Primary Site >> Colorectal Cancer

Gene >> FOXP3

Journal: J Transl Med. 2006 Dec 13;4:52.
Title: In situ analysis of FOXP3+ regulatory T cells in human colorectal cancer.
Author: Loddenkemper, Christoph|Schernus, Martin|Noutsias, Michel|Stein, Harald|Thiel, Eckhard|Nagorsen, Dirk
PMID: 17166272
Journal: Clin Cancer Res. 2006 Dec 15;12(24):7465-75.
Title: Enhancement of immunologic tumor regression by intratumoral administration of dendritic cells in combination with cryoablative tumor pretreatment and Bacillus Calmette-Guerin cell wall skeleton stimulation.
Author: Udagawa, Masaru|Kudo-Saito, Chie|Hasegawa, Go|Yano, Kazuhito|Yamamoto, Aiko|Yaguchi, Masae|Toda, Masahiro|Azuma, Ichiro|Iwai, Takehisa|Kawakami, Yutaka
PMID: 17189420
Journal: PLoS One. 2006 Dec 27;1:e129.
Title: CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer.
Author: Clarke, Sarah L|Betts, Gareth J|Plant, Andrea|Wright, Kate L|El-Shanawany, Tariq M|Harrop, Richard|Torkington, Jared|Rees, Brian I|Williams, Geraint T|Gallimore, Awen M|Godkin, Andrew J
PMID: 17205133
Journal: Cancer Res. 2007 Jan 1;67(1):227-36.
Title: Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells.
Author: Kurooka, Masayuki|Kaneda, Yasufumi
PMID: 17210703
Journal: Clin Cancer Res. 2007 Feb 1;13(3):958-64.
Title: A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy.
Author: O'Mahony, Deirdre|Morris, John C|Quinn, Cate|Gao, Wendy|Wilson, Wyndham H|Gause, Barry|Pittaluga, Stefania|Neelapu, Sattva|Brown, Margaret|Fleisher, Thomas A|Gulley, James L|Schlom, Jeffrey|Nussenblatt, Robert|Albert, Paul|Davis, Thomas A|Lowy, Israel|Pet
PMID: 17289891
Journal: Cancer Immun. 2007 Mar 28;7:7.
Title: Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients.
Author: Ling, Khoon Lin|Pratap, Sarah E|Bates, Gaynor J|Singh, Baljit|Mortensen, Neil J|George, Bruce D|Warren, Bryan F|Piris, Juan|Roncador, Giovanna|Fox, Stephen B|Banham, Alison H|Cerundolo, Vincenzo
PMID: 17388261
Journal: Cancer Immunol Immunother. 2007 Oct;56(10):1597-604.
Title: Single administration of low dose cyclophosphamide augments the antitumor effect of dendritic cell vaccine.
Author: Liu, Ji-Yan|Wu, Yang|Zhang, Xiao-Shi|Yang, Jin-Liang|Li, Hong-Li|Mao, Yong-Qiu|Wang, Yi|Cheng, Xia|Li, Yong-Qiang|Xia, Jian-Chuan|Masucci, Maria|Zeng, Yi-Xin
PMID: 17440723
Journal: Gut. 2007 Nov;56(11):1572-8. Epub 2007 Jun 12.
Title: The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer.
Author: Atreya, Imke|Schimanski, Carl C|Becker, Christoph|Wirtz, Stefan|Dornhoff, Heike|Schnurer, Elke|Berger, Martin R|Galle, Peter R|Herr, Wolfgang|Neurath, Markus F
PMID: 17566017
Journal: Carcinogenesis. 2007 Dec;28(12):2614-23. Epub 2007 Aug 27.
Title: Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma.
Author: Poutahidis, Theofilos|Haigis, Kevin M|Rao, Varada P|Nambiar, Prashant R|Taylor, Christie L|Ge, Zhongming|Watanabe, Koichiro|Davidson, Anne|Horwitz, Bruce H|Fox, James G|Erdman, Susan E
PMID: 17724375
Journal: Uirusu. 2007 Jun;57(1):19-27.
Title: [Anticancer immunotherapy using inactivated Sendai virus particles].
Author: Kurooka, Masayuki|Kaneda, Yasufumi
PMID: 18040151
Journal: J Transl Med. 2007 Nov 29;5:62.
Title: Tumor-infiltrating macrophages and dendritic cells in human colorectal cancer: relation to local regulatory T cells, systemic T-cell response against tumor-associated antigens and survival.
Author: Nagorsen, Dirk|Voigt, Sabine|Berg, Erika|Stein, Harald|Thiel, Eckhard|Loddenkemper, Christoph
PMID: 18047662
Journal: Cancer Immunol Immunother. 2008 Jun;57(6):813-21. Epub 2007 Oct 26.
Title: Regulatory T cells in colorectal cancer patients suppress anti-tumor immune activity in a COX-2 dependent manner.
Author: Yaqub, Sheraz|Henjum, Karen|Mahic, Milada|Jahnsen, Frode L|Aandahl, Einar M|Bjornbeth, Bjorn A|Tasken, Kjetil
PMID: 17962941
Journal: Gut. 2008 Jun;57(6):772-9. Epub 2007 Oct 26.
Title: High prevalence of Foxp3 and IL17 in MMR-proficient colorectal carcinomas.
Author: Le Gouvello, S|Bastuji-Garin, S|Aloulou, N|Mansour, H|Chaumette, M-T|Berrehar, F|Seikour, A|Charachon, A|Karoui, M|Leroy, K|Farcet, J-P|Sobhani, I
PMID: 17965063
Journal: Cancer Immun. 2008 Feb 29;8:5.
Title: Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tumor tissue infiltration of seemingly activated immune cells in colorectal cancer.
Author: Lonnroth, Christina|Andersson, Marianne|Arvidsson, Annette|Nordgren, Svante|Brevinge, Hans|Lagerstedt, Kristina|Lundholm, Kent
PMID: 18307280
Journal: J Transl Med. 2008 Apr 22;6:19.
Title: Foxp3 expression in human cancer cells.
Author: Karanikas, Vaios|Speletas, Matthaios|Zamanakou, Maria|Kalala, Fani|Loules, Gedeon|Kerenidi, Theodora|Barda, Angeliki K|Gourgoulianis, Konstantinos I|Germenis, Anastasios E
PMID: 18430198
Journal: Gut. 2008 Jun;57(6):725-6.
Title: Foxp3 and microsatellite stability phenotype in colorectal cancer.
Author: Loddenkemper, Christoph|Nagorsen, Dirk|Zeitz, Martin
PMID: 18477674
Journal: Cancer Immun. 2008 Jun 12;8:10.
Title: Dysregulation in immune functions is reflected in tumor cell cytotoxicity by peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients.
Author: Bose, Anamika|Chakraborty, Tathagata|Chakraborty, Krishnendu|Pal, Smarajit|Baral, Rathindranath
PMID: 18547033
Journal: Carcinogenesis. 2008 Sep;29(9):1799-806.
Title: Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis.
Author: Kotakadi, Venkata S|Jin, Yu|Hofseth, Anne B|Ying, Lei|Cui, Xiangli|Volate, Suresh|Chumanevich, Alexander|Wood, Patricia A|Price, Robert L|McNeal, Anna|Singh, Udai P|Singh, Narendra P|Nagarkatti, Mitzi|Nagarkatti, Prakash S|Matesic, Lydia E|Auclair, Karine
PMID: 18567620
Journal: Clin Cancer Res. 2008 Aug 1;14(15):4883-90.
Title: T-cell responses to survivin in cancer patients undergoing radiation therapy.
Author: Schaue, Dorthe|Comin-Anduix, Begonya|Ribas, Antoni|Zhang, Li|Goodglick, Lee|Sayre, James W|Debucquoy, Annelies|Haustermans, Karin|McBride, William H
PMID: 18676762
Journal: Infect Immun. 2008 Dec;76(12):5834-42.
Title: Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis.
Author: Watanabe, Koichiro|Rao, Varada P|Poutahidis, Theofilos|Rickman, Barry H|Ohtani, Masahiro|Xu, Shilu|Rogers, Arlin B|Ge, Zhongming|Horwitz, Bruce H|Fujioka, Toshio|Erdman, Susan E|Fox, James G
PMID: 18824539
Journal: Br J Cancer. 2008 Dec 2;99(11):1867-73.
Title: High density of FOXP3-positive T cells infiltrating colorectal cancers with microsatellite instability.
Author: Michel, S|Benner, A|Tariverdian, M|Wentzensen, N|Hoefler, P|Pommerencke, T|Grabe, N|von Knebel Doeberitz, M|Kloor, M
PMID: 18985040
Journal: Int J Colorectal Dis. 2009 Feb;24(2):151-7.
Title: High expression of Foxp3, IL-23p19 and survivin mRNA in colorectal carcinoma.
Author: Stanilov, Noyko|Miteva, Lyuba|Mintchev, Nikolay|Stanilova, Spaska
PMID: 18825388
Journal: Gut. 2009 Apr;58(4):520-9.
Title: Identification of CD8+CD25+Foxp3+ suppressive T cells in colorectal cancer tissue.
Author: Chaput, N|Louafi, S|Bardier, A|Charlotte, F|Vaillant, J-C|Menegaux, F|Rosenzwajg, M|Lemoine, F|Klatzmann, D|Taieb, J
PMID: 19022917
Journal: J Clin Oncol. 2009 Jan 10;27(2):186-92.
Title: Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer.
Author: Salama, Paul|Phillips, Michael|Grieu, Fabienne|Morris, Melinda|Zeps, Nik|Joseph, David|Platell, Cameron|Iacopetta, Barry
PMID: 19064967
Journal: Cancer Res. 2009 Jan 15;69(2):599-608.
Title: Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue.
Author: Wieczorek, Georg|Asemissen, Anne|Model, Fabian|Turbachova, Ivana|Floess, Stefan|Liebenberg, Volker|Baron, Udo|Stauch, Diana|Kotsch, Katja|Pratschke, Johann|Hamann, Alf|Loddenkemper, Christoph|Stein, Harald|Volk, Hans Dieter|Hoffmuller, Ulrich|Grutzkau, An
PMID: 19147574
Journal: Allergy. 2009 Apr;64(4):505-19.
Title: T cell-mediated immunoregulation in the gastrointestinal tract.
Author: Saurer, L|Mueller, C
PMID: 19210347
Journal: Cancer Res. 2009 May 1;69(9):3995-4000.
Title: FOXP3 defines regulatory T cells in human tumor and autoimmune disease.
Author: Kryczek, Ilona|Liu, Rebecca|Wang, Guobin|Wu, Ke|Shu, Xiaogong|Szeliga, Wojciech|Vatan, Linhua|Finlayson, Emily|Huang, Emina|Simeone, Diane|Redman, Bruce|Welling, Theodore H|Chang, Alfred|Zou, Weiping
PMID: 19383912
Journal: Int J Oncol. 2009 Jun;34(6):1533-40.
Title: Regulatory T cells actively infiltrate metastatic brain tumors.
Author: Sugihara, Adam Quasar|Rolle, Cleo E|Lesniak, Maciej S
PMID: 19424570
Journal: Gut. 2009 Jun;58(6):743-4.
Title: Critical role for CD8+FoxP3+ regulatory T cells in colon cancer immune response in humans.
Author: Sobhani, Iradj|Le Gouvello, Sabine
PMID: 19433592
Journal: Int J Oncol. 2009 Jul;35(1):167-73.
Title: Antibody-mediated FOXP3 protein therapy induces apoptosis in cancer cells in vitro and inhibits metastasis in vivo.
Author: Heinze, Emil|Baldwin, Scott|Chan, Grace|Hansen, James|Song, Jason|Clements, Douglas|Aragon, Robert|Nishimura, Robert|Reeves, Mark|Weisbart, Richard
PMID: 19513564
Journal: Cancer Sci. 2009 Jun;100(6):1112-7.
Title: Regulatory (FOXP3+) T cells as target for immune therapy of cervical intraepithelial neoplasia and cervical cancer.
Author: Loddenkemper, Christoph|Hoffmann, Corinna|Stanke, Jonas|Nagorsen, Dirk|Baron, Udo|Olek, Sven|Huehn, Jochen|Ritz, Joerg-Peter|Stein, Harald|Kaufmann, Andreas M|Schneider, Achim|Cichon, Gunter
PMID: 19514119
Journal: Gastroenterology. 2009 Oct;137(4):1270-9.
Title: Intraepithelial effector (CD3+)/regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma.
Author: Sinicrope, Frank A|Rego, Rafaela L|Ansell, Stephen M|Knutson, Keith L|Foster, Nathan R|Sargent, Daniel J
PMID: 19577568
Journal: Clin Cancer Res. 2009 Sep 15;15(18):5878-87.
Title: Association of inflammation-related and microRNA gene expression with cancer-specific mortality of colon adenocarcinoma.
Author: Schetter, Aaron J|Nguyen, Giang Huong|Bowman, Elise D|Mathe, Ewy A|Yuen, Siu Tsan|Hawkes, Jason E|Croce, Carlo M|Leung, Suet Yi|Harris, Curtis C
PMID: 19737943
Journal: J Immunol. 2009 Dec 1;183(11):7196-203.
Title: Ineffective vaccination against solid tumors can be enhanced by hematopoietic cell transplantation.
Author: Filatenkov, Alexander|Muller, Antonia M S|Tseng, William Wei-Lin|Dejbakhsh-Jones, Sussan|Winer, Daniel|Luong, Richard|Shizuru, Judith A|Engleman, Edgar G|Strober, Samuel
PMID: 19890041
Journal: Clin Cancer Res. 2009 Dec 1;15(23):7256-65.
Title: A novel synergistic combination of cyclophosphamide and gene transfer of interleukin-12 eradicates colorectal carcinoma in mice.
Author: Malvicini, Mariana|Rizzo, Miguel|Alaniz, Laura|Pinero, Federico|Garcia, Mariana|Atorrasagasti, Catalina|Aquino, Jorge B|Rozados, Viviana|Scharovsky, O Graciela|Matar, Pablo|Mazzolini, Guillermo
PMID: 19920110
Journal: World J Gastroenterol. 2009 Dec 21;15(47):5898-906.
Title: Invasive front of colorectal cancer: dynamic interface of pro-/anti-tumor factors.
Author: Zlobec, Inti|Lugli, Alessandro
PMID: 20014453
Journal: Int J Cancer. 2010 Jun 1;126(11):2635-43.
Title: High frequency of tumor-infiltrating FOXP3(+) regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients.
Author: Frey, Daniel M|Droeser, Raoul A|Viehl, Carsten T|Zlobec, Inti|Lugli, Alessandro|Zingg, Urs|Oertli, Daniel|Kettelhack, Christoph|Terracciano, Luigi|Tornillo, Luigi
PMID: 19856313
Journal: Cancer Immunol Immunother. 2010 May;59(5):653-61.
Title: Intratumoral CD8(+) T/FOXP3 (+) cell ratio is a predictive marker for survival in patients with colorectal cancer.
