Primary Site >> Colorectal Cancer

Gene >> FYN

Journal: Oncogene. 1993 Oct;8(10):2627-35.
Title: c-Yes tyrosine kinase activity in human colon carcinoma.
Author: Park, J|Meisler, A I|Cartwright, C A
PMID: 7690925
Journal: Curr Biol. 1999 Sep 23;9(18):1039-42.
Title: Ubiquitin-dependent degradation of active Src.
Author: Hakak, Y|Martin, G S
PMID: 10508617
Journal: Int J Cancer. 1999 Nov 26;83(5):579-84.
Title: Comparative tyrosine-kinase profiles in colorectal cancers: enhanced arg expression in carcinoma as compared with adenoma and normal mucosa.
Author: Chen, W S|Kung, H J|Yang, W K|Lin, W c
PMID: 10521789
Journal: J Biol Chem. 2004 Apr 30;279(18):19335-49. Epub 2004 Feb 12.
Title: Pleckstrin homology and phosphotyrosine-binding domain-dependent membrane association and tyrosine phosphorylation of Dok-4, an inhibitory adapter molecule expressed in epithelial cells.
Author: Bedirian, Arda|Baldwin, Cindy|Abe, Jun-ichi|Takano, Tomoko|Lemay, Serge
PMID: 14963042
Journal: J Cell Biol. 2004 Nov 22;167(4):687-98.
Title: Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance.
Author: Meriane, Mayya|Tcherkezian, Joseph|Webber, Christine A|Danek, Eric I|Triki, Ibtissem|McFarlane, Sarah|Bloch-Gallego, Evelyne|Lamarche-Vane, Nathalie
PMID: 15557120
Journal: Cancer Res. 2005 Feb 15;65(4):1335-42.
Title: Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior.
Author: Brunton, Valerie G|Avizienyte, Egle|Fincham, Valerie J|Serrels, Bryan|Metcalf, Chester A 3rd|Sawyer, Tomi K|Frame, Margaret C
PMID: 15735019
Journal: Cancer Res. 2007 Nov 1;67(21):10129-37.
Title: PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation.
Author: Zhu, Shudong|Bjorge, Jeffrey D|Fujita, Donald J
PMID: 17974954
Journal: Int J Cancer. 2008 May 1;122(9):1999-2007.
Title: Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi.
Author: Zheng, Xinmin|Resnick, Ross J|Shalloway, David
PMID: 18183590
Journal: Neurosignals. 2008;16(2-3):235-45.
Title: Tyrosine phosphorylation of netrin receptors in netrin-1 signaling.
Author: Ren, Xiu-Rong|Hong, Yan|Feng, Zhu|Yang, Hong-Mei|Mei, Lin|Xiong, Wen-Cheng
PMID: 18253061
Journal: J Biol Chem. 2008 Aug 15;283(33):22709-22.
Title: Potential molecular mechanism for c-Src kinase-mediated regulation of intestinal cell migration.
Author: Mathew, Sijo|George, Sudeep P|Wang, Yaohong|Siddiqui, Mohammad Rizwan|Srinivasan, Kamalakkannan|Tan, Langzhu|Khurana, Seema
PMID: 18482983
Journal: Biochim Biophys Acta. 2008 Dec;1783(12):2323-31.
Title: Early adhesion induces interaction of FAK and Fyn in lipid domains and activates raft-dependent Akt signaling in SW480 colon cancer cells.
Author: Baillat, Gilbert|Siret, Carole|Delamarre, Estelle|Luis, Jose
PMID: 18805444
Journal: Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16478-83.
Title: Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells.
Author: Baldwin, Amy|Li, Wenliang|Grace, Miranda|Pearlberg, Joseph|Harlow, Ed|Munger, Karl|Grueneberg, Dorre A
PMID: 18948598
Journal: Biol Cell. 2009 Feb;101(2):77-90.
Title: Compartmentalized DCC signalling is distinct from DCC localized to lipid rafts.
Author: Petrie, Ryan J|Zhao, Beibei|Bedford, Fiona|Lamarche-Vane, Nathalie
PMID: 18616430
Journal: Cancer Prev Res (Phila). 2011 Jul;4(7):1095-106.
Title: Endocytosis of resveratrol via lipid rafts and activation of downstream signaling pathways in cancer cells.
Author: Colin, Didier|Limagne, Emeric|Jeanningros, Sylvie|Jacquel, Arnaud|Lizard, Gerard|Athias, Anne|Gambert, Philippe|Hichami, Aziz|Latruffe, Norbert|Solary, Eric|Delmas, Dominique
PMID: 21467134
Journal: Clin Cancer Res. 2011 Sep 1;17(17):5546-52.
Title: Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors.
Author: Montero, Juan Carlos|Seoane, Samuel|Ocana, Alberto|Pandiella, Atanasio
PMID: 21670084
Journal: Cancer Sci. 2011 Feb;102(2):400-6.
Title: Cellular prion protein promotes glucose uptake through the Fyn-HIF-2alpha-Glut1 pathway to support colorectal cancer cell survival.
