Primary Site >> Stomach Cancer

Gene >> GKN2

Journal: Zhonghua Yi Xue Za Zhi. 2003 Jul 10;83(13):1166-8.
Title: [Down-regulated full-length novel gene GDDR and its effect on gastric cancer].
Author: Du, Jian-jun|Dou, Ke-feng|Peng, Shu-you|Wang, Wei-zhong|Wang, Zhong-hua|Xiao, Hua-sheng|Guan, Wen-xian|Liu, Ying-bin|Gao, Zhi-qing
PMID: 12921637
Journal: Zhonghua Wai Ke Za Zhi. 2005 Jan 1;43(1):10-3.
Title: [Study on novel gene GDDR related to gastric cancer].
Author: Du, Jian-jun|Dou, Ke-feng|Peng, Shu-you|Li, Jiang-tao|Wang, Wei-zhong|Guan, Wen-xian|Gao, Zhi-qing
PMID: 15774165
Journal: Biochemistry. 2005 Jun 7;44(22):7967-75.
Title: Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C.
Author: Westley, Bruce R|Griffin, S Michael|May, Felicity E B
PMID: 15924415
Journal: Cell Physiol Biochem. 2007;20(1-4):193-204.
Title: Cytokine regulation of the trefoil factor family binding protein GKN2 (GDDR/TFIZ1/blottin) in human gastrointestinal epithelial cells.
Author: Baus-Loncar, Mirela|Lubka, Maria|Pusch, Carsten M|Otto, William R|Poulsom, Richard|Blin, Nikolaus
PMID: 17595528
Journal: Clin Cancer Res. 2008 Jul 1;14(13):4161-7.
Title: Decreased expression of gastrokine 1 and the trefoil factor interacting protein TFIZ1/GKN2 in gastric cancer: influence of tumor histology and relationship to prognosis.
Author: Moss, Steven F|Lee, Jin-Woo|Sabo, Edmond|Rubin, Anna K|Rommel, John|Westley, Bruce R|May, Felicity E B|Gao, John|Meitner, Patricia A|Tavares, Rose|Resnick, Murray B
PMID: 18593995
Journal: Int J Biochem Cell Biol. 2009 Mar;41(3):632-40.
Title: The trefoil factor interacting protein TFIZ1 binds the trefoil protein TFF1 preferentially in normal gastric mucosal cells but the co-expression of these proteins is deregulated in gastric cancer.
Author: May, Felicity E B|Griffin, S Michael|Westley, Bruce R
PMID: 18722547
Journal: Gastroenterology. 2010 May;138(5):1823-35.
Title: A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of adaptive gene loss in humans.
Author: Menheniott, Trevelyan R|Peterson, Anthony J|O'Connor, Louise|Lee, Kai Syin|Kalantzis, Anastasia|Kondova, Ivanela|Bontrop, Ronald E|Bell, Katrina M|Giraud, Andrew S
PMID: 20138039
Journal: Int J Clin Exp Pathol. 2010 Nov 1;3(8):782-91.
Title: Detection of beta-catenin, gastrokine-2 and embryonic stem cell expressed ras in gastric cancers.
Author: Zhang, Fan|Tang, Jian Min|Wang, Li|Shen, Jing Ying|Zheng, Lin|Wu, Ping Ping|Zhang, Mei|Yan, Zhao Wen
PMID: 21151392
Journal: Mol Cell Biochem. 2012 Jan;359(1-2):369-74.
Title: Gastrointestinal tract specific gene GDDR inhibits the progression of gastric cancer in a TFF1 dependent manner.
Author: Chu, Guanghui|Qi, Shengbin|Yang, Guodong|Dou, Kefeng|Du, Jianjun|Lu, Zifan
PMID: 21870107
Journal: Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15;304(2):G109-21.
Title: Gastrokines: stomach-specific proteins with putative homeostatic and tumor suppressor roles.
Author: Menheniott, Trevelyan R|Kurklu, Bayzar|Giraud, Andrew S
PMID: 23154977
Journal: J Proteome Res. 2014 Jan 3;13(1):314-20.
Title: Exploring the proteomic landscape of a gastric cancer biopsy with the shotgun imaging analyzer.
Author: Aquino, Priscila Ferreira|Lima, Diogo Borges|de Saldanha da Gama Fischer, Juliana|Melani, Rafael Donadelli|Nogueira, Fabio C S|Chalub, Sidney R S|Soares, Elzalina R|Barbosa, Valmir C|Domont, Gilberto B|Carvalho, Paulo C
PMID: 24283986
Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Mar;30(3):306-8.
Title: [Expression and clinical significance of gastric dramatic down-related gene in gastric cancer and precancerous lesions].
Author: Zhao, Zhanwei|Fang, Cheng|Wang, Fei|Shuang, Jianbo|Wang, Gang|Hua, Jin|DU, Jianjun
PMID: 24606753
Journal: Virol J. 2014 Jan 24;11:12.