Author: Suzuki, Hiroyuki|Chikazawa, Nobuhito|Tasaka, Takehiko|Wada, Junji|Yamasaki, Akio|Kitaura, Yoshiki|Sozaki, Masae|Tanaka, Masao|Onishi, Hideya|Morisaki, Takashi|Katano, Mitsuo
PMID: 19908042
Journal: J Biol Chem. 2010 Mar 12;285(11):7995-8002.
Title: Foxp3 expression in p53-dependent DNA damage responses.
Author: Jung, Da-Jung|Jin, Dong-Hoon|Hong, Seung-Woo|Kim, Jee-Eun|Shin, Jae-Sik|Kim, Daejin|Cho, Byung-Joo|Hwang, Young-Il|Kang, Jae-Seung|Lee, Wang-Jae
PMID: 20075077
Journal: BMC Cancer. 2010 Mar 7;10:82.
Title: Evaluation of immunological escape mechanisms in a mouse model of colorectal liver metastases.
Author: Grimm, Martin|Gasser, Martin|Bueter, Marco|Strehl, Johanna|Wang, Johann|Nichiporuk, Ekaterina|Meyer, Detlef|Germer, Christoph T|Waaga-Gasser, Ana M|Thalheimer, Andreas
PMID: 20205946
Journal: Gut. 2010 Mar;59(3):419-20.
Title: Low Foxp3 expression in negative sentinel lymph nodes is associated with node metastases in colorectal cancer.
Author: Matera, Lina|Sandrucci, Sergio|Mussa, Antonio|Boffa, Cinzia|Castellano, Isabella|Cassoni, Paola
PMID: 20207654
Journal: J Immunother. 2010 May;33(4):435-41.
Title: Regulatory (FoxP3+) T-cell tumor infiltration is a favorable prognostic factor in advanced colon cancer patients undergoing chemo or chemoimmunotherapy.
Author: Correale, Pierpaolo|Rotundo, Maria Saveria|Del Vecchio, Maria Teresa|Remondo, Cinzia|Migali, Cristina|Ginanneschi, Chiara|Tsang, Kwong Y|Licchetta, Antonella|Mannucci, Susanna|Loiacono, Lucia|Tassone, Pierfrancesco|Francini, Guido|Tagliaferri, Pierosandro
PMID: 20386463
Journal: Clin Cancer Res. 2010 May 15;16(10):2781-91.
Title: Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals.
Author: Mitsui, Jun|Nishikawa, Hiroyoshi|Muraoka, Daisuke|Wang, Linan|Noguchi, Takuro|Sato, Eiichi|Kondo, Satoshi|Allison, James P|Sakaguchi, Shimon|Old, Lloyd J|Kato, Takuma|Shiku, Hiroshi
PMID: 20460483
Journal: Mol Cancer Ther. 2010 Jun;9(6):1788-97.
Title: Antitumor activity and immune response induction of a dual agonist of Toll-like receptors 7 and 8.
Author: Wang, Daqing|Precopio, Melissa|Lan, Tao|Yu, Dong|Tang, Jimmy X|Kandimalla, Ekambar R|Agrawal, Sudhir
PMID: 20515950
Journal: Nat Rev Clin Oncol. 2010 Jun;7(6):299.
Title: Risk factors. CD8+:FOXP3+ cell ratio is a novel survival marker for colorectal cancer.
Author: Kirk, Rebecca
PMID: 20527684
Journal: BMC Cancer. 2010 Jun 30;10:340.
Title: Putative contribution of CD56 positive cells in cetuximab treatment efficacy in first-line metastatic colorectal cancer patients.
Author: Marechal, Raphael|De Schutter, Jef|Nagy, Nathalie|Demetter, Pieter|Lemmers, Arnaud|Deviere, Jacques|Salmon, Isabelle|Tejpar, Sabine|Van Laethem, Jean-Luc
PMID: 20591136
Journal: Int J Oncol. 2010 Sep;37(3):707-18.
Title: Characterization of rectal, proximal and distal colon cancers based on clinicopathological, molecular and protein profiles.
Author: Minoo, P|Zlobec, I|Peterson, M|Terracciano, L|Lugli, A
PMID: 20664940
Journal: Cancer. 2010 Nov 15;116(22):5188-99.
Title: Clinical impact of tumor-infiltrating lymphocytes for survival in stage II colon cancer.
Author: Lee, Won-Suk|Park, Sanghui|Lee, Woo Yong|Yun, Seong Hyeon|Chun, Ho-Kyung
PMID: 20665489
Journal: Clin Cancer Res. 2010 Aug 15;16(16):4105-12.
Title: Accumulation of foxp3+ T regulatory cells in draining lymph nodes correlates with disease progression and immune suppression in colorectal cancer patients.
Author: Deng, Liufu|Zhang, Haizeng|Luan, Yan|Zhang, Jianfeng|Xing, Qiao|Dong, Shuxiao|Wu, Xiaoran|Liu, Mingyue|Wang, Shengdian
PMID: 20682706
Journal: PLoS One. 2010 Aug 10;5(8):e12070.
Title: The Mutyh base excision repair gene influences the inflammatory response in a mouse model of ulcerative colitis.
Author: Casorelli, Ida|Pannellini, Tania|De Luca, Gabriele|Degan, Paolo|Chiera, Federica|Iavarone, Ivano|Giuliani, Alessandro|Butera, Alessia|Boirivant, Monica|Musiani, Piero|Bignami, Margherita
PMID: 20706593
Journal: Cancer Res. 2010 Oct 15;70(20):7960-9.
Title: Dietary fish oil alters T lymphocyte cell populations and exacerbates disease in a mouse model of inflammatory colitis.
Author: Woodworth, Hillary L|McCaskey, Sarah J|Duriancik, David M|Clinthorne, Jonathan F|Langohr, Ingeborg M|Gardner, Elizabeth M|Fenton, Jenifer I
PMID: 20798218
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2010 Sep;13(9):661-3.
Title: [Influence of FOLFOX regimen on the immunologic function in patients with advanced colorectal cancer].
Author: Huang, Chang-xin|Li, Zhao-yang|Jiang, Yi-qian|Duan, Guang-liang|Wang, Qing-qing
PMID: 20878571
Journal: J Pathol. 2010 Dec;222(4):350-66.
Title: Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review.
Author: Nosho, Katsuhiko|Baba, Yoshifumi|Tanaka, Noriko|Shima, Kaori|Hayashi, Marika|Meyerhardt, Jeffrey A|Giovannucci, Edward|Dranoff, Glenn|Fuchs, Charles S|Ogino, Shuji
PMID: 20927778
Journal: PLoS One. 2010 Dec 10;5(12):e14282.
Title: TIA-1 cytotoxic granule-associated RNA binding protein improves the prognostic performance of CD8 in mismatch repair-proficient colorectal cancer.
Author: Zlobec, Inti|Karamitopoulou, Eva|Terracciano, Luigi|Piscuoglio, Salvatore|Iezzi, Giandomenica|Muraro, Manuele Giuseppe|Spagnoli, Giulio|Baker, Kristi|Tzankov, Alexandar|Lugli, Alessandro
PMID: 21179245
Journal: Gan To Kagaku Ryoho. 2010 Nov;37(12):2234-6.
Title: [Immunoregulatory effects of PSK on the Th1/Th2 balance and regulatory T-cells in patients with colorectal cancer].
Author: Yoshino, Shigefumi|Yoshimura, Kiyoshi|Suzuki, Nobuaki|Iida, Michihisa|Yoshida, Shin|Maeda, Yoshinari|Maeda, Kazunari|Hazama, Shoichi|Oka, Masaaki
PMID: 21224532
Journal: J Leukoc Biol. 2011 Jan;89(1):85-91.
Title: Foxp3+IL-17+ T cells promote development of cancer-initiating cells in colorectal cancer.
Author: Yang, Shaobo|Wang, Binquan|Guan, Chunying|Wu, Benyan|Cai, Changhao|Wang, Mengwei|Zhang, Binsheng|Liu, Tao|Yang, Pingchang
PMID: 20952660
Journal: Int J Cancer. 2011 Nov 15;129(10):2417-26.
Title: CD103 is a hallmark of tumor-infiltrating regulatory T cells.
Author: Anz, David|Mueller, Wolfgang|Golic, Michaela|Kunz, Wolfgang G|Rapp, Moritz|Koelzer, Viktor H|Ellermeier, Jonathan|Ellwart, Joachim W|Schnurr, Max|Bourquin, Carole|Endres, Stefan
PMID: 21207371
Journal: World J Gastroenterol. 2011 Jan 21;17(3):343-8.
Title: T-regulatory lymphocytes in peripheral blood of gastric and colorectal cancer patients.
Author: Szczepanik, Antoni M|Siedlar, Maciej|Sierzega, Marek|Goroszeniuk, Dominika|Bukowska-Strakova, Karolina|Czupryna, Antoni|Kulig, Jan
PMID: 21253393
Journal: Scand J Immunol. 2011 Jul;74(1):47-51.
Title: Colorectal cancer-derived Foxp3(+) IL-17(+) T cells suppress tumour-specific CD8+ T cells.
Author: Ma, C|Dong, X
PMID: 21352252
Journal: J Immunol. 2011 Apr 1;186(7):4388-95.
Title: IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancer.
Author: Kryczek, Ilona|Wu, Ke|Zhao, Ende|Wei, Shuang|Vatan, Linhua|Szeliga, Wojciech|Huang, Emina|Greenson, Joel|Chang, Alfred|Rolinski, Jacek|Radwan, Piotr|Fang, Jingyuan|Wang, Guobin|Zou, Weiping
PMID: 21357259
Journal: Gastroenterology. 2011 Jun;140(7):2019-30.
Title: Human colonic myofibroblasts promote expansion of CD4+ CD25high Foxp3+ regulatory T cells.
Author: Pinchuk, Irina V|Beswick, Ellen J|Saada, Jamal I|Boya, Gushyalatha|Schmitt, David|Raju, Gottumukkala S|Brenmoehl, Julia|Rogler, Gerhard|Reyes, Victor E|Powell, Don W
PMID: 21376048
Journal: Int J Colorectal Dis. 2011 Dec;26(12):1511-8.
Title: IL-23/IL-23R: potential mediator of intestinal tumor progression from adenomatous polyps to colorectal carcinoma.
Author: Lan, Feng|Zhang, Le|Wu, Junchao|Zhang, Jie|Zhang, Sen|Li, Kai|Qi, Yanyu|Lin, Ping
PMID: 21547355
Journal: PLoS One. 2011 Apr 29;6(4):e19495.
Title: Tumor-associated macrophages recruit CCR6+ regulatory T cells and promote the development of colorectal cancer via enhancing CCL20 production in mice.
Author: Liu, Jinlin|Zhang, Ning|Li, Qun|Zhang, Weiwei|Ke, Fang|Leng, Qibin|Wang, Hong|Chen, Jinfei|Wang, Honglin
PMID: 21559338
Journal: Cancer Prev Res (Phila). 2011 Aug;4(8):1198-208.
Title: Selective PGE(2) suppression inhibits colon carcinogenesis and modifies local mucosal immunity.
Author: Nakanishi, Masako|Menoret, Antoine|Tanaka, Takuji|Miyamoto, Shingo|Montrose, David C|Vella, Anthony T|Rosenberg, Daniel W
PMID: 21576350
Journal: Fam Cancer. 2011 Sep;10(3):557-65.
Title: Dendritic cell and macrophage infiltration in microsatellite-unstable and microsatellite-stable colorectal cancer.
Author: Bauer, Kathrin|Michel, Sara|Reuschenbach, Miriam|Nelius, Nina|von Knebel Doeberitz, Magnus|Kloor, Matthias
PMID: 21598004
Journal: Cancer Immunol Immunother. 2011 Jul;60(7):909-18.
Title: Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer.
Author: Ladoire, Sylvain|Martin, Francois|Ghiringhelli, Francois
PMID: 21644034
Journal: PLoS One. 2011;6(7):e22047.
Title: SPARC, FOXP3, CD8 and CD45 correlation with disease recurrence and long-term disease-free survival in colorectal cancer.
Author: Chew, Angela|Salama, Paul|Robbshaw, Anneli|Klopcic, Borut|Zeps, Nikolajs|Platell, Cameron|Lawrance, Ian C
PMID: 21818290
Journal: Cancer Res. 2011 Sep 1;71(17):5670-7.
Title: Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy.
Author: Halama, Niels|Michel, Sara|Kloor, Matthias|Zoernig, Inka|Benner, Axel|Spille, Anna|Pommerencke, Thora|von Knebel, Doeberitz Magnus|Folprecht, Gunnar|Luber, Birgit|Feyen, Nadine|Martens, Uwe M|Beckhove, Philipp|Gnjatic, Sacha|Schirmacher, Peter|Herpel, Est
PMID: 21846824
Journal: J Exp Clin Cancer Res. 2011 Aug 24;30:78.
Title: T cell subpopulations in lymph nodes may not be predictive of patient outcome in colorectal cancer.
Author: Kemp, Roslyn A|Black, Michael A|McCall, John|Yoon, Han-Seung|Phillips, Vicky|Anjomshoaa, Ahmad|Reeve, Anthony E
PMID: 21864372
Journal: Histopathology. 2011 Aug;59(2):207-15.
Title: Low expression of Granzyme B in colorectal cancer is associated with signs of early metastastic invasion.
Author: Salama, Paul|Phillips, Michael|Platell, Cameron|Iacopetta, Barry
PMID: 21884199
Journal: Clin Dev Immunol. 2011;2011:734036.
Title: Comparative approach to define increased regulatory T cells in different cancer subtypes by combined assessment of CD127 and FOXP3.
Author: Beyer, Marc|Classen, Sabine|Endl, Elmar|Kochanek, Matthias|Weihrauch, Martin R|Debey-Pascher, Svenja|Knolle, Percy A|Schultze, Joachim L
PMID: 21904560
Journal: J Clin Immunol. 2011 Dec;31(6):1095-104.
Title: Behavior of circulating CD4+CD25+Foxp3+ regulatory T cells in colon cancer patients undergoing surgery.
Author: Sellitto, Ausilia|Galizia, Gennaro|De Fanis, Umberto|Lieto, Eva|Zamboli, Anna|Orditura, Michele|De Vita, Ferdinando|Giunta, Riccardo|Lucivero, Giacomo|Romano, Ciro
PMID: 21915633
Journal: Cell Stem Cell. 2011 Oct 4;9(4):289-90.
Title: Not so lonely at the top for cancer stem cells.
Author: Zeuner, Ann|De Maria, Ruggero
PMID: 21982226
Journal: Histopathology. 2011 Sep;59(3):482-95.
Title: Characterization of the immunological microenvironment of tumour buds and its impact on prognosis in mismatch repair-proficient and -deficient colorectal cancers.
Author: Zlobec, Inti|Minoo, Parham|Terracciano, Luigi|Baker, Kristi|Lugli, Alessandro
PMID: 22034888
Journal: Anticancer Res. 2011 Dec;31(12):4569-74.
Title: Impact of chemotherapy for colorectal cancer on regulatory T-cells and tumor immunity.
