ref: Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription. PMID: 18357592 Ref: Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation. PMID: 18410405 Ref: Expression of Sonic hedgehog signaling pathway correlates with the tumorigenesis of intraductal papillary mucinous neoplasm of the pancreas. PMID: 18425375 Ref: Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer. PMID: 18515410 Ref: An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer. PMID: 18790753 Ref: SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of suppressor-of-fused in pancreatic cancer cell. PMID: 18829525 Ref: Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana. PMID: 18842418 |
Ref: Cathepsin B is a target of Hedgehog signaling in pancreatic cancer. PMID: 19004543 Ref: The expression pattern of PDX-1, SHH, Patched and Gli-1 is associated with pathological and clinical features in human pancreatic cancer. PMID: 19077462 Ref: GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. PMID: 19136624 Ref: Integrative genomic analyses on GLI1: positive regulation of GLI1 by Hedgehog-GLI, TGFbeta-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals. PMID: 19513567 Ref: Gli1 maintains cell survival by up-regulating IGFBP6 and Bcl-2 through promoter regions in parallel manner in pancreatic cancer cells. PMID: 19736394 Ref: Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. PMID: 19860666 |
Ref: Small-molecule modulators of the Sonic Hedgehog signaling pathway. PMID: 20024066 Ref: Integrative genomic analyses of CXCR4: transcriptional regulation of CXCR4 based on TGFbeta, Nodal, Activin signaling and POU5F1, FOXA2, FOXC2, FOXH1, SOX17, and GFI1 transcription factors. PMID: 20043076 Ref: Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. PMID: 20098680 Ref: Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts. PMID: 20215540 Ref: Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer. PMID: 20814245 |
Ref: GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin. PMID: 20972463 Ref: New hedgehog/GLI-signaling inhibitors from Adenium obesum. PMID: 21170436 Ref: Structural analysis of the cancer-specific promoter in mesothelin and in other genes overexpressed in cancers. PMID: 21288909 Ref: Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. PMID: 21300762 Ref: Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer. PMID: 21338440 Ref: Identification of RegIV as a novel GLI1 target gene in human pancreatic cancer. PMID: 21494603 Ref: Cyclopamine reverts acquired chemoresistance and down-regulates cancer stem cell markers in pancreatic cancer cell lines. PMID: 21630164 Ref: The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened. PMID: 21757753 Ref: Holoclone forming cells from pancreatic cancer cells enrich tumor initiating cells and represent a novel model for study of cancer stem cells. PMID: 21826251 Ref: Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PMID: 22087285 Ref: Expression of DNMT1 and DNMT3a are regulated by GLI1 in human pancreatic cancer. PMID: 22110720 Ref: Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish. PMID: 22164219 Ref: Resveratrol inhibits proliferation and induces apoptosis through the hedgehog signaling pathway in pancreatic cancer cell. PMID: 22301921 |
Ref: Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics. PMID: 21796625 Ref: A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists. PMID: 22027695 Ref: Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas. PMID: 22076568 Ref: GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells. PMID: 22086851 Ref: SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial-mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway. PMID: 22450749 Ref: Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer. PMID: 22486854 Ref: Direct histological processing of EUS biopsies enables rapid molecular biomarker analysis for interventional pancreatic cancer trials. PMID: 22487467 Ref: The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis. PMID: 22493246 Ref: Plasma Shh levels reduced in pancreatic cancer patients. PMID: 22513293 Ref: GLI1 modulates EMT in pancreatic cancer--letter. PMID: 22761339 Ref: Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer. PMID: 22859707 Ref: Genome-wide screening reveals an EMT molecular network mediated by Sonic hedgehog-Gli1 signaling in pancreatic cancer cells. PMID: 22900095 Ref: [Effects and mechanisms of combined suppression of epidermal growth factor receptor and hedgehog signaling on proliferation in pancreatic cancer cells]. PMID: 22944238 Ref: Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal. PMID: 23029396 |
