Primary Site >> Stomach Cancer

Gene >> GKN1

Journal: J Pathol. 2004 Jul;203(3):789-97.
Title: Gastrokine 1 is abundantly and specifically expressed in superficial gastric epithelium, down-regulated in gastric carcinoma, and shows high evolutionary conservation.
Author: Oien, Karin A|McGregor, Fiona|Butler, Sharlene|Ferrier, Rod K|Downie, Ian|Bryce, Steven|Burns, Sharon|Keith, W Nicol
PMID: 15221938
Journal: Mol Cancer. 2006 Dec 25;5:75.
Title: Proteomic alteration in gastic adenocarcinomas from Japanese patients.
Author: Yoshihara, Takahiro|Kadota, Yoshito|Yoshimura, Yoshiyuki|Tatano, Yutaka|Takeuchi, Naohiro|Okitsu, Hiroshi|Umemoto, Atsushi|Yamauchi, Takashi|Itoh, Kohji
PMID: 17187689
Journal: Dig Liver Dis. 2007 Feb;39(2):122-9.
Title: Gastrokine 1 expression in patients with and without Helicobacter pylori infection.
Author: Nardone, G|Rippa, E|Martin, G|Rocco, A|Siciliano, R A|Fiengo, A|Cacace, G|Malorni, A|Budillon, G|Arcari, P
PMID: 17092786
Journal: Cell Physiol Biochem. 2007;20(1-4):193-204.
Title: Cytokine regulation of the trefoil factor family binding protein GKN2 (GDDR/TFIZ1/blottin) in human gastrointestinal epithelial cells.
Author: Baus-Loncar, Mirela|Lubka, Maria|Pusch, Carsten M|Otto, William R|Poulsom, Richard|Blin, Nikolaus
PMID: 17595528
Journal: Clin Cancer Res. 2008 Jul 1;14(13):4161-7.
Title: Decreased expression of gastrokine 1 and the trefoil factor interacting protein TFIZ1/GKN2 in gastric cancer: influence of tumor histology and relationship to prognosis.
Author: Moss, Steven F|Lee, Jin-Woo|Sabo, Edmond|Rubin, Anna K|Rommel, John|Westley, Bruce R|May, Felicity E B|Gao, John|Meitner, Patricia A|Tavares, Rose|Resnick, Murray B
PMID: 18593995
Journal: Cancer Biol Ther. 2008 Dec;7(12):1890-5. Epub 2008 Dec 7.
Title: Molecular expression of Gastrokine 1 in normal mucosa and in Helicobacter pylori-related preneoplastic and neoplastic gastric lesions.
Author: Nardone, Gerardo|Martin, Giovanni|Rocco, Alba|Rippa, Emilia|La Monica, Giovanna|Caruso, Flora|Arcari, Paolo
PMID: 18927498
Journal: PLoS One. 2008;3(12):e3854.
Title: Biochemical properties of gastrokine-1 purified from chicken gizzard smooth muscle.
Author: Hnia, Karim|Notarnicola, Cecile|de Santa Barbara, Pascal|Hugon, Gerald|Rivier, Francois|Laoudj-Chenivesse, Dalila|Mornet, Dominique
PMID: 19057650
Journal: Gastroenterology. 2010 May;138(5):1823-35.
Title: A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of adaptive gene loss in humans.
Author: Menheniott, Trevelyan R|Peterson, Anthony J|O'Connor, Louise|Lee, Kai Syin|Kalantzis, Anastasia|Kondova, Ivanela|Bontrop, Ronald E|Bell, Katrina M|Giraud, Andrew S
PMID: 20138039
Journal: J Pathol. 2011 Apr;223(5):618-25.
Title: Inactivation of the Gastrokine 1 gene in gastric adenomas and carcinomas.
Author: Yoon, Jung Hwan|Song, Jae Hwi|Zhang, Cao|Jin, Meishan|Kang, Young Hwi|Nam, Suk Woo|Lee, Jung Young|Park, Won Sang
PMID: 21341273
Journal: Proteomics. 2011 Sep;11(18):3657-64.
Title: Proteomics characterization of gastrokine 1-induced growth inhibition of gastric cancer cells.
Author: Yan, Guang-Rong|Xu, Song-Hui|Tan, Zi-Lu|Yin, Xin-Feng|He, Qing-Yu
PMID: 21751384
Journal: J Cell Physiol. 2011 Oct;226(10):2571-8.
Title: Overexpression of gastrokine 1 in gastric cancer cells induces Fas-mediated apoptosis.