Author: Maeda, Kazunari|Hazama, Shoichi|Tokuno, Kazuhisa|Kan, Shin|Maeda, Yoshinari|Watanabe, Yusaku|Kamei, Ryoji|Shindo, Yoshitaro|Maeda, Noriko|Yoshimura, Kiyoshi|Yoshino, Shigefumi|Oka, Masaaki
PMID: 22199332
Journal: Coll Antropol. 2011 Sep;35 Suppl 2:65-8.
Title: Augmentation of regulatory T cells (CD4+CD25+Foxp3+) correlates with tumor stage in patients with colorectal cancer.
Author: Bacic, Dordano|Uravic, Miljenko|Bacic, Roberta|Sutic, Ivana|Petrosic, Neno
PMID: 22220406
Journal: Int J Cancer. 2012 Jun 1;130(11):2618-28.
Title: Administration of 6-gingerol greatly enhances the number of tumor-infiltrating lymphocytes in murine tumors.
Author: Ju, Seong-A|Park, Sang-Min|Lee, Yea-Sol|Bae, Jun-Hyeong|Yu, Rina|An, Won G|Suh, Jae-Hee|Kim, Byung-Sam
PMID: 21792901
Journal: Cancer Treat Rev. 2012 Aug;38(5):451-66.
Title: The role of the in situ local inflammatory response in predicting recurrence and survival in patients with primary operable colorectal cancer.
Author: Roxburgh, C S D|McMillan, D C
PMID: 21945823
Journal: Stress. 2012 Jul;15(4):403-15.
Title: Chronic psychosocial stress increases the risk for inflammation-related colon carcinogenesis in male mice.
Author: Peters, Sebastian|Grunwald, Nicole|Rummele, Petra|Endlicher, Esther|Lechner, Anja|Neumann, Inga D|Obermeier, Florian|Reber, Stefan O
PMID: 22044139
Journal: Clin Cancer Res. 2012 Feb 1;18(3):850-7.
Title: Tumor infiltration by T lymphocytes expressing chemokine receptor 7 (CCR7) is predictive of favorable outcome in patients with advanced colorectal carcinoma.
Author: Correale, Pierpaolo|Rotundo, Maria Saveria|Botta, Cirino|Del Vecchio, Maria Teresa|Ginanneschi, Chiara|Licchetta, Antonella|Conca, Raffaele|Apollinari, Serena|De Luca, Fabio|Tassone, Pierfrancesco|Tagliaferri, Pierosandro
PMID: 22142823
Journal: Gut. 2012 Aug;61(8):1163-71.
Title: Suppression of tumour-specific CD4(+) T cells by regulatory T cells is associated with progression of human colorectal cancer.
Author: Betts, Gareth|Jones, Emma|Junaid, Syed|El-Shanawany, Tariq|Scurr, Martin|Mizen, Paul|Kumar, Mayur|Jones, Sion|Rees, Brian|Williams, Geraint|Gallimore, Awen|Godkin, Andrew
PMID: 22207629
Journal: PLoS One. 2012;7(1):e30422.
Title: In vivo expansion of naive CD4+ CD25(high) FOXP3+ regulatory T cells in patients with colorectal carcinoma after IL-2 administration.
Author: Beyer, Marc|Schumak, Beatrix|Weihrauch, Martin R|Andres, Bettina|Giese, Thomas|Endl, Elmar|Knolle, Percy A|Classen, Sabine|Limmer, Andreas|Schultze, Joachim L
PMID: 22276195
Journal: PLoS One. 2012;7(2):e30695.
Title: Accumulation of CCR4(+)CTLA-4 FOXP3(+)CD25(hi) regulatory T cells in colon adenocarcinomas correlate to reduced activation of conventional T cells.
Author: Svensson, Helena|Olofsson, Veronica|Lundin, Samuel|Yakkala, Chakradhar|Bjorck, Stellan|Borjesson, Lars|Gustavsson, Bengt|Quiding-Jarbrink, Marianne
PMID: 22319577
Journal: World J Gastroenterol. 2012 Mar 7;18(9):971-8.
Title: B7-H1 expression is associated with expansion of regulatory T cells in colorectal carcinoma.
Author: Hua, Dong|Sun, Jing|Mao, Yong|Chen, Lu-Jun|Wu, Yu-Yu|Zhang, Xue-Guang
PMID: 22408358
Journal: Semin Cancer Biol. 2012 Aug;22(4):327-34.
Title: What are regulatory T cells (Treg) regulating in cancer and why?
Author: Whiteside, Theresa L
PMID: 22465232
Journal: J Immunotoxicol. 2012 Oct-Dec;9(4):368-73.
Title: In vitro selective depletion of CD4(+)CD25(+) regulatory T-cells from PBMC using anti-tac-SAP.
Author: Akbari, Akbar|Rezaei, Abbas
PMID: 22506556
Journal: Clin Cancer Res. 2012 Jun 1;18(11):3022-9.
Title: The prognostic value of FoxP3+ tumor-infiltrating lymphocytes in cancer: a critical review of the literature.
Author: deLeeuw, Ronald J|Kost, Sara E|Kakal, Juzer A|Nelson, Brad H
PMID: 22510350
Journal: Radiother Oncol. 2012 Jul;104(1):131-8.
Title: Circulating regulatory T cells of cancer patients receiving radiochemotherapy may be useful to individualize cancer treatment.
Author: Schmidt, Manuel A|Fortsch, Claudia|Schmidt, Manfred|Rau, Tilman T|Fietkau, Rainer|Distel, Luitpold V
PMID: 22682747
Journal: J Clin Pathol. 2012 Nov;65(11):996-1002.
Title: Prognostic impact of beta-2-microglobulin expression in colorectal cancers stratified by mismatch repair status.
Author: Koelzer, Viktor Hendrik|Baker, Kristi|Kassahn, Daniela|Baumhoer, Daniel|Zlobec, Inti
PMID: 22859396
Journal: PLoS One. 2012;7(8):e42274.
Title: Prognostic impact of FoxP3+ regulatory T cells in relation to CD8+ T lymphocyte density in human colon carcinomas.
Author: Yoon, Harry H|Orrock, Jared M|Foster, Nathan R|Sargent, Daniel J|Smyrk, Thomas C|Sinicrope, Frank A
PMID: 22879926
Journal: Oncoimmunology. 2012 Aug 1;1(5):593-599.
Title: Sequential metastases of colorectal cancer: Immunophenotypes and spatial distributions of infiltrating immune cells in relation to time and treatments.
Author: Keim, Sophia|Zoernig, Inka|Spille, Anna|Lahrmann, Bernd|Brand, Karsten|Herpel, Esther|Grabe, Niels|Jager, Dirk|Halama, Niels
PMID: 22934251
Journal: Cell Immunol. 2012 Sep;279(1):21-4.
Title: T cell subsets and colorectal cancer: discerning the good from the bad.
Author: Scurr, Martin|Gallimore, Awen|Godkin, Andrew
PMID: 23041206
Journal: Rozhl Chir. 2012 Aug;91(8):427-32.
Title: [K-ras mutational status and tumour-infiltrating lymphocytes in human colon cancer: state of the art and future perspectives].
Author: Kocian, P|Sedivcova, M|Drgac, J|Cerna, K|Hoch, J|Kodet, R|Bartunkova, J|Spisek, R|Fialova, A
PMID: 23153426
Journal: World J Gastroenterol. 2012 Oct 28;18(40):5688-94.
Title: Regulatory T cells in inflammatory bowel diseases and colorectal cancer.
Author: Muzes, Gyorgyi|Molnar, Bela|Sipos, Ferenc
PMID: 23155308
Journal: Sci Transl Med. 2012 Dec 12;4(164):164fs44.
Title: Treg cells in cancer: a case of multiple personality disorder.
Author: Bos, Paula D|Rudensky, Alexander Y
PMID: 23241741
Journal: Sci Transl Med. 2012 Dec 12;4(164):164ra159.
Title: Expression of RORgammat marks a pathogenic regulatory T cell subset in human colon cancer.
Author: Blatner, Nichole R|Mulcahy, Mary F|Dennis, Kristen L|Scholtens, Denise|Bentrem, David J|Phillips, Joseph D|Ham, Soo|Sandall, Barry P|Khan, Mohammad W|Mahvi, David M|Halverson, Amy L|Stryker, Steven J|Boller, Anne-Marie|Singal, Ashima|Sneed, Rebekka K|Sarr
PMID: 23241743
Journal: World J Gastroenterol. 2012 Dec 21;18(47):6865-73.
Title: Role of nuclear receptor NR4A2 in gastrointestinal inflammation and cancers.
Author: Han, Yi-Fang|Cao, Guang-Wen
PMID: 23322982
Journal: Cancer Microenviron. 2013 Apr;6(1):31-9.
Title: FoxP3- and CD8-positive Infiltrating Immune Cells Together Determine Clinical Outcome in Colorectal Cancer.
Author: Zeestraten, Eliane C M|Van Hoesel, Anneke Q|Speetjens, Frank M|Menon, Anand G|Putter, Hein|van de Velde, Cornelis J H|Kuppen, Peter J K
PMID: 21732187
Journal: Int J Cancer. 2013 Mar 15;132(6):1341-50.
Title: Activated but not resting regulatory T cells accumulated in tumor microenvironment and correlated with tumor progression in patients with colorectal cancer.
Author: Lin, Yung-Chang|Mahalingam, Jayashri|Chiang, Jy-Ming|Su, Po-Jung|Chu, Yu-Yi|Lai, Hsin-Yi|Fang, Jian-He|Huang, Ching-Tai|Chiu, Cheng-Tang|Lin, Chun-Yen
PMID: 22907255
Journal: Hepatology. 2013 Jan;57(1):183-94.
Title: Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer.
Author: Pedroza-Gonzalez, Alexander|Verhoef, Cornelis|Ijzermans, Jan N M|Peppelenbosch, Maikel P|Kwekkeboom, Jaap|Verheij, Joanne|Janssen, Harry L A|Sprengers, Dave
PMID: 22911397
Journal: Cancer Immunol Immunother. 2013 Feb;62(2):383-91.
Title: Metronomic chemotherapy with low-dose cyclophosphamide plus gemcitabine can induce anti-tumor T cell immunity in vivo.
Author: Tongu, Miki|Harashima, Nanae|Monma, Hiroyuki|Inao, Touko|Yamada, Takaya|Kawauchi, Hideyuki|Harada, Mamoru
PMID: 22926062
Journal: Int Immunol. 2013 Jan;25(1):35-44.
Title: Interplay between T(h)1 and T(h)17 effector T-cell pathways in the pathogenesis of spontaneous colitis and colon cancer in the Galphai2-deficient mouse.
Author: Gotlind, Yu-Yuan|Fritsch Fredin, Maria|Kumawat, Ashok Kumar|Strid, Hilja|Willen, Roger|Rangel, Ignacio|Bland, Paul W|Hornquist, Elisabeth Hultgren
PMID: 22962436
Journal: Int J Cancer. 2013 Apr 15;132(8):1842-50.
Title: Inflammatory and regulatory T cells contribute to a unique immune microenvironment in tumor tissue of colorectal cancer patients.
Author: Girardin, Adam|McCall, John|Black, Michael A|Edwards, Francesca|Phillips, Vicky|Taylor, Edward S|Reeve, Anthony E|Kemp, Roslyn A
PMID: 23002055
Journal: Ann Surg Oncol. 2013 Mar;20(3):946-55.
Title: Regulatory T cell infiltration predicts outcome following resection of colorectal cancer liver metastases.
Author: Katz, Steven C|Bamboat, Zubin M|Maker, Ajay V|Shia, Jinru|Pillarisetty, Venu G|Yopp, Adam C|Hedvat, Cyrus V|Gonen, Mithat|Jarnagin, William R|Fong, Yuman|D'Angelica, Michael I|DeMatteo, Ronald P
PMID: 23010736
Journal: Clin Immunol. 2013 Jan;146(1):26-33.
Title: Intratumoral FOXP3+VEGFR2+ regulatory T cells are predictive markers for recurrence and survival in patients with colorectal cancer.
Author: Suzuki, Hiroyuki|Onishi, Hideya|Morisaki, Takashi|Tanaka, Masao|Katano, Mitsuo
PMID: 23202541
Journal: PLoS One. 2013;8(1):e53630.
Title: Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer.
Author: Kim, Mia|Grimmig, Tanja|Grimm, Martin|Lazariotou, Maria|Meier, Eva|Rosenwald, Andreas|Tsaur, Igor|Blaheta, Roman|Heemann, Uwe|Germer, Christoph-Thomas|Waaga-Gasser, Ana Maria|Gasser, Martin
PMID: 23382847
Journal: Int J Cancer. 2013 Aug 15;133(4):825-34.
Title: Targeting the EP1 receptor reduces Fas ligand expression and increases the antitumor immune response in an in vivo model of colon cancer.
Author: O'Callaghan, Grace|Ryan, Aideen|Neary, Peter|O'Mahony, Caitlin|Shanahan, Fergus|Houston, Aileen
PMID: 23390011
Journal: PLoS One. 2013;8(3):e58006.
Title: Tim-3 expression defines regulatory T cells in human tumors.
Author: Yan, Jing|Zhang, Yi|Zhang, Jing-Ping|Liang, Jing|Li, Lian|Zheng, Limin
PMID: 23526963
Journal: PLoS One. 2013 Apr 15;8(4):e61001.
Title: Regulatory T lymphocytes are associated with less aggressive histologic features in microsatellite-unstable colorectal cancers.
Author: Tougeron, David|Maby, Pauline|Elie, Nicolas|Fauquembergue, Emilie|Le Pessot, Florence|Cornic, Marie|Sabourin, Jean-Christophe|Michel, Pierre|Frebourg, Thierry|Latouche, Jean-Baptiste
PMID: 23613769
Journal: Cancer Res. 2013 Jun 15;73(12):3591-603.
Title: Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors.
Author: Duraiswamy, Jaikumar|Kaluza, Karen M|Freeman, Gordon J|Coukos, George
PMID: 23633484
Journal: Carcinogenesis. 2013 Sep;34(9):2099-108.
Title: Myeloid TGF-beta signaling contributes to colitis-associated tumorigenesis in mice.
Author: Li, Jingyi|Liu, Yun|Wang, Boshi|Xu, Yingqian|Ma, Aihui|Zhang, Feng|Ge, Chao|Yang, Zhaojuan|Li, Jinjun|Liu, Yongzhong
PMID: 23695722
Journal: Clin Immunol. 2013 Aug;148(2):246-53.
Title: The role of IL-17-producing Foxp3+ CD4+ T cells in inflammatory bowel disease and colon cancer.
Author: Li, Lequn|Boussiotis, Vassiliki A
PMID: 23773923
Journal: Br J Cancer. 2013 Sep 17;109(6):1618-24.
Title: Digital pattern recognition-based image analysis quantifies immune infiltrates in distinct tissue regions of colorectal cancer and identifies a metastatic phenotype.