Ref: Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway. PMID: 23129257 Ref: MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2. PMID: 23178452 Ref: GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. PMID: 23200667 Ref: Pharmacokinetic and pharmacodynamic modeling of hedgehog inhibitor TAK-441 for the inhibition of Gli1 messenger RNA expression and antitumor efficacy in xenografted tumor model mice. PMID: 23298863 Ref: Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation. PMID: 23482563 Ref: Curcumin reverses the epithelial-mesenchymal transition of pancreatic cancer cells by inhibiting the Hedgehog signaling pathway. PMID: 23563640 Ref: Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice. PMID: 23684930 Ref: Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1. PMID: 23762360 Ref: Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner. PMID: 23786654 Ref: Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo. PMID: 23791879 Ref: Inhibiting K-ras signaling reserves the epithelial-mesenchymal transition of pancreatic cancer cells and its mechanisms. PMID: 23803380 Ref: Nuclear expression of glioma-associated oncogene homolog 1 and nuclear factor-kappaB is associated with a poor prognosis of pancreatic cancer. PMID: 23860225 Ref: Structural and logical analysis of a comprehensive hedgehog signaling pathway to identify alternative drug targets for glioma, colon and pancreatic cancer. PMID: 23935937 Ref: Arsenic trioxide inhibits viability of pancreatic cancer stem cells in culture and in a xenograft model via binding to SHH-Gli. PMID: 23990729 Ref: GLI1 interferes with the DNA mismatch repair system in pancreatic cancer through BHLHE41-mediated suppression of MLH1. PMID: 24165159 Ref: [Correlation between Gli1 expression and clinicopathological significance in human pancreatic cancer]. PMID: 24433772 |
Ref: The clinicopathological significance and relationship of Gli1, MDM2 and p53 expression in resectable pancreatic cancer. PMID: 24289472 Ref: Metabolites in vertebrate Hedgehog signaling. PMID: 24486313 Ref: alpha-Mangostin inhibits hypoxia-driven ROS-induced PSC activation and pancreatic cancer cell invasion. PMID: 24513179 Ref: Perifosine inhibits S6K1-Gli1 signaling and enhances gemcitabine-induced anti-pancreatic cancer efficiency. PMID: 24519751 Ref: Suppression of Hedgehog signalling promotes pro-tumourigenic integrin expression and function. PMID: 24573955 Ref: The Activation of beta1-integrin by Type I Collagen Coupling with the Hedgehog Pathway Promotes the Epithelial-Mesenchymal Transition in Pancreatic Cancer. PMID: 24720337 Ref: Inactivation of the transcription factor GLI1 accelerates pancreatic cancer progression. PMID: 24737325 Ref: Sonic hedgehog expression in a rat model of chronic pancreatitis. PMID: 24782623 Ref: Copolymeric micelles for delivery of EGCG and cyclopamine to pancreatic cancer cells. PMID: 24798568 Ref: Sonic hedgehog-Gli1 signaling pathway regulates the epithelial mesenchymal transition (EMT) by mediating a new target gene, S100A4, in pancreatic cancer cells. PMID: 25072505 Ref: The transcription factor GLI1 modulates the inflammatory response during pancreatic tissue remodeling. PMID: 25104358 Ref: The Yes-associated protein controls the cell density regulation of Hedgehog signaling. PMID: 25111861 Ref: Expression of Gli1 and Wnt2B correlates with progression and clinical outcome of pancreatic cancer. PMID: 25120849 Ref: [The role of Gli1 in the invasion and migration of pancreatic cancer cells]. PMID: 25262609 Ref: Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma. PMID: 25278454 |