Author: Li, Qing-Quan|Sun, Yan-Ping|Ruan, Can-Ping|Xu, Xin-Yun|Ge, Jun-Hui|He, Jin|Xu, Zu-De|Wang, Qiang|Gao, Wen-Chao
PMID: 21265952
Journal: J Biol Chem. 2012 Aug 3;287(32):27126-38.
Title: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.
Author: Purohit, Anish A|Li, Weiquan|Qu, Chao|Dwyer, Trisha|Shao, Qiangqiang|Guan, Kun-Liang|Liu, Guofa
PMID: 22685302
Journal: Oncol Rep. 2012 Dec;28(6):2029-34.
Title: Cellular prion protein accelerates colorectal cancer metastasis via the Fyn-SP1-SATB1 axis.
Author: Wang, Qianwei|Qian, Jianming|Wang, Fangrui|Ma, Zhenyu
PMID: 22972305
Journal: Oncogene. 2013 Sep 5;32(36):4304-12.
Title: Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.
Author: Zheng, Y|Gierut, J|Wang, Z|Miao, J|Asara, J M|Tyner, A L
PMID: 23027128
Journal: Mol Cell Biol. 2013 Feb;33(4):739-51.
Title: Tyrosine phosphorylation of the Rho guanine nucleotide exchange factor Trio regulates netrin-1/DCC-mediated cortical axon outgrowth.
Author: DeGeer, Jonathan|Boudeau, Jerome|Schmidt, Susanne|Bedford, Fiona|Lamarche-Vane, Nathalie|Debant, Anne
PMID: 23230270
Journal: PLoS One. 2013 May 17;8(5):e64309.
Title: Src-mediated phosphorylation of the tyrosine phosphatase PRL-3 is required for PRL-3 promotion of Rho activation, motility and invasion.
Author: Fiordalisi, James J|Dewar, Brian J|Graves, Lee M|Madigan, James P|Cox, Adrienne D
PMID: 23691193
Journal: Ann Surg. 2014 Jul;260(1):94-102.
Title: Introducing a novel and robust technique for determining lymph node status in colorectal cancer.
Author: Hogan, John|Judge, Conor|O'Callaghan, Michael|Aziz, Amir|O'Connor, Cormac|Burke, John|Dunne, Colum|Walsh, Stewart|Kalady, Matthew|Coffey, J Calvin
PMID: 24169164
Journal: J Biol Chem. 2014 Jan 24;289(4):1917-29.
Title: Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress.
Author: Stachel, Imke|Geismann, Claudia|Aden, Konrad|Deisinger, Florian|Rosenstiel, Philip|Schreiber, Stefan|Sebens, Susanne|Arlt, Alexander|Schafer, Heiner
PMID: 24311782
Journal: Stem Cells Dev. 2014 Aug 15;23(16):1870-82.
Title: Netrin-1 induces MMP-12-dependent E-cadherin degradation via the distinct activation of PKCalpha and FAK/Fyn in promoting mesenchymal stem cell motility.
Author: Lee, Sei-Jung|Jung, Young Hyun|Oh, Sang Yub|Yong, Min Sik|Ryu, Jung Min|Han, Ho Jae
PMID: 24738865
Journal: EMBO J. 2014 Jul 1;33(13):1474-91.
Title: c-Src drives intestinal regeneration and transformation.
Author: Cordero, Julia B|Ridgway, Rachel A|Valeri, Nicola|Nixon, Colin|Frame, Margaret C|Muller, William J|Vidal, Marcos|Sansom, Owen J
PMID: 24788409
Journal: Cell. 2014 Nov 6;159(4):844-56.
Title: A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.
Author: Gujral, Taranjit S|Chan, Marina|Peshkin, Leonid|Sorger, Peter K|Kirschner, Marc W|MacBeath, Gavin
PMID: 25417160
Journal: Oncotarget. 2015 Apr 20;6(11):9476-87.
Title: Lyn modulates Claudin-2 expression and is a therapeutic target for breast cancer liver metastasis.
Author: Tabaries, Sebastien|Annis, Matthew G|Hsu, Brian E|Tam, Christine E|Savage, Paul|Park, Morag|Siegel, Peter M
PMID: 25823815
Journal: Oncol Lett. 2018 Feb;15(2):2085-2090.
Title: Fyn knockdown inhibits migration and invasion in cholangiocarcinoma through the activated AMPK/mTOR signaling pathway.
Author: Lyu, Shao-Cheng|Han, Dong-Dong|Li, Xian-Liang|Ma, Jun|Wu, Qiao|Dong, Hong-Meng|Bai, Chun|He, Qiang
PMID: 29434909
Journal: Int J Mol Med. 2018 Jul;42(1):368-380.
Title: Inflammatory genes are novel prognostic biomarkers for colorectal cancer.
Author: Jiang, Hao|Dong, Li|Gong, Fangyan|Gu, Yuping|Zhang, Henghun|Fan, Dong|Sun, Zhiguo
PMID: 29693170