Author: Angell, H K|Gray, N|Womack, C|Pritchard, D I|Wilkinson, R W|Cumberbatch, M
PMID: 23963148
Journal: J Cancer Res Clin Oncol. 2013 Nov;139(11):1845-52.
Title: The appearance of Tregs in cancer nest is a promising independent risk factor in colon cancer.
Author: Xu, Wei|Liu, Hao|Song, Jun|Fu, Hai-Xiao|Qiu, Lei|Zhang, Bao-Fu|Li, Hui-Zhong|Bai, Jin|Zheng, Jun-Nian
PMID: 24005418
Journal: Br J Cancer. 2013 Oct 1;109(7):1839-47.
Title: Detailed analysis of inflammatory cell infiltration in colorectal cancer.
Author: Vayrynen, J P|Tuomisto, A|Klintrup, K|Makela, J|Karttunen, T J|Makinen, M J
PMID: 24008661
Journal: Br J Cancer. 2013 Oct 15;109(8):2207-16.
Title: The in situ local immune response, tumour senescence and proliferation in colorectal cancer.
Author: Roxburgh, C S|Richards, C H|Macdonald, A I|Powell, A G|McGlynn, L M|McMillan, D C|Horgan, P G|Edwards, J|Shiels, P G
PMID: 24022192
Journal: Pathol Res Pract. 2013 Dec;209(12):774-8.
Title: Potential role of plasmacytoid dendritic cells for FOXP3+ regulatory T cell development in human colorectal cancer and tumor draining lymph node.
Author: Gai, Xiao Dong|Song, Yang|Li, Chun|Lei, Yan Ming|Yang, Baoxue
PMID: 24080284
Journal: Korean J Pathol. 2013 Oct;47(5):443-51.
Title: Progressive Increase of Regulatory T Cells and Decrease of CD8+ T Cells and CD8+ T Cells/Regulatory T Cells Ratio during Colorectal Cancer Development.
Author: Jang, Tae Jung
PMID: 24255632
Journal: Cancer Immunol Res. 2013 Dec;1(6).
Title: Escalating regulation of 5T4-specific IFN-gamma(+) CD4(+) T cells distinguishes colorectal cancer patients from healthy controls and provides a target for in vivo therapy.
Author: Scurr, Martin|Bloom, Anja|Pembroke, Tom|Srinivasan, Rohit|Brown, Clare|Smart, Kathryn|Bridgeman, Hayley|Davies, Mike|Hargest, Rachel|Phillips, Simon|Christian, Adam|Hockey, Tom|Gallimore, Awen|Godkin, Andrew
PMID: 24409450
Journal: Biomed Rep. 2013 Mar;1(2):207-212.
Title: In situ analysis of FOXP3(+) regulatory T cells and myeloid dendritic cells in human colorectal cancer tissue and tumor-draining lymph node.
Author: Gai, Xiao-Dong|Li, Chun|Song, Yang|Lei, Yan-Ming|Yang, Bao-Xue
PMID: 24648920
Journal: Mucosal Immunol. 2014 Mar;7(2):428-39.
Title: Highly prevalent colorectal cancer-infiltrating LAP(+) Foxp3(-) T cells exhibit more potent immunosuppressive activity than Foxp3(+) regulatory T cells.
Author: Scurr, M|Ladell, K|Besneux, M|Christian, A|Hockey, T|Smart, K|Bridgeman, H|Hargest, R|Phillips, S|Davies, M|Price, D|Gallimore, A|Godkin, A
PMID: 24064667
Journal: Eur J Cancer. 2014 Jan;50(2):309-19.
Title: The clinical utility of the local inflammatory response in colorectal cancer.
Author: Richards, Colin H|Roxburgh, Campbell S D|Powell, Arfon G|Foulis, Alan K|Horgan, Paul G|McMillan, Donald C
PMID: 24103145
Journal: Br J Cancer. 2014 Jan 21;110(2):459-68.
Title: Combined analysis of HLA class I, HLA-E and HLA-G predicts prognosis in colon cancer patients.
Author: Zeestraten, E C M|Reimers, M S|Saadatmand, S|Goossens-Beumer, Ines J|Dekker, J-W T|Liefers, G J|van den Elsen, P J|van de Velde, C J H|Kuppen, P J K
PMID: 24196788
Journal: Clin Biochem. 2014 Feb;47(3):201-5.
Title: FoxP3 demethylation is increased in human colorectal cancer and rat cholangiocarcinoma tissue.
Author: Schultze, Frank Christian|Andag, Reiner|Alwahsh, Salamah Mohammad|Toncheva, Draga|Maslyankov, Svilen|Yaramov, Nikolay|von Ahsen, Nicolas|Brandhorst, Gunnar|Walson, Philip D|Oellerich, Michael|Petrova, Darinka Todorova
PMID: 24291052
Journal: Cell Immunol. 2014 Feb;287(2):100-5.
Title: Intratumoral regulatory T cells are associated with suppression of colorectal carcinoma metastasis after resection through overcoming IL-17 producing T cells.
Author: Wang, Quanrongzi|Feng, Min|Yu, Tongfu|Liu, Xisheng|Zhang, Peijian
PMID: 24487033
Journal: Br J Cancer. 2014 Mar 18;110(6):1595-605.
Title: Tumour-infiltrating inflammation and prognosis in colorectal cancer: systematic review and meta-analysis.
Author: Mei, Z|Liu, Y|Liu, C|Cui, A|Liang, Z|Wang, G|Peng, H|Cui, L|Li, C
PMID: 24504370
Journal: Ann Surg Oncol. 2014 Jun;21 Suppl 3:S414-21.
Title: CD8+ and FOXP3+ tumor-infiltrating T cells before and after chemoradiotherapy for rectal cancer.
Author: Shinto, Eiji|Hase, Kazuo|Hashiguchi, Yojiro|Sekizawa, Akinori|Ueno, Hideki|Shikina, Atsushi|Kajiwara, Yoshiki|Kobayashi, Hirotoshi|Ishiguro, Megumi|Yamamoto, Junji
PMID: 24566864
Journal: Br J Cancer. 2014 May 13;110(10):2551-9.
Title: The intratumoural subsite and relation of CD8(+) and FOXP3(+) T lymphocytes in colorectal cancer provide important prognostic clues.
Author: Ling, A|Edin, S|Wikberg, M L|Oberg, A|Palmqvist, R
PMID: 24675384
Journal: PLoS Biol. 2014 Apr 8;12(4):e1001833.
Title: CD4CD8alphaalpha lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease.
Author: Sarrabayrouse, Guillaume|Bossard, Celine|Chauvin, Joe-Marc|Jarry, Anne|Meurette, Guillaume|Quevrain, Elodie|Bridonneau, Chantal|Preisser, Laurence|Asehnoune, Karim|Labarriere, Nathalie|Altare, Frederic|Sokol, Harry|Jotereau, Francine
PMID: 24714093
Journal: Cancer Immunol Immunother. 2014 Aug;63(8):807-19.
Title: Altered chemokine production and accumulation of regulatory T cells in intestinal adenomas of APC(Min/+) mice.
Author: Akeus, Paulina|Langenes, Veronica|von Mentzer, Astrid|Yrlid, Ulf|Sjoling, Asa|Saksena, Pushpa|Raghavan, Sukanya|Quiding-Jarbrink, Marianne
PMID: 24777614
Journal: Mol Med Rep. 2014 Aug;10(2):977-82.
Title: Peripheral Foxp3+ regulatory T cells and natural killer group 2, member D expression levels in natural killer cells of patients with colorectal cancer.
Author: Shen, Yajuan|Wang, Qian|Qi, Yuanying|Cui, Bin|Zhang, Zhifen|Su, Jingran|Liu, Xiaowen|Lu, Chao|Ye, Hui|Ju, Ying|Lu, Zhiming
PMID: 24819058
Journal: PLoS One. 2014 May 14;9(5):e94376.
Title: Prognostic value of tumor-infiltrating FoxP3+ T cells in gastrointestinal cancers: a meta analysis.
Author: Huang, Yong|Liao, Huaiwei|Zhang, Yong|Yuan, Rongfa|Wang, Fengmei|Gao, Yingtang|Wang, Peng|Du, Zhi
PMID: 24827118
Journal: Cancer Immunol Res. 2014 Jun;2(6):568-80.
Title: TLR7 ligand augments GM-CSF-initiated antitumor immunity through activation of plasmacytoid dendritic cells.
Author: Narusawa, Megumi|Inoue, Hiroyuki|Sakamoto, Chika|Matsumura, Yumiko|Takahashi, Atsushi|Inoue, Tomoko|Watanabe, Ayumi|Miyamoto, Shohei|Miura, Yoshie|Hijikata, Yasuki|Tanaka, Yoshihiro|Inoue, Makoto|Takayama, Koichi|Okazaki, Toshihiko|Hasegawa, Mamoru|Nakani
PMID: 24830413
Journal: Int J Oncol. 2014 Aug;45(2):861-8.
Title: Exercise effects on polyp burden and immune markers in the ApcMin/+ mouse model of intestinal tumorigenesis.
Author: McClellan, Jamie L|Steiner, Jennifer L|Day, Stani D|Enos, Reilly T|Davis, Mark J|Singh, Udai P|Murphy, E Angela
PMID: 24859893
Journal: Cancer Res. 2014 Aug 15;74(16):4258-69.
Title: Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer.
Author: Pastille, Eva|Bardini, Katrin|Fleissner, Diana|Adamczyk, Alexandra|Frede, Annika|Wadwa, Munisch|von Smolinski, Dorthe|Kasper, Stefan|Sparwasser, Tim|Gruber, Achim D|Schuler, Martin|Sakaguchi, Shimon|Roers, Axel|Muller, Werner|Hansen, Wiebke|Buer, Jan|West
PMID: 24906621
Journal: Mol Cancer. 2014 Jun 18;13:153.
Title: Higher FOXP3-TSDR demethylation rates in adjacent normal tissues in patients with colon cancer were associated with worse survival.
Author: Zhuo, Changhua|Li, Zhiyuan|Xu, Ye|Wang, Yuwei|Li, Qingguo|Peng, Junjie|Zheng, Hongtu|Wu, Peng|Li, Bin|Cai, Sanjun
PMID: 24938080
Journal: BMC Cancer. 2014 Jul 5;14:486.
Title: Prognostic value of HLA class I, HLA-E, HLA-G and Tregs in rectal cancer: a retrospective cohort study.
Author: Reimers, Marlies S|Engels, Charla C|Putter, Hein|Morreau, Hans|Liefers, Gerrit Jan|van de Velde, Cornelis J H|Kuppen, Peter J K
PMID: 24997850
Journal: Med Oncol. 2014 Aug;31(8):82.
Title: The effect of immune microenvironment on the progression and prognosis of colorectal cancer.
Author: Chen, Jinxiang|Chen, Zihua
PMID: 25034363
Journal: Acta Histochem. 2014 Sep;116(7):1163-8.
Title: B7-H1 and B7-H4 expression in colorectal carcinoma: correlation with tumor FOXP3(+) regulatory T-cell infiltration.
Author: Zhao, Li-wei|Li, Chun|Zhang, Rui-lan|Xue, Hao-gang|Zhang, Fu-xi|Zhang, Fan|Gai, Xiao-dong
PMID: 25053455
Journal: Oncoimmunology. 2014 Jun 25;3:e29256.
Title: Characterization of an adaptive immune response in microsatellite-instable colorectal cancer.
Author: Boissiere-Michot, Florence|Lazennec, Gwendal|Frugier, Helene|Jarlier, Marta|Roca, Lise|Duffour, Jacqueline|Du Paty, Emilie|Laune, Daniel|Blanchard, France|Le Pessot, Florence|Sabourin, Jean-Christophe|Bibeau, Frederic
PMID: 25101223
Journal: Int J Clin Exp Med. 2014 Jul 15;7(7):1781-5. eCollection 2014.
Title: Presence of FOXP3(+)Treg cells is correlated with colorectal cancer progression.
Author: Liu, Zhengcai|Huang, Qike|Liu, Guangxin|Dang, Lili|Chu, Dake|Tao, Kaishan|Wang, Weizhong
PMID: 25126180
Journal: Br J Cancer. 2014 Oct 14;111(8):1581-9.
Title: Expression and DNA methylation of TNF, IFNG and FOXP3 in colorectal cancer and their prognostic significance.
Author: Ganapathi, S K|Beggs, A D|Hodgson, S V|Kumar, D
PMID: 25225903
Journal: PLoS One. 2014 Sep 30;9(9):e108554.
Title: CD4(+) T cells expressing latency-associated peptide and Foxp3 are an activated subgroup of regulatory T cells enriched in patients with colorectal cancer.
Author: Mahalingam, Jayashri|Lin, Chun-Yen|Chiang, Jy-Ming|Su, Po-Jung|Chu, Yu-Yi|Lai, Hsin-Yi|Fang, Jian-He|Huang, Ching-Tai|Lin, Yung-Chang
PMID: 25268580
Journal: Med Oncol. 2014 Dec;31(12):374.
Title: Association of FoxP3 rs3761548 polymorphism with susceptibility to colorectal cancer in the Chinese population.
Author: Chen, Lei|Yu, Qiming|Liu, Bixia|Zhu, Liming
PMID: 25416053
Journal: J Immunother Cancer. 2014 Nov 18;2(1):38.
Title: Detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities.
Author: Kovacsovics-Bankowski, Magdalena|Chisholm, Lana|Vercellini, Jonna|Tucker, Christopher G|Montler, Ryan|Haley, Daniel|Newell, Philippa|Ma, Jun|Tseng, Paul|Wolf, Ronald|Vetto, John T|Hammill, Chet|Hansen, Paul|Weinberg, Andrew D
PMID: 25436113
Journal: Ann Surg Oncol. 2015 Jan;22(1):180-6.
Title: Low infiltration of peritumoral regulatory T cells predicts worse outcome following resection of colorectal liver metastases.
Author: Nakagawa, Kazuya|Tanaka, Kuniya|Homma, Yuki|Nojiri, Kazunori|Kumamoto, Takafumi|Takeda, Kazuhisa|Endo, Itaru
PMID: 25120248
Journal: Expert Opin Ther Targets. 2015 Feb;19(2):147-61.
Title: Novel expression of Neuropilin 1 on human tumor-infiltrating lymphocytes in colorectal cancer liver metastases.
Author: Chaudhary, Belal|Elkord, Eyad
PMID: 25351619
Journal: Immunol Res. 2015 Mar;61(3):338-47.
Title: FOXP3+ Tregs: heterogeneous phenotypes and conflicting impacts on survival outcomes in patients with colorectal cancer.
Author: Zhuo, Changhua|Xu, Ye|Ying, Mingang|Li, Qingguo|Huang, Liyong|Li, Dawei|Cai, Sanjun|Li, Bin
PMID: 25608795
Journal: J Transl Med. 2015 Feb 1;13:47.
Title: Tumor-induced myeloid-derived suppressor cells promote tumor progression through oxidative metabolism in human colorectal cancer.