Ref: Phase I dose-escalation trial of the oral investigational Hedgehog signaling pathway inhibitor TAK-441 in patients with advanced solid tumors. PMID: 25501576 Ref: Biodegradable polymeric micelles encapsulated JK184 suppress tumor growth through inhibiting Hedgehog signaling pathway. PMID: 25581613 Ref: Establishment of a pancreatic cancer stem cell model using the SW1990 human pancreatic cancer cell line in nude mice. PMID: 25684468 Ref: Cyclopamine-loaded core-cross-linked polymeric micelles enhance radiation response in pancreatic cancer and pancreatic stellate cells. PMID: 25936695 Ref: Gli1 promotes transforming growth factor-beta1- and epidermal growth factor-induced epithelial to mesenchymal transition in pancreatic cancer cells. PMID: 25979438 Ref: Anthothecol-encapsulated PLGA nanoparticles inhibit pancreatic cancer stem cell growth by modulating sonic hedgehog pathway. PMID: 26199979 Ref: Crocetinic acid inhibits hedgehog signaling to inhibit pancreatic cancer stem cells. PMID: 26317547 Ref: Sonic Hedgehog-GLI Family Zinc Finger 1 Signaling Pathway Promotes the Growth and Migration of Pancreatic Cancer Cells by Regulating the Transcription of Eukaryotic Translation Initiation Factor 5A2. PMID: 26465952 Ref: Phenolic alkaloids from Menispermum dauricum inhibits BxPC-3 pancreatic cancer cells by blocking of Hedgehog signaling pathway. PMID: 26600712 |
Ref: Hypoxia but not normoxia promotes Smoothened transcription through upregulation of RBPJ and Mastermind-like 3 in pancreatic cancer. PMID: 26655998 Ref: Reduced proliferation and increased apoptosis of the SGC7901 gastric cancer cell line on exposure to GDC0449. PMID: 26676867 Ref: Nicotine induces self-renewal of pancreatic cancer stem cells via neurotransmitter-driven activation of sonic hedgehog signalling. PMID: 26689865 Ref: Resveratrol inhibits hypoxia-driven ROS-induced invasive and migratory ability of pancreatic cancer cells via suppression of the Hedgehog signaling pathway. PMID: 26707376 Ref: SHh-Gli1 signaling pathway promotes cell survival by mediating baculoviral IAP repeat-containing 3 (BIRC3) gene in pancreatic cancer cells. PMID: 26815504 Ref: Curcumin inhibits hypoxia-induced epithelialmesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway. PMID: 27035865 Ref: Regulation of GLI Underlies a Role for BET Bromodomains in Pancreatic Cancer Growth and the Tumor Microenvironment. PMID: 27169995 Ref: Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition. PMID: 27349387 Ref: A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cells. PMID: 27698879 Ref: Ski modulate the characteristics of pancreatic cancer stem cells via regulating sonic hedgehog signaling pathway. PMID: 27734340 Ref: GLI1, a master regulator of the hallmark of pancreatic cancer. PMID: 27862693 |
Ref: Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells. PMID: 26400206 Ref: Gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathway. PMID: 26988754 Ref: Inhibition of Pancreatic Cancer Cell-Induced Paracrine Hedgehog Signaling by Liver X Receptor Agonists and Oxy16, a Naturally Occurring Oxysterol. PMID: 27490478 Ref: Prometastatic mechanisms of CAF-mediated EMT regulation in pancreatic cancer cells. PMID: 27878234 Ref: Diarylheptanoids suppress proliferation of pancreatic cancer PANC-1 cells through modulating shh-Gli-FoxM1 pathway. PMID: 28258481 Ref: Sclareolide enhances gemcitabineinduced cell death through mediating the NICD and Gli1 pathways in gemcitabineresistant human pancreatic cancer. PMID: 28259943 Ref: Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer. PMID: 28490735 Ref: Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines. PMID: 28565875 Ref: Terminating the criminal collaboration in pancreatic cancer: Nanoparticle-based synergistic therapy for overcoming fibroblast-induced drug resistance. PMID: 28837958 Ref: Sanguinarine inhibits pancreatic cancer stem cell characteristics by inducing oxidative stress and suppressing sonic hedgehog-Gli-Nanog pathway. PMID: 28968696 |
Ref: Palmatine suppresses glutamine-mediated interaction between pancreatic cancer and stellate cells through simultaneous inhibition of survivin and COL1A1. PMID: 29414301 Ref: Overexpression of Gremlin 1 by sonic hedgehog signaling promotes pancreatic cancer progression. PMID: 30272371 Ref: The role of GLI-SOX2 signaling axis for gemcitabine resistance in pancreatic cancer. PMID: 30382189 |