Primary Site >> Colorectal Cancer
Gene >> FYN
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Ref: c-Yes tyrosine kinase activity in human colon carcinoma. PMID: 7690925 |
Ref: Ubiquitin-dependent degradation of active Src. PMID: 10508617 Ref: Comparative tyrosine-kinase profiles in colorectal cancers: enhanced arg expression in carcinoma as compared with adenoma and normal mucosa. PMID: 10521789 |
Ref: Pleckstrin homology and phosphotyrosine-binding domain-dependent membrane association and tyrosine phosphorylation of Dok-4, an inhibitory adapter molecule expressed in epithelial cells. PMID: 14963042 Ref: Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance. PMID: 15557120 |
Ref: Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior. PMID: 15735019 |
Ref: PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation. PMID: 17974954 |
Ref: Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi. PMID: 18183590 Ref: Tyrosine phosphorylation of netrin receptors in netrin-1 signaling. PMID: 18253061 Ref: Potential molecular mechanism for c-Src kinase-mediated regulation of intestinal cell migration. PMID: 18482983 Ref: Early adhesion induces interaction of FAK and Fyn in lipid domains and activates raft-dependent Akt signaling in SW480 colon cancer cells. PMID: 18805444 Ref: Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells. PMID: 18948598 |
Ref: Compartmentalized DCC signalling is distinct from DCC localized to lipid rafts. PMID: 18616430 |
Ref: Cellular prion protein promotes glucose uptake through the Fyn-HIF-2alpha-Glut1 pathway to support colorectal cancer cell survival. PMID: 21265952 Ref: Endocytosis of resveratrol via lipid rafts and activation of downstream signaling pathways in cancer cells. PMID: 21467134 Ref: Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors. PMID: 21670084 |
Ref: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. PMID: 22685302 Ref: Cellular prion protein accelerates colorectal cancer metastasis via the Fyn-SP1-SATB1 axis. PMID: 22972305 |
Ref: Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT. PMID: 23027128 Ref: Tyrosine phosphorylation of the Rho guanine nucleotide exchange factor Trio regulates netrin-1/DCC-mediated cortical axon outgrowth. PMID: 23230270 Ref: Src-mediated phosphorylation of the tyrosine phosphatase PRL-3 is required for PRL-3 promotion of Rho activation, motility and invasion. PMID: 23691193 |
Ref: Introducing a novel and robust technique for determining lymph node status in colorectal cancer. PMID: 24169164 Ref: Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress. PMID: 24311782 Ref: Netrin-1 induces MMP-12-dependent E-cadherin degradation via the distinct activation of PKCalpha and FAK/Fyn in promoting mesenchymal stem cell motility. PMID: 24738865 Ref: c-Src drives intestinal regeneration and transformation. PMID: 24788409 Ref: A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. PMID: 25417160 |
Ref: Lyn modulates Claudin-2 expression and is a therapeutic target for breast cancer liver metastasis. PMID: 25823815 |
Ref: Fyn knockdown inhibits migration and invasion in cholangiocarcinoma through the activated AMPK/mTOR signaling pathway. PMID: 29434909 Ref: Inflammatory genes are novel prognostic biomarkers for colorectal cancer. PMID: 29693170 |