Author: OuYang, Li-Ying|Wu, Xiao-Jun|Ye, Shu-Biao|Zhang, Rong-Xin|Li, Ze-Lei|Liao, Wei|Pan, Zhi-Zhong|Zheng, Li-Min|Zhang, Xiao-Shi|Wang, Zhong|Li, Qing|Ma, Gang|Li, Jiang
PMID: 25638150
Journal: Tumour Biol. 2015 Jul;36(7):5407-14.
Title: Increased number of forkhead box P3+ tumor-infiltrating lymphocytes correlates with high preoperative albumin level and better survival in patients with stage II or III colorectal cancer.
Author: Wang, Dong-liang|Liu, Yan-yan|Gu, Yuan-long|Qin, Yu|Ji, Hong-fei|Wu, Li-hua|Qi, Ning|Su, Dan|Huang, Sun-hui|Zhang, Yan-qiao
PMID: 25697896
Journal: Eur J Immunol. 2015 Jun;45(6):1654-66.
Title: Treg-cell depletion promotes chemokine production and accumulation of CXCR3(+) conventional T cells in intestinal tumors.
Author: Akeus, Paulina|Langenes, Veronica|Kristensen, Jonas|von Mentzer, Astrid|Sparwasser, Tim|Raghavan, Sukanya|Quiding-Jarbrink, Marianne
PMID: 25754875
Journal: J BUON. 2015 Jan-Feb;20(1):114-9.
Title: The prognostic value of FOXP3+ T regulatory cells in colorectal cancer.
Author: Vlad, Catalin|Kubelac, Paul|Fetica, Bogdan|Vlad, Diana|Irimie, Alexandru|Achimas-Cadariu, Patriciu
PMID: 25778305
Journal: J Gastrointest Surg. 2015 Jun;19(6):999-1006.
Title: Immunoprofiling for prognostic assessment of colon cancer: a novel complement to ultrastaging.
Author: Lavotshkin, Simon|Jalas, John R|Torisu-Itakura, Hitoe|Ozao-Choy, Junko|Lee, Ji Hey|Sim, Myung Shin|Stojadinovic, Alexander|Wainberg, Zev|Bifulco, Carlo B|Fox, Bernard A|Bilchik, Anton J
PMID: 25808375
Journal: Virchows Arch. 2015 Jun;466(6):655-63.
Title: In rectal cancer, the type of desmoplastic response after preoperative chemoradiotherapy is associated with prognosis.
Author: Ueno, Hideki|Shinto, Eiji|Hashiguchi, Yojiro|Shimazaki, Hideyuki|Kajiwara, Yoshiki|Sueyama, Takahiro|Yamamoto, Junji|Hase, Kazuo
PMID: 25820417
Journal: Oncotarget. 2015 Apr 10;6(10):8261-70.
Title: Peripheral myeloid-derived suppressor and T regulatory PD-1 positive cells predict response to neoadjuvant short-course radiotherapy in rectal cancer patients.
Author: Napolitano, Maria|D'Alterio, Crescenzo|Cardone, Eleonora|Trotta, Anna Maria|Pecori, Biagio|Rega, Daniela|Pace, Ugo|Scala, Dario|Scognamiglio, Giosue|Tatangelo, Fabiana|Cacciapuoti, Carmela|Pacelli, Roberto|Delrio, Paolo|Scala, Stefania
PMID: 25823653
Journal: Carcinogenesis. 2015 May;36(5):543-52.
Title: Leukocyte mitochondrial DNA content: a novel biomarker associated with prognosis and therapeutic outcome in colorectal cancer.
Author: Qu, Falin|Chen, Yibing|Wang, Xin|He, Xianli|Ren, Tingting|Huang, Qichao|Zhang, Jing|Liu, Xiaonan|Guo, Xu|Gu, Jian|Xing, Jinliang
PMID: 25823896
Journal: Chest. 2015 Sep;148(3):711-721.
Title: Tumor Budding Correlates With the Protumor Immune Microenvironment and Is an Independent Prognostic Factor for Recurrence of Stage I Lung Adenocarcinoma.
Author: Kadota, Kyuichi|Yeh, Yi-Chen|Villena-Vargas, Jonathan|Cherkassky, Leonid|Drill, Esther N|Sima, Camelia S|Jones, David R|Travis, William D|Adusumilli, Prasad S
PMID: 25836013
Journal: Dig Dis Sci. 2015 Aug;60(8):2477-87.
Title: Systemic Analysis of Predictive Biomarkers for Recurrence in Colorectal Cancer Patients Treated with Curative Surgery.
Author: Mori, Koichiro|Toiyama, Yuji|Saigusa, Susumu|Fujikawa, Hiroyuki|Hiro, Junichiro|Kobayashi, Minako|Ohi, Masaki|Araki, Toshimitsu|Inoue, Yasuhiro|Tanaka, Koji|Mohri, Yasuhiko|Kusunoki, Masato
PMID: 25840921
Journal: Oncol Rep. 2015 Jun;33(6):2837-44.
Title: Recombinant Salmonella-based CEACAM6 and 4-1BBL vaccine enhances T-cell immunity and inhibits the development of colorectal cancer in rats: In vivo effects of vaccine containing 4-1BBL and CEACAM6.
Author: Jin, Chunhui|Liu, Yingying|Zhu, Jianhong|Xia, Tingting|Zhang, Baonan|Fei, Yajun|Ma, Bo|Ye, Jianxin|Chen, Weichang
PMID: 25872647
Journal: PLoS One. 2015 Apr 15;10(4):e0122183.
Title: Image analyzer-based assessment of tumor-infiltrating T cell subsets and their prognostic values in colorectal carcinomas.
Author: Kim, Younghoon|Bae, Jeong Mo|Li, Gang|Cho, Nam Yun|Kang, Gyeong Hoon
PMID: 25875774
Journal: Oncotarget. 2015 May 20;6(14):12763-73.
Title: The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers.
Author: Ong, Chee Wee|Chong, Pei Yi|McArt, Darragh G|Chan, Jason Yongsheng|Tan, Hwee Tong|Kumar, Alan Prem|Chung, Maxey C M|Clement, Marie-Veronique|Soong, Richie|Van Schaeybroeck, Sandra|Waugh, David J J|Johnston, Patrick G|Dunne, Philip D|Salto-Tellez, Manuel
PMID: 25906747
Journal: PLoS One. 2015 May 13;10(5):e0124612.
Title: Immune response gene expression in colorectal cancer carries distinct prognostic implications according to tissue, stage and site: a prospective retrospective translational study in the context of a hellenic cooperative oncology group randomised trial.
Author: Pentheroudakis, George|Raptou, Georgia|Kotoula, Vassiliki|Wirtz, Ralph M|Vrettou, Eleni|Karavasilis, Vasilios|Gourgioti, Georgia|Gakou, Chryssa|Syrigos, Konstantinos N|Bournakis, Evangelos|Rallis, Grigorios|Varthalitis, Ioannis|Galani, Eleni|Lazaridis, Ge
PMID: 25970543
Journal: Biochem J. 2015 Jul 15;469(2):267-78.
Title: Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions.
Author: Gurav, Ashish|Sivaprakasam, Sathish|Bhutia, Yangzom D|Boettger, Thomas|Singh, Nagendra|Ganapathy, Vadivel
PMID: 25984582
Journal: Cancer Sci. 2015 Aug;106(8):1008-15.
Title: Inhibition of indoleamine 2,3-dioxygenase 1 expression alters immune response in colon tumor microenvironment in mice.
Author: Takamatsu, Manabu|Hirata, Akihiro|Ohtaki, Hirofumi|Hoshi, Masato|Ando, Tatsuya|Ito, Hiroyasu|Hatano, Yuichiro|Tomita, Hiroyuki|Kuno, Toshiya|Saito, Kuniaki|Seishima, Mitsuru|Hara, Akira
PMID: 26033215
Journal: Cancer Immunol Immunother. 2015 Sep;64(9):1185-91.
Title: Preferential expansion of pro-inflammatory Tregs in human non-small cell lung cancer.
Author: Phillips, Joseph D|Knab, Lawrence M|Blatner, Nichole R|Haghi, Leila|DeCamp, Malcolm M|Meyerson, Shari L|Heiferman, Michael J|Heiferman, Jeffrey R|Gounari, Fotini|Bentrem, David J|Khazaie, Khashayarsha
PMID: 26047578
Journal: Cancer Res. 2015 Sep 1;75(17):3446-55.
Title: Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy.
Author: Maby, Pauline|Tougeron, David|Hamieh, Mohamad|Mlecnik, Bernhard|Kora, Hafid|Bindea, Gabriela|Angell, Helen K|Fredriksen, Tessa|Elie, Nicolas|Fauquembergue, Emilie|Drouet, Aurelie|Leprince, Jerome|Benichou, Jacques|Mauillon, Jacques|Le Pessot, Florence|Ses
PMID: 26060019
Journal: Oncotarget. 2015 Aug 14;6(23):19671-84.
Title: The MUTYH base excision repair gene protects against inflammation-associated colorectal carcinogenesis.
Author: Grasso, Francesca|Di Meo, Serena|De Luca, Gabriele|Pasquini, Luca|Rossi, Stefania|Boirivant, Monica|Biffoni, Mauro|Bignami, Margherita|Di Carlo, Emma
PMID: 26109431
Journal: Oncoimmunology. 2015 Mar 19;4(6):e1008355.
Title: Tumor-infiltrating plasmacytoid dendritic cells promote immunosuppression by Tr1 cells in human liver tumors.
Author: Pedroza-Gonzalez, Alexander|Zhou, Guoying|Vargas-Mendez, Ernesto|Boor, Patrick Pc|Mancham, Shanta|Verhoef, Cornelis|Polak, Wojciech G|Grunhagen, Dirk|Pan, Qiuwei|Janssen, Harry LA|Garcia-Romo, Gina S|Biermann, Katharina|Tjwa, Eric Ttl|IJzermans, Jan Nm|Kw
PMID: 26155417
Journal: JAMA Oncol. 2015 Aug;1(5):653-61.
Title: Fusobacterium nucleatum and T Cells in Colorectal Carcinoma.
Author: Mima, Kosuke|Sukawa, Yasutaka|Nishihara, Reiko|Qian, Zhi Rong|Yamauchi, Mai|Inamura, Kentaro|Kim, Sun A|Masuda, Atsuhiro|Nowak, Jonathan A|Nosho, Katsuhiko|Kostic, Aleksandar D|Giannakis, Marios|Watanabe, Hideo|Bullman, Susan|Milner, Danny A|Harris, Curti
PMID: 26181352
Journal: Cancer Discov. 2015 Oct;5(10):1098-109.
Title: Regulatory T-cell Response to Enterotoxigenic Bacteroides fragilis Colonization Triggers IL17-Dependent Colon Carcinogenesis.
Author: Geis, Abby L|Fan, Hongni|Wu, Xinqun|Wu, Shaoguang|Huso, David L|Wolfe, Jaime L|Sears, Cynthia L|Pardoll, Drew M|Housseau, Franck
PMID: 26201900
Journal: Transl Res. 2015 Dec;166(6):721-732.e1.
Title: Tumor-infiltrating lymphocytes, forkhead box P3, programmed death ligand-1, and cytotoxic T lymphocyte-associated antigen-4 expressions before and after neoadjuvant chemoradiation in rectal cancer.
Author: Teng, Feifei|Meng, Xiangjiao|Kong, Li|Mu, Dianbin|Zhu, Hui|Liu, Sujing|Zhang, Jianbo|Yu, Jinming
PMID: 26209749
Journal: J Natl Cancer Inst. 2015 Aug 22;107(11). pii: djv224.
Title: Treg-Mediated Immune Tolerance and the Risk of Solid Cancers: Findings From EPIC-Heidelberg.
Author: Barth, Sebastian Dietmar|Schulze, Janika Josephine|Kuhn, Tilman|Raschke, Eva|Husing, Anika|Johnson, Theron|Kaaks, Rudolf|Olek, Sven
PMID: 26298011
Journal: Int J Clin Exp Pathol. 2015 Jul 1;8(7):8227-35. eCollection 2015.
Title: High intratumoral FOXP3(+) T regulatory cell (Tregs) density is an independent good prognosticator in nodal negative colorectal cancer.
Author: Hanke, Tim|Melling, Nathaniel|Simon, Ronald|Sauter, Guido|Bokemeyer, Carsten|Lebok, Patrick|Terracciano, Luigi M|Izbicki, Jakob R|Marx, Andreas H
PMID: 26339391
Journal: Oncotarget. 2015 Aug 28;6(25):20840-50.
Title: Negative prognostic impact of regulatory T cell infiltration in surgically resected esophageal cancer post-radiochemotherapy.
Author: Vacchelli, Erika|Semeraro, Michaela|Enot, David P|Chaba, Kariman|Poirier Colame, Vichnou|Dartigues, Peggy|Perier, Aurelie|Villa, Irene|Rusakiewicz, Sylvie|Gronnier, Caroline|Goere, Diane|Mariette, Christophe|Zitvogel, Laurence|Kroemer, Guido
PMID: 26369701
Journal: Oncotarget. 2015 Nov 10;6(35):37588-99.
Title: OX40 expression enhances the prognostic significance of CD8 positive lymphocyte infiltration in colorectal cancer.
Author: Weixler, Benjamin|Cremonesi, Eleonora|Sorge, Roberto|Muraro, Manuele Giuseppe|Delko, Tarik|Nebiker, Christian A|Daster, Silvio|Governa, Valeria|Amicarella, Francesca|Soysal, Savas D|Kettelhack, Christoph|von Holzen, Urs W|Eppenberger-Castori, Serenella|Sp
PMID: 26439988
Journal: Cancer Res. 2015 Dec 15;75(24):5235-47.
Title: TNF Receptor-2 Facilitates an Immunosuppressive Microenvironment in the Liver to Promote the Colonization and Growth of Hepatic Metastases.
Author: Ham, Boram|Wang, Ni|D'Costa, Zarina|Fernandez, Maria Celia|Bourdeau, France|Auguste, Patrick|Illemann, Martin|Eefsen, Rikke Loevendahl|Hoyer-Hansen, Gunilla|Vainer, Ben|Evrard, Maximilien|Gao, Zu-Hua|Brodt, Pnina
PMID: 26483205
Journal: Oncoimmunology. 2015 May 29;4(12):e1051297.
Title: GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo.
Author: Pedroza-Gonzalez, Alexander|Zhou, Guoying|Singh, Simar Pal|Boor, Patrick Pc|Pan, Qiuwei|Grunhagen, Dirk|de Jonge, Jeroen|Tran, Tc Khe|Verhoef, Cornelis|IJzermans, Jan Nm|Janssen, Harry LA|Biermann, Katharina|Kwekkeboom, Jaap|Sprengers, Dave
PMID: 26587321
Journal: J Exp Med. 2015 Dec 14;212(13):2253-66.
Title: IKKbeta acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.
Author: Pallangyo, Charles K|Ziegler, Paul K|Greten, Florian R
PMID: 26621452
Journal: Br J Cancer. 2015 Dec 22;113(12):1677-86.