Title: EBNA1 binding and epigenetic regulation of gastrokine tumor suppressor genes in gastric carcinoma cells.
Author: Lu, Fang|Tempera, Italo|Lee, Hyunna T|Dewispelaere, Karen|Lieberman, Paul M
PMID: 24460791
Journal: Tumour Biol. 2014 May;35(5):4199-207.
Title: Gastrokine-2 is downregulated in gastric cancer and its restoration suppresses gastric tumorigenesis and cancer metastasis.
Author: Dai, Jin|Zhang, Ning|Wang, Jinhui|Chen, Minhu|Chen, Jie
PMID: 24408014
Journal: J Cell Physiol. 2014 Jun;229(6):762-71.
Title: GKN2 contributes to the homeostasis of gastric mucosa by inhibiting GKN1 activity.
Author: Kim, Olga|Yoon, Jung Hwan|Choi, Won Suk|Ashktorab, Hassan|Smoot, Duane T|Nam, Suk Woo|Lee, Jung Young|Park, Won Sang
PMID: 24151046
Journal: Histochem Cell Biol. 2015 Sep;144(3):281-91.
Title: Trophoblast expression dynamics of the tumor suppressor gene gastrokine 2.
Author: Fahlbusch, Fabian B|Ruebner, Matthias|Huebner, Hanna|Volkert, Gudrun|Bartunik, Hannah|Winterfeld, Ilona|Hartner, Andrea|Menendez-Castro, Carlos|Noegel, Stephanie C|Marek, Ines|Wachter, David|Schneider-Stock, Regine|Beckmann, Matthias W|Kehl, Sven|Rascher,
PMID: 26070363
Journal: Tumour Biol. 2016 Aug;37(8):10303-15.
Title: A possible role of GDDR in the development of Helicobacter pylori-associated gastric cancer.
Author: Zhao, Zhanwei|Wang, Fei|Fang, Cheng|Wang, Gang|Shuang, Jianbo|Chu, Guanghui|Hu, Sijun|Chen, Lin|Du, Jianjun
PMID: 26842925
Journal: J Clin Invest. 2016 Apr 1;126(4):1383-400.
Title: Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression.
Author: Menheniott, Trevelyan R|O'Connor, Louise|Chionh, Yok Teng|Dabritz, Jan|Scurr, Michelle|Rollo, Benjamin N|Ng, Garrett Z|Jacobs, Shelley|Catubig, Angelique|Kurklu, Bayzar|Mercer, Stephen|Minamoto, Toshinari|Ong, David E|Ferrero, Richard L|Fox, James G|Wang,
PMID: 26974160
Journal: Dig Dis Sci. 2016 Jul;61(7):1941-9.
Title: Gastrointestinal Factor GDDR Attenuates Epithelial-Mesenchymal Transition in Gastric Cancer via Inhibiting AKT Signal.
Author: Fang, Cheng|Zhang, Ziqiang|Liu, Chaoxu|Wang, Gang|Wang, Fei|Zhao, Zhanwei|Li, Wenhui|Hua, Jin|Shuang, Jianbo|Du, Jianjun
PMID: 27017226
Journal: Tumour Biol. 2016 Sep;37(9):12403-12410.
Title: Gastrokine-2 suppresses epithelial mesenchymal transition through PI3K/AKT/GSK3beta signaling in gastric cancer.
Author: Dai, Jin|Qian, Chenchen|Su, Mingli|Chen, Minhu|Chen, Jie
PMID: 27323966
Journal: Gastric Cancer. 2017 Sep;20(5):772-783.
Title: Heterodimeric interaction between GKN2 and TFF1 entails synergistic antiproliferative and pro-apoptotic effects on gastric cancer cells.
Author: Kim, Olga|Yoon, Jung Hwan|Choi, Won Suk|Ashktorab, Hassan|Smoot, Duane T|Nam, Suk Woo|Lee, Jung Young|Park, Won Sang
PMID: 28150071
Journal: Am J Transl Res. 2017 Feb 15;9(2):803-811. eCollection 2017.
Title: GKN2 increases apoptosis, reduces the proliferation and invasion ability of gastric cancer cells through down-regulating the JAK/STAT signaling pathway.
Author: Ouyang, Jun|Pan, Xiaohui|Lin, Hui|Hu, Zecheng|Xiao, Ping|Hu, Haobin
PMID: 28337309
Journal: Mol Med Rep. 2017 Dec;16(6):8673-8684.
Title: Global transcriptomewide analysis of the function of GDDR in acute gastric lesions.
Author: Zhang, Ziqiang|Zhu, Jie|Dong, Yuanqiang|Xu, Hongyuan|Jiang, Tao|Li, Wenshuai|Xu, Diannan|Shi, Liubin|Yu, Jianghong|Zhang, Jun|Du, Jianjun
PMID: 28990076