Author: Rippa, Emilia|La Monica, Giovanna|Allocca, Rosa|Romano, Maria Fiammetta|De Palma, Maurizio|Arcari, Paolo
PMID: 21792914
Journal: J Cancer Res Clin Oncol. 2011 Nov;137(11):1697-704.
Title: Gastrokine 1 functions as a tumor suppressor by inhibition of epithelial-mesenchymal transition in gastric cancers.
Author: Yoon, Jung Hwan|Kang, Young Hwi|Choi, Yoo Jin|Park, In Soo|Nam, Suk Woo|Lee, Jung Young|Lee, Yun Sil|Park, Won Sang
PMID: 21898090
Journal: World J Gastroenterol. 2012 Mar 21;18(11):1216-28.
Title: Proteomic analysis of gastric cancer and immunoblot validation of potential biomarkers.
Author: Kocevar, Nina|Odreman, Federico|Vindigni, Alessandro|Grazio, Snjezana Frkovic|Komel, Radovan
PMID: 22468085
Journal: Asian Pac J Cancer Prev. 2012;13(11):5897-901.
Title: Relationship between expression of gastrokine 1 and clinicopathological characteristics in gastric cancer patients.
Author: Xiao, Jiang-Wei|Chen, Jia-Hui|Ren, Ming-Yang|Tian, Xiao-Bing|Wang, Chong-Shu
PMID: 23317277
Journal: Oncol Rep. 2012 Oct;28(4):1257-62.
Title: Role of trefoil factor 1 in gastric cancer and relationship between trefoil factor 1 and gastrokine 1.
Author: Mao, Wei|Chen, Jie|Peng, Tie-Li|Yin, Xiao-Fei|Chen, Lian-Zhou|Chen, Min-Hu
PMID: 22842654
Journal: J Exp Clin Cancer Res. 2012 May 23;31:49.
Title: Downregulation of gastrokine-1 in gastric cancer tissues and restoration of its expression induced gastric cancer cells to apoptosis.
Author: Mao, Wei|Chen, Jie|Peng, Tie-Li|Yin, Xiao-Fei|Chen, Lian-Zhou|Chen, Min-Hu
PMID: 22621392
Journal: Gut. 2012 Jan;61(1):43-52.
Title: Gastrokine 1 induces senescence through p16/Rb pathway activation in gastric cancer cells.
Author: Xing, Rui|Li, Wenmei|Cui, Jiantao|Zhang, Jun|Kang, Bin|Wang, Yuan|Wang, Zhaohui|Liu, Siqi|Lu, Youyong
PMID: 21676900
Journal: Mol Biosyst. 2013 Mar;9(3):412-21.
Title: Structural characterization and biological properties of human gastrokine 1.
Author: Pavone, Luigi Michele|Del Vecchio, Pompea|Mallardo, Paolo|Altieri, Filomena|De Pasquale, Valeria|Rea, Silviana|Martucci, Nicola M|Di Stadio, Chiara Stella|Pucci, Pietro|Flagiello, Angela|Masullo, Mariorosario|Arcari, Paolo|Rippa, Emilia
PMID: 23319233
Journal: J Cell Biochem. 2013 Aug;114(8):1800-9.
Title: Gastrokine 1 regulates NF-kappaB signaling pathway and cytokine expression in gastric cancers.
Author: Yoon, Jung Hwan|Cho, Mi La|Choi, Yoo Jin|Back, Ji Yeon|Park, Mi Kyung|Lee, Suk Woo|Choi, Byung Joon|Ashktorab, Hassan|Smoot, Duane T|Nam, Suk Woo|Lee, Jung Young|Park, Won Sang
PMID: 23444260
Journal: Clin Cancer Res. 2013 Sep 1;19(17):4599-610.
Title: GKN1-miR-185-DNMT1 axis suppresses gastric carcinogenesis through regulation of epigenetic alteration and cell cycle.
Author: Yoon, Jung Hwan|Choi, Yoo Jin|Choi, Won Suk|Ashktorab, Hassan|Smoot, Duane T|Nam, Suk Woo|Lee, Jung Young|Park, Won Sang
PMID: 23846337
Journal: Placenta. 2013 Nov;34(11):1027-35.
Title: The tumor suppressor gastrokine-1 is expressed in placenta and contributes to the regulation of trophoblast migration.
Author: Fahlbusch, F B|Ruebner, M|Huebner, H|Volkert, G|Zuern, C|Thiel, F|Koch, M|Menendez-Castro, C|Wachter, D L|Hartner, A|Rascher, W
PMID: 23993393
Journal: Biochem Biophys Res Commun. 2013 Nov 1;440(4):689-95.