Title: Low stromal Foxp3+ regulatory T-cell density is associated with complete response to neoadjuvant chemoradiotherapy in rectal cancer.
Author: McCoy, M J|Hemmings, C|Miller, T J|Austin, S J|Bulsara, M K|Zeps, N|Nowak, A K|Lake, R A|Platell, C F
PMID: 26645238
Journal: Gut. 2016 Feb;65(2):296-304.
Title: Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status.
Author: Song, Mingyang|Nishihara, Reiko|Wang, Molin|Chan, Andrew T|Qian, Zhi Rong|Inamura, Kentaro|Zhang, Xuehong|Ng, Kimmie|Kim, Sun A|Mima, Kosuke|Sukawa, Yasutaka|Nosho, Katsuhiko|Fuchs, Charles S|Giovannucci, Edward L|Wu, Kana|Ogino, Shuji
PMID: 25591978
Journal: Cancer Immunol Res. 2016 Jan;4(1):33-40.
Title: MicroRNA MIR21 and T Cells in Colorectal Cancer.
Author: Mima, Kosuke|Nishihara, Reiko|Nowak, Jonathan A|Kim, Sun A|Song, Mingyang|Inamura, Kentaro|Sukawa, Yasutaka|Masuda, Atsuhiro|Yang, Juhong|Dou, Ruoxu|Nosho, Katsuhiko|Baba, Hideo|Giovannucci, Edward L|Bowden, Michaela|Loda, Massimo|Giannakis, Marios|Bass,
PMID: 26419959
Journal: Ann Surg Oncol. 2016 Mar;23(3):919-27.
Title: A High RORgammaT/CD3 Ratio is a Strong Prognostic Factor for Postoperative Survival in Advanced Colorectal Cancer: Analysis of Helper T Cell Lymphocytes (Th1, Th2, Th17 and Regulatory T Cells).
Author: Yoshida, Naohiro|Kinugasa, Tetsushi|Miyoshi, Hiroaki|Sato, Kensaku|Yuge, Kotaro|Ohchi, Takafumi|Fujino, Shinya|Shiraiwa, Sachiko|Katagiri, Mitsuhiro|Akagi, Yoshito|Ohshima, Koichi
PMID: 26564244
Journal: Ann Surg Oncol. 2016 Mar;23(3):826-32.
Title: A Novel Immune Marker Model Predicts Oncological Outcomes of Patients with Colorectal Cancer.
Author: Chen, Yufeng|Yuan, Ruixue|Wu, Xianrui|He, Xiaosheng|Zeng, Yang|Fan, Xinjuan|Wang, Lei|Wang, Jianping|Lan, Ping|Wu, Xiaojian
PMID: 26581202
Journal: Int J Oncol. 2016 Feb;48(2):493-505.
Title: Treatment with cyclophosphamide supported by various dendritic cell-based vaccines induces diversification in CD4(+) T cell response against MC38 colon carcinoma.
Author: Wojas-Turek, Justyna|Szczygiel, Agnieszka|Kicielinska, Jagoda|Rossowska, Joanna|Piasecki, Egbert|Pajtasz-Piasecka, Elzbieta
PMID: 26648160
Journal: Pathol Res Pract. 2016 Feb;212(2):106-12.
Title: Accumulation of FoxP3+ T regulatory cells in the tumor microenvironment of human colorectal adenomas.
Author: Hua, Wei|Yuan, Aping|Zheng, Wei|Li, Can|Cui, Jing|Pang, Zhigang|Zhang, Li|Li, Zhenfeng|Goll, Rasmus|Cui, Guanglin
PMID: 26724144
Journal: World J Gastroenterol. 2016 Jan 14;22(2):557-66.
Title: Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer.
Author: Nosho, Katsuhiko|Sukawa, Yasutaka|Adachi, Yasushi|Ito, Miki|Mitsuhashi, Kei|Kurihara, Hiroyoshi|Kanno, Shinichi|Yamamoto, Itaru|Ishigami, Keisuke|Igarashi, Hisayoshi|Maruyama, Reo|Imai, Kohzoh|Yamamoto, Hiroyuki|Shinomura, Yasuhisa
PMID: 26811607
Journal: Int J Clin Oncol. 2016 Oct;21(5):946-952.
Title: Implication of programmed cell death ligand 1 expression in tumor recurrence and prognosis in rectal cancer with neoadjuvant chemoradiotherapy.
Author: Saigusa, Susumu|Toiyama, Yuji|Tanaka, Koji|Inoue, Yasuhiro|Mori, Koichiro|Ide, Shozo|Imaoka, Hiroki|Kawamura, Mikio|Mohri, Yasuhiko|Kusunoki, Masato
PMID: 26919982
Journal: Front Oncol. 2016 Mar 7;6:50.
Title: Enrichment of Inflammatory IL-17 and TNF-alpha Secreting CD4(+) T Cells within Colorectal Tumors despite the Presence of Elevated CD39(+) T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1.
Author: Dunne, Margaret R|Ryan, Ciara|Nolan, Blathnaid|Tosetto, Miriam|Geraghty, Robert|Winter, Des C|O'Connell, P Ronan|Hyland, John M|Doherty, Glen A|Sheahan, Kieran|Ryan, Elizabeth J|Fletcher, Jean M
PMID: 27014625
Journal: Int J Cancer. 2016 Aug 15;139(4):854-68.
Title: Body mass index and risk of colorectal cancer according to tumor lymphocytic infiltrate.
Author: Hanyuda, Akiko|Ogino, Shuji|Qian, Zhi Rong|Nishihara, Reiko|Song, Mingyang|Mima, Kosuke|Inamura, Kentaro|Masugi, Yohei|Wu, Kana|Meyerhardt, Jeffrey A|Chan, Andrew T|Fuchs, Charles S|Giovannucci, Edward L|Cao, Yin
PMID: 27037951
Journal: Oncoimmunology. 2015 Nov 11;5(2):e1075692.
Title: Low density of FOXP3-positive T cells in normal colonic mucosa is related to the presence of beta2-microglobulin mutations in Lynch syndrome-associated colorectal cancer.
Author: Echterdiek, Fabian|Janikovits, Jonas|Staffa, Laura|Muller, Meike|Lahrmann, Bernd|Fruhschutz, Monika|Hartog, Benjamin|Nelius, Nina|Benner, Axel|Tariverdian, Mirjam|von Knebel Doeberitz, Magnus|Grabe, Niels|Kloor, Matthias
PMID: 27057447
Journal: Nat Med. 2016 Jun;22(6):679-84.
Title: Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers.
Author: Saito, Takuro|Nishikawa, Hiroyoshi|Wada, Hisashi|Nagano, Yuji|Sugiyama, Daisuke|Atarashi, Koji|Maeda, Yuka|Hamaguchi, Masahide|Ohkura, Naganari|Sato, Eiichi|Nagase, Hirotsugu|Nishimura, Junichi|Yamamoto, Hirofumi|Takiguchi, Shuji|Tanoue, Takeshi|Suda, Wat
PMID: 27111280
Journal: JAMA Oncol. 2016 Sep 1;2(9):1197-206.
Title: Marine omega-3 Polyunsaturated Fatty Acid Intake and Risk of Colorectal Cancer Characterized by Tumor-Infiltrating T Cells.
Author: Song, Mingyang|Nishihara, Reiko|Cao, Yin|Chun, Eunyoung|Qian, Zhi Rong|Mima, Kosuke|Inamura, Kentaro|Masugi, Yohei|Nowak, Jonathan A|Nosho, Katsuhiko|Wu, Kana|Wang, Molin|Giovannucci, Edward|Garrett, Wendy S|Fuchs, Charles S|Ogino, Shuji|Chan, Andrew T
PMID: 27148825
Journal: Adv Med Sci. 2016 Sep;61(2):306-310.
Title: The number of regulatory Foxp3+ T-cells in different stages of malignant transformation of large intestinal polyps.
Author: Rubinkiewicz, Mateusz|Migaczewski, Marcin|Hankus, Jerzy|Dembinski, Marcin|Pedziwiatr, Michal|Okon, Krzysztof|Pisarska, Magdalena|Budzynski, Andrzej
PMID: 27152766
Journal: J Am Coll Surg. 2016 Jul;223(1):134-40.
Title: Prognostic Utility of Immunoprofiling in Colon Cancer: Results from a Prospective, Multicenter Nodal Ultrastaging Trial.
Author: Flaherty, Devin C|Lavotshkin, Simon|Jalas, John R|Torisu-Itakura, Hitoe|Kirchoff, Daniel D|Sim, Myung S|Lee, Delphine J|Bilchik, Anton J
PMID: 27282965
Journal: Oncol Lett. 2016 Jun;11(6):3693-3701.
Title: FOXP3 and CEACAM6 expression and T cell infiltration in the occurrence and development of colon cancer.
Author: Liu, Yingying|Xia, Tingting|Jin, Chunhui|Gu, Dongmei|Yu, Jie|Shi, Weiqiang|Zhang, K E|Zhang, Liping|Ye, Jianxin|Li, Ling
PMID: 27284373
Journal: Med Hypotheses. 2016 Aug;93:74-6.
Title: Microsatellite instability as a predictive factor for immunotherapy in malignant melanoma.
Author: Kubecek, Ondrej|Trojanova, Petronela|Molnarova, Veronika|Kopecky, Jindrich
PMID: 27372860
Journal: PLoS One. 2016 Jul 21;11(7):e0159373.
Title: The Immune Landscapes of Polypoid and Nonpolypoid Precancerous Colorectal Lesions.
Author: Maglietta, Antonella|Maglietta, Rosalia|Staiano, Teresa|Bertoni, Ramona|Ancona, Nicola|Marra, Giancarlo|Resta, Leonardo
PMID: 27441558
Journal: Clin Exp Metastasis. 2016 Oct;33(7):727-39.
Title: Tumor-infiltrating lymphocyte subsets and tertiary lymphoid structures in pulmonary metastases from colorectal cancer.
Author: Schweiger, Thomas|Berghoff, Anna Sophie|Glogner, Christoph|Glueck, Olaf|Rajky, Orsolya|Traxler, Denise|Birner, Peter|Preusser, Matthias|Klepetko, Walter|Hoetzenecker, Konrad
PMID: 27449756
Journal: J Environ Pathol Toxicol Oncol. 2016;35(2):121-31.
Title: The Prognostic Significance of FoxP3+ T Cells and CD8+ T Cells in Colorectal Carcinomas.
Author: Argon, Asuman|Vardar, Enver|Kebat, Tulu|Erdinc, Omer|Erkan, Nazif
PMID: 27481490
Journal: Oncotarget. 2016 Sep 13;7(37):60383-60394.
Title: Spatial distribution of FoxP3+ and CD8+ tumour infiltrating T cells reflects their functional activity.
Author: Posselt, Rebecca|Erlenbach-Wunsch, Katharina|Haas, Matthias|Jessberger, Jonas|Buttner-Herold, Maike|Haderlein, Marlen|Hecht, Markus|Hartmann, Arndt|Fietkau, Rainer|Distel, Luitpold V
PMID: 27494875
Journal: Zhonghua Zhong Liu Za Zhi. 2016 Aug;38(8):596-601.
Title: [Phenotypic characteristics of LAP(+) CD4(+) T lymphocytes in colorectal cancer tissues].
Author: Zhong, W|Jiang, Z Y|Zhong, S B|Zhang, L C|Huang, J H|Zhang, S|Chen, L S|Cao, Y F
PMID: 27531479
Journal: Biomed Pharmacother. 2016 Oct;83:1247-1252.
Title: Xenogeneic cell-based vaccine therapy for colorectal cancer: Safety, association of clinical effects with vaccine-induced immune responses.
Author: Seledtsova, G V|Shishkov, A A|Kaschenko, E A|Seledtsov, V I
PMID: 27565847
Journal: Tumour Biol. 2016 Nov;37(11):14659-14666.
Title: Determination of a CD4(+)CD25(-)FoxP3(+) T cells subset in tumor-draining lymph nodes of colorectal cancer secreting IL-2 and IFN-gamma.
Author: Jafarinia, Morteza|Mehdipour, Fereshteh|Hosseini, Seyed Vahid|Ghahramani, Leila|Hosseinzadeh, Masood|Ghaderi, Abbas
PMID: 27619682
Journal: Oncoimmunology. 2016 Aug 12;5(8):e1105430.
Title: Inflammatory regulatory T cells in the microenvironments of ulcerative colitis and colon carcinoma.
Author: Kryczek, Ilona|Wang, Lin|Wu, Ke|Li, Wei|Zhao, Ende|Cui, Tracy|Wei, Shuang|Liu, Yan|Wang, Yin|Vatan, Linda|Szeliga, Wojciech|Greenson, Joel K|Rolinski, Jacek|Zgodzinski, Witold|Huang, Emina|Tao, Kaixiong|Wang, Guobin|Zou, Weiping
PMID: 27622054
Journal: Tumour Biol. 2016 Nov;37(11):15165-15173.
Title: Arsenic trioxide inhibits lung metastasis of mouse colon cancer via reducing the infiltration of regulatory T cells.
Author: Wang, Lei|Hu, Xiang|Xu, Yingxin|Liu, Zhong
PMID: 27677289
Journal: Cancer Immunol Res. 2016 Nov;4(11):927-935.
Title: MicroRNA let-7, T Cells, and Patient Survival in Colorectal Cancer.
Author: Dou, Ruoxu|Nishihara, Reiko|Cao, Yin|Hamada, Tsuyoshi|Mima, Kosuke|Masuda, Atsuhiro|Masugi, Yohei|Shi, Yan|Gu, Mancang|Li, Wanwan|da Silva, Annacarolina|Nosho, Katsuhiko|Zhang, Xuehong|Meyerhardt, Jeffrey A|Giovannucci, Edward L|Chan, Andrew T|Fuchs, Char
PMID: 27737877
Journal: J Huazhong Univ Sci Technolog Med Sci. 2016 Oct;36(5):677-682.
Title: Foxp3 expression in CD4(+)CD25(+)Foxp3(+) regulatory T cells promotes development of colorectal cancer by inhibiting tumor immunity.
Author: Zhu, Xiao-Wen|Zhu, Hai-Zhen|Zhu, You-Qing|Feng, Mao-Hui|Qi, Jian|Chen, Zhi-Fen
PMID: 27752897
Journal: Oncotarget. 2016 Dec 6;7(49):81778-81790.
Title: Immunoscore encompassing CD3+ and CD8+ T cell densities in distant metastasis is a robust prognostic marker for advanced colorectal cancer.
Author: Kwak, Yoonjin|Koh, Jiwon|Kim, Duck-Woo|Kang, Sung-Bum|Kim, Woo Ho|Lee, Hye Seung
PMID: 27835889
Journal: Cancer Res. 2016 Dec 15;76(24):7106-7117.
Title: Surface Expression of TGFbeta Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer.
Author: Metelli, Alessandra|Wu, Bill X|Fugle, Caroline W|Rachidi, Saleh|Sun, Shaoli|Zhang, Yongliang|Wu, Jennifer|Tomlinson, Stephen|Howe, Philip H|Yang, Yi|Garrett-Mayer, Elizabeth|Liu, Bei|Li, Zihai
PMID: 27913437
Journal: Gut. 2017 Aug;66(8):1463-1473.
Title: Tumour CD274 (PD-L1) expression and T cells in colorectal cancer.
Author: Masugi, Yohei|Nishihara, Reiko|Yang, Juhong|Mima, Kosuke|da Silva, Annacarolina|Shi, Yan|Inamura, Kentaro|Cao, Yin|Song, Mingyang|Nowak, Jonathan A|Liao, Xiaoyun|Nosho, Katsuhiko|Chan, Andrew T|Giannakis, Marios|Bass, Adam J|Hodi, F Stephen|Freeman, Gordo
PMID: 27196573
Journal: Clin Cancer Res. 2017 Apr 1;23(7):1698-1709.
Title: Signal Transduction and Activator of Transcription-3 (STAT3) in Patients with Colorectal Cancer: Associations with the Phenotypic Features of the Tumor and Host.
Author: Park, James H|van Wyk, Hester|McMillan, Donald C|Quinn, Jean|Clark, Jennifer|Roxburgh, Campbell S D|Horgan, Paul G|Edwards, Joanne
PMID: 27678454
Journal: J Nutr Biochem. 2017 Jan;39:126-133.
Title: Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity.
Author: Niku, Mikael|Pajari, Anne-Maria|Sarantaus, Laura|Paivarinta, Essi|Storvik, Markus|Heiman-Lindh, Anu|Suokas, Santeri|Nystrom, Minna|Mutanen, Marja
PMID: 27833053
Journal: J Clin Pathol. 2017 May;70(5):443-447.
Title: The role of lymph node size and FOXP3+ regulatory T cells in node-negative colon cancer.
Author: Markl, Bruno|Paul, Beate|Schaller, Tina|Kretsinger, Hallie|Kriening, Bernadette|Schenkirsch, Gerhard
PMID: 27879345
Journal: Cancer Gene Ther. 2017 Feb;24(2):57-63.
Title: Tumor-associated immune factors are associated with recurrence and metastasis in non-small cell lung cancer.
Author: Yan, X|Jiao, S-C|Zhang, G-Q|Guan, Y|Wang, J-L
PMID: 28084319
Journal: Cancer Immunol Immunother. 2017 Apr;66(4):515-522.
Title: Inclusion of BLIMP-1(+) effector regulatory T cells improves the Immunoscore in a cohort of New Zealand colorectal cancer patients: a pilot study.
Author: Ward-Hartstonge, Kirsten A|McCall, John L|McCulloch, Timothy R|Kamps, Ann-Kristin|Girardin, Adam|Cretney, Erika|Munro, Fran M|Kemp, Roslyn A
PMID: 28116480
Journal: Oncotarget. 2017 Mar 21;8(12):19803-19813.
Title: Tumour-infiltrating regulatory T cell density before neoadjuvant chemoradiotherapy for rectal cancer does not predict treatment response.
Author: McCoy, Melanie J|Hemmings, Chris|Anyaegbu, Chidozie C|Austin, Stephanie J|Lee-Pullen, Tracey F|Miller, Timothy J|Bulsara, Max K|Zeps, Nikolajs|Nowak, Anna K|Lake, Richard A|Platell, Cameron F
PMID: 28177891
Journal: JCI Insight. 2017 Feb 9;2(3):e91078.
Title: Diverse repetitive element RNA expression defines epigenetic and immunologic features of colon cancer.
Author: Desai, Niyati|Sajed, Dipti|Arora, Kshitij S|Solovyov, Alexander|Rajurkar, Mihir|Bledsoe, Jacob R|Sil, Srinjoy|Amri, Ramzi|Tai, Eric|MacKenzie, Olivia C|Mino-Kenudson, Mari|Aryee, Martin J|Ferrone, Cristina R|Berger, David L|Rivera, Miguel N|Greenbaum, Ben
PMID: 28194445
Journal: World J Gastroenterol. 2017 Jan 21;23(3):455-463.
Title: Role of LAP(+)CD4(+) T cells in the tumor microenvironment of colorectal cancer.
Author: Zhong, Wu|Jiang, Zhi-Yuan|Zhang, Lei|Huang, Jia-Hao|Wang, Shi-Jun|Liao, Cun|Cai, Bin|Chen, Li-Sheng|Zhang, Sen|Guo, Yun|Cao, Yun-Fei|Gao, Feng
PMID: 28210081
Journal: Ann Surg Oncol. 2017 Jul;24(7):1835-1842.
Title: Tumor-Associated Macrophage Infiltration in Colorectal Cancer Liver Metastases is Associated With Better Outcome.
Author: Cavnar, Michael J|Turcotte, Simon|Katz, Steven C|Kuk, Deborah|Gonen, Mithat|Shia, Jinru|Allen, Peter J|Balachandran, Vinod P|D'Angelica, Michael I|Kingham, T Peter|Jarnagin, William R|DeMatteo, Ronald P
PMID: 28213791
Journal: Immunol Rev. 2017 Mar;276(1):97-111.
Title: Tim-3 and its role in regulating anti-tumor immunity.
Author: Das, Madhumita|Zhu, Chen|Kuchroo, Vijay K
PMID: 28258697
Journal: Arch Immunol Ther Exp (Warsz). 2017 Oct;65(5):445-454.
Title: Tumor-Associated Macrophages and Regulatory T Cells Infiltration and the Clinical Outcome in Colorectal Cancer.
Author: Waniczek, Dariusz|Lorenc, Zbigniew|Snietura, Miroslaw|Wesecki, Mariusz|Kopec, Agnieszka|Muc-Wierzgon, Malgorzata
PMID: 28343267
Journal: Histopathology. 2017 Sep;71(3):366-374.
Title: The PD-1 expressing immune phenotype of T cell exhaustion is prominent in the 'immunoreactive' microenvironment of colorectal carcinoma.
Author: Prall, Friedrich|Huhns, Maja
PMID: 28383777
Journal: Oncoimmunology. 2017 Jan 31;6(3):e1284720.
Title: Tumor SQSTM1 (p62) expression and T cells in colorectal cancer.
Author: Kosumi, Keisuke|Masugi, Yohei|Yang, Juhong|Qian, Zhi Rong|Kim, Sun A|Li, Wanwan|Shi, Yan|da Silva, Annacarolina|Hamada, Tsuyoshi|Liu, Li|Gu, Mancang|Twombly, Tyler S|Cao, Yin|Barbie, David A|Nosho, Katsuhiko|Baba, Hideo|Garrett, Wendy S|Meyerhardt, Jeffer
PMID: 28405513
Journal: Oncoimmunology. 2017 Feb 10;6(3):e1290034.
Title: Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3(+) regulatory T cells in murine colon cancer.
Author: Chen, Xiaowei|Takemoto, Yoshihiro|Deng, Huan|Middelhoff, Moritz|Friedman, Richard A|Chu, Timothy H|Churchill, Michael J|Ma, Yan|Nagar, Karan K|Tailor, Yagnesh H|Mukherjee, Siddhartha|Wang, Timothy C
PMID: 28405523
Journal: Am J Transl Res. 2017 Apr 15;9(4):1866-1875. eCollection 2017.
Title: Curcumin up regulates T helper 1 cells in patients with colon cancer.
Author: Xu, Bin|Yu, Lin|Zhao, Li-Zhong
PMID: 28469791
Journal: Oncotarget. 2017 Jun 20;8(25):41401-41411.
Title: Trans-scirpusin A showed antitumor effects via autophagy activation and apoptosis induction of colorectal cancer cells.
Author: Hong, Eun-Hye|Heo, Eun-Young|Song, Jae-Hyoung|Kwon, Bo-Eun|Lee, Jae-Young|Park, Yaejeong|Kim, Jinwoong|Chang, Sun-Young|Chin, Young-Won|Jeon, Sang-Min|Ko, Hyun-Jeong
PMID: 28489607
Journal: Oncol Lett. 2017 May;13(5):3529-3537.
Title: KDM3A promotes inhibitory cytokines secretion by participating in TLR4 regulation of Foxp3 transcription in lung adenocarcinoma cells.
Author: Li, Yinan|Yang, Wei|Wu, Bin|Liu, Yaqing|Li, Dongbei|Guo, Yantong|Fu, Haiying|Li, Yi
PMID: 28521455
Journal: Oncol Lett. 2017 May;13(5):3753-3759.
Title: T cell immunity induced by a bivalent Salmonella-based CEACAM6 and 4-1BBL vaccines in a rat colorectal cancer model.
Author: Jin, Chunhui|Duan, Xiaoqing|Liu, Yingying|Zhu, Jianhong|Zhang, Ke|Zhang, Yuanting|Xia, Tingting|Fei, Yajun|Ye, Jianxin
PMID: 28521477
Journal: Oncol Rep. 2017 Jul;38(1):449-455.
Title: Tumor growth limited to subcutaneous site vs tumor growth in pulmonary site exhibit differential effects on systemic immunities.
Author: Masuda, Junko|Takayama, Eiji|Strober, Warren|Satoh, Ayano|Morimoto, Yuji|Honjo, Yasuko|Ichinohe, Tatsuo|Tokuno, Shin-Ichi|Ishizuka, Toshiaki|Nakata, Takahiro|Mizutani, Akifumi|Umemura, Naoki|Kitani, Atsushi|Fuss, Ivan J|Shigehiro, Tsukasa|Kawaki, Harumi|M
PMID: 28535011
Journal: Int Immunopharmacol. 2017 Aug;49:95-101.
Title: Colorectal tumors are enriched with regulatory plasmablasts with capacity in suppressing T cell inflammation.
Author: Mao, Hui|Pan, Fei|Wu, Zhiyong|Wang, Zhikuan|Zhou, Yanhua|Zhang, Pengfei|Gou, Miaomiao|Dai, Guanghai
PMID: 28558303
Journal: Int J Immunopathol Pharmacol. 2017 Jun;30(2):201-206.
Title: Expression of Foxp3 and its prognostic significance in colorectal cancer.
Author: Sun, Xiuwei|Feng, Zhanjun|Wang, Yunxuan|Qu, Yao|Gai, Yunzhu
PMID: 28560891
Journal: Oncotarget. 2017 Jul 4;8(27):44694-44704.
Title: FOXP3 inhibits cancer stem cell self-renewal via transcriptional repression of COX2 in colorectal cancer cells.
Author: Liu, Shuo|Zhang, Cun|Zhang, Kuo|Gao, Yuan|Wang, Zhaowei|Li, Xiaoju|Cheng, Guang|Wang, Shuning|Xue, Xiaochang|Li, Weina|Zhang, Wei|Zhang, Yingqi|Xing, Xianghui|Li, Meng|Hao, Qiang
PMID: 28591725
Journal: Front Immunol. 2017 May 26;8:619.
Title: Intratumoral FoxP3(+)Helios(+) Regulatory T Cells Upregulating Immunosuppressive Molecules Are Expanded in Human Colorectal Cancer.
Author: Syed Khaja, Azharuddin Sajid|Toor, Salman M|El Salhat, Haytham|Ali, Bassam R|Elkord, Eyad
PMID: 28603527
Journal: Front Immunol. 2017 May 30;8:620.
Title: Molecular Signatures of Human Regulatory T Cells in Colorectal Cancer and Polyps.
Author: Johdi, Nor Adzimah|Ait-Tahar, Kamel|Sagap, Ismail|Jamal, Rahman
PMID: 28611777
Journal: Int J Cancer. 2017 Oct 15;141(8):1654-1666.
Title: The clinical impact of tumour-infiltrating lymphocytes in colorectal cancer differs by anatomical subsite: A cohort study.
Author: Berntsson, Jonna|Svensson, Maria C|Leandersson, Karin|Nodin, Bjorn|Micke, Patrick|Larsson, Anna H|Eberhard, Jakob|Jirstrom, Karin
PMID: 28677162
Journal: Oncoimmunology. 2017 Apr 20;6(6):e1319027.
Title: Oral IL-10 suppresses colon carcinogenesis via elimination of pathogenicCD4(+) T-cells and induction of antitumor CD8(+) T-cell activity.
Author: Gu, Tao|De Jesus, Magdia|Gallagher, Heather C|Burris, Thomas P|Egilmez, Nejat K
PMID: 28680752
Journal: Inflamm Bowel Dis. 2017 Sep;23(9):1524-1534.
Title: CD103+ Dendritic Cell Function Is Altered in the Colons of Patients with Ulcerative Colitis.
Author: Matsuno, Hiroshi|Kayama, Hisako|Nishimura, Junichi|Sekido, Yuki|Osawa, Hideki|Barman, Soumik|Ogino, Takayuki|Takahashi, Hidekazu|Haraguchi, Naotsugu|Hata, Taishi|Matsuda, Chu|Yamamoto, Hirofumi|Uchino, Motoi|Ikeuchi, Hiroki|Doki, Yuichiro|Mori, Masaki|Tak
PMID: 28700533
Journal: DNA Cell Biol. 2017 Oct;36(10):870-877.
Title: CD19(lo)CD27(hi) Plasmablasts Suppress Harmful Th17 Inflammation Through Interleukin 10 Pathway in Colorectal Cancer.
Author: Mao, Hui|Pan, Fei|Wu, Zhiyong|Wang, Zhikuan|Zhou, Yanhua|Zhang, Pengfei|Gou, Miaomiao|Dai, Guanghai
PMID: 28829194
Journal: Cell Physiol Biochem. 2017;42(6):2330-2341.
Title: Bifidobacterium Infantis Ameliorates Chemotherapy-Induced Intestinal Mucositis Via Regulating T Cell Immunity in Colorectal Cancer Rats.
Author: Mi, Hui|Dong, Yan|Zhang, Bin|Wang, Haonan|Peter, Chung C K|Gao, Ping|Fu, Hong|Gao, Yajie
PMID: 28848081
Journal: Cancer Microenviron. 2017 Dec;10(1-3):69-76.
Title: Upregulation of Treg-Related Genes in Addition with IL6 Showed the Significant Role for the Distant Metastasis in Colorectal Cancer.
Author: Miteva, L D|Stanilov, N S|Cirovski, G capital EM, Cyrillic|Stanilova, Spaska Angelova
PMID: 28868572
Journal: Hum Pathol. 2017 Oct;68:193-202.
Title: Neutrophil infiltration is a favorable prognostic factor in early stages of colon cancer.
Author: Wikberg, Maria L|Ling, Agnes|Li, Xingru|Oberg, Ake|Edin, Sofia|Palmqvist, Richard
PMID: 28882699
Journal: Clin Transl Immunology. 2017 Sep 15;6(9):e154.
Title: Regulatory T-cell heterogeneity and the cancer immune response.
Author: Ward-Hartstonge, Kirsten A|Kemp, Roslyn A
PMID: 28983402
Journal: J Pathol Clin Res. 2017 Oct 7;3(4):268-278.
Title: Histopathological and genotypic characterization of metastatic colorectal carcinoma with PD-L1 (CD274)-expression: Possible roles of tumour micro environmental factors for CD274 expression.