Title: Functional analysis of the NH2-terminal hydrophobic region and BRICHOS domain of GKN1.
Author: Yoon, Jung Hwan|Choi, Yoo Jin|Choi, Won Suk|Nam, Suk Woo|Lee, Jung Young|Park, Won Sang
PMID: 24099765
Journal: Gastric Cancer. 2014 Apr;17(2):247-54.
Title: Aberrant expression of SOX9 is associated with gastrokine 1 inactivation in gastric cancers.
Author: Choi, Yoo Jin|Song, Jae Hwi|Yoon, Jung Hwan|Choi, Won Suk|Nam, Suk Woo|Lee, Jung Young|Park, Won Sang
PMID: 23812904
Journal: World J Gastroenterol. 2014 Nov 28;20(44):16702-6.
Title: Decreased expression of gastrokine 1 in gastric mucosa of gastric cancer patients.
Author: Guo, Xiao-Yan|Dong, Lei|Qin, Bin|Jiang, Jiong|Shi, A-Meng
PMID: 25469040
Journal: Oncotarget. 2014 Nov 30;5(22):11695-708.
Title: Gastrokine 1 induces senescence and apoptosis through regulating telomere length in gastric cancer.
Author: Yoon, Jung Hwan|Seo, Ho Seok|Choi, Won Seok|Kim, Olga|Nam, Suk Woo|Lee, Jung Young|Park, Won Sang
PMID: 25344918
Journal: J Gastric Cancer. 2014 Sep;14(3):147-55.
Title: The role of gastrokine 1 in gastric cancer.
Author: Yoon, Jung Hwan|Choi, Won Suk|Kim, Olga|Park, Won Sang
PMID: 25328759
Journal: Biochimie. 2014 Nov;106:91-100.
Title: Anti-amyloidogenic property of human gastrokine 1.
Author: Altieri, Filomena|Di Stadio, Chiara Stella|Severino, Valeria|Sandomenico, Annamaria|Minopoli, Giuseppina|Miselli, Giuseppina|Di Maro, Antimo|Ruvo, Menotti|Chambery, Angela|Quagliariello, Vincenzo|Masullo, Mariorosario|Rippa, Emilia|Arcari, Paolo
PMID: 25139219
Journal: PLoS One. 2014 Jan 3;9(1):e84158.
Title: Discovery of tumor markers for gastric cancer by proteomics.
Author: Wu, Jeng-Yih|Cheng, Chun-Chia|Wang, Jaw-Yuan|Wu, Deng-Chyang|Hsieh, Jan-Sing|Lee, Shui-Cheng|Wang, Wen-Ming
PMID: 24404153
Journal: Subcell Biochem. 2014;77:137-48.
Title: Lipid hydroperoxide-derived modification of proteins in gastrointestinal tract.
Author: Naito, Yuji|Takagi, Tomohisa|Handa, Osamu|Yoshikawa, Toshikazu
PMID: 24374925
Journal: J Cell Physiol. 2014 Jun;229(6):762-71.
Title: GKN2 contributes to the homeostasis of gastric mucosa by inhibiting GKN1 activity.
Author: Kim, Olga|Yoon, Jung Hwan|Choi, Won Suk|Ashktorab, Hassan|Smoot, Duane T|Nam, Suk Woo|Lee, Jung Young|Park, Won Sang
PMID: 24151046
Journal: Virol J. 2014 Jan 24;11:12.
Title: EBNA1 binding and epigenetic regulation of gastrokine tumor suppressor genes in gastric carcinoma cells.
Author: Lu, Fang|Tempera, Italo|Lee, Hyunna T|Dewispelaere, Karen|Lieberman, Paul M
PMID: 24460791
Journal: Discov Med. 2015 Feb;19(103):65-71.
Title: GKN1 inhibits cell invasion in gastric cancer by inactivating the NF-kappaB pathway.
Author: Xing, Rui|Cui, Jian-Tao|Xia, Nan|Lu, You-Yong
PMID: 25725220
Journal: Pathol Res Pract. 2015 Aug;211(8):577-83.
Title: Ectopic expression of gastrokine 1 in gastric cancer cells up-regulates tight and adherens junction proteins network.
Author: Rippa, Emilia|Altieri, Filomena|Di Stadio, Chiara Stella|Miselli, Giuseppina|Lamberti, Annalisa|Federico, Antonella|Quagliariello, Vincenzo|Papale, Ferdinando|Guerra, Germano|Arcari, Paolo
PMID: 26008777
Journal: Histochem Cell Biol. 2015 Sep;144(3):281-91.
Title: Trophoblast expression dynamics of the tumor suppressor gene gastrokine 2.