Author: Inaguma, Shingo|Lasota, Jerzy|Felisiak-Golabek, Anna|Kowalik, Artur|Wang, Zengfeng|Zieba, Sebastian|Kalisz, Joanna|Ikeda, Hiroshi|Miettinen, Markku
PMID: 29085667
Journal: Oncotarget. 2017 Jun 7;8(43):75361-75371.
Title: Tumor-infiltrating FoxP3(+) Tregs predict favorable outcome in colorectal cancer patients: A meta-analysis.
Author: Hu, Guoming|Li, Zhi'an|Wang, Shimin
PMID: 29088871
Journal: Pathology. 2017 Dec;49(7):721-730.
Title: The prognostic value of cancer stem-like cell markers SOX2 and CD133 in stage III colon cancer is modified by expression of the immune-related markers FoxP3, PD-L1 and CD3.
Author: Miller, T J|McCoy, M J|Hemmings, C|Bulsara, M K|Iacopetta, B|Platell, C F
PMID: 29102042
Journal: Oncotarget. 2017 Jul 25;8(45):79793-79802.
Title: Prediction of radio-responsiveness with immune-profiling in patients with rectal cancer.
Author: Park, In Ja|An, Soyeon|Kim, Sang-Yeob|Lim, Hye Min|Hong, Seung-Mo|Kim, Mi-Ju|Kim, Yun Jae|Yu, Chang Sik
PMID: 29108360
Journal: Front Physiol. 2017 Nov 21;8:950.
Title: The Clinicopathological and Prognostic Implications of FoxP3(+) Regulatory T Cells in Patients with Colorectal Cancer: A Meta-Analysis.
Author: Xu, Peipei|Fan, Wei|Zhang, Zheng|Wang, June|Wang, Ping|Li, Yirong|Yu, Mingxia
PMID: 29209232
Journal: Oncotarget. 2017 Nov 30;8(65):109609-109618.
Title: The synergistic antitumor effect of arsenic trioxide combined with cytotoxic T cells in pulmonary metastasis model of colon cancer.
Author: Wang, Lei|Liang, Wentao|Peng, Na|Hu, Xiang|Xu, Yingxin|Liu, Zhong
PMID: 29312633
Journal: Mucosal Immunol. 2018 Jan;11(1):131-143.
Title: Unique invariant natural killer T cells promote intestinal polyps by suppressing TH1 immunity and promoting regulatory T cells.
Author: Wang, Y|Sedimbi, S|Lofbom, L|Singh, A K|Porcelli, S A|Cardell, S L
PMID: 28401935
Journal: Clin Exp Immunol. 2018 Jan;191(1):32-41.
Title: An increased CD25-positive intestinal regulatory T lymphocyte population is dependent upon Cox-2 activity in the Apc(min/+) model.
Author: Faluyi, O O|Fitch, P|Howie, S E M
PMID: 28940183
Journal: Cancer Epidemiol Biomarkers Prev. 2018 Jan;27(1):103-112.
Title: Regulatory T-cell Genes Drive Altered Immune Microenvironment in Adult Solid Cancers and Allow for Immune Contextual Patient Subtyping.
Author: Brouwer-Visser, Jurriaan|Cheng, Wei-Yi|Bauer-Mehren, Anna|Maisel, Daniela|Lechner, Katharina|Andersson, Emilia|Dudley, Joel T|Milletti, Francesca
PMID: 29133367
Journal: Hum Pathol. 2018 Feb;72:135-143.
Title: Mismatch repair-deficient colorectal cancer: a model of immunogenic and immune cell-rich tumor despite nonsignificant programmed cell death ligand-1 expression in tumor cells.
Author: Le Flahec, Glen|Badic, Bogdan|Guibourg, Briac|Doucet, Laurent|Bail, Jean-Pierre|Marcorelles, Pascale|Schick, Ulrike|Uguen, Arnaud
PMID: 29208565
Journal: J Cancer. 2018 Jan 1;9(1):41-53.
Title: Modulated electro-hyperthermia induced loco-regional and systemic tumor destruction in colorectal cancer allografts.
Author: Vancsik, Tamas|Kovago, Csaba|Kiss, Eva|Papp, Edina|Forika, Gertrud|Benyo, Zoltan|Meggyeshazi, Nora|Krenacs, Tibor
PMID: 29290768
Journal: Sci Signal. 2018 Jan 2;11(511). pii: 11/511/eaan0790.
Title: Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer.
Author: Nie, Yingjie|He, Jiang|Shirota, Hidekazu|Trivett, Anna L|Yang, De|Klinman, Dennis M|Oppenheim, Joost J|Chen, Xin
PMID: 29295954
Journal: J Cancer. 2018 Jan 1;9(2):239-249.
Title: Early and Partial Reduction in CD4(+)Foxp3(+) Regulatory T Cells during Colitis-Associated Colon Cancer Induces CD4(+) and CD8(+) T Cell Activation Inhibiting Tumorigenesis.
Author: Olguin, Jonadab E|Medina-Andrade, Itzel|Molina, Emmanuel|Vazquez, Armando|Pacheco-Fernandez, Thalia|Saavedra, Rafael|Perez-Plasencia, Carlos|Chirino, Yolanda I|Vaca-Paniagua, Felipe|Arias-Romero, Luis E|Gutierrez-Cirlos, Emma B|Leon-Cabrera, Sonia A|Rodri
PMID: 29344269
Journal: Oncoimmunology. 2017 Nov 27;7(3):e1396402.
Title: Tumor lymphocyte immune response to preoperative radiotherapy in locally advanced rectal cancer: The LYMPHOREC study.
Author: Mirjolet, C|Charon-Barra, C|Ladoire, S|Arbez-Gindre, F|Bertaut, A|Ghiringhelli, F|Leroux, A|Peiffert, D|Borg, C|Bosset, J F|Crehange, G
PMID: 29399395
Journal: J Natl Cancer Inst. 2018 Sep 1;110(9):975-984.
Title: The Heterogeneity Between Lynch-Associated and Sporadic MMR Deficiency in Colorectal Cancers.
Author: Liu, Guo-Chen|Liu, Ran-Yi|Yan, Jun-Ping|An, Xin|Jiang, Wu|Ling, Yi-Hong|Chen, Jie-Wei|Bei, Jin-Xin|Zuo, Xiao-Yu|Cai, Mu-Yan|Liu, Ze-Xian|Zuo, Zhi-Xiang|Liu, Ji-Hong|Pan, Zhi-Zhong|Ding, Pei-Rong
PMID: 29471527
Journal: Ann Surg Oncol. 2018 May;25(5):1374-1380.
Title: The Negative Impact of Body Mass Index on the Tumor Microenvironment in Colon Cancer: Results of a Prospective Trial.
Author: Flaherty, Devin C|Jalas, John R|Sim, Myung S|Stojadinovic, Alexander|Protic, Mladjan|Lee, Delphine J|Bilchik, Anton J
PMID: 29532344
Journal: J Immunol. 2018 May 1;200(9):3291-3303.
Title: Deregulated Mucosal Immune Surveillance through Gut-Associated Regulatory T Cells and PD-1(+) T Cells in Human Colorectal Cancer.
Author: Fujimoto, Hanae|Saito, Yoriko|Ohuchida, Kenoki|Kawakami, Eiryo|Fujiki, Saera|Watanabe, Takashi|Ono, Rintaro|Kaneko, Akiko|Takagi, Shinsuke|Najima, Yuho|Hijikata, Atsushi|Cui, Lin|Ueki, Takashi|Oda, Yoshinao|Hori, Shohei|Ohara, Osamu|Nakamura, Masafumi|Sai
PMID: 29581358
Journal: Transl Oncol. 2018 Aug;11(4):890-899.
Title: Skin Allografting Activates Anti-tumor Immunity and Suppresses Growth of Colon Cancer in Mice.
Author: Li, Xiang|Lan, Xu|Wang, Grace|Liu, Yi|Zhao, Ke|Lu, Shan-Zheng|Xu, Xiao-Xi|Shi, Gang-Gang|Ye, Kui|Zhang, Bao-Ren|Zhao, Yi-Ming|Han, Hong-Qiu|Du, Cai-Gan|Ichim, Thomas E|Wang, Hao
PMID: 29793087
Journal: Invest New Drugs. 2018 May 28. pii: 10.1007/s10637-018-0609-6.
Title: Immuno-therapeutic potential of Schistosoma mansoni and Trichinella spiralis antigens in a murine model of colon cancer.
Author: Eissa, Maha M|Ismail, Cherine A|El-Azzouni, Mervat Z|Ghazy, Amany A|Hadi, Mona A
PMID: 29808307
Journal: Anticancer Res. 2018 Jun;38(6):3367-3373.
Title: Programmed Cell Death Ligand 1 Expression Is an Independent Prognostic Factor in Colorectal Cancer.
Author: Enkhbat, Tumenjin|Nishi, Masaaki|Takasu, Chie|Yoshikawa, Kozo|Jun, Higashijima|Tokunaga, Takuya|Kashihara, Hideya|Ishikawa, Daichi|Shimada, Mitsuo
PMID: 29848685
Journal: Oncotarget. 2018 May 18;9(38):25216-25224.
Title: Peritumoral endothelial indoleamine 2, 3-dioxygenase expression is an early independent marker of disease relapse in colorectal cancer and is influenced by DNA mismatch repair profile.
Author: Meireson, Annabel|Chevolet, Ines|Hulstaert, Eva|Ferdinande, Liesbeth|Ost, Piet|Geboes, Karen|De Man, Marc|Van de Putte, Dirk|Verset, Laurine|Kruse, Vibeke|Demetter, Pieter|Brochez, Lieve
PMID: 29861865
Journal: Oncoimmunology. 2018 Feb 22;7(6):e1435227.
Title: Potential immune priming of the tumor microenvironment with FOLFOX chemotherapy in locally advanced rectal cancer.
Author: Roxburgh, Campbell S|Shia, Jinru|Vakiani, Efsevia|Daniel, Tanisha|Weiser, Martin R
PMID: 29872576
Journal: JCI Insight. 2018 Jun 7;3(11). pii: 120631.
Title: Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.
Author: Gyori, David|Lim, Ee Lyn|Grant, Francis M|Spensberger, Dominik|Roychoudhuri, Rahul|Shuttleworth, Stephen J|Okkenhaug, Klaus|Stephens, Len R|Hawkins, Phillip T
PMID: 29875321
Journal: J Surg Oncol. 2018 Jul;118(1):68-76.
Title: Prognostic value of intra-tumoral CD8(+) /FoxP3(+) lymphocyte ratio in patients with resected colorectal cancer liver metastasis.
Author: Sideras, Kostandinos|Galjart, Boris|Vasaturo, Angela|Pedroza-Gonzalez, Alexander|Biermann, Katharina|Mancham, Shanta|Nigg, Alex L|Hansen, Bettina E|Stoop, Hans A|Zhou, Guoying|Verhoef, Cornelis|Sleijfer, Stefan|Sprengers, Dave|Kwekkeboom, Jaap|Bruno, Marc
PMID: 29878369
Journal: Clin Exp Pharmacol Physiol. 2018 Oct;45(10):1002-1009.
Title: Co-expression of LAG3 and TIM3 identifies a potent Treg population that suppresses macrophage functions in colorectal cancer patients.
Author: Ma, Qiang|Liu, Junning|Wu, Guoliang|Teng, Mujian|Wang, Shaoxuan|Cui, Meng|Li, Yuantao
PMID: 29905955
Journal: Anticancer Res. 2018 Jul;38(7):4159-4167.
Title: The Impact of Immune Interaction on the Metastatic Infiltration of Colorectal Carcinoma to Lymph Nodes.
Author: Vycital, Ondrej|Dubova, Magdalena|Palek, Richard|Hosek, Petr|Branzovsky, Jindrich|Treska, Vladislav|Daum, Ondrej|Liska, Vaclav
PMID: 29970545
Journal: Cancer Immunol Res. 2018 Sep;6(9):1082-1092.
Title: RORgammat-Expressing Tregs Drive the Growth of Colitis-Associated Colorectal Cancer by Controlling IL6 in Dendritic Cells.
Author: Rizzo, Angelamaria|Di Giovangiulio, Martina|Stolfi, Carmine|Franze, Eleonora|Fehling, Hans-Joerg|Carsetti, Rita|Giorda, Ezio|Colantoni, Alfredo|Ortenzi, Angela|Rugge, Massimo|Mescoli, Claudia|Monteleone, Giovanni|Fantini, Massimo C
PMID: 29991500
Journal: J Immunol Res. 2018 Jun 14;2018:6985031.
Title: STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4(+) T Cells of Patients with Colorectal Cancer.
Author: Ma, Hulin|Gao, Weishi|Sun, Xiaoxia|Wang, Weixing
PMID: 30013992
Journal: Cell Immunol. 2018 Oct;332:129-133.
Title: Deletion of GARP on mouse regulatory T cells is not sufficient to inhibit the growth of transplanted tumors.
Author: Vermeersch, E|Lienart, S|Collignon, A|Lucas, S|Gallimore, A|Gysemans, C|Unutmaz, D|Vanhoorelbeke, K|De Meyer, S F|Maes, W|Deckmyn, H
PMID: 30093071
Journal: Pathology. 2018 Oct;50(6):607-612.
Title: Immunological environment in colorectal cancer: a computer-aided morphometric study of whole slide digital images derived from tissue microarray.
Author: Eyraud, Daniel|Granger, Benjamin|Bardier, Armelle|Loncar, Yann|Gottrand, GaElle|Le Naour, Gilles|Siksik, Jean-Michel|Vaillant, Jean-Christophe|Klatzmann, David|Puybasset, Louis|Charlotte, Frederic|Augustin, Jeremy
PMID: 30166125
Journal: Cancer Immunol Res. 2018 Sep 18. pii: 2326-6066.CIR-18-0174.
Title: Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status.
Author: Hamada, Tsuyoshi|Zhang, Xuehong|Mima, Kosuke|Bullman, Susan|Sukawa, Yasutaka|Nowak, Jonathan A|Kosumi, Keisuke|Masugi, Yohei|Twombly, Tyler S|Cao, Yin|Song, Mingyang|Liu, Li|da Silva, Annacarolina|Shi, Yan|Gu, Mancang|Li, Wanwan|Koh, Hideo|Nosho, Katsuhik
PMID: 30228205
Journal: J Natl Cancer Inst. 2018 Oct 11. pii: 5127125.
Title: Smoking and Risk of Colorectal Cancer Sub-Classified by Tumor-Infiltrating T Cells.
Author: Hamada, Tsuyoshi|Nowak, Jonathan A|Masugi, Yohei|Drew, David A|Song, Mingyang|Cao, Yin|Kosumi, Keisuke|Mima, Kosuke|Twombly, Tyler S|Liu, Li|Shi, Yan|da Silva, Annacarolina|Gu, Mancang|Li, Wanwan|Nosho, Katsuhiko|Keum, NaNa|Giannakis, Marios|Meyerhardt, J
PMID: 30312431