Author: Fahlbusch, Fabian B|Ruebner, Matthias|Huebner, Hanna|Volkert, Gudrun|Bartunik, Hannah|Winterfeld, Ilona|Hartner, Andrea|Menendez-Castro, Carlos|Noegel, Stephanie C|Marek, Ines|Wachter, David|Schneider-Stock, Regine|Beckmann, Matthias W|Kehl, Sven|Rascher,
PMID: 26070363
Journal: Oncotarget. 2015 Sep 29;6(29):28425-39.
Title: NKX6.3 controls gastric differentiation and tumorigenesis.
Author: Yoon, Jung Hwan|Choi, Won Suk|Kim, Olga|Choi, Sung Sook|Lee, Eun Kyung|Nam, Suk Woo|Lee, Jung Young|Park, Won Sang
PMID: 26314965
Journal: Gastric Cancer. 2016 Apr;19(2):381-91.
Title: Gastrokine 1 inhibits gastrin-induced cell proliferation.
Author: Kim, Olga|Yoon, Jung Hwan|Choi, Won Suk|Ashktorab, Hassan|Smoot, Duane T|Nam, Suk Woo|Lee, Jung Young|Park, Won Sang
PMID: 25752269
Journal: Biochem Biophys Res Commun. 2016 Sep 30;478(4):1624-9.
Title: The E3 ligase UBR5 regulates gastric cancer cell growth by destabilizing the tumor suppressor GKN1.
Author: Yang, Min|Jiang, Nan|Cao, Qi-Wei|Ma, Mao-Qiang|Sun, Qing
PMID: 27590582
Journal: J Negat Results Biomed. 2016 Jul 25;15(1):14.
Title: Gastrokine 1 mRNA in human sera is not informative biomarker for gastric cancer.
Author: Villano, Valentina|Di Stadio, Chiara Stella|Federico, Antonella|Altieri, Filomena|Miselli, Giuseppina|De Palma, Maurizio|Rippa, Emilia|Arcari, Paolo
PMID: 27452910
Journal: Biochimie. 2016 Feb;121:151-60.
Title: AMP18 interacts with the anion exchanger SLC26A3 and enhances its expression in gastric cancer cells.
Author: Di Stadio, Chiara Stella|Altieri, Filomena|Miselli, Giuseppina|Elce, Ausilia|Severino, Valeria|Chambery, Angela|Quagliariello, Vincenzo|Villano, Valentina|de Dominicis, Gianfranco|Rippa, Emilia|Arcari, Paolo
PMID: 26700142
Journal: Gastric Cancer. 2017 Mar;20(2):274-285.
Title: Gastrokine 1 inhibits gastric cancer cell migration and invasion by downregulating RhoA expression.
Author: Yoon, Jung Hwan|Choi, Won Suk|Kim, Olga|Choi, Byung Joon|Nam, Suk Woo|Lee, Jung Young|Park, Won Sang
PMID: 27250838
Journal: Oncotarget. 2017 Mar 7;8(10):16899-16911.
Title: Epigenetic alterations of gastrokine 1 gene expression in gastric cancer.
Author: Altieri, Filomena|Di Stadio, Chiara Stella|Federico, Antonella|Miselli, Giuseppina|De Palma, Maurizio|Rippa, Emilia|Arcari, Paolo
PMID: 28129645
Journal: Biochimie. 2017 Apr;135:149-153.
Title: Role of human GKN1 on APP processing in gastric cancer.
Author: Di Stadio, Chiara Stella|Altieri, Filomena|Minopoli, Giuseppina|Miselli, Giuseppina|Rippa, Emilia|Arcari, Paolo
PMID: 28214529
Journal: Int J Oncol. 2018 Mar;52(3):955-966.
Title: Identification of significant biomarkers and pathways associated with gastric carcinogenesis by whole genome-wide expression profiling analysis.
Author: Fei, Hong-Jun|Chen, Song-Chang|Zhang, Jun-Yu|Li, Shu-Yuan|Zhang, Lan-Lan|Chen, Yi-Yao|Chang, Chun-Xin|Xu, Chen-Ming
PMID: 29328368
Journal: Gastric Cancer. 2018 Apr 27. pii: 10.1007/s10120-018-0828-8.
Title: Gastrokine 1 protein is a potential theragnostic target for gastric cancer.
Author: Yoon, Jung Hwan|Ham, In-Hye|Kim, Olga|Ashktorab, Hassan|Smoot, Duane T|Nam, Suk Woo|Lee, Jung Young|Hur, Hoon|Park, Won Sang
PMID: